Research Staff - Centre for Brain Ageing and Vitality (CBAV)

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Dr Grainne Gorman
Biomedical Research Centre Fellow

Email: grainne.gorman@ncl.ac.uk
Telephone: +44 (0) 191 222 6365
Address: Mitochondrial Research Group
Institute for Ageing and Health
Medical School
Framlington Place
newcastle University

Publications

Jones KL, Whittaker RG, Miller JA, Jakovljevic DG, Turnbull DM, Gorman GS. Can high intensity interval training improve functional capacity and clinical symptoms in inflammatory and mitochondrial myopathies?. In: 6th Annual Translational Research Conference. 2013, Oxford, UK.
Bates MG, Hollingsworth KG, Newman J, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodeling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. European Heart Journal - Cardiovascular Imaging 2013, (epub ahead of print).
Elson JL, Cadogan M, Apabhai S, Whittaker RG, Phillips A, Trennell MI, Horvath R, Taylor RW, McFarland R, McColl E, Turnbull DM, Gorman GS. Initial development and validation of a mitochondrial disease quality of life scale. Neuromuscular Disorders 2013, 23(4), 324-329.
Horvath R, Czermin B, Gulati S, Demuth S, Houge G, Pyle A, Dineiger C, Blakely EL, Hassani A, Foley C, Brodhun M, Storm K, Kirschner J, Gorman GS, Lochmuller H, Holinski-Feder E, Taylor RW, Chinnery PF. Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3. Journal of Neurology, Neurosurgery and Psychiatry 2012, 83(2), 174-178.
Pitceathly RDS, Smith C, Fratter C, Alston CL, He LP, Craig K, Blakely EL, Evans JC, Taylor J, Shabbir Z, Deschauer M, Pohl U, Roberts ME, Jackson MC, Halfpenny CA, Turnpenny PD, Lunt PW, Hanna MG, Schaefer AM, McFarland R, Horvath R, Chinnery PF, Turnbull DM, Poulton J, Taylor RW, Gorman GS. Adults with RRM2B-related mitochondrial disease have distinct clinical and molecular characteristics. Brain 2012, 135(11), 3392-3403.
Hollingsworth KG, Gorman GS, Trenell MI, McFarland R, Taylor RW, Turnbull DM, Macgowan GA, Blamire AM, Chinnery PF. Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load. Neuromuscular Disorders 2012, 22(7), 592-596.
Maddison J, Straub V, Lochmuller H, Turnbull D, Chinnery P, Trennell M, McFarland R, Gorman G, Horvath R, Busbhy K. Clinical research activity in Newcastle MRC centre. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
Bates MGD, Hollingsworth KG, Newman J, Jakovljevic DG, Keavney BD, Blamire AM, MacGowan GA, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. In: Annual Conference of the British Cardiovascular Society (BCS). 2012, Manchester, UK: BMJ Group.
Bates M, Hollingsworth K, Taylor R, Turnbull D, Trenell MI, Gorman G. Concentric remodeling and increased myocardial torsion in mitochondrial DNA point mutation carriers. In: 61st Annual Scientific Session and Expo of the American College of Cardiology (ACC). 2012, Chicago, Illinois, USA: Elsevier Inc.
Yu-Wai-Man P, Gorman GS, Taylor RW, Turnbull DM. Diagnostic investigations of patients with chronic progressive external ophthalmoplegia. British Journal of Ophthalmology 2012, 96(12), 1536-1536.
Bates MG, Hollingsworth KG, Newman J, Jakovljevic D, Dixon BJ, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Evidence of early cardiac impairment in m.3243A > G mutation carriers. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
Piceathly RDS, Smith C, Fratter C, Blakely EL, Alston CL, Deschauer M, Horvath R, Hanna MG, Chinnery PF, Turnbull DM, Poulton J, Taylor RW, Gorman GS. Expanding the phenotypic and genotypic spectrum of adult RRM2B-related mitochondrial disease. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
Newman J, Jakovljevic D, Bates MG, Turnbull DM, Galna B, Trenell MI, Gorman GS. Improving clinical trials evaluation: physiological and functional correlates in mitochondrial disease. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
McNeill A, Gorman G, Khan A, Horvath R, Blamire AM, Chinnery PF. Progressive Brain Iron Accumulation in Neuroferritinopathy Measured by the Thalamic T2*Relaxation Rate. American Journal of Neuroradiology 2012, 33(9), 1810-1813.
Murphy JL, Newman J, Ratnaike TE, Spendiff S, Falkous G, Blakely EL, Alston CL, Taylor RW, Trenell MI, Gorman GS, Turnbull DM. Resistance training in patients with mitochondrial myopathy. In: United Nations Environment Programme, Mineral Resources Forum. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
Smith C, Evans J, Alston CL, Blakely EL, Seller A, Paceathly RDS, Schaefer AM, Turnbull DM, Taylor RW, Gorman GS, Poulton J, Fratter C. The c.48G > A variant in the mitochondrial DNA maintenance gene, RRM2B, causes adult-onset autosomal dominant PEO via aberrant splicing. In: British Human Genetics Conference. 2012, Coventry, UK: BMJ Group.
Narayan SK, Gorman G, Kalaria RN, Ford GA, Chinnery PF. The minimum prevalence of CADASIL in northeast England. Neurology 2012, 78(13), 1025-1027.
Neeve VCM, Samuels DC, Bindoff LA, van den Bosch B, Van Goethem G, Smeets H, Lombes A, Jardel C, Hirano M, DiMauro S, De Vries M, Smeitink J, Smits BW, de Coo IFM, Saft C, Klopstock T, Keiling BC, Czermin B, Abicht A, Lochmuller H, Hudson G, Gorman GG, Turnbull DM, Taylor RW, Holinski-Feder E, Chinnery PF, Horvath R. What is influencing the phenotype of the common homozygous polymerase-gamma mutation p.Ala467Thr?. Brain 2012, 135(12), 3614-3626.
Fratter C, Raman P, Alston CL, Blakely EL, Craig K, Smith C, Evans J, Seller A, Czermin B, Pitceathly RDS, Hanna MG, Poulton J, Brierley C, Staunton TG, Tumpenny PD, Schaefer AM, Chinnery PF, Horvath R, Tumbull DM, Gorman GS. Dominant and recessive RRM2B mutations are frequent in familial PEO with multiple mtDNA deletions. In: Journal of Medical Genetics: British Human Genetics Conference. 2011, Warwick, Coventry: BMJ Group.
Fratter C, Raman P, Alston C, Blakely EL, Craig K, Smith C, Evans J, Seller A, Czermin B, Hanna MG, Poulton J, Brierley C, Staunton TG, Turnpenny PD, Schaefer AM, Chinnery PF, Horvath R, Turnbull DM, Gorman GS, Taylor RW. Dominant and recessive RRM2B mutations cause familial PEO and multiple mtDNA deletions in muscle. In: Neuromuscular Disorders: United Kingdom Neuromuscular Translational Research Conference. 2011, London, UK: Elsevier Ltd.
Apabhai S, Gorman GS, Sutton L, Elson JL, Ploetz T, Turnbull DM, Trenell MI. Habitual Physical Activity in Mitochondrial Disease. PLoS One 2011, 6(7), e22294.
Horvath R, Reilich R, Krause S, Turnbull DM, Trenell M, Hollingsworth KG, Gorman GS, Czermin B, Holinski-Feder E, Walter MC, Schoser B, Lochmüller H. Neutral lipid storage myopathy due to PNPLA2 mutations may respond to beta-adrenergic treatment. In: UK Neuromuscular Translational Research Conference. 2011, London: Neuromuscular Disorders: Pergamon.
Fratter C, Raman P, Alston CL, Blakely EL, Craig K, Smith C, Evans J, Seller A, Czermin B, Hanna MG, Poulton J, Brierley C, Staunton TG, Turnpenny PD, Schaefer AM, Chinnery PF, Horvath R, Turnbull DM, Gorman GS, Taylor RW. RRM2B mutations are frequent in familial peo with multiple mtDNA deletions. Neurology 2011, 76(23), 2032-2034.
Reilich P, Horvath R, Krause S, Schramm N, Turnbull DM, Trenell M, Hollingsworth KG, Gorman GS, Hans VH, Reimann J, MacMillan A, Turner L, Schollen A, Witte G, Czermin B, Holinski-Feder E, Walter MC, Schoser B, Lochmuller H. The phenotypic spectrum of neutral lipid storage myopathy due to mutations in the PNPLA2 gene. Journal of Neurology 2011, 258(11), 1987-1997.

Centre for Brain Ageing and Vitality
Newcastle Biomedicine
Campus for Ageing & Vitality
Newcastle University, Newcastle upon Tyne
NE4 5PL, United Kingdom.
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Newcastle University

Centre for Brain Ageing and Vitality

Dr Grainne Gorman Biomedical Research Centre Fellow

Dr Grainne Gorman
Biomedical Research Centre Fellow