People - Institute for Cell and Molecular Bioscience

Alan Leake
Technician

Email: alan.leake@ncl.ac.uk
Telephone: NGH ext 22507
Fax: +44 (0) 191 256 3445
Address: Institute for Ageing and Health
Newcastle University
Ageing Research Laboratories
Campus for Ageing and Vitality
Newcastle upon Tyne, NE4 5PL

Publications

Kurz T, Leake A, von Zglinicki T, Brunk UT. Lysosomal redox-active iron is important for oxidative stress-induced DNA damage. In: Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May be Forseeable. 2004, Cambridge, UK: New York Academy of Sciences.
Kurz T, Leake A, Von Zglinicki T, Brunk UT. Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochemical Journal 2004, 378(3), 1039-1045.
Kurz T, Leake A, von Zglinicki T, Brunk UT. Lysosomal redox-active iron is important for oxidative stress-induced DNA damage. In: Free Radical Research: Meeting on Free Radicals and Oxidative Stress. 2003, Ioannina, Greece: Informa Healthcare.
Burkle A, Beneke S, Brabeck C, Leake A, Meyer R, Muiras M-L, Pfeiffer R. Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity. In: 2nd Euroconference on Biological Ageing. 2002, Spetses, Greece: Experimental Gerontology, Elsevier.
Neill D, Hughes D, Leake A, Morris C, Jones D, Oakley A, Edwardson J, Estibeiro P. Neuritogenic-neurotoxic effects of membrane-associated forms of amyloid precursor protein. Dementia and Geriatric Cognitive Disorders 2001, 12(1), 40-51.
Leake A, Morris CM, Whateley J. Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease. Neuroscience Letters 2000, 291(3), 201-203.
Lamb, H., Christie, J., Singleton, A.B., Leake, A., Perry, R.H., Ince, P.G., Mckeith, I.G., Melton, L.M., Edwardson, J.A., Morris, C.M. Apolipoprotein and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies. Neurology 1998, 50, 388-391.
Lamb, H., Christie, J., Singleton, A.B., Leake, A., Perry, R.H., Ince, P.G., McKeith, I.G., Melton, L.M., Edwardson, J.A., Morris, C.M. Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies - Distinctions between diseases. Neurology 1998, 50, 388-391.
Singleton AB, Lamb H, Leake A, McKeith IG, Ince PG, Perry RH, Morris CM. No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies. NeuroReport 1997, 8(16), 3637-3639.
Singleton AB, Lamb H, Leake A, McKeith IG, Perry RH, Morris CM. No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease. Neuroscience Letters 1997, 234(1), 19-22.
Benjamin, R., Leake, A., McArthur, F.K., Candy, J.M., Ince, P.G., Edwardson, J.A., Torvik, A., Morris, C.M., Bjertness, E. Apolipoprotein genotype and Alzheimer's disease in an elderly Norwegian cohort. Neurodegeneration 1996, 5, 43-47.
Christie, J., Lamb, H., Singleton, A.B., Leake, A., Melton, L.S., Perry, R.H., McKeith, I.G., Morris, C.M. Determination of the alpha-1 anti-chymotrypsin polymorphism in Alzheimer's disease. Alzheimer's Research 1996, 2, 201-204.
Neill, D., Leake, A., Hughes, D., Keith, A.B., Taylor, G.A., Allsop, D., Rima, B.K., Morris, C.M., Candy, J.M., Edwardson, J.A. Effect of aluminium on expression and processing of amyloid precursor protein. Journal of Neuroscience Research 1996, 46, 395-403.
Morris CM, Massey HM, Benjamin R, Leake A, Broadbent C, Griffiths M, Lamb H, Brown A, Ince PG, Tyrer S, Thompson P, McKeith IG, Edwardson JA, Perry RH, Perry EK. Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias. In: Meeting on New Trends in the Diagnosis and Therapy of Non-Alzheimer's Dementia. 1996, Vienna, Austria: Springer Wien.
Morris, C.M., Benjamin, R., Leake, A., McArthur, F.K., Candy, J.M., Ince, P.G., Torvik, A., Bjertness, E., Edwardson, J.A. Effect of apolipoprotein genotype on Alzheimer's disease neuropathology in a cohort of elderly Norwegians. Neuroscience Letters 1995, 201, 45-48.
Benjamin R, Leake A, Ince PG, Perry RH, McKeith IG, Edwardson JA, Morris CM. Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy body and Alzheimer's disease. Neurodegeneration 1995, 4(4), 443-448.
Benjamin, R., Leake, A., Edwardson, J.A., McKeith, I.G., Ince, P.G., Perry, R.H., Morris, C.M. Apolipoprotein genes in Lewy body and Parkinson's disease. Lancet 1994, 343, 1565.
Benjamin, R., Leake, A., McArthur, F.K., Ince, P.G., Candy, J.M., Edwardson, J.A., Morris, C.M., Bjertness, E. Protective effect of ApoE 2 in Alzheimer's disease. Lancet 1994, 344, 473.
Leake, A., Ferrier, I.N. Alterations in neuropeptides in aging and disease: pathophysiology and potential for clinical intervention. Drugs and Aging 1993, 3, 408-427.
Gilchrist, A.B., Leake, A., Charlton, B.G. Innervation of the human adrenal cortex: simultaneous visualisation using acetylcholin-esterase histochemistry and dopamine ß-hydroxylase immunohistochemisty. Acta Anat 1993, 146, 31-35.
Leake, A., Moore, P.B., Leitch, M., Ayre, K., Perry, R.H., Ince, P.G., Ferrier, I.N. The serotonergic system Alzheimer's disease and normal neocortical post-mortem brain: neurochemical and clinical correlates. Neurology, Psychiatry Brain Research 1993, 2, 53-59.
Ferrier, I.N., Lister, E.S., Riordan, D.M., Scott, J.L., Lett, D.J., Leake, A., McKeith, I.G. A follow-up study of elderly depressives and Alzheimer-type dementia - relationship with DST status. International Journal of Geriatric Psychiatry 1991, 6, 279-286.
Leake, A., Perry, E.K., Perry, R.H., Jabeen, S., Fairbairn, A.F., McKeith, I.G., Ferrier, I.N. Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations. Biological Psychiatry 1991, 29(4), 357-364.
Leake, A., Fairbairn, A.F., McKeith, I.G., Ferrier, I.N. Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: neurochemical and clinical correlates. Psychiatry Research 1991, 39, 155-165.
Yates, M., Leake, A., Candy, J.M., Fairbairn, A.F., McKeith, I.G., Ferrier, I.N. 5HT2 receptor changes in major depression. Biological Psychiatry 1990, 27(5), 489-496.
Leake, A., Perry, E.K., Perry, R.H., Fairbairn, A.F., Ferrier, I.N. Cortical concentrations of corticotropin-releasing hormone and its receptor in Alzheimer type dementia and major depression. Biological Psychiatry 1990, 28(7), 603-608.
Ferrier, I.N., Leake, A. Peptides in the neocortex in Alzheimer's disease and ageing. Psychoneuroendocrinology 1990, 15(2), 89-95.
Leake, A., Charlton, B.G., Lowry, P.J., Jackson, S., Fairbairn, A., Ferrier, I.N. Plasma N-POMC, ACTH and cortisol concentrations in a psychogeriatric population. British Journal of Psychiatry 1990, 156, 676-679.
Ferrier, I.N., Leake, A., Taylor, G.A., McKeith, I.G., Fairbairn, A.F., Robinson, C.J., Francis, R.M., Edwardson, J.A. Reduced gastrointestinal absorption of calcium in dementia. Age and Ageing 1990, 19(6), 368-375.
Leake, A., Griffiths, H.W., Pascual, J.A., Ferrier, I.N. Corticosteroid-binding globulin in depression. Clinical Endocrinology 1989, 30(1), 39-45.
Leake, A., Griffiths, H.W., Ferrier, I.N. Plasma N-POMC, ACTH and cortisol following hCRH administration in major depression and dysthymia. Journal of Affective Disorders 1989, 17(1), 57-64.
Charlton, B.G., Ferrier, I.N., Leake, A., Edwardson, J.A., Eccleston, D., Crowcombe, K., McLean, J., Jackson, S., Lowry, P. A multiple timepoint study of N-terminal pro-opiomelanocortin in depression using a two-site recognition immunoradiometric assay. Clinical Endocrinology 1988, 28(2), 165-172.
Ferrier, I.N., Pascual, J., Charlton, B.G., Wright, C., Leake, A., Griffiths, H.W., Fairbairn, A.F., Edwardson, J.A. Cortisol, ACTH, and dexamethasone concentrations in a psychogeriatric population. Biological Psychiatry 1988, 23(3), 252-260.
Ferrier, I.N., Perry, R.H., Fairbairn, A.F., McKeith, I.G., Leake, A., Yates, M. Post-mortem investigation of neurochemical and neuro-peptidergic hypothesis of depression. Psychopharmacology 1988, 96 (suppl), 98.
Ferrier, I.N., Leake, A., Charlton, B.G., Griffiths, H.W. Pro-opiomelanocortin related peptides in depression. Psychopharmacology 1988, 96 (suppl), 96.
Charlton, B.G., Leake, A., Wright, C., Fairbairn, A.F., McKeith, I.G., Candy, J.M., Ferrier, I.N. Somatostatin content and receptors in the cerebral cortex of depressed and control subjects. Journal of Neurology, Neurosurgery & Psychiatry 1988, 51(5), 719-721.
Charlton, B.G., Wright, C., Leake, A., Ferrier, I.N., Cheetham, S.C., Horton, R.W., Crompton, M.R., Katona, C.L. Somatostatin immunoreactivity in postmortem brain from depressed suicides. Archives of General Psychiatry 1988, 45(6), 597-598.
O'Brien, G., Hassanyeh, F., Leake, A., Schapira, K., White, M., Ferrier, I.N. The dexamethasone suppression test in bulimia nervosa. British Journal of Psychiatry 1988, 152, 654-656.
Charlton, B.G., Leake, A., Wright, C., Griffiths, H.W., Ferrier, I.N. A combined study of cortisol, ACTH and dexamethasone concentrations in major depression. Multiple time-point sampling. British Journal of Psychiatry 1987, 150, 791-796.
Charlton, B.G., Ferrier, I.N., Gibson, A.M., Biggins, J.A., Leake, A., Wright, C., Edwardson, J.A. A preliminary study of plasma alpha MSH concentrations in depressed patients and normal subjects. Biological Psychiatry 1987, 22(10), 1276-1279.
Charlton, B.G., Leake, A., Ferrier, I.N., Linton, E.A., Lowry, P.J. Corticotropin-releasing factor in plasma of depressed patients and controls. Lancet 1986, 1(8473), 161-162.
Ferrier, I.N., Charlton, B.G., Leake, A., Wright, C., Eccleston, D., Edwardson, J.A. Cortisol and ACTH secretion in major depression. Journal of Endocrinological Investigation 1985, 8, 62.
Habib, F.K., Leake, A., Chisholm, G.D. Evidence for the presence of a prolactin receptor in the human prostate. Advances in Urology, Oncology and Endocrinology 1984, 143-150.
Leake, A., Chisholm, G.D., Habib, F.K. Interaction between prolactin and zinc in the human prostate gland. Journal of Endocrinology 1984, 102(73-76).
Habib, F.K., Leake, A., Benyon, L., Chisholm, G.D. Studies on the relationship between zinc and androgens in the human prostate. Advances in Urology, Oncology and Endocrinology 1984, 63-70.
Leake, A., Chisholm, G.D., Busuttil, A., Habib, F.K. Sub-cellular distribution of zinc in the malignant human prostate: evidence for a direct zinc and androgen interaction. Acta Endocrinologica 1984, 281-288.
Leake, A., Chisholm, G.D., Habib, F.K. The effect of zinc on the 5 -reduction of testosterone by the hyperplastic human prostate gland. Journal of Steroid Biochemistry 1984, 20, 651-655.
Leake, A., Chisholm, G.D., Habib, F.K. Characterization of the prolactin receptor in human prostate. Journal of Endocrinology 1983, 99, 321-328.
Habib, F.K., Leake, A., Chisholm, G.D. Does zinc regulate the actions of androgens in the human prostate?. Prostate 1983, 6, 655.
Bowman, S.P., Jones, C.A., Leake, A., Morris, I.D. The biological activity of a single dose of tamoxifen in the adult ovariectomized rat. British Journal of Pharmacology 1983, 78, 617-622.
Bowman, S.P., Leake, A., Morris, I.D. Biological activity and steroid receptor interactions of cyclofenil with oestrogen target tissues of the brain, pituitary and uterus of the rat. Journal of Reproductive Fertility 1982, 65, 355-366.
Bowman, S.P., Leake, A., Morris, I.D. Hypothalamic, pituitary and uterine cytoplasmic and nuclear oestrogen receptors and their relationship to the serum concentration of tamoxifen and its metabolite, 4-hydrotamoxifen, in the ovariectomized rat. Journal of Endocrinology 1982, 94, 167-175.
Bowman, S.P., Leake, A., Miller, M., Morris, I.D. Agonist and antagonist activity of en-clomiphene upon oestrogen-mediated events in the uterus, pituitary gland and brain of the rat. Journal of Endocrinology 1981, 88, 367-374.
Bowman, S.P., Leake, A., Morris, I.D. Time-related effects of en-clomiphene upon central and peripheral oestrogen target tissues and cytoplasmic receptors. Journal of Endocrinology 1981, 89, 117-128.

Newcastle University

Institute for Cell and Molecular Biosciences

Alan Leake Technician

Alan Leake
Technician