Dr Djordje Jakovljevic
Senior Lecturer (Research) in Cardiovascular Ageing and Heart Failure
- Email: email@example.com
- Telephone: +44 (0) 191 208 8257
- Fax: +44 (0) 191 208 1151
- Address: Medical School
Institute of Cellular Medicine
UKRC Centre for Ageing and Vitality
William Leech Building M4.074
Newcastle upon Tyne
I joined the Faculty of Medical Sciences of Newcastle University in 2009, having moved from London to Newcastle. I completed Doctoral training in Clinical Cardiovascular Physiology and Heart Failure at Buckinghamshire University and Harefield Hospital (London, UK) under the mentorship of Prof David Brodie and Prof Sir Magdi Yacoub. Prior to my doctoral training I also completed an MSc (Brunel University, London) and BSc (University of Belgrade, Serbia) as the best student of the year. Due to excellent academic achievements at undergraduate and postgraduate level I received several highly prestigious scholarships and awards, including those from the Serbian Royal Family, Government of Serbia, Brunel and Buckinghamshire Universities.
Currently I am leading research programmes in cardiovascular ageing and heart failure within the multidisciplinary team consisted of clinicians, allied health professionals, basic and behavioural scientists. My work is supported by the UK Medical Research Council grant to the Newcastle Centre for Ageing and Vitality.
Roles and Responsibilities
To lead and implement an independent research programme in cardiovascular ageing and heart failure.
To advise on non-invasive clinical physiological (cardiovascular and metabolic) measurements.
Contribute to postgraduate teaching, supervision of postgraduate (MRes and PhD) students, and development of specialist postgraduate modules.
B.Sc. - University of Belgrade, Belgrade, Serbia (First-class honours)
M.Sc. - Brunel University, London, UK
Ph.D. - Buckinghamshire University/Harefield Hospital, Buckinghamshire, UK A.C.S.M. - American College of Sports Medicine Certified
2008 – present European Society of Cardiology
2008 – present Heart Failure Association of the European Society of Cardiology
2008 – present European Association for Cardiovascular Prevention and Rehabilitation
2014 – present Member of the ESC Working Group on Myocardial Function
English, German, Yugoslavian (Serbo-Croatian)
The focus of my research is on Cardiovascular Ageing and Heart Failure.
(1) Cardiovascular Ageing:
The growing ageing population represents one of the greatest societal challenges of our times. Identifying strategies to improve cardiovascular function and risk stratification is a key determinant of successful ageing because the age-related cardiovascular dysfunction and associated heart disease is the leading cause of morbidity and mortality in older people. Physical activity, exercise and associated high level of the functional capacity of the cardiorespiratory system reduce all-cause and cardiovascular mortality across the lifespan but their effect on cardiovascular function and underpinning molecular and cellular mechanisms in later life is not well understood.
Our research aims to develop an intervention that will help people maintain and improve their cardiovascular function and quality of life in older age, while reducing mortality and morbidity. In short-term we will define physiological, molecular and cellular basis underpinning cardiovascular changes with ageing and lifestyle. We are particularly interested to investigate malleability of age-related changes in mitochondria function and inflammation with lifestyle interventions in cardiac and vascular tissues and how this impact on overall cardiovascular function. In long-term, in collaboration with our colleagues from basic, applied and clinical sciences we will develop a unique intervention combining both physiological and pharmacological therapies to improve cardiovascular function and extend healthy lifespan. We will be working with our study participants, general public, clinical and research teams to design clinical pathways and implement large scale interventions to improve cardiovascular function in older people. This research will provide evidence to delay the onset of age-related cardiovascular diseases and provide new therapeutic targets for improving cardiovascular and overall health of our ageing society.
(2) Heart Failure:
Heart Failure is one of the most common forms of heart condition in older age and affects around 1 million people in the UK. The incidence and prevalence of heart failure have increased steeply as a result of improved prognosis of coronary artery disease, ageing of the population, and better treatments. Aside from the obvious individual burden, heart failure also accounts for 2% of all NHS inpatient bed-days and 5% of all emergency medical admissions to hospital. Hospital admissions because of heart failure are projected to rise by 50% over the next 25 years. There is a pressing need to explore effective ways to manage the individual and societal burden of heart failure with the ageing population of the UK.
Our research programme in Heart Failure focuses on the following four areas:
i) Improving Diagnosis and Monitoring of Heart Failure (DIAGNOSE-HF). Whilst early diagnosis and management of heart failure lead to better patient outcomes and more cost effective care, there is evidence to suggest that heart failure can often be misdiagnosed or underdiagnosed. When based on presenting clinical features alone, there may remain considerable diagnostic uncertainty, particularly in the setting where more advanced diagnostic tests such as echocardiography are not readily available. Non-invasive assessment of cardiac function may have major clinical implications in heart failure as it can improve diagnosis, risk stratification and monitoring of heart failure. Our research aims to evaluate clinical (i.e. diagnostic and prognostic) and cost-effectiveness of non-invasive haemodynamic assessment in Heart Failure. This research has the potential to improve quality and length of life in those living with Heart Failure and Clinical Care Pathway.
ii) Investigation of New Medication in Heart Failure. We lead Newcastle in the international RELAX-Cardio programme sponsored by Novartis Pharmaceuticals. A multicentre, randomized, double-blind, cross-over placebo-controlled phase II study will assess the effect of serelaxin on cardiac protection and high-sensitivity cardiac troponin release in response to exercise stress test in patients with chronic heart failure.
iii) Development and Implementation of Home-based Cardiac Rehabilitation in Heart Failure. Exercise-based cardiac rehabilitation programmes are safe and recommended to improve symptoms and outcomes in heart failure. However, national audit data show that only 2% of people participating in cardiac rehabilitation in the UK are referred because of heart failure, with the main reasons being lack of resources and absence of heart failure in local commissioning agreements. We are therefore developing home-based physical activity intervention programme that holds great potential to improve patient outcomes and clinical practice.
iv) Mechanical Circulatory Support. The use of Left Ventricular Assist Devices (LVADs) has been shown to be a successful therapy for patients with advanced heart failure as a bridge to transplantation, improving their functional capacity and quality of life. In some patients myocardial function can be recovered during LVAD support, allowing device to be explanted. In our research programmes we are identifying physiological markers that can predict recovery of patients with advanced heart failure, and improve decision making of clinical care teams about continuing with LVAD support or considering device explantation.
Doctor of Philosophy (PhD)
Katherine Jones, PhD (completed 2010/10-2014/06). Project: The effect of interval training on clinical and physiological outcomes in patients with inclusion body myositis and mitochondial disorders (Joint-lead supervisor with Prof Doug Turnbull).
Sophie Cassidy, PhD (completed 2012/10 – 2015/12). Project: The effect of exercise on metabolic control, liver lipid and cardiac function in patients with type 2 diabetes (Joint-lead supervisor with Prof Mike Trenell).
Nduka Charles Okwose, PhD candidate (2014/10-expected completion 2017/09). Cardiovascular function and physical activity in patients with chronic heart failure (Lead supervisor).
Ghazaleh Alimohammadiha, PhD Candidate (2015/10 -
2018/09). Defining the molecular and
physiological links between the ageing and cardiac
disease and their malleability with exercise training (Joint-lead supervisor with Dr
Doctor of Medicine (MD)
Dr Sasiharan Sithamparanathan, MD candidate (2014/09–expected completion 2016/06). Project: Improving clinical and physiological outcomes using non-invasive haemodynamic assessment in patients with pulmonary hypertension. (Co-supervision with Profs Corris, Trenell, Gorman).
Master of Research (MRes)
Dr Hugo Njemanze (MBBS, Mres 2015). Cardiac autonomic changes with ageing – the impact of physical activity.
Dr Maria Nathania (MBBS, MRes 2016). The role of cardiac high energy metabolism on cardiac pumping capability and performance.
Dr Jose Syrianegara (MBBS, MRes 2016). The effect of high intensity interval training on cardiac performance in people with type 2 diabetes.
Dr Vivek Vaidya (MBBS, MRes 2017). The effect of high intensity interval training on cardiac autonomic regulation in patients with type 2 diabetes.
Jadine Scragg (MSci, 2017). Relationship between physical activity in cardiac function in heart failure.
Internal PhD examiner at Newcastle University – Candidate David Burns. Thesis title “Ageing in the zebrafish heart” (September 2014).
Jody McCoy (BSc thesis 2016). Pathophysiology of exercise intolerance in chronic diseases.
Ruth Perkins (BSc Faculty of Medical Sciences Summer Placement Scholarship 2016). Relationship between stroke volume estimates by magnetic resonance imaging and bioreactance.
Esther Apkan (BSc, School of Biomedical Sciences 2016). The effect of age on mechanisms of exercise intolerance.
Ellie Brown (BSc thesis 2017). The effect of age on cardiac and metabolic function.
Charlotte Jones (BSc thesis 2017). The effect of physical activity in cardiac and metabolic function.
Medical Research Council Confidence in Concept (06/16-05/17). Sensitivity and specificity of non-invasive haemodynamic assessment to diagnose heart failure in primary care. Principal investigator £102,254.
Novartis Pharmaceuticals (04/16-03/17). A multicentre, randomized, double-blind, cross-over placebo-controlled Phase II study to assess the effect of serelaxin versus placebo on high sensitivity cardiac troponin release in patients with chronic heart failure after exercise stress testing in addition to standard of care. Chief Investigator for Newcastle Site £74,000.
National Institute for Health Research Biomedical Research Centre (01/15-04/16). Development and evaluation of a personalised home-based physical activity intervention in older adults with Heart Failure. Principal Investigator £72,684
Medical Research Council Centre for Ageing and Vitality (06/14-03/19). Co-applicant and Co-investigator with ProfessorsTurnbull, Trenell, Mann, Mathers, and Dr Greaves £5,550,483
Medical Research Council, Arthritis Research UK (01/13-05/14) Effects of dietary nitrate supplementation on cardiovascular function in older subjects. Co-applicant and Co-investigator with Dr Siervo £39,700
British Heart Foundation, NIHR BRC and MRC CBAV (11/12). Ageing Heart Symposium. Lead applicant £12,500
Travel Grant Diabetes and Cardiovascular Diseases EASD Study Group (10/11) €1,200
Invited ad hoc reviewer for:
• Peer reviewed journals including: International Journal of Cardiology, BMJ Heart, European Journal of Heart Failure, American Journal of Cardiology, Future Cardiology, European Journal of Applied Physiology, Journal of Cardiac Failure, Journal of Clinical Monitoring and Computing, Circulation Heart Failure, PLoS One, BMJ Open
• Research Funding Bodies including: National Institute for Health Research, Medical Research Council, Heart Research UK, Austrian Science Fund.
Editorial board member for the new scientific journal Heart Health: Open Access (USA, Aperito)
For full list of publications follow the Pubmed link: http://www.ncbi.nlm.nih.gov/pubmed/?term=jakovljevic+dg
For full citation and h-index follow the Google Scholar link: http://scholar.google.co.uk/citations?user=ifsD-rkAAAAJ&hl=en
For RG score follow the Research Gate link: https://www.researchgate.net/profile/Djordje_Jakovljevic
Physical activity and cardiovascular ageing. International Sports Medicine Conference, Newcastle University, UK, 31 August – 2 September 2016.
How to gas rebreathing and electrical signal processing technologies to assess cardiac function during stress testing? European Society of Cardioloy Association for Cardiovascular Prevention and Rehabilitation, EuroPrevent Annual Congress. Istanbul, Turkey 5-7 May 2016.
Clinical consequences of haemodynamic measurements under stress testing. Qatar Cardiovascular Research Centre and Hamad Heart Hospital, Doha, Qatar, 11-14 May 2014.
Heart failure in diabetes: mollecular and metabolic mechanisms. 12th International Congress on Clinical Cardiology and Heart Failure. Belgrade, Serbia, 24-27 April 2014.
The impact of age and physical activity on cardiac function and performance. A cross-council research programme: New Dynamics of Ageing Annual Meeting. Birmingham, 22 May 2013.
The role of advanced glycation end products in cardiovascular disease. Meet the expert of translational research: Molecular Basis of Heart Failure. 11th International Congress on Clinical Cardiology and Heart Failure, Belgrade, Serbia, 26-27 April 2013.
Physical activity and age-related changes in aerobic and cardiac function. MRC Centre for Integrated Research into Musculoskeletal Ageing. Liverpool, 27 February 2013.
Current tendencies in cardiopulmonary exercise testing: non-invasive assessment of cardiac power output. Magdi Yacoub Heart Foundation, Aswan Heart Centre, Egypt, 13-14 October 2012.
Neurohumoral system activation blockade: basis for prevention and treatment of heart failure. European Society of Cardiology Heart Failure Congress, Belgrade, Serbia, 19-22 May 2012.
Congress Highlights - Basic Sciences. European Society of Cardiology Heart Failure Congress, Belgrade, Serbia, 19-22 May 2012.
Left ventricular assist devices improve cardiac and physical function in patients with severe heart failure. Medical School, University of Novi Sad, Novi Sad, Serbia. 29 May 2011
The effect of mechanical circulatory support on cardiac and exercise performance in patients with chronic heart failure. Coventry University – Best Applied Research Competition First Award Winner, 30 June 2010
Exercise intolerance and cardiac power output in chronic heart failure. Freeman Hospital, Newcastle upon Tyne, 16 March 2010.
Cardiopulmonary exercise testing in heart failure. Staff Symposium, Faculty of Society and Health, Buckinghamshire New University, Chalfont Campus, 09 January 2009.
Cardiac power output in patients with heart failure undergoing mechanical circulatory support. Thematic Meeting on Clinical Consequences of Hemodynamic Measurements under Exercise Testing, Copenhagen, Denmark, 24 – 25 September 2007.
1. MRes Programme (MMB8037) Cardiovascular Science in Health and Disease, Newcastle University (since 2013)
2. MSc in Clinical Sciences, Newcastle University; Module CVR8007 Diagnostic Approaches and Current Treatment of Cardiovascular Disorders (since 2012)
- Jakovljevic DG, Yacoub MH, Schueler S, MacGowan AG, Velicki L, Seferovic PM, Hothi S, Tzeng BT, Brodie DA, Birks EJ, Tan LB. Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure. Journal of the American College of Cardiology 2017, 69(15), 1924-1933.
- Nathania M, Hollingsworth KG, Bates M, Eggett C, Trenell MI, Velicki L, Seferovic PM, MacGowan GA, Turnbull DM, Jakovljevic DG. Impact of age on the association between cardiac high-energy phosphate metabolism and cardiac power in women. Heart 2017, e-pub ahead of print.
- Jakovljevic DG. Physical activity and cardiovascular aging: Physiological and molecular insights. Experimental Gerontology 2017, Epub ahead of print.
- Okwose NC, Chowdhury S, Houghton D, Trenell MI, Eggett C, Bates M, Macgowan GA, Jakovljevic DG. Comparison of cardiac output estimates by bioreactance and inert gas rebreathing methods during cardiopulmonary exercise testing. Clinical Physiology and Functional Imaging 2017, Epub ahead of print.
- Oggioni C, Jakovljevic DG, Klonizakis M, Ashor AW, Ruddock A, Ranchordas M, Williams E, Siervo M. Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults: a randomised cross-over study. International Journal of Food Sciences and Nutrition 2017, Epub ahead of print.
- Njemanze H, Warren C, Eggett C, MacGowan GA, Bates MGD, Siervo M, Ivkovic S, Trenell MI, Jakovljevic DG. Age-related decline in cardiac autonomic function is not attenuated with increased physical activity. Oncotarget 2016, 7(47), 76390-76397.
- Perkins RE, Hollingsworth KG, Eggett C, MacGowan GA, Bates MG, Trenell MI, Jakovljevic DG. Relationship between bioreactance and magnetic resonance imaging stroke volumes. British Journal of Anaesthesia 2016, 117(1), 134-136.
- Houghton D, Jones TW, Cassidy S, Siervo M, MacGowan GA, Trenell MI, Jakovljevic DG. The effect of age on the relationship between cardiac and vascular function. Mechanisms of Ageing and Development 2016, 153, 1-6.
- Ninkovic VM, Ninkovic SM, Miloradovic V, Stanojevic D, Babic M, Giga V, Dobric M, Trenell MI, Lalic N, Seferovic PM, Jakovljevic DG. Prevalence and risk factors for prolonged QT interval and QT dispersion in patients with type 2 diabetes. Acta Diabetologica 2016, 53(5), 737-744.
- Charman SJ, van Hees VT, Quinn L, Dunford JR, Bawamia B, Veerasamy M, Trenell MI, Jakovljevic DG, Kunadian V. The effect of percutaneous coronary intervention on habitual physical activity in older patients. BMC Cardiovascular Disorders 2016, 16(1), 248.
- Siervo M, Oggioni C, Jakovljevic DG, Trenell M, Mathers JC, Houghton D, Celis-Morales C, Ashor AW, Ruddock A, Ranchordas M, Klonizakis M, Williams EA. Dietary nitrate does not affect physical activity or outcomes in healthy older adults in a randomized, cross-over trial. Nutrition Research 2016, 36(12), 1361-1369.
- Moore SA, Jakovljevic DG, Ford GA, Rochester L, Trenell MI. Exercise induces peripheral muscle but not cardiac output adaptations after stroke. A randomised controlled pilot trial. Archives of Physical Medicine and Rehabilitation 2016, 97(4), 596-603.
- Jones T, Houghton D, Cassidy S, MacGowan GA, Trenell MI, Jakovljevic DG. Bioreactance is a reliable method for estimating cardiac output at rest and during exercise. British Journal of Anaesthesia 2015, 115(3), 386-391.
- Jakovljevic DG, Papakonstantinou L, Blamire AM, MacGowan GA, Taylor R, Hollingsworth KG, Trenell MI. Effect of Physical Activity on Age-Related Changes in Cardiac Function and Performance in Women. Circulation: Cardiovascular Imaging 2015, 8, e002086.
- Newman J, Galna B, Jakovljevic D, Bates M, Schaefer A, McFarland R, Turnbull D, Trenell M, Taylor R, Rochester L, Gorman G. Preliminary Evaluation of Clinician Rated Outcome Measures in Mitochondrial Disease. Journal Of Neuromuscular Diseases 2015, 2(2), 151-155.
- Jakovljevic DG, Trenell MI, MacGowan GA. Bioimpedance and bioreactance methods for monitoring cardiac output. Best Practice & Research: Clinical Anaesthesiology 2014, 28(4), 381-394.
- Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Taylor R, Jakovljevic DG, Trenell MI. High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial. Diabetologia 2016, 59(1), 56-66.
- Cassidy S, Hallsworth K, Thoma C, MacGowan GA, Hollingsworth KG, Day CP, Taylor R, Jakovljevic DG, Trenell MI. Cardiac structure and function are altered in type 2 diabetes and Non-alcoholic fatty liver disease and associate with glycemic control. Cardiovascular Diabetology 2015, 14, 23.
- Moore SA, Hallsworth K, Jakovljevic DG, Blamire AM, He JB, Ford GA, Rochester L, Trenell MI. Effects of Community Exercise Therapy on Metabolic, Brain, Physical, and Cognitive Function Following Stroke: A Randomized Controlled Pilot Trial. Neurorehabilitation & Neural Repair 2015, 29(7), 623-635.
- Jakovljevic DG, McDiarmid A, Hallsworth K, Seferovic PM, Ninkovic VM, Parry G, Schueler S, Trenell MI, MacGowan GA. Effect of Left Ventricular Assist Device Implantation and Heart Transplantation on Habitual Physical Activity and Quality of Life. American Journal of Cardiology 2014, 114(1), 88-93.
- Ashor AW, Lara J, Siervo M, Celis-Morales C, Oggioni C, Jakovljevic DG, Mathers JC. Exercise Modalities and Endothelial Function: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Sports Medicine 2015, 45(2), 279-296.
- Galna B, Newman J, Jakovljevic DG, Bates MG, Schaefer AM, McFarland R, Turnbull DM, Trenell MI, Gorman GS, Rochester L. Discrete gait characteristics are associated with m.3243A > G and m.8344A > G variants of mitochondrial disease and its pathological consequences. Journal of Neurology 2014, 261(1), 73-82.
- Nunan D, Sandercock GR, George RS, Jakovljevic DG, Donovan G, Bougard R, Yacoub MH, Brodie DA, Birks EJ. Cardiovascular autonomic control in patients undergoing left ventricular assist device (LVAD) support and pharmacologic therapy. International Journal of Cardiology 2013, 168(4), 4145-4149.
- Bates MG, Newman JH, Jakovljevic DG, Hollingsworth KG, Alston CL, Zalewski P, Klawe JJ, Blamire AM, Macgowan GA, Keavney BD, Bourke JP, Schaefer A, McFarland R, Newton JL, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Defining cardiac adaptations and safety of endurance training in patients with m.3243A>g-related mitochondrial disease. International Journal of Cardiology 2013, 168(4), 3599-3608.
- Jakovljevic DG, Hallsworth K, Zalewski P, Thoma C, Klawe J, Day CP, Newton J, Trenell MI. Resistance exercise improves autonomic regulation at rest and haemodynamic response to exercise in non-alcoholic fatty liver disease. Clinical Science 2013, 125(3), 143-149.
- Campbell MD, Walker M, Trenell MI, Jakovljevic DG, Stevenson EJ, Bracken RM, Bain SC, West DJ. Large pre- and postexercise rapid-acting insulin reductions preserves glycemia and prevents early- but not late-onset hypoglycemia in patients with type 1 diabetes. Diabetes Care 2013, 36(8), 2217-2224.
- Bates MG, Hollingsworth KG, Newman J, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodeling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. European Heart Journal - Cardiovascular Imaging 2013, 14(7), 650-658.
- Detko E, OHara JP, Thelwall PE, Smith FE, Jakovljevic DG, King RF, Trenell MI. Addition of protein and amino acids to maltodextrin and galactose does not enhance post-exercise liver and muscle glycogen synthesis. British Journal of Nutrition 2013. In Press.
- Klasnja AV, Jakovljevic DG, Barak OF, Popadic-Gacesa JZ, Lukac DD, Grujic NG. Cardiac power output and its response to exercise in athletes and non-athletes. Clinical Physiology and Functional Imaging 2013, 33(3), 201-205.
- Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic DG, MacGowan GA, Anstee QM, Taylor R, Day CP, Trenell MI. Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. Journal of Hepatology 2013, 58(4), 757-762.
- Jakovljevic DG, Moore SA, Tan LB, Rochester L, Ford GA, Trenell MI. Discrepancy between cardiac and physical functional reserves in stroke. Stroke 2012, 43, 1422-1425.
- Jakovljevic DG, Moore SA, Trenell MI. Response to Letter Regarding Article, "Discrepancy Between Cardiac and Physical Functional Reserves in Stroke". Stroke 2012, 43(9), E92-E92.
- Jakovljevic DG, Popadic-Gacesa JZ, Barak OF, Nunan D, Donovan G, Trenell MI, Grujic NG, Brodie DA. Relationship between peak cardiac pumping capability and indices of cardio-respiratory fitness in healthy individuals. Clinical Physiology and Functional Imaging 2012, 32(5), 388-393.
- Jakovljevic DG, Moore S, Hallsworth K, Fattakhova G, Thoma C, Trenell MI. Comparison of cardiac output determined by bioimpedance and bioreactance methods at rest and during exercise. Journal of Clinical Monitoring and Computing 2012, 26(2), 63-68.
- Jakovljevic DG, Seferovic PM, Nunan D, Donovan GC, Trenell MI, Grocott-Mason R, Brodie DA. Reproducibility of cardiac power output and other cardiopulmonary exercise indices in patients with chronic heart failure. Clinical Science 2011, 122(4), 175-181.
- Jakovljevic DG, Birks EJ, George RS, Trenell MI, Seferovic PM, Yacoub MH, Brodie DA. Relationship between peak cardiac pumping capability and selected exercise-derived prognostic indicators in patients treated with left ventricular assist devices. European Journal of Heart Failure 2011, 13(9), 992-999.
- Jones DEJ, Hollingsworth KG, Jakovljevic DG, Fattakhova G, Pairman J, Blamire AM, Trenell MI. Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: A case control study. European Journal of Clinical Investigation 2012, 42(2), 186-194.
- Barak OF, Ovcin ZB, Jakovljevic DG, Lozanov-Crvenkovic Z, Brodie DA, Grujic NG. Heart rate recovery after submaximal exercise in four different recovery protocols in male athletes and non-athletes. Journal of Sports Science and Medicine 2011, 10(2), 369-375.
- Gacesa J, Jakovljevic D, Kozic D, Dragnic N, Brodie D, Grujic N. Morpho-functional response of the elbow extensor muscles to twelve-week self-perceived maximal resistance training. Clinical Physiology and Functional Imaging 2010, 30(6), 413-419.
- Jakovljevic DG, George RS, Nunan D, Donovan G, Bougard RS, Yacoub MH, Birks EJ, Brodie DA. The impact of acute reduction of continuous-flow left ventricular assist device support on cardiac and exercise performance. Heart 2010, 96(17), 1390-1395.
- Jakovljevic DG, George RS, Donovan G, Nunan D, Henderson K, Bougard RS, Yacoub MH, Birks EJ, Brodie DA. Comparison of cardiac power output and exercise performance in patients with left ventricular assist devices, explanted (recovered) patients and those with moderate to severe heart failure . The American Journal of Cardiology 2010, 105(12), 1780-1785.
- Jakovljevic DG, Donovan G, Nunan D, McDonagh S, Trenell MI, Grocott-Mason R, Brodie DA. The effect of aerobic versus resistance exercise training on peak cardiac power output and physical functional capacity in patients with chronic heart failure. International Journal of Cardiology 2010, 145(3), 526-528.
- Nunan D, Jakovljevic DG, Donovan G, Singleton LD, Sandercock GRH, Brodie DA. Resting autonomic modulations and the heart rate response to exercise. Clinical Autonomic Research 2010, 20(4), 213-221.
- Hagget A, Hull J, Nunan D, Jakovljevic DG, Brodie DA, Amsley L. Application of bioreactance for cardiac output assessment in healthy individuals. European Journal of Applied Physiology 2010, 109(5), 945-951.
- Barak OF, Jakovljevic DG, Popadic-Gacesa JZ, Brodie DA, Grujic NG. Comparison of heart rate variability before and after cycle exercise in relation to different body positions. Journal of Sport Science and Medicine 2010, 9, 176-182.
- Ostojic SM, Markovic G, Calleja-Gonzalez J, Jakovljevic DG, Vucetic V, Stojanovic MD. Ultra short-term heart rate recovery after maximal exercise in continuous versus intermittent endurance athletes. European Journal of Applied Physiology 2010, 108(5), 1055-1059.
- Nunan D, Donovan G, Jakovljevic DG, Hodges LD, Sandercock GR, Brodie DA. Validity and reliability of short-term heart-rate variability from the Polar S810. Medicine and Science in Sports and Exercise 2009, 41(1), 243-250.
- Jakovljevic DG, McConnell AK. Influence of different breathing frequencies on the severity of inspiratory muscle fatigue induced by high-intensity front crawl swimming. Journal of Strength and Conditioning Research 2009, 23(4), 1169-1174.
- Popadic Gacesa JZ, Kozic DB, Dragnic NR, Jakovljevic DG, Brodie DA, Grujic NG. Changes of functional status and volume of triceps brachii measured by magnetic resonance imaging after maximal resistance training. Journal of Magnetic Resonance Imaging 2009, 29(3), 671-676.
- Jakovljevic DG, Nunan D, Donovan G, Hodges LD, Sandercock GR, Brodie DA. Comparison of cardiac output determined by different rebreathing methods at rest and at peak exercise. European Journal of Applied Physiology 2008, 102(5), 593-599.
- Nunan D, Jakovljevic DG, Donovan G, Hodges LD, Sandercock GR, Brodie DA. Levels of agreement for RR intervals and short-term heart rate variability obtained from the Polar S810 and an alternative system. European Journal of Applied Physiology 2008, 103(5), 529-537.
- Jakovljevic DG, Nunan D, Donovan G, Hodges LD, Sandercock GRH, Brodie DA. Lack of agreement between gas exchange variables measured by two metabolic systems. Journal of Sports Science and Medicine 2008, 7(1), 15-22.
- Jones KL, Whittaker RG, Miller JA, Jakovljevic DG, Turnbull DM, Gorman GS. Can high intensity interval training improve functional capacity and clinical symptoms in inflammatory and mitochondrial myopathies?. In: 6th Annual Translational Research Conference. 2013, Oxford, UK.
- Jakovljevic DG, Mc Diarmid A, MacGowan GA, Parry G, Schueler S, Trenell MI. Left Ventricular Assist Device Implantation Significantly Improves Everyday Physical Activity and Quality of Life in Patients with Chronic Heart Failure. In: 32nd Anniversary Meeting of the International Society for Heart and Lung Transplantatio. 2012, Prague, Czech Republic: Elsevier Inc.
- Moore SA, Jakovljevic DG, Ford GA, Rochester L, Trenell MI. The effect of a community exercise intervention on physiological and physical function following stroke: a randomized, controlled trial. In: UK Stroke Forum 2012 Conference. 2012, Harrogate, UK: Wiley-Blackwell Publishing Ltd.
- Newman J, Jakovljevic D, Bates MG, Turnbull DM, Galna B, Trenell MI, Gorman GS. Improving clinical trials evaluation: physiological and functional correlates in mitochondrial disease. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
- Bates MG, Hollingsworth KG, Newman J, Jakovljevic D, Dixon BJ, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Evidence of early cardiac impairment in m.3243A > G mutation carriers. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
- Jakovljevic DG, Papakonstantinou L, Taylor R, MacGowan G, Trenell MI. Every day physical activity protects against the age related decline in aerobic function but not cardiac pumping capability in normoglycemic women. In: Diabetes and Cardiovascular Disease EASD Study Group. 2010, Belgrade, Serbia.
- Jakovljevic DG, Birks EJ, Yacoub MH, Goldspink DF, Tan LB, Brodie DA. Can non-pulsatile continuous-flow left ventricular assist devices confer physiologically desirable cardiac and physical functional benefits during peak exercise?. In: British Cardiovascular Society Annual Conference. 2010, Manchester, UK: Heart.
- Jakovljevic DG, George R, Donovan G, Nunan D, Bougard R, Birks E, Yacoub M, Brodie DA. Resting and exercise haemodynamic and metabolic responses to acute reduction of continuous-flow left ventricular assist device support. European Heart Journal Supplements 2009, 30, 388.
- Donovan G, George R, Jakovljevic DG, Nunan D, Bougard R, Yacoub M, Birks E, Brodie DA. Effects of left ventricular assist devices on heart rate and Vo2 recovery trends following peak exercise: optimal vs reduced unloading speed. European Heart Journal Supplements 2009, 30, 388.
- Nunan D, Jakovljevic DG, Donovan G, Sandercock GRH, Grocott-Mason R, McDonagh S, Brodie DA. Measures of heart rate variability from the Polar S810 and HRV analysis software 1.1: A validity and reliability study in chronic heart failure. In: European Society of Cardiology Congress. 2009, Barcelona, Spain: European Heart Journal, Oxford University Press.
- Jakovljevic DG, Donovan G, Nunan D, GrocottMason R, McDonagh S, Brodie DA. The effect of aerobic versus resistance exercise training on cardiac power output and selected cardio-respiratory variables in patients with stable chronic heart failure. European Journal of Heart Failure 2009, 8(2), 138.
- Donovan G, Nunan D, Jakovljevic DG, Brodie DA. The effects of body positions and gender on heart rate recovery. In: British Association for Sport and Exercise Science Conference. 2009, Leeds Metropolitan University: British Association for Sport and Exercise Science.
- Jakovljevic DG, Donovan G, Nunan D, George R, Bougard R, Birks E, Yacoub M, Brodie DA. Cardiac power output measurements in patients on left ventricular assist devices, explanted (recovered) patients and those with severe heart failure. European Journal of Cardiovascular Prevention & Rehabilitation 2008, 15(s1), 111 no. 487.
- Donovan G, Nunan D, Jakovljevic DG, GrocottMason R, McDonagh S, Brodie DA. Heart rate recovery following either an aerobic or resistance exercise intervention in two participants with chronic heart failure: a case study. In: British Cardiovascular Society, Association for Cardiac Rehabilitation. 2008, York,UK.
- Jakovljevic DG, Donovan G, Nunan D, George R, Bougard R, Birks E, Yacoub M, Brodie DA. Relationship between peak cardiac power output and selected cardio-pulmonary variables in patients on left ventricular assist devices, explanted (recovered) patients and those with severe heart failure. European Journal of Heart Failure 2008, 7(1), 73 no. 287.
- Nunan D, Donovan G, Jakovljevic DG, George R, Bougard R, Birks E, Yacoub M, Brodie DA. Assessing autonomic and cardiac function during ‘bridge-to-recovery’ using left ventricular assist device combination therapy – a case study comparison. In: British Cardiovascular Society, Association for Cardiac Rehabilitation. 2007, Cardiff, Wales.
- Jakovljevic DG, Donovan G, Nunan D, George R, Bougard R, Birks E, Yacoub M, Brodie DA. Current tendencies in cardiopulmonary exercise testing in heart failure – role of cardiac power output. In: Physical Activity and Health. 2007, Belgrade,Serbia: International Council of Sport Science and Physical Education (ICSSPE).
- Jakovljevic DG, Nunan D, Donovan G, Hodges L, Sandercock GRH, Brodie DA. Direct comparison of two automated metabolic gas analysis systems during exercise. In: 12th Annual Congress of the European College of Sports Science. 2007, Jyvaskyla, Finland: European College of Sport Science.
- Nunan D, Jakovljevic DG, Donovan G, Hodges L, Sandercock GRH, Brodie DA. The reliability of the Polar S810 heart rate monitor and advanced analysis software to assess heart rate variability. In: European College of Sport Science. 2007, Jyvaskyla, Finland.
- Jakovljevic D, Nunan D, Donovan G, Hodges L, Sandercock G, Brodie D. Three different rebreathing methods for measuring cardiac output at rest. In: 12th Annual Congress of the European College of Sport Science. 2007, Jyvaskyla, Finland.
- Jakovljevic DG, Nunan D, Donovan G, George RS, Bougard R, Birks EJ, Yacoub MH, Brodie DA. Cardiac power output in patients with severe heart failure, including those with implanted and explanted left ventricular assist devices. In: Thematic Meeting - Clinical Consequences of Haemodynamic Measurements under Exercise Testing. 2007, Copenhagen, Denmark.
- Hodges L, Jakovljevic DG, Brodie DA. The measurement of cardiac power output using a non-invasive rebreathing method. In: Main Meeting of the Physiological Society. 2006, London, England: Physiological Society.
- Jakovljevic DG, McConnell AK. Influence of different breathing frequencies upon inspiratory muscle fatigue induced by high intensity front crawl swimming. In: 10th Annual Congress of the European College of Sport Science. 2005, Belgrade,Serbia: European College of Sport Science.
- Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic DG, MacGowan GA, Anstee QM, Day CP, Taylor R, Trenell MI. Cardiac function improves following high intensity intermittent exercise in adults with non-alcoholic fatty liver disease. In: Diabetes UK Annual Professional Conference. 2013, Manchester, UK: Diabetes UK.
- Detko E, O'Hara JP, Thelwall PE, Smith FE, Jakovljevic DG, King RFGJ, Trenell MI. Liver and muscle glycogen repletion using C-13 magnetic resonance spectroscopy following ingestion of maltodextrin, galactose, protein and amino acids. British Journal of Nutrition 2013, 110(5), 848-855.
- Jones K, Whittaker R, Miller J, Jakovljevic D, Turnbull D, Gorman G. The Effects of High Intensity Interval Training on Clinical Symptoms and Functional Capacity in Adults with Neuromuscular Disease. In: Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP). 2013, London, UK: BMJ Publishing Group.
- Newman J, Galna B, Jakovljevic D, Bates M, Schaefer A, McFarland R, Turnbull D, Trenell M, Rochester L, Gorman G. Evaluation of Functional Outcome Measures as a Surrogate Marker of Disease Severity in Patients with Mitochondrial Disease. In: Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP). 2013, London, UK: BMJ Publishing Group.
- Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic D, MacGowan GA, Anstee QM, Day CP, Taylor R, Trenell MI. Cardiac function improves following high intensity intermittent exercise in adults with non-alcoholic fatty liver disease. In: Diabetes UK Professional Conference 2013. 2013, Manchester, UK: Wiley-Blackwell.
- Denton SJ, vanHees VT, Bawamia B, Veerasamy M, Quinn L, Dunford JR, Trenell MI, Jakovljevic DG, Kunadian V. Sedentary Behaviour and Physical Activity Among Older Patients Following Percutaneous Coronary Intervention Presented with Stable Angina versus Acute Coronary Syndrome. In: American Heart Association's 2014 Scientific Sessions and Resuscitation Science Symposium. 2014, Chicago, Illinois: American Heart Association , Inc.
- Cassidy S, Thoma C, Hallsworth K, Parikh J, Hollingsworth KG, Day CP, Jakovljevic DG, Taylor R, Trenell MI. High intensity intermittent training improves cardiac function and reduces liver fat in adults with Type 2 diabetes: an MRI/S study. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
- Moore S, Hallsworth K, Jakovljevic D, Blamire A, He J, Ford G, Rochester L, Trenell M. Effects of exercise therapy on metabolic risk factors, brain atrophy and cerebral blood flow following stroke: A randomised controlled trial. In: UK Stroke Forum 2014. 2014, Harrogate: Wiley-Blackwell Publishing Asia.
- Campbell MD, Walker M, Trenell MI, Stevenson EJ, Jakovljevic DG, Bracken RM, Bain SC, Turner D, West DJ. The preservation of glycaemia through large pre- and post-exercise rapid-acting insulin reductions prevents early, but not late-onset hypoglycaemia in individuals with Type 1 diabetes. In: Diabetes UK Professional Conference. 2013, Manchester, UK: John Wiley & Sons Ltd.
- Cassidy SA, Thoma C, Hallsworth K, Jakovljevic DG, Parikh J, Hollingsworth KG, Taylor R, Trenell MI. High intensity intermittent exercise reverses abnormal cardiac function in people with type 2 diabetes: an MRI/S study. In: 50th General Assembly of the European Association for the Study of Diabetes. 2014, Vienna, Austria: Springer.