Publication:
Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage (1999)
Author(s): K. Chapman;Z. Mustafa;C. Irven;A. J. Carr;K. Clipsham;A. Smith;J. Chitnavis;J. S. Sinsheimer;V. A. Bloomfield;M. McCartney;O. Cox;L. R. Cardon;B. Sykes;J. Loughlin
- : Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage
Abstract: We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P
Notes: Journal Article Research Support, Non-U.S. Gov't United states
- Short Title: Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage
- Alternate Journal: American journal of human genetics
- Date: Jul
- Journal: Am J Hum Genet
- Volume: 65
- Issue: 1
- Pages: 167-74
- Publication type: Article
- Bibliographic status: Published
- Author Address: Wellcome Trust Centre for Human Genetics, Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10364529
Keywords: Arthroplasty, Replacement Arthroplasty, Replacement, Hip *Chromosomes, Human, Pair 11 Female *Genetic Predisposition to Disease Humans *Linkage (Genetics) Lod Score Male Microsatellite Repeats Middle Aged Osteoarthritis/*genetics
