Newcastle University

Research Projects

Regulation of mammalian gene expression by zinc

Assessing the transfer to bacteria, of plant derived transgenic DNA in the human small intestine

PhD

Dietary and genetic modulation of nucleotide excision repair

Research interests

Molecular nutrition; DNA repair; nutrient-gene interactions; diet cancer and ageing.

• Caple F, Williams EA, Spiers A, Tyson J, Burtle B, Daly AK, Mathers JC, Hesketh JE. Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype. British Journal of Nutrition 2010, 103(11), 1585-1593.
• Tyson J, Caple F, Spiers A, Burtle B, Daly AK, Williams EA, Hesketh JE, Mathers JC. Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype. British Journal of Nutrition 2009, 101(9), 1316-1323.
• Mathers JC, Coxhead JM, Tyson J. Nutrition and DNA repair - Potential molecular mechanisms of action. Current Cancer Drug Targets 2007. , 7(5), 425-431.
• Tyson J, Mathers JC. Dietary and genetic modulation of DNA repair in healthy human adults. In: Proceedings of the Nutrition Society: Summer Meeting of the Nutrition Society. 2007, Aberdeen, UK: Cambridge University Press.
• Tyson J, Spiers A, Caple F, Hesketh JE, Mathers JC. Effects of age, body mass index and genotype on nucleotide excision repair in healthy adults. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.
• Tyson J, Spiers A, Caple F, Hesketh JE, Mathers JC. Inter-individual variation in nucleotide excision repair capacity: potential scope for dietary modulation of DNA repair. In: Proceedings of the Nutrition Society. 2005, University of East Anglia, Norwich: Cambridge University Press.