Newcastle University

Publications

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• Kalaria R. "Brain awareness" in Africa. NeuroReport: for rapid communication of neuroscience research 2000, 11(12), A1-A1.
• Poulton J, Turnbull DM. 74th ENMC International Workshop: Mitochondrial Diseases 19-20 November 1999, Naarden, The Netherlands. Neuromuscular Disorders 2000, 10(6), 460-462.
• Grace JB, Walker MP, McKeith IG. A comparison of sleep profiles in patients with dementia with Lewy bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry 2000, 15(11), 1028-1033.
• Adamson A, Curtis P, Loughridge J, Rugg-Gunn A, Spendiff A, Mathers J. A family-based intervention to increase consumption of starchy foods. Nutrition and Food Science 2000, 30(1), 19-23.
• Kowald A, Kirkwood TBL. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells. Journal of Theoretical Biology 2000, 202, 145-160.
• von Zglinicki T, Pilger R, Sitte N. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radical Biology and Medicine 2000, 28(1), 64-74.
• Newton JL. Action stat. Amiodarone overdose. Nursing 2000, 30(2), 33.
• Daly ME, Vale C, Walker M, Littlefield A, George K, Alberti MM, Mathers J. Acute fuel selection in response to high-sucrose and high-starch meals in healthy men. American Journal of Clinical Nutrition 2000, 71(6), 1516-1524.
• Marsden PJ, Murdoch AP, Taylor R. Adipocyte insulin action in hypogonadotrophic hypogonadism. Human Reproduction 2000, 15(8), 1672-1678.
• Martin K, Potten CS, Kirkwood TBL. Age-Related Changes in Irradiation-Induced Apoptosis and Expression of p21 and p53 in Crypt Stem Cells of Murine Intestine. Annals of the New York Academy of Sciences 2000, 908, 315-318.
• McKeith IG. Alzheimer's disease and related disorders: Etiology, pathogenesis and therapeutics. Review. Aging & Mental Health 2000, 4(1), 91-91.
• Perry S, Shaw C, Assassa P, Dallosso H, Williams K, Brittain KR. An epidemiological study to establish the prevalence of urinary symptoms and felt need in the community. Journal of Public Health Medicine 2000, 22(3), 427-434.
• Taylor RW, Wardell TM, Blakely EL, Borthwick GM, Brierley EJ, Turnbull DM. Analysis of Mitochondrial DNA Mutations. Methods in Molecular Medicine: Aging Methods and Protocols 2000, 38, 245-264.
• Taylor RW, Andrews RM, Chinnery PF, Turnbull DM. Analysis of mitochondrial DNA mutations: point mutations. In: Barnett, YA; Barnett, CR, ed. Ageing Methods and Protocols. New Jersey: Humana Press, 2000, pp.265-277.
• Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI. Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles. Diabetes 2000, 49(1), 126-130.
• Loughlin J, Dowling B, Mustafa Z, Smith A, Sykes B, Chapman K. Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: comment on the article by Meulenbelt et al. Arthritis Rheum 2000, 43(6), 1423-1425.
• Taylor R, Davies R, Fox C, Sampson M, Weaver JU, Wood L. Appropriate Insulin Regimes for Type 2 Diabetes: a multicenter randomized crossover study. Diabetes Care 2000, 23(11), 1612-1618.
• Taylor R, Davies R, Fox C, Sampson M, Weaver JU, Wood L. Appropriate insulin regimes for type 2 diabetes: A multicenter randomized crossover study. Diabetes Care 2000, 23(11), 1612-1618.
• Loughlin J, Sinsheimer JS, Mustafa Z, Carr AJ, Clipsham K, Bloomfield VA, Chitnavis J, Bailey A, Sykes B, Chapman K. Association analysis of the vitamin D receptor gene, the type I collagen gene COL1A1, and the estrogen receptor gene in idiopathic osteoarthritis. Journal of Rheumatology 2000, 27(3), 779-784.
• Lee MA, Blamire AM, Pendlebury S, Ho KH, Mills KR, Styles P, Palace J, Matthews PM. Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis. Archives of Neurology 2000, 57(1), 65-70.
• Harrington F, Clayton R, Saxby B, Murray A, Ford GA. Baroreflex sensitivity and blood pressure in the elderly. J Hypertension 2000, 18, 1-5.
• McKeith IG. Behavioral and psychological symptoms of dementia and dementia with Lewy bodies. In: International Psychogeriatrics. 2000, Cambridge University Press.
• Kirkwood TBL. Biological origins of aging. In: Evans, J.G., Williams T.F., Beattie, B.L., Michel, J.P., Wilcock, G.K, ed. Oxford Textbook of Geriatric Medicine. Oxford: Oxford University Press, 2000, pp.35-42.
• Toussaint O, Remacle J, Clark BFC, Gonos ES, Franceschi C, Kirkwood TBL. Biology of ageing. BioEssays 2000, 22(10), 954-956.
• Leake A, Morris CM, Whateley J. Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease. Neuroscience Letters 2000, 291(3), 201-203.
• Twist SJ, Taylor GA, Weddell A, Weightman DR, Edwardson JA, Morris CM. Brain oestradiol and testosterone levels in Alzheimer's disease. Neuroscience Letters 2000, 286(1), 1-4.
• Blank SC, Lyall R, Bushby KMD, Keers S, Coulthard A, Street E, Morris C, Kalaria RN, Ince P, Burn DJ. CADASIL in a British family: a multidisciplinary approach with NOTCH 3 mutation analysis. BRAIN, (In Press)<br>(Article) 2000.
• Kirkwood TBL, Shanley DP. Caloric restriction, hormesis and life history plasticity. Human and Experimental Toxicology 2000, 19(6), 338-339.
• Kirkwood TBL, Shanley DP. Caloric restriction, hormesis and life-history plasticity. BELLE Newsletter 2000, 8(3).
• Shanley DP, Kirkwood TBL. Calorie Restriction and Aging: A Life-History Analysis. Evolution 2000, 54(3), 740-750.
• Shaw FE, Richardson DA, Dawson P, Steen IN, McKeith IG, Bond J, Kenny RA. Can multi-disciplinary intervention prevent falls in patients with cognitive impairment and dementia attending a casualty department?. In: British Geriatrics Society Communications to the Autumn Meeting 1999. 2000, London: Oxford University Press.
• Shaw FE, Richardson DA, Dawson P, Steen IN, McKeith IG, Bond J, Kenny RA. Can multi-disciplinary intervention prevent falls in patients with cognitive impairment and dementia attending a casualty department?. Irish Journal of Medicine 2000, 169(2), 30.
• Shaw FE, Richardson DA, Dawson P, Steen IN, McKeith IG, Bond J, Kenny RA. Can multi-disciplinary intervention prevent falls in patients with cognitive impairment and dementia attending an accident and emergency facility?. In: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2000.
• Rowan AD, Billington CJ, Knight CG, Cawston TE. Cartilage destruction in arthritis: Collagen and aggrecan-degrading proteinases. In: Conference on Tissue Inhibitors of Metalloproteinases in Development and Disease. 2000, Banff, Canada: Harwood Academic Publishers, Gmbh.
• Rowan AD, Billington CJ, Knight CG, Cawston TE. Cartilage destruction in Arthritis: Collagen and Aggrecan-degrading Proteins. In: Tissue inhibitors of metalloproteinases in development and diseases: proceedings of the Inhibitors of Metalloproteinases Conference. 2000, Banff, Canada: Harwood Academic.
• Toussaint O, Medrano EE, Von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Experimental Gerontology 2000, 35(8), 927-945.
• Finch CE, Kirkwood TBL. Chance, Development and Aging. New York: Oxford University Press, 2000.
• Oldroyd JC, Unwin NC, Mathers JC, White M. Changes in diet, exercise and coronary heart disease risk factors: results of a lifestyle intervention in men and women with impaired glucose tolerance after 6 months follow-up. In: PROCEEDINGS OF THE NUTRITION SOCIETY. 2000.
• Howard A, Jordinson M, Goodlad RA, Walters JR, Ford D, Hirst BH. Changes in expression of intestinal peptide and amino acid transporters in rats fed by total parenteral nutrition. In: GASTROENTEROLOGY. 2000.
• Birkett AM, Mathers JC, Jones GP, Walker KZ, Roth MJ, Muir JG. Changes to the quantity and processing of starchy foods in a Western diet can increase polysaccharides escaping digestion and improve in vitro fermentation variables. British Journal of Nutrition 2000, 84(1), 63-72.
• Shaw FE, Richardson DA, Steen IN, McKeith IG, Bond J, Kenny RA. Clinical characteristics of fallers with cognitive impairment and dementia who comply with multi-disciplinary post-fall intervention. Age and Ageing 2000, 29(s2), A22.
• McKeith IG. Clinical Lewy body syndromes. Annals of the New York Academy of Science: Molecular Basis of Dementia 2000, 920, 1-8.
• Harrington F, Saxby BK, McKeith IG, Wesnes K, Ford GA. Cognitive performance in hypertensive and normotensive older subjects. Hypertension 2000, 36(6), 1079-1082.
• Harrington F, Saxby BK, McKeith IG, Wesnes K, Ford GA. Cognitive performance in hypertensive and normotensive older subjects. Hypertension 2000, 36(6), 1079-1082.
• Singhal P, Barker S, Taylor G, Caumo A, Cobelli C, Taylor R. Control of postprandial hepatic glucose output in type 2 diabetes and matched controls. In: Diabetologia. 2000, Springer.
• Pendlebury ST, Lee MA, Blamire AM, Styles P, Matthews PM. Correlating magnetic resonance imaging markers of axonal injury and demyelination in motor impairment secondary to stroke and multiple sclerosis. Magnetic Resonance Imaging 2000, 18(4), 369-378.
• Ford GA, Wood SM, Daly AK. CYP2D6 and CYP2C19 genotypes of patients with terodilin cardiotoxicity identified through the yellow card system. British Journal of Clinical Pharmacology 2000, 50(1), 77-80.
• Ford GA, Wood SM, Daly A. CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system. British Journal of Clinical Pharmacology 2000, 50(1), 77-80.
• Walker M, Jackson S, Yeaman SJ, Turnbull DM. Decreased glucose uptake in myoblasts from insulin resistant non-diabetic relatives of type 2 diabetic families. Diabetes 2000, 48(s1), A263-A264 abstract no. 1154.
• Jackson S, Bagstaff SM, Lynn S, Yeaman SJ, Turnbull DM, Walker M. Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells: From insulin-resistant nondiabetic relatives of type 2 diabetic families. Diabetes 2000, 49(7), 1169-1177.
• Ballard C, Piggott M, Johnson M, Cairns N, Perry R, McKeith I, Jaros E, O'Brien J, Holmes C, Perry E. Delusions associated with elevated muscarinic binding in dementia with Lewy bodies. Annals of Neurology 2000, 48(6), 868-876.
• Del Ser T, McKeith I, Anand R, Cicin-Sain A, Ferrara R, Spiegel R. Dementia with Lewy bodies: Findings from an international multicentre study. International Journal of Geriatric Psychiatry 2000, 15(11), 1034-1045.
• Unlu M, de Lange RPJ, de Silva R, Kalaria R, Clair DS. Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry. Neuroscience Letters 2000, 282(3), 149-152.
• Williams KS, Assassa RP, Smith N, Jagger C, Perry S, Shaw C, Dallosso H, McGrother C, Clarke M, Brittain K. Development, implementation and evaluation of a new nurse-led continence service: a pilot study. Journal of Clinical Nursing 2000, 9(4), 566-573.
• Mathers JC. Dietary strategies to reduce the burden of cancer and cardiovascular disease in the UK. British Journal of Nutrition 2000, 84(2), S211-S216.
• Thomas AJ, Morris CM, Ferrier IN, Kalaria RN. Distribution of amyloid beta(42) in relation to the cerebral microvasculature in an elderly cohort with Alzheimer's disease. Annals of the New York Academy of Science 2000, 903, 83-88.
• Thomas AJ, Morris CM, Ferrier IN, Kalaria RN. Distribution of amyloid β42 in relation to the cerebral microvasculature in an elderly cohort with Alzheimer's disease. Annals of the New York Academy of Sciences 2000, 903, 83-88.
• Coulthard A, Blank SC, Bushby K, Kalaria RN, Burn DJ. Distribution of cranial MRI abnormalities in patients with symptomatic and subclinical CADASIL. British Journal of Radiology 2000, 73(867), 256-265.
• Barnett YA, Barnett CR, Von Zglinicki T. DNA damage and telomere length in human T cells. JOURNAL OF ANTI-AGING MEDICINE 2000, 3(4), 383-388.
• Selwood SP, Chrzanowska-Lightowlers ZMA, Lightowlers RN. Does the mitochondrial transcription-termination complex play an essential role in controlling differential transcription of mitochondrial DNA?. In: Colloquium on Organisms, Organs, Cells and Organelles - In Vivo and In Vitro Experimental Systems. 2000, University College Cork, Ireland: Biochemical Society Transactions, Portland Press.
• Crome P, Ford GA. Drug Therapy in an Older Population. United Kingdom: Imperial College Press, 2000.
• Garnett MR, Blamire AM, Corkill RG, Cadoux-Hudson TAD, Rajagopalan B, Styles P. Early proton magnetic resonance spectroscopy in normal- appearing brain correlates with outcome in patients following traumatic brain injury. Brain 2000, 123(10), 2046-2054.
• Mellon AF, Deshpande SA, Mathers JC, Bartlett K. Effect of oral antibiotics on intestinal production of propionic acid. Archives of Disease in Childhood 2000, 82(2), 169-172.
• Majmudar NG, Robson SC, Ford GA. Effects of the Menopause, Gender, and Estrogen Replacement Therapy on Vascular Nitric Oxcide activity. The Journal of Clinical Endocrinology & Metabolism 2000, 85(4), 1577-1583.
• Majmudar NG, Robson SC, Ford GA. Effects of the menopause, gender, and estrogen replacement therapy on vascular nitric oxide activity. Journal of Clinical Endocrinology and Metabolism 2000, 85(4), 1577-1583.
• McKeith I, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, Cicin-Sain A, Ferrara R, Spiegel R. Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study. Lancet 2000, 356(9247), 2031-2036.
• Thomas AJ, Ferrier IN, Kalaria RN, Woodward SA, Ballard C, Oakley A, Perry RH, O'Brien JT. Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex. United States: American Psychiatric Association, 2000. American Journal of Psychiatry.
• Thomas AJ, Ferrier IN, Kalaria RN, Woodward SA, Ballard C, Oakley A, Perry RH, O'Brien JT. Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex. American Journal of Psychiatry 2000, 157(10), 1682-1684.
• Buck D, Jacoby A, Massey A, Ford G. Evaluation of Measures Used to Assess Quality of Life After Stroke. Stroke 2000, 31(8), 2004-2010.
• Buck D, Massey A, Ford GA, Jacoby A. Evaluation of measures used to assess Quality of Life and Stroke. Stroke 2000, 31, 2004-2010.
• Fernando M, O'Brien J, Gholkar A, Esiri M, Rossi M, Lowe J, Xuereb J, Ince P. Evaluation of white matter lesions in a large community derived sample of demented and non-demented elderly people. In: Neuropathology 2000 - XIVth International Congress of Neuropathology. 2000, Birmingham, England.
• Denise Robertson M, Livesey G, Hampton SM, Mathers JC. Evidence for altered control of glucose disposal after total colectomy. British Journal of Nutrition 2000, 84(6), 813-819.
• Garnett MR, Blamire AM, Rajagopalan B, Styles P, Cadoux-Hudson TAD. Evidence for cellular damage in normal-appearing white matter correlates with injury severity in patients following traumatic brain injury - A magnetic resonance spectroscopy study. Brain 2000, 123(7), 1403-1409.
• Cassell PG, Saker PJ, Huxtable SJ, Kousta E, Jackson AE, Hattersley AT, Frayling TM, Walker M, Kopelman PG, Ramachandran A, Snehelatha C, Hitman GA, McCarthy MI. Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin. Diabetologia 2000, 43(12), 1558-1564.
• Kirkwood TBL. Evolution of aging: how genetic factors affect the end of life. Generations 2000, 24, 12-18.
• Kirkwood TBL. Evolution of aging: How genetic factors affect the end of life. GENERATIONS-JOURNAL OF THE AMERICAN SOCIETY ON AGING 2000, 24(1), 12-18.
• Kirkwood TBL, Kapahi P, Shanley DP. Evolution, stress, and longevity. Journal of Anatomy 2000, 197, 587-590.
• Tyrer SP, Margallo-Lana ML, Moore PD, Kay DW, Perry RH, Berney TP, Morris C. Factors associated with cognitive decline in Down syndrome. In: 11th World Congress of the International Association for the Scientific Study of Intellectual Disabilities (IASSID). 2000, Seattle, Washington, USA: John Wiley & Sons.
• Robertson MD, Mathers JC. Gastric emptying rate of solids is reduced in a group of ileostomy patients. Digestive Diseases and Sciences 2000, 45(7), 1285-1292.
• Taylor RW, McGregor A, Lightowlers RN, Turnbull DM. Gene therapy for mitochondrial DNA defects. In: Ebadi, MS, ed. Mitochondrial Ubiquinone (Coenzyme Q10): biochemical, functional, medical and therapeutic aspects in human health and diseases. Prominent Press, Arizona, 2000.
• Henderson S, Sillence D, Loughlin J, Bennetts B, Sykes B. Germline and somatic mosaicism in achondroplasia. Journal of Medical Genetics 2000, 37(12), 956-958.
• Bennett SMA, Littlefield AC, Shearing PA, Walker M. Glucose-mediated glucose disposal in relatives of Type 2 diabetic patients. In: DIABETOLOGIA. 2000.
• McDermott CJ, Dayaratne RK, Tomkins J, Johnson MA, Casari G, Turnbull DM, Bushby K, Shaw PJ. Hereditary spastic paraparesis with amyotrophy and OXPHOS muscle defect associated with a deletion in the paraplegin (SPG7) gene with apparent autosomal dominant transmission. Neurology 2000, 54, A425-A425.
• Thomas NJ, Morris CM, Scaravilli F, Johansson J, Rossor M, De Lange R, St Clair D, Nicoll J, Blank C, Coulthard A, Bushby K, Ince PG, Burn D, Kalaria RN. Hereditary vascular dementia linked to notch 3 mutations - CADASIL in British families. Annals of the New York Academy of Sciences 2000, 903, 293-298.
• Thomas NJ, Morris CM, Scaravilli F, Johansson J, Rossor M, De Lange R, St Clair D, Nicoll J, Blank C, Coulthard A, Bushby K, Ince PG, Burn D, Kalaria RN. Hereditary vascular dementia linked to Notch 3 mutations: CADASIL in British families. Annals of the New York Academy of Sciences 2000, 903, 293-298.
• Armstrong F, Kirby J, Higgins CA, Coaker J, Mathers JC. High dose Hylon VII increases tumourigenesis and decreases lymphocyte proliferation in Min mice. In: PROCEEDINGS OF THE NUTRITION SOCIETY. 2000.
• Kirkwood TBL, Westendorp RGJ. Human longevity at the cost of reproductive success: trade-offs in the life history. In: Robine, J-M ; Kirkwood, TBL; Allard, M, ed. Sex and Longevity: Sexuality, Gender, Reproduction, Parenthood. New York: Springer, 2000, pp.1-6.
• Edwards R, Unwin N, Mugusi F, Whiting D, Rashid S, Kissima J, Aspray TJ, Alberti KGMM. Hypertension prevalence and care in an urban and rural area of Tanzania. Journal of Hypertension 2000, 18(2), 145-152.
• Ballard CG, McKeith IG, Ayre G, Gray A, Cormack F, Tovee M, O'Brien JT, Walker MP. Impairments in attention and fluctuating attention distinguish between dementia with Lewy bodies and Alzheimer's disease. Neurology 2000, 54(3), A451.
• Walker M. Insulin resistance: a problem for clinicians and scientists. Diabetic Medicine 2000, 17(5), 406-408.
• Taylor R, Marsden PJ. Insulin sensitivity and fertility. Human Fertility 2000, 3(1), 65-69.
• Mickleburgh I, Buddles M, West SP, Mathers JC, Curtis A. Interaction of selected food constituents with APC function in enterocytes. In: JOURNAL OF MEDICAL GENETICS. 2000.
• Blamire AM, Anthony DC, Rajagopalan B, Sibson NR, Perry VH, Styles P. Interleukin-1 beta-induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: A magnetic resonance study. The Journal of Neuroscience 2000, 20(21), 8153-8159.
• Lynn S, Hattersley AT, McCarthy MI, Frayling TM, Turnbull DM, Walker M. Intermediate expansions of a X25/frataxin gene GAA repeat and Type II diabetes: Assessment using parent-offspring trios [1]. Diabetologia 2000, 43(3), 384-385.
• Armstrong F, Mathers JC. Kill and cure: Dietary augmentation of immune defences against colon cancer. Proceedings of the Nutrition Society 2000, 59(2), 215-220.
• Birch-Machin MA, Taylor RW, Cochran B, Ackrell BAC, Turnbull DM. Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene. Annals of Neurology 2000, 48(3), 330-335.
• Mustafa Z, Chapman K, Irven C, Carr AJ, Clipsham K, Chitnavis J, Sinsheimer JS, Bloomfield VA, McCartney M, Cox O, Sykes B, Loughlin J. Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritis. Rheumatology 2000, 39(3), 299-306.
• Loughlin J, Mustafa Z, Smith A, Irven C, Carr AJ, Clipsham K, Chitnavis J, Bloomfield VA, McCartney M, Cox O, Sinsheimer JS, Sykes B, Chapman KE. Linkage analysis of chromosome 2q in osteoarthritis. Rheumatology 2000, 39(4), 377-381.
• Shaw FE, Richardson DA, Steen IN, McKeith IG, Bond J, Kenny RA. Longer term health and social outcomes in patients with cognitive impairment and dementia who attend the casualty department with a fall. In: Communications to the Spring Meeting of the British Geriatrics Society. 2000, Warwick: Oxford University Press.
• Diener HC, Cortens M, Ford G, Grotta J, Hacke W, Kaste M, Koudstaal PJ, Wessel T. Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. Stroke 2000, 31(11), 2543-2551.
• Crilley JG, Boehm EA, Rajagopalan B, Blamire AM, Styles P, Muntoni F, Hilton-Jones D, Clarke K. Magnetic resonance spectroscopy evidence of abnormal cardiac energetics in Xp21 muscular dystrophy. Journal of the American College of Cardiology 2000, 36(6), 1953-1958.
• Clark IM, Rowan AD, Cawston TE. Matrix metalloproteinases inhibitors in the treatment of arthritis. Current Opinions in Anti-inflammatory and Immunomodulatory Investigative Drugs 2000, 2, 16-25.
• Bigg HF, McLeod R, Waters JG, Cawston TE, Clark IM. Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor. FEBS Journal 2000, 267(13), 4150-4156.
• O'Brien JT, Metcalfe S, Swann A, Hobson J, Jobst K, Ballard C, McKeith I, Gholkar A. Medial temporal lobe width on CT scanning in Alzheimer's disease: Comparison with vascular dementia, depression and dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 2000, 11(2), 114-118.
• Kalaria RN, Cookson NJ, Mizuno T, Oakley A, Singleton AB, Morris CM, Coulthard A, Blank SC, Bushby KMD, Nicoll J, De Lange RPJ, Burn DJ, St Clair D. Microvascular pathology in familial multi-infarct dementia or CADASIL: implications for cerebral blood flow. In: Fukuuchi, Y; Tomita, M; Koto, A, ed. Ischemic Blood Flow in the Brain. Tokyo, New York: Springer, 2000, pp.431-442.
• Cottrell DA, Turnbull DM. Mitochondria and ageing. Current Opinion in Clinical Nutrition and Metabolic Care 2000, 3(6), 473-478.
• Cottrell DA, Turnbull DM. Mitochondria and Aging (Review). Current Opinion in Clinical Nutrition and Metabolic Care 2000, 3(6), 473-478.
• Chinnery PF, Taylor GA, Howell N, Andrews RM, Morris CM, Taylor RW, McKeith IG, Perry RH, Edwardson JA, Turnbull DM. Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies. Neurology 2000, 55(2), 302-304.
• Chinnery PF, Turnbull DM. Mitochondrial DNA mutations in the pathogenesis of human disease. Molecular Medicine Today 2000, 6(11), 425-432.
• Taylor RW, Wardell TM, Lightowlers RN, Turnbull DM. Molecular basis for treatment of mitochondrial myopathies. Neurological Sciences 2000, 21(9), S909-S912.
• Kirkwood TBL. Molecular gerontology. Bridging the simple and the complex. Annals of the New York Academy of Sciences 2000, 908, 14-20.
• Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT. MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry 2000, 15(10), 911-916.
• Morris HR, Vaughan JR, Datta SR, Bandopadhyay R, de Silva HAR, Schrag A, Cairns NJ, Burn D, Nath U, Lantos PL, Daniel S, Lees AJ, Quinn NP, Wood NW. Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE. Neurology 2000, 55(12), 1918-1920.
• Pandit RJ, Taylor R. Mydriasis and glaucoma: exploding the myth. A systematic review. Diabetic Medicine 2000, 17(10), 693-699.
• Cottrell DA, Ince PG, Blakely EL, Johnson MA, Chinnery PF, Hanna M, Turnbull DM. Neuropathological and histochemical changes in a multiple mitochondrial DNA deletion disorder. Journal of Neuropathology and Experimental Neurology 2000, 59(7), 621-627.
• Ballard C, McKeith I, O'Brien J, Kalaria R, Jaros E, Ince P, Perry R. Neuropathological substrates of dementia and depression in vascular dementia. with a particular focus on cases with small infarct volumes. Dementia and Geriatric Cognitive Disorders 2000, 11(2), 59-65.
• Court JA, Piggott MA, Lloyd S, Cookson N, Ballard CG, McKeith IG, Perry RH, Perry EK. Nicotine binding in human striatum: Elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience 2000, 98(1), 79-87.
• Frayling TM, McCarthy MI, Walker M, Levy JC, O'Rahilly S, Hitman GA, Subba Rao PV, Bennett AJ, Jones EC, Menzel S, Ellard S, Hattersley AT. No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians. Journal of Clinical Endocrinology and Metabolism 2000, 85(2), 853-857.
• Kalaria RN. Notch in health and disease. In: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000.
• Ballard C, O'Brien J, Swann A, Neill D, Lantos P, Holmes C, Burn D, Ince P, Perry R, McKeith I. One year follow-up of parkinsonism in dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 2000, 11(4), 219-222.
• Newton JL, Rawlings D, Prince MI, James OFW, Bassendine MF, Jones DEJ. Osteoporosis is not a specific complication of primary biliary cirrhosis (PBC). In: JOURNAL OF HEPATOLOGY. 2000.
• Singleton AB, Hall R, Ballard CG, Perry RH, Xuereb JH, Rubinsztein DC, Tysoe C, Matthews P, Cordell B, Kumar-Singh S, De Jonghe C, Cruts M, van Broeckhoven C, Morris CM. Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation. Brain 2000, 123(12), 2467-2474.
• Buck D, Jacoby A, Massey A, Ford G. Pre-testing items in a stroke-specific quality of life measure: the value of cognitive interviewing. In: JOURNAL OF NEUROLINGUISTICS. 2000.
• Shaw FE, Richardson DA, Steen IN, McKeith IG, Bond J, Kenny RA. Predictors of further falls in patients with cognitive impairment and dementia attending an accident and emergency facility. In: American Geriatrics Society/AFAR 2000 Annual Scientific Meeting. 2000, Nashville, TN: Wiley-Blackwell Publishing Ltd.
• Newton JL, Jones DE, Metcalf JV, Park JB, Burt AD, Bassendine MF, James OFW. Presentation and mortality of primary biliary cirrhosis in older patients. Age and Ageing 2000, 29(4), 305-309.
• Brittain KR, Perry S, Shaw C, Peet SM, Shaw C, Dallosso H, Assassa RP, Williams K, Jagger C, Potter JF, Castleden CM. Prevalence and impact of urinary symptoms among community-dwelling stroke survivors. Stroke 2000, 31, 886-891.
• O'Brien JT, Paling S, Barber R, Ballard C, McKeith I. Progressive brain atrophy on serial MRI in dementia with Lewy bodies: A comparison with Alzheimer's disease and vascular dementia. Neurobiology of Aging 2000, 21(1S), S130.
• Sitte N, Huber M, Grune T, Ladhoff A, Doecke WD, von Zglinicki TW, Davies KJA. Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts. FASEB Journal 2000, 14, 1490-1498.
• Sitte N, Merker K, Zglinicki vonT, Grune T, Davies KJA. Protein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part I -Effects of proliferative senescence. FASEB Journal 2000, 14, 2495-2502.
• Sitte N, Merker K, Zglinicki vonT, Davies KJA, Grune T. Protein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part II -Aging of non-dividing cells. FASEB Journal 2000, 14, 2503-2510.
• Sitte N, Merker K, von Zglinicki T, Grune T. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radical Biology and Medicine 2000, 28(5), 701-708.
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