Nucleic Acid-Protein Interfaces
Ribonucleoproteins (RNPs) assembled onto non-coding transcripts, are essential for gene expression and maintenance of chromatin structure.
The RNA-biology group at ICaMB working in this research area studies transcription through to the biogenesis of ribonucleoproteins including:
- Biogenesis and function of box C/D small nucleolar RNAs (snoRNAs)
- Gene regulation by natural antisense transcripts
Outstanding insights have been revealed into the:
- Molecular basis of snoRNP assembly
- SnoRNP biogenesis
- Details of human ribosome biogenesis
- Atypical mechanism of primer synthesis for DNA-replication by RNA polymerase
- Proof reading function of RNA polymerase
Other exciting areas of emphasis within this research area are:
- Generation of DNA polymerases with novel improved properties
- Drug/DNA interactions
- The molecular pharmacology of anti DNA topoisomerase drugs
- Impact of single nucleotide polymorphisms in the variability of plasma exposure to drug molecules
Find out more about our people.
