Newcastle University

Publications

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• Jordan N, Newton J, Pearson J, Allen A. A novel method for the visualization of the in situ mucus layer in rat and man. Clin Sci (Lond) 1998, 95(1), 97-106.
• Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radical Biology & Medicine 1998, 24, 885-893.
• Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in flbroblasts after extended periods of confluency. Free Radical Biology and Medicine 1998, 24, 885-893.
• Martin K, Kirkwood TBL, Potten CS. Age changes in stem cells of murine small intestinal crypts. Experimental Cell Research 1998, 241, 316-323.
• T.B.L. Kirkwood. Age-related changes in stem cells. In: Intervention in Aging VI. 1998, Rome: Societa' Italiana Di Gerontologia E Geriatria.
• Kirkwood TBL. Alex Comfort and the measure of aging. Experimental Gerontology 1998, 33, 135-140.
• Martin K, Potten CS, Roberts SA, Kirkwood TBL. Altered stem cell regeneration in irradiated intestinal crypts of senescent mice. Journal of Cell Science 1998, 111, 2297-2303.
• Billington CJ, Clark IM, Cawston TE. An aggrecan-degrading activity associated with chondrocyte membranes. Biochemical Journal 1998, 336(1), 207-212.
• Kirkwood TBL. Biological theories of aging: An overview. Aging-Clinical and Experimental Research 1998, 10, 144-146.
• T.B.L. Kirkwood. Book review of 'Ageing and Human Longevity' by Schulz-Aellen M-F. Cell Proliferation 1998, 31, 172.
• T.B.L. Kirkwood. Book review of 'Why We Age' by Austad SN. Age and Ageing 1998, 27, 661-662.
• Pountain, G., Hazleman, B. and Cawston, T.E. Circulating levels of IL-1 beta, IL-6 and soluble IL-2 receptor in polymyalgia rheumatics and giant cell arteritis and rheumatoid arthritis. British Journal of Rheumatology 1998, 37, 797-798.
• Shaw FE, Richardson DA, Bond J, McKeith IG, Kenny RA. Clinical characteristics of patients with cognitive impairment and dementia attending an accident and emergency facility with falls. In: Journal of the American Geriatrics Society. 1998, Wiley-Blackwell Publishing, Inc.
• MRC CFAS Medical Research Council Cognitive Function & Ageing Study, (McKeith I), (Hrisos S), (Bond J). Cognitive function and dementia in six areas of England and Wales: The distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. Psychological Medicine 1998, 28(2), 319-35.
• Kirkwood TBL. Design and analysis of aging studies. Aging-Clinical and Experimental Research 1998, 9, 438-439.
• Rowe J, Blamire AM, Domingo Z, Moody V, Molyneux A, Byrne J, Cadoux-Hudson T, Radda G. Discrepancies between cerebral perfusion and metabolism after subarachnoid haemorrhage: a magnetic resonance approach. Journal of Neurology, Neurosurgery and Psychiatry 1998, 64(1), 98-103.
• T.B.L. Kirkwood. Disposable soma theory (and other contributions). In: P. Calow, ed. The Encyclopaedia of Ecology & Environmental Management. Oxford: Blackwell Science, 1998, pp.192-193.
• Sommerburg O, Ullrich O, Sitte N, von Zglinicki T, Siems W, Grune T. Dose- and wavelength-dependent oxidation of crystallins by UV light - Selective recognition and degradation by the 20S proteasome. Free Radical Biology and Medicine 1998, 24, 1369-1374.
• Unwin N, Alberti G, Aspray T, Edwards R, Mbanya JC, Sobngwi E, Mugusi F, Rashid S, Setel P, Whiting D. Economic globalisation and its effect on health - Some diseases could be eradicated for the cost of a couple of fighter planes. British Medical Journal 1998, 316(7142), 1401-1402.
• M. E. Hurles,C. Irven,J. Nicholson,P. G. Taylor,F. R. Santos,J. Loughlin,M. A. Jobling,B. C. Sykes. European Y-chromosomal lineages in Polynesians: a contrast to the population structure revealed by mtDNA. Am J Hum Genet 1998, 63(6), 1793-806.
• T.B.L. Kirkwood. Evolution theory and the mechanisms of ageing. In: J.C. Brocklehurst;R.C. Tallis, ed. Textbook of Geriatric Medicine and Gerontology. London: Churchill Livingstone, 1998, pp.45-49.
• Newton JL, Jordan N, Oliver L, Strugala V, Pearson J, James OFW, Allen A. Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised. Gut 1998, 43(4), 470-475.
• Ballard C, Shaw F, McKeith I, Kenny R. High prevalence of neurovascular instability in neurodegenerative dementias. Neurology 1998, 51(6), 1760-1762.
• Westendorp RGJ, Kirkwood TBL. Human longevity at the cost of reproductive success. Nature 1998, 396, 743-746.
• J. Loughlin,C. Irven,Z. Mustafa,M. D. Briggs,A. Carr,S. A. Lynch,R. G. Knowlton,D. H. Cohn,B. Sykes. Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia. Hum Mutat 1998, Suppl 1, S10-7.
• Relton CL, Turnbull DM, Walker M. Increased expression of alpha-cardiac actin in cultured human skeletal muscle cells treated with troglitazone. Diabetes 1998, 47, A398.
• Perry RH, McKeith IG, Perry EK. Lewy body dementia. Neuroscience News 1998, 1(3), 28-35.
• Mueller JD, Haegle N, Keller G, Mueller E, Saretzky G, Bethke B, Stolte M, Hofler H. Loss of heterozygosity and microsatellite instability in de novo versus ex-adenoma carcinomas of the colorectum. Am J Pathol 1998, 153(6), 1977-84.
• Beauregard DA, Thelwall PE, Chaplin DJ, Hill SA, Adams GE, Brindle KM. Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status. British Journal of Cancer 1998, 77(11), 1761-7.
• Cawson TE. Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases. Molecular Medicine Today 1998, 4(3), 130-137.
• Cawston TE. Mechanisms of joint destruction and therapeutic approaches. Medicine 1998, 26(5), 4-10.
• Bamford C, Gregson B, Farrow G, Buck D, Dowswell T, McNamee P, Bond J, Wright K. Mental and physical frailty in older people: the costs and benefits of informal care. Ageing and Society 1998, 18(3), 317-354.
• R. Taylor, D. M. Broadbent, R. Greenwood, D. Hepburn, D. R. Owens and H. Simpson. Mobile retinal screening in Britain. Diabetic Medicine 1998, 15, 344-347.
• T.B.L. Kirkwood,A Kowald. Modeling mitochondrial DNA mutations. In: K.K. Singh, ed. Mitochondrial DNA Mutations in Aging, Disease and Cancer. Austin: Springer-Verlag and R.G. Landes Biomedical, 1998, pp.129-145.
• D. J. Wilkin,J. K. Szabo,R. Cameron,S. Henderson,G. A. Bellus,M. L. Mack,I. Kaitila,J. Loughlin,A. Munnich,B. Sykes,J. Bonaventure,C. A. Francomano. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet 1998, 63(3), 711-6.
• Kirkwood TBL. Ovarian ageing and the general biology of senescence. Maturitas 1998, 30, 105-111.
• Petersen S, Saretzki G, von Zglinicki T. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Experimental Cell Research 1998, 239(1), 152-160.
• Linnane AW, Ernster L, Nohl H, Orrenius S, Harman D, Ozawa T, Ji LL, Beckman K, Aiken JM, Pepe S, Feuers RJ, Wei YH, Mori A, Barja G, Hipkiss AR, von Zglinicki T, Driver C, Goto S, Curtay JP. Roundtable discussion - How best to ameliorate the normal increase in mitochondrial superoxide formation with advancing age. Towards Prolongation of the Healthy Life Span 1998, 854, 251-267.
• R. Taylor, G. D. Stainsby and D. L. Richardson. Rupture of the plantar fascia in the diabetic foot leads to toe dorsiflexion deformity. Diabetologia 1998, 41, 1071.
• Saretzki G, Feng JL, von Zglinicki T, Villeponteau B. Similar gene expression pattern in senescent and hyperoxic- treated fibroblasts. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 1998, 53, B438-B442.
• Saretzki G, Feng J, von Zglinicki T, Villeponteau B. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts. Journals of Gerontology Series A-Biological Sciences & Medical Sciences 1998, 53, B438-B442.
• Saretzki G, von Zglinicki T, Villeponteau B. Similar gene expression patterns in senescent and hyperoxically blocked fibroblasts. Towards Prolongation of the Healthy Life Span 1998, 854, 482-482.
• Brittain KR, Peet SM, Castleden CM. Stroke and incontinence. Stroke 1998, 29, 524-528.
• Ford D, Thwaites D, Simmons N, Gilbert H, Hirst B. Substrate upregulation of the human small intestinal peptide transporter, hPepT1. Journal of Physiology 1998, 507(3), 697-706.
• Muller A, Saretzki G, von Zglinicki T. Telomerase inhibition by induced expression of antisense RNA. Gene Therapy of Cancer 1998, 451, 23-26.
• Muller A, Saretzki G, von Zglinicki T. Telomerase inhibition by induced expression of antisense RNA. Advances in Experimental Medicine & Biology 1998, 451, 23-26.
• von Zglinicki T. Telomeres: Influencing the rate of aging. Towards Prolongation of the Healthy Life Span 1998, 854, 318-327.
• McGee MA, Johnson AL, Kay DWK, Med Res Council Cognitive Function Ageing Study, (Bond J, Gregson B, Hrisos S, McKeith I). The description of activities of daily living in five centres in England and Wales. Age and Ageing 1998, 27(5), 605-613.
• McKeith IG, Ince P, Jaros EB, Fairbairn A, Ballard C, Grace J, Morris CM, Perry RH. What are the relations between Lewy body disease and AD?. Journal of Neural Transmission Supplement 1998, (54), 107-116.