Dr Heather LambSenior Research Associate
Email: heather.lamb@ncl.ac.uk Telephone: +44 (0) 191 222 7673 / 7954 Address: Institute for Cell and Molecular Biosciences
Varsaki A, Lamb HK, Eleftheriadou O, Vandera E, Thompson P, Moncalian G, de la Cruz F, Hawkins AR, Drainas C. Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1 .
FEBS Letters 2012, 586 (6), 675-679.
Tizon L, Otero JM, Prazeres VFV, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, Gonzalez-Bello C. A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors .
Journal of Medicinal Chemistry 2011, 54 (17), 6063-6084.
Stamp AL, Owen P, El Omari K, Lockyer M, Lamb HK, Charles IG, Hawkins AR, Stammers DK. Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351 .
Proteins 2011, 79 (7), 2352-2357.
Paz S, Tizon L, Otero JM, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Lapthorn AJ, Castedo L, Gonzalez-Bello C. Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase .
ChemMedChem 2011, 6 (2), 266-272.
Peón A, Otero J, Tizón L, Prazeres V, Llamas-Saiz A, Fox G, Van Raaij M, Lamb H, Hawkins A, Gago F, Castedo L, González-Bello C. Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids .
ChemMedChem 2010, 5 (10), 1726-1733.
Lamb HK, Leslie K, Dodds AL, Nutley M, Cooper A, Johnson C, Thompson P, Stammers DK, Hawkins AR. The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides .
Journal of Biological Chemistry 2003, 278 (34), 32107-32114.
Lamb H, Lowes C, O'Connor K, Walter JM. Demonstration of Hot Start characteristics in Transgenomic Optimase (TM) polymerase .
In: European Journal of Human Genetics: European Society of Human Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics . 2002, Strasbourg, France: Nature Publishing Group.
Watts C, Si-Hoe SM, Lamb HK, Levett LJ, Coggins JR, Hawkins AR. Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins .
Proteins: Structure, Function and Genetics 2002, 48 (2), 161-168.
Spiers A, Lamb HK, Cocklin S, Wheeler KA, Budworth J, Dodds AL, Pallen MJ, Maskell DJ, Charles IG, Hawkins AR. PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide .
Journal of Biological Chemistry 2002, 277 (42), 39443-39449.
Lowes C, Lamb H, O'Connor K, Walter J. Predicting the optimal PCR primer annealing temperature for use with the Transgenomic Optimase (TM) polymerase .
In: European Journal of Human Genetics: European Society of Human Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics . 2002, Strasbourg, France: Nature Publishing Group.
Nichols CE, Cocklin S, Dodds A, Ren J, Lamb H, Hawkins AR, Stammers DK. Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression .
Acta Crystallographica Section D: Biological Crystallography 2001, 57 (11), 1722-1725.
Nichols CE, Ren J, Lamb H, Haldane F, Hawkins AR, Stammers DK. Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase .
Acta Crystallographica Section D: Biological Crystallography 2001, 57 (2), 306-309.
Stammers DK, Ren J, Leslie K, Nichols CE, Lamb HK, Cocklin S, Dodds A, Hawkins AR. The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases .
EMBO Journal 2001, 20 (23), 6619-6626.
Levett LJ, Si-Hoe SM, Liddle S, Wheeler K, Smith D, Lamb HK, Newton GH, Coggins JR, Hawkins AR. Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein .
Biochemical Journal 2000, 350 (1), 189-197.
