Honorary Consultant Neurologist, Newcastle upon Tyne Hospitals NHS Foundation Trust
Clinical Director, Parkinson's UK
Director, Newcastle NIHR Biomedical Research Unit in Lewy Body Dementia
Director, Newcastle NIHR Clinical Ageing Research Unit
My research aims to improve the diagnosis and management of Parkinson’s disease, the Lewy body dementias and Progressive Supranuclear Palsy (PSP). I played a key role in an International Task Force to develop the first set of Diagnostic Criteria for Dementia associated with Parkinson's disease and the International Consortium to define new diagnostic criteria for Dementia with Lewy Bodies. My group is identifying predictors of dementia in Parkinson's disease, supported by a programme grant from Parkinson's UK to identify people with Parkinson's disease at high risk of incident dementia (ICICLE-PD). Recent outputs from this work have highlighted the high burden of non-motor symptoms, and a putative cholinergic basis underpinning impaired gait speed and attention, in early Parkinson’s. More recently, my work has involved the study of apomorphine as a putative anti-amyloid agent (using clinicopathological methods) and ghrelin as a biomarker for cognitive impairment in Parkinson's.
I have contributed towards the development of new treatments for patients with movement disorders including a multi-centre randomised controlled trial of rivastigmine in the treatment of dementia in Parkinson's. The results from this trial were incorporated into 2006 NICE-PD guidelines. I lead a multicentre NIHR HTA-funded study to establish the clinical and cost effectiveness of donepezil in early dementia associated with Parkinson's disease (MUSTARDD-PD). My work in dementia with Lewy bodies has shown that physicians may prescribe levodopa safely to people with this disorder, although motor response may be sub-optimal.
I have made a significant impact in our understanding of the neurodegenerative disease PSP (average life-span 6-7 years). My work has highlighted the prevalence of PSP in the UK, its protean clinical features at presentation and the natural history. The PSP (Europe) Association used outcomes from this work to raise public and professional awareness of the disorder, to lobby parliament, and establish a UK-wide “best clinical care” model for people.
1. Co-applicant: Establishment of a Clinical Ageing Research Unit (CARU). Wellcome Trust: 2006 (£7.5 million) (G Ford, D Burn, JT O'Brien, R Taylor, IG McKeith, J Edwardson, T Kirkwood).
2. Co-applicant: The role of mitochondrial DNA in the pathogenesis of Parkinson’s disease. Parkinson’s Disease Society, UK: June 2007- May 2010 (£181207) (Chinnery PF, Burn DJ).
3. Co-applicant: Does cueing improve gait in people with Parkinson’s disease with dementia? Parkinson’s Disease Society, UK: August 2007 - July 2008 (£8184) (Rochester L, Burn DJ, Nieuwboer A).
4. Lead investigator: Visual symptoms in Parkinson’s disease and Parkinson’s disease dementia: Association with ocular and retinal pathology, visuo-perceptual deficits and impact on daily living and quality of life. Parkinson’s UK: November 2007-October 2010 (£206,446) (Archibald N, Mosimann UP, Clarke MP, Burn DJ).
5. Co-applicant: The role of common DNA variants in Parkinson’s disease. Wellcome Trust: February 2008 – January 2009 (£53,885) (Wood NW, Barker RA, Burn DJ, Chinnery PF, Hardy J, Morris HR, Morrison K, Clarke CE, Williams N).
6. Chief investigator: Predicting Dementia in Parkinson’s disease: A genotypic and phenotypic study (ICICLE-PD). Parkinson’s UK REF J0802, UK: October 2007 – September 2012 (£1,184,209) (Burn DJ, Barker RA, Brooks DJ, O’Brien JT, McKeith IG, Chinnery PF, Owen AM, Brayne CEG, Robbins T, Sawcer S, Coleman S).
7. Co-applicant: Genome-wide association studies in Parkinson’s disease. Parkinson’s UK REF J-0804: January 2009 – December 2010 (£292,590) (Wood NW, Hardy J, Barker RA, Burn DJ, Chinnery PF, Morris HR, Morrison K, Williams NM).
8. Chief investigator: Multicentre UK Study of the acetylcholinesterase inhibitor donepezil in early dementia associated with Parkinson's disease (MUSTARDD-PD). NIHR Health Technology Assessment Programme Project REF: 08/14/13: 1st Sept 2010 – 31st Aug 2015 (£2,119,113) (Burn DJ, Barker RA, Braithwaite B, Burns A, Clarke CE, Hindle JV, Knapp M, Lees AJ, Leroi I, McColl E, McKeith IG, O’Brien JT, Steen IN, Wheatley K).
9. Co-applicant: The Parkinson’s Repository of Biomarkers and Networked Datasets (PROBAND) programme: A UK national clinical consortium linking novel biomarker research to clinical expression, and progression rates, in Parkinson’s disease. Parkinson’s UK: 2011-2015 (£1,633,503) (Grosset D, Burn DJ, Barker RA, Ben-Shlomo Y, Bajaj N, Hardy J, Wood NW, Morris HR).
10. Principal applicant: Apomorphine: A modifier of amyloid deposition in Parkinson’s disease? Parkinson’s UK REF K-1101: October 2011 - April 2012 (£29,318) (Burn DJ, Revesz T, Lees AJ).
11. Principal applicant: Clinical trial to compare cognitive scales. Michael J Fox Foundation: 1st October 2011 - 30th September 2016 ($1,480,548) (Burn DJ, Weintraub D).
12. Principal applicant: A Biomedical Research Unit in Lewy Body Dementia. NIHR: 1st April 2012 - 31st March 2017 (£4.5M) (Burn DJ, McKeith IG, O’Brien JT, Kirkwood TBL, Chinnery PF, Ford GA).
13. Principal applicant: Predicting cognitive profiles in Parkinson’s disease: A multimodal approach. Michael J Fox Foundation: 1st November 2011 - 31st October 2013 ($153,342) (Burn DJ, Rochester L, O’Brien JT, Coleman SY, Baker MR).
14. Principle investigator in Parkinson's disease drug studies, including trials of cholinesterase inhibitors (rivastigmine and donepezil), memantine, ACP-103 (pimavanserin; UK Chief Investigator), droxidopa, rasagiline (ADAGIO UK Chief Investigator), rotigotine, istradefylline, intranasal apomorphine, entacapone, preladenant (UK Chief Investigator) and putative neuroprotective agents. Also UK Chief Investigator in NIH-funded tolerability of low dose lithium in PSP, davudenant as a neuroprotectant in PSP (Allon) studies.
Stage 2 MB BS Thoughts, Senses and Movement Course
Stage 3 MB BS Foundations of Clinical Practice