Prof. Brian Morgan
Professor of Yeast Molecular Biology
- Email: B.A.Morgan@ncl.ac.uk
- Telephone: +44 (0) 191 222 7694
- Fax: +44 (0) 191 222 7424
- Address: Institute for Cell and Molecular Biosciences
The Medical School
University of Newcastle upon Tyne
Framlington Place
Newcastle upon Tyne
NE2 4HH
Research Interests
My laboratory is interested in the regulation of the oxidative stress response and the regulation of the cell division cycle in eukaryotes. Specifically we are investigating the regulation of gene expression important for these cellular events and exploring the signal transduction pathways which regulate this gene expression. We use the yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe as model organisms to study these regulatory mechanisms as many aspects of these cellular processes are conserved in all eukaryotes. This choice of organisms allows us to apply a wide range of experimental tools including classical genetic and biochemical approaches as well as standard molecular biology techniques.
Selected Publications
- Oláhová M, Taylor SR, Khazaiphoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc. Natl. Acad. Sci 2008, 105, 19839-44.
- B. A. Morgan;E. A. Veal. Functions of typical 2-Cys peroxiredoxins in yeast. Subcell Biochem 2007, 44, 253-65.
- Veal EA, Day AM, Morgan BA. Hydrogen peroxide-sensing and signaling. Molecular Cell 2007, 26(1), 1-14.
- Darieva Z, Bulmer R, Pic-Taylor A, Doris KS, Geymonat M, Sedgwick SG, Morgan BA, Sharrocks AD. Polo kinase controls cell-cycle-dependent transcription by targeting a coactivator protein. Nature 2006, 444(7118), 494-498.
- Bozonet SM, Findlay VJ, Day AM, Cameron J, Veal EA, Morgan BA. Oxidation of a Eukaryotic 2-Cys Peroxiredoxin Is a Molecular Switch Controlling the Transcriptional Response to Increasing Levels of Hydrogen Peroxide. The Journal of Biological Chemistry 2005, 280(24), 23319-23327.
- Veal EA, Findlay VJ, Day AM, Bozonet SM, Evans JM, Quinn J, Morgan BA. A 2-Cys Peroxiredoxin Regulates Peroxide-Induced Oxidation and Activation of a Stress-Activated MAP Kinase. Molecular Cell 2004, 15(1), 129-139.
Qualifications
BSc Molecular Biology (University of Glasgow)
PhD Molecular Biology (University of Edinburgh)
