Dynamic control of the DNA replication initiation protein DnaA by Soj/ParA
Heath Murray and Jeff Errington
Context and Significance:
parABS genes are conserved throughout the prokaryotic kingdom. Previous work has revealed that parABS mutations are pleiotropic, affecting DNA replication, chromosome segregation, cell division, and various developmental processes. However, the mechanism underlying the activities of the parABS genes has remained unclear. Murray and Errington have found that the Bacillus subtilis ParA/Soj protein is a dynamically localized regulator of the key DNA replication initiation protein DnaA. Their work suggests that this primary activity of ParA/Soj accounts for several of the diverse parABS mutant phenotypes, underscoring the general importance of regulating the initiation of DNA replication for proper cell growth and development.
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