Newcastle University

Qualifications 

 BSc (Hons) Biomedical Science (Physiology), University of Aberdeen, 2000

PhD, University of Newcastle upon Tyne, 2004

Memberships

The Physiological Society

Nutrient and Drug Transporters in Epithelia

• SLC solute carriers
• Amino acid and di/tripeptide transporters 
• H⁺-coupled transporters
• Neurohormonal and nutrient regulation of transport
• Drug transport in the small intestine
• Intracellular pH regulation
• Nutrient and drug transporters in cancer

Undergraduate Teaching

PSC1002 Physiology

1 lecture on "Homeostasis and The Autonomic Nervous System"
3 lectures on "Gastrointestinal Tract"

• Thwaites DT, Anderson CMH. The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. British Journal of Pharmacology 2011, 164(7), 1802-1816.
• Edwards N, Anderson CMH, Gatfield KM, Jevons MP, Ganapathy V, Thwaites DT. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (SLC36A2). Biochimica et Biophysica Acta: Biomembranes 2011, 1808(1), 260-270.
• Anderson CMH, Thwaites DT. Hijacking solute carriers for proton-coupled drug transport. Physiology 2010,25 6 364-377.
• Anderson CMH, Jevons M, Thangaraju M, Edwards N, Conlon NJ, Woods S, Ganapathy V, Thwaites DT. Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H⁺-coupled nutrient carriers co-expressed in the small intestine. Journal of Pharmacology and Experimental Therapeutics 2010, 332(1), 220-228.
• Anderson CMH, Howard A, Walters JRF, Ganapathy V, Thwaites DT. Taurine uptake across the human intestinal brush-border membrane is via two transporters: H⁺-coupled PAT1 (SLC36A1) and Na⁺- and Cl^--dependent TauT (SLC6A6). Journal of Physiology 2009, 587(4), 731-744.
• Anderson CMH, Ganapathy V, Thwaites DT. Human solute carrier SLC6A14 is the beta-alanine carrier. Journal of Physiology 2008, 586(17), 4061-4067.
• Anderson CMH, Thwaites DT. Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3). Biochimica et Biophysica Acta: Biomembranes 2007, 1768(7), 1822-1829.
• Thwaites DT, Anderson CMH. H⁺-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Experimental Physiology 2007, 92(4), 603-619.
• Thwaites DT, Anderson CMH. Deciphering the mechanisms of intestinal imino (and amino) acid transport: The redemption of SLC36A1. Biochimica et Biophysica Acta: Biomembranes 2007, 1768(2), 179-197.
• Anderson CMH, Thwaites DT. Indirect regulation of the intestinal H⁺-coupled amino acid transporter hPAT1 (SLC36A1). Journal of Cellular Physiology 2005, 204(2), 604-613.
• Anderson CMH, Grenade DS, Boll M, Foltz M, Wake KA, Kennedy DJ, Munck LK, Miyauchi S, Taylor PM, Campbell FC, Munck BG, Daniel H, Ganapathy V, Thwaites DT. H⁺/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat. Gastroenterology 2004, 127(5), 1410-1422.
• Anderson CMH, Mendoza ME, Kennedy DJ, Raldua D, Thwaites DT. Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC₁ receptor in a human enterocyte-like cell line (Caco-2). British Journal of Pharmacology 2003, 138(4), 564-573.
• Chen Z, Fei Y-J Y, Anderson CMH, Wake K, Miyauchi S, Huang W, Thwaites DT, Ganapathy V. Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. Journal of Physiology 2003, 546(2), 349-361.
• Boll M, Foltz M, Anderson CMH, Oechsler C, Kottra G, Thwaites DT, Daniel H. Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1. Molecular Membrane Biology 2003, 20(3), 261-269.
• Thwaites DT, Kennedy D, Raldua D, Anderson CMH, Mendoza ME, Bladen C, Simmons N. H⁺/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na⁺/H⁺ exchanger. Gastroenterology 2002, 122(5), 1322-1333.