Dr Julian Rutherford
Academic Fellow
- Email: j.c.rutherford@ncl.ac.uk
- Telephone: +44 (0) 191 222 6282
- Fax: +44 (0) 191 222 7424
- Address: Institute for Cell and Molecular Biosciences
Medical School
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4HH
Research Interests
We use the model yeasts Saccharomyces cerevisiae and Cryptococcus neoformans to study the molecular processes involved in nutrient metabolism. We are particularly interested in how these organisms sense the need for and availability of specific nutrients with an emphasis on mechanisms that are likely to be conserved in higher eukaryotic organisms.
Selected Publications
- Rutherford J.C, Chua G, Hughes T. Cardenas M.E. and Heitman J. A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. Molecular Biology of the Cell 2008, 19, 3028-3039.
- Rutherford JC, Lin X, Nielsen K, and Heitman J. Amt2 Permease Is Required To Induce Ammonium-Responsive Invasive Growth and Mating in Cryptococcus neoformans. Eukaryotic Cell 2008, 7, 237-246.
- Teichert S, Rutherford JC, Wottawa, M Heitman J, and Tudzynski B. Impact of Ammonium Permeases MepA, MepB, and MepC on Nitrogen-Regulated Secondary Metabolism in Fusarium fujikuroi. Eukaryotic Cell 2008, 7, 187-201.
- Bahn YS, Xue C, Idnurm A, Rutherford JC, Heitman J, Cardenas ME. Sensing the environment: lessons from fungi. Nature Reviews Microbiology 2007, 5, 57-69.
- Ojeda L, Keller G, Muhlenhoff U, Rutherford JC, Lill R, Winge DR. Role of glutaredoxin-3 and glutaredoxin-4 in the iron-regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae. Journal of Biological Chemistry 2006, 28(26), 17661-17669.
- Rutherford JC, Ojeda L, Balk J, Mulenhoff U, Lill R, Winge DR. Activation of the Iron Regulon by the Yeast Aft1/Aft2 Transcription Factors Depends on Mitochondrial but Not Cytosolic Iron-Sulphur Protein Biogenesis. The Journal of Biological Chemistry 2005, 280(11), 10135-10140.
