Professor Colin Brooks
Professor of Cellular Immunology
- Email: colin.brooks@ncl.ac.uk
- Telephone: +44 (0) 191 222 7813
- Fax: +44 (0) 191 222 7736
- Personal Website: http://www.staff.ncl.ac.uk/colin.brooks
- Address: Institute for Cell and Molecular Biosciences
Medical School
University of Newcastle upon Tyne
2nd Floor William Leech Building
Framlington Place
Newcastle upon Tyne
NE2 4HH
Research Interests
The major interest of my lab. is NK cells, a set of immune cells with prominent granules that plays an important role in defence against infectious disease and cancer. Our research is focussed on the development and recognition capabilities of these cells. Both are controlled by surface receptors, many of which belong to multigene families such as the NKRP1, NKG2, and Ly49 families, and in recent years my lab. has been involved in studies of each of these families. The group has an international reputation, collaborates with several laboratories in the UK and abroad, and over the last 20 years has been continuously funded by grants from the BBSRC and MRC.Postgraduate Supervision
Yes
- Gays F, Koh AS, Mickiewicz KM, Aust JG, Brooks CG. Comprehensive analysis of transcript start sites in Ly49 genes reveals an unexpected relationship with gene function and a lack of upstream promoters. PLoS ONE 2011, 6(3), e18475.
- Aust JG, Gays F, Hussain F, Butcher GW, Kist R, Peters H, Brooks CG. Mice Lacking Ly49E Show Normal NK Cell Development and Provide Evidence for Probabilistic Expression of Ly49E in NK Cells and T Cells. Journal of Immunology 2011, 186(4), 2013-2023.
- Kveberg L, Dai KZ, Inngjerdingen M, Brooks CG, Fossum S, Vaage JT. Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse. Immunogenetics 2011, 63(7), 429-436.
- Fortenbery NR, Paraiso KH, Taniguchi M, Brooks C, Ibrahim L, Kerr WG. SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation.. Journal of Immunology 2010, 184, 5065-74.
- Aust JG, Gays F, Mickiewicz KM, Buchanan E, Brooks CG. The Expression and Function of the NKRP1 Receptor Family in C57BL/6 Mice. Journal of Immunology 2009, 183(1), 106-116.
- Brooks CG. Ly49 receptors: not always a class I act?. Blood 2008. , 112(13), 4789-4790.
- Rouhi A, Brooks CG, Takei F, Mager DL. Plasticity of Ly49g expression is due to epigenetics. Molecular Immunology 2007, 44(5), 821-826.
- Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG. Ly49B is expressed on multiple subpopulations of myeloid cells. Journal of Immunology 2006, 177(9), 5840-5851.
- Ugrinovic S, Brooks CG, Robson J, Blacklaws A, Hormaeche CE, Robinson JH. H2-M3 MHC Class Ib-restricted CD8 T Cells Induced by S. typhimurium Infection Recognize Proteins Released by Salmonella. Infection and Immunity 2005,73 12 8002-8008.
- Brooks CG, Anderson SK, Makrigiannis AP. Ly49F. London, UK:Nature Publishing Group,2005. Available at :http://dx.doi.org/10.1038/mp.a001425.01.
- Gays F, Martin K, Kenefeck R, Aust JG, Brooks CG. Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. Journal of Immunology 2005, 175(5), 2938-2947.
- Toomey JA, Gays F, Foster D, Brooks CG. Cytokine requirements for the growth and development of mouse NK cells in vitro. Journal of Leukocyte Biology 2003,74 2 233-242.
- Fraser KP, Gays F, Robinson JH, Van Beneden K, Leclercq G, Vance RE, Raulet DH, Brooks CG. NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2. European Journal of Immunology 2002, 32(3), 868-878.
- Gays F, Fraser KP, Toomey JA, Diamond AG, Millrain MM, Dyson PJ, Brooks CG. Functional analysis of the molecular factors controlling Qa1-mediated protection of target cells from NK lysis. Journal of Immunology 2001, 166(3), 1601-1610.
- Robinson R, Brooks C, Halsall JP, Hopkins PM, Iles DE, Shaw MA, West SP, Ellis FR, Curran JL, Brown S, Hall WJ. Towards best practice guidelines for the genetic diagnosis of malignant hyperthermia susceptibility. In: JOURNAL OF MEDICAL GENETICS. 2000.
