Institute for Cell and Molecular Biosciences

Staff Profile

Dr Filippo Scialo

Research Associate

Background

 

I obtained my PhD in Biology in 2011 inItaly after receiving additional training at Max Planck Institute in Jena (Germany) funded by an EMBO short term fellowship. After graduation, I became interested in studying the role mitochondria play in the aging process and in 2012 I started my postdoctoral research at the Institute of Biomedical Technology (Finland) in the laboratory of Dr Alberto Sanz. There I acquired expertise in the use of Drosophila melanogaster in ageing research, working on novel fly models in order to manipulate mitochondrial function in vivo. In March 2014, I started as a Research Associate at the Institute of Ageing, Newcastle University where I am exploring the possibilities of using alternative enzymes to modify mitochondrial function in normal and pathological situations. My current project is focused on understanding the role that mitochondrial reactive oxygen species (mtROS) play in the process of ageing. Using Drosophila melanogaster as model system we have created novel fly models and tools that allow the modulation of mitochondrial Reactive Oxygen Species production in vivo. Through changes in mtROS I am able to alter the lifespan of the flies. Currently, I am investigating the pathway(s) involved in lifespan extension in order to identify new strategies to delay ageing and the onset of age-related diseases.

Publications