Publications
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- Johns CE, May FEB, Newton JL. "Anorexia of ageing": Are gut hormones the answer?.
In: Annual Meeting of the British Society of Gastroenterology. 2004, Glasgow: BMJ Group.
- Gilbert HJ, O'Donnell AG, Mathers JC. 'Informative' horizontal gene transfer.
Nature Biotechnology 2004, 22(9), 1076-.
- Hartland S, Newton JL, Griffin SM, Donaldson PT. A Functional Polymorphism in the Interleukin-1 Receptor-1 Gene Is Associated with Increased Risk of Helicobacter pylori Infection but Not with Gastric Cancer.
Digestive Diseases and Sciences 2004, 49(9), 1545-1550.
- O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N. A Longitudinal Study of Hippocampal Volume, Cortisol Levels, and Cognition in Older Depressed Subjects.
American Journal of Psychiatry 2004, 161(11), 2081-2090.
- Gillespie C, Proctor CJ, Boys R, Shanley D, Wilkinson D, Kirkwood T. A mathematical model of ageing in yeast.
Journal of Theoretical Biology 2004, 229(2), 189-196.
- Hui W, Cawston TE, Richards CD, Rowan AD. A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.
Arthritis Research & Therapy 2004, 7(1), R57-R64.
- Maniura-Weber K, Taylor RW, Johnson MA, Chrzanowska-Lightowlers Z, Morris AAM, Charlton CPJ, Turnbull DM, Bindoff LA. A novel point mutation in the mitochondrial tRNA(Trp) gene produces a neurogastrointestinal syndrome.
European Journal of Human Genetics 2004, 12(6), 509-512.
- McFarland R, Taylor RW, Chinnery PF, Howell N, Turnbull DM. A novel sporadic mutation in cytochrome c oxidase subunit II as a cause of rhabdomyolysis.
Neuromuscular Disorders 2004, 14(2), 162-166.
- Shenfine J, McNamee P, Steen N, Glendinning S, Bond J, Griffin SM. A pragmatic, randomised controlled trial of the cost-effectiveness of palliative therapies for patients with inoperable oesophageal cancer.
British Journal of Surgery 2004, 91(S1), 101-102.
- Kienzl E, Attems J, Bergmann J, Janetzky B, Dal-Bianco P, Steindl F, Rattay F, Preddie E, Jellinger K. A proteomic and immunhistochemical approach to the study of Alzheimer disease.
In: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, Pennsylvania, USA: Neurobiology of Aging: Elsevier.
- Armstrong L, Lako M, van Herpe I, Evans J, Saretzki G, Hole N. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.
Mechanisms of Development 2004, 121(12), 1509-1522.
- Lodi R, Rajagopalan B, Blamire AM, Crilley JG, Styles P, Chinnery PF. Abnormal cardiac energetics in patients carrying the A3243G mtDNA mutation measured in vivo using phosphorus MR spectroscopy.
Biochimica et Biophysica Acta: Bioenergetics 2004, 1657(2-3), 146-150.
- Allan L, Johns E, Doshi M, Kenny RA, Newton JL. Abnormalities of sympathetic and parasympathetic autonomic function in subjects with defaecation syncope.
Europace 2004, 6(3), 192-198.
- Hudelist G, Koestler W, Attems J, Czerwenka K, Mueller R, Manavi M, Steger G, Kubista E, Zielinski CJ, Singer CF. Active Her-2/neu signal transduction in breast cancer - relevance of a ligand-independent activation mechanism and impact an the efficacy of trastuzumab-based treatment.
In: 40th Annual Meeting of the American Society of Clinical Oncology. 2004, New Orleans, Louisiana, USA: Journal of Clinical Oncology: American Society of Clinical Oncology.
- Howell N, Elson JL, Turnbull DM, Herrnstadt C. African haplogroup L mtDNA sequences show violations of clock-like evolution.
Molecular Biology and Evolution 2004, 21(10), 1843-1854.
- Johns CE, Newton JL, Westley BR, May FEB. Ageing and H pylori infection alter the diurnal rhythm of the gastric cytoprotective trefoil protein TFF2.
In: Annual Meeting of the British Society of Gastroenterology. 2004, Glasgow: Gut.
- Nor AM, McAllister C, Louw SJ, Dyker AG, Davis M, Jenkinson D, Ford GA. Agreement between ambulance paramedic- and physician-recorded neurological signs with Face Arm Speech Test (FAST) in acute stroke patients.
Stroke 2004, 35(6), 1355-1359.
- Kirkwood TBL. Alchemy of aging (Book review of Merchants of Immortality: Chasing the Dream of Human Life Extension).
Nature Medicine 2004, 10(6), 575.
- Attems J, Lintner F, Jellinger KA. Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology.
Acta Neuropathologica 2004, 107(4), 283-291.
- Andrews HE, Barron MJ, Edgar J, Turnbull DM, Bates D, Griffiths IR, Nichols P. AN INVESTIGATION INTO THE ROLE OF MITOCHONDRIA IN THE AXONAL RESPONSE TO DEMYELINATION USING A MYELIN BASIC PROTEIN MUTANT (SHIVERER) MOUSE MODEL.
In: Association of British Neurologists’ Spring Meeting. 2004.
- Ballard CG, Morris CM, Rao H, O'Brien JT, Barber R, Stephens S, Rowan E, Gibson A, Kalaria RN, Kenny RA. APOE ε4 and cognitive decline in older stroke patients with early cognitive impairment.
Neurology 2004, 63(8), 1399-1402.
- Burton L, Norton M, Newton JL. Are some antihypertensives more prone to induce hypotensive side effects than others?.
Age and Ageing 2004, 33(6), 626-628.
- Netherwood T, Martin-Orue SM, O'Donnell AG, Gockling S, Graham J, Mathers JC, Gilbert HJ. Assessing the survival of transgenic plant DNA in the human gastrointestinal tract.
Nature Biotechnology 2004, 22(2), 204-209.
- McFarland R, Elson JL, Taylor RW, Howell N, Turnbull DM. Assigning pathogenicity to mitochondrial tRNA mutations: when 'definitely maybe' is not good enough.
Trends in Genetics 2004, 20(12), 591-596.
- Newton JL, Bhalla N, Jones DE. Autonomic dysfunction is common in both cirrhotic and precirrhotic primary biliary cirrhosis.
In: Hepatology: 55th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2004, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
- Warren NM, Piggott MA, Greally E, Lake M, Kilford L, Lees AJ, Burn DJ. Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy.
In: Journal of Neurology, Neurosurgery and Psychiatry: Spring Meeting of the Association of British Neurologists. 2004, London, UK: BMJ Group.
- Corner L, Bond J. Being at risk of dementia: Fears and anxieties of older adults.
Journal of Aging Studies 2004, 18(2), 143-155.
- Molloy S, O'Brien JT, McKeith IG, Burn DJ. Can parkinsonian phenotype be used to predict levodopa response in extrapyramidal syndromes with and without dementia?.
In: Journal of Neurology, Neurosurgery and Psychiatry: Spring Meeting of the Association of British Neurologists. 2004, London, UK: BMJ Group.
- Kenny RA, Shaw FE, O'Brien JT, Scheltens PH, Kalaria R, Ballard C. Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions.
Journal of Neurology, Neurosurgery and Psychiatry 2004, 75(7), 966-971.
- Taylor RW, Schaefer AM, McDonnell MT, Petty RKH, Thomas AM, Blakely EL, Hayes CM, McFarland R, Turnbull DM. Catastrophic presentation of mitochondrial disease due to a mutation in the tRNAHis gene.
Neurology 2004, 62(8), 1420-1423.
- Taylor R. Causation of Type 2 Diabetes - The Gordian Knot Unravels.
New England Journal of Medicine 2004, 350(7), 639-641.
- Burton EJ, Karas G, Paling SM, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT. Cerebral atrophy in dementia with Lewy bodies studied using voxel-based morphometry.
In: 2nd Meeting of the Alzheimers Imaging Consortium. 2004, Stockholm, Sweden: Neurobiology of Aging: Elsevier.
- Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. Cerebral atrophy in Parkinson's disease with and without dementia: A comparison with Alzheimer's disease, dementia with Lewy bodies and controls.
Brain 2004, 127(4), 791-800.
- Minett TS, Dean JL, Firbank M, English P, O'Brien JT. Cerebral white matter lesions and subjective memory complaints in the elderly.
In: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, PA: Neurobiology of Aging: Elsevier.
- McNamee P, Glendinning S, Shenfine J, Steen N, Griffin S, Bond J. Chained time trade-off and standard gamble methods: Applications in oesophageal cancer.
European Journal of Health Economics 2004, 5(1), 81-86.
- Mathers JC. Chairman's introduction: What can we expect to learn from genomics?.
In: Summer Meeting of the Nutrition Society: Symposium on 'How and why measure individual variability'. 2004, King's College, London: Cambridge University Press.
- Craigie AM, Mathers JC, Rugg-Gunn AJ, Adamson AJ. Change in nutrient intake between adolescence and adulthood: A 21-year longitudial study.
Nutrition Bulletin 2004, 29(3), 204-212.
- Newton JL. Changes in upper gastrointestinal physiology with age.
Mechanisms of Ageing and Development 2004, 125(12), 867-870.
- Zohouri FV, Rugg-Gunn AJ, Fletcher ES, Hackett AF, Moynihan PJ, Mathers JC, Adamson AJ. Changes in water intake of Northumbrian adolescents 1980 to 2000.
British Dental Journal 2004, 196(9), 547-552.
- Fletcher ES, Rugg-Gunn AJ, Matthews JNS, Hackett A, Moynihan PJ, Mathers JC, Adamson AJ. Changes over 20 years in macronutrient intake and body mass index in 11- to 12-year-old adolescents living in Northumberland.
British Journal of Nutrition 2004, 92(2), 321-333.
- MacIntyre E, Neely D, Aspray T, Quinton R. Chronic, severe osteomalacia with hypocalcaemia: I. Standard doses of Vitamin D replacement may be inadequate. II. Plasma PTH level is a sensitive and reliable marker of treatment response.
In: 12th International Congress of Endocrinology Poster Presentation: Series A, Calcium Bone. 2004, Lisbon, Portugal.
- Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH, Duyckaerts C, Stankoff B, Pillon B, Skullerud K, Cruz-Sanchez FF, Bigio EH, Mackenzie IRA, Gearing M, Juncos JL, Glass JD, Yokoo H, Nakazato Y, Mosaheb S, Thorpe JR, Uryu K, Lee VMY, Trojanowski JQ. Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease.
Neurology 2004, 63(8), 1376-1384.
- Burn DJ, Mosimann UP, McKeith IG. Clinical Diagnosis of Dementia with Lewy Bodies.
In: Litvan, I, ed. Atypical Parkinsonian Disorders: Clinical and Research Aspects. Totowa, NJ: Humana Press Inc, 2004, pp.361-373.
- Burn DJ. Common errors and service deficiencies in the investigation and management of Parkinson’s disease.
In: Findley, L., Hurwitz, B., Miles, A, ed. The Effective Management of Parkinson’s Disease. London, UK: Aesculapius Medical Press, 2004, pp.219-228.
- Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA, Hattersley AT, Frayling TM. Common variants of the hepatocyte nuclear factor-4α P2 promoter are associated with type 2 diabetes in the U.K. population.
Diabetes 2004, 53(11), 3002-3006.
- Forster T, Chapman K, Loughlin J. Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis.
Human Genetics 2004, 114(4), 391-395.
- Elson JL, Turnbull DM, Howell N. Comparative Genomics and the Evolution of Human Mitochondrial DNA: Assessing the Effects of Selection.
American Journal of Human Genetics 2004, 74(2), 229-238.
- Ballmaier M, O'Brien JT, Burton EJ, Thompson PM, Rex DE, Narr KL, McKeith IG, DeLuca H, Toga AW. Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: Diagnosis and gender effects.
NeuroImage 2004, 23(1), 325-335.
- Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG. Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain.
Neuropathology and Applied Neurobiology 2004, 30(4), 385-395.
- Burn DJ. Cortical Lewy body disease.
Journal of Neurology, Neurosurgery and Psychiatry 2004, 75(2), 175-178.
- McIntyre EA, Halse R, Yeaman SJ, Walker M. Cultured muscle cells from insulin-resistant type 2 diabetes patients have impaired insulin, but normal 5-amino-4-imidazolecarboxamide riboside-stimulated, glucose uptake.
Journal of Clinical Endocrinology and Metabolism 2004, 89(7), 3440-3448.
- McFarland R, Kirby DM, Fowler KJ, Ohtake A, Ryan MT, Amor DJ, Fletcher JM, Dixon JW, Collins FA, Turnbull DM, Taylor RW, Thorburn DR. De Novo Mutations in the Mitochondrial ND3 Gene as a Cause of Infantile Mitochondrial Encephalopathy and Complex I Deficiency.
Annals of Neurology 2004, 55(1), 58-64.
- Mukaetova-Ladinska EB, McKeith IG. Delirium and dementia.
Medicine 2004, 32(8), 44-47.
- McKeith I. Dementia in Parkinson's disease: common and treatable.
Lancet Neurology 2004, 3(8), 456-456.
- McKeith I, Mintzer J, Aarsland D, Burn D, Chiu H, Cohen-Mansfield J, Dickson D, Dubois B, Duda JE, Feldman H, Gauthier S, Halliday G, Lawlor B, Lippa C, Lopez OL, Carlos MacHado J, O'Brien J, Playfer J, Reid W, On behalf of the International Psychogeriatric Association Expert Meeting on DLB. Dementia with Lewy bodies.
Lancet Neurology 2004, 3(1), 19-28.
- Burn DJ, Perry EK, O'Brien JT, et al. Dementia with Lewy Bodies.
In: Charney, D.S., Nestler, E.J, ed. Neurobiology of Mental Illness. Oxford, UK: Oxford University Press, 2004, pp.881-895.
- McKeith IG, Mosimann UP. Dementia with Lewy bodies and Parkinson's disease.
In: 8th International Symposium on the Treatment of Parkinsons Disease. 2004, Kobe, Japan: Parkinsonism & Related Disorders: Elsevier.
- Buck D, Jacoby A, Massey A, Steen N, Sharma A, Ford GA. Development and validation of NEWSQOL (R), the Newcastle Stroke-Specific Quality of Life Measure.
Cerebrovascular Diseases 2004, 17(2-3), 143-152.
- Nor AM, Shipsey D, Sen B, Davis J, Dyker AG, Louw SJ, Davis M, Ford GA. Development and validation of the ROSIER scale: A stroke recognition instrument for the emergency room.
In: Stroke. 2004, San Diego, California: American Heart Association.
- Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE. Developmental plasticity and human health.
Nature 2004, 430(6998), 419-421.
- Lake AA, Adamson AJ, Hyland RM, Mathers JC. Dietary change and perceptions of change over time.
Nutrition Bulletin 2004, 29(3), 199-203.
- Relton CL, Daniel CP, Hammal DM, Parker L, Tawn EJ, Burn J. DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns.
Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis 2004, 545(1-2), 49-57.
- Relton CL, Daniel CP, Hammal DM, Parker L, Tawn EJ, Burn J. DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2004, 545(1-2), 49-57.
- White M, Bunting J, Williams E, Raybould S, Adamson A, Mathers JC. Do 'food deserts' exist? A multi-level, geographical analysis of the relationship between retail food access, socio-economic position and dietary intake.
London: Food Standards Agency, 2004.
- Stewart D, Morgan E, Burn D, Grosset D, Chaudhuri KR, MacMahon D, Needleman F, Macphee G, Heywood P. Dopamine agonist switching in Parkinson's disease.
Hospital Medicine 2004, 65(4), 215-219.
- O'Brien JT, Colloby S, Burn D, Williams D. Dopamine transporter loss visualised with FP-CIT spect indementia with Lewy bodies.
In: Neurobiology of Aging: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, Pennsylvania, USA: Elsevier Inc.
- O'Brien JT, Colloby S, Fenwick J, Williams D, Firbank M, Burn DJ, McKeith IG. Dopamine transporter loss visualized with FP-CIT SPECT in dementia with Lewy bodies.
Archives of Neurology 2004, 61(6), 919-925.
- O'Brien JT, Colloby S, Fenwick J, Williams ED, Firbank M, Burn D, Aarsland D, McKeith IG. Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with lewy bodies.
Archives of Neurology 2004, 61(6), 919-925.
- Adamson AJ, Mathers JC. Effecting dietary change.
Proceedings of the Nutrition Society 2004, 63(4), 537-547.
- Krams M, Lees KR, Hacke W, Grieve AP, Orgogozo JM, Ford GA. Effectively bridging the preclinical/clinical gap: The results of the ASTIN trial - Response.
Stroke 2004, 35(4), E81-E82.
- Burkle A, Leake A, Muller M, Kirkwood TB, Pfeiffer R. Efficiency of repair of DNA single-strand breaks correlates with life span of mammalian species.
In: Naunyn-Schmiedeberg's Archives of Pharmacology. 2004, Mainz, Germany: Springer.
- Thomas AJ, Davis S, Ferrier IN, Kalaria RN, O'Brien JT. Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder.
Biological Psychiatry 2004, 55(6), 652-655.
- Sanderson P, Johnson IT, Mathers JC, Powers HJ, Downes CS, McGlynn AP, Dare R, Kampman E, Pool-Zobel BL, Bingham SA, Rafter JJ. Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report.
British Journal of Nutrition 2004, 91(2), 315-322.
- Forrest IA, Murphy D, Lordan JL, Pritchard GE, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Corris PA, Ward C. Epithelial to mesenchymal transition in clinically stable lung transplantation.
In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
- Kirkwood TBL. Expectations of Life.
British Actuarial Journal 2004, 10(1), 75-100.
- Sobngwi E, Mbanya J-C, Unwin NC, Porcher R, Kengne A-P, Fezeu L, Minkoulou EM, Tournoux C, Gautier J-F, Aspray TJ, Alberti K. Exposure over the life course to an urban environment and its relation with obesity, diabetes, and hypertension in rural and urban Cameroon.
International Journal of Epidemiology 2004, 33(4), 769-776.
- Loughlin J. Familial inheritance of osteoarthritis: documented family subsets.
Clinical Orthopaedics and Related Research 2004, 427(supplement), S22-25.
- McFarland R, Schaefer AM, Gardner JL, Lynn S, Hayes CM, Barron MJ, Walker M, Chinnery PF, Taylor RW, Turnbull DM. Familial Myopathy: New Insights into the T14709C Mitochondrial tRNA Mutation.
Annals of Neurology 2004, 55(4), 478-484.
- Forster T, Chapman K, Marcelline L, Mustafa Z, Southam L, Loughlin J. Finer linkage mapping of primary osteoarthritis susceptibility loci on chromosomes 4 and 16 in families with affected women.
Arthritis & Rheumatism 2004, 50(1), 98-102.
- McKay JA, Williams EA, Mathers JC. Folate and DNA methylation during in utero development and aging.
Biochemical Society Transactions 2004, 32(6), 1006-1007.
- Allcock LM, Ullyart K, Kenny RA, Burn DJ. Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease.
Journal of Neurology, Neurosurgery and Psychiatry 2004, 75(10), 1470-1471.
- Colloby S, O'Brien J. Functional imaging in Parkinson's disease and dementia with Lewy bodies.
Journal of Geriatric Psychiatry and Neurology 2004, 17(3), 158-163.
- Chrzanowska-Lightowlers ZMA, Temperley RJ, Smith PM, Seneca SH, Lightowlers RN. Functional polypeptides can be synthesized from human mitochondrial transcripts lacking termination codons.
Biochemical Journal 2004, 377(3), 725-731.
- Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, Ferreira A, Ciesielski C, Carson DA, Corr M. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.
Proceedings of the National Academy of Sciences of the United States of America 2004, 101(26), 9757-9762.
- Relton CL, Wilding CS, Pearce MS, Laffling AJ, Jonas PA, Lynch SA, Tawn EJ, Burn J. Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population.
Journal of Medical Genetics 2004, 41(4), 256-260.
- McKeith IG, Wesnes KA, Perry E, Ferrara R. Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodies.
Dementia and Geriatric Cognitive Disorders 2004, 18(1), 94-100.
- Ross R, Newton JL. Heart rate and blood pressure changes during gastroscopy in healthy older subjects.
Gerontology 2004, 50(3), 182-186.
- Mills GW, Avery PJ, McCarthy MI, Hattersley AT, Levy JC, Hitman GA, Sampson M, Walker M. Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to Type 2 diabetes.
Diabetologia 2004, 47(4), 732-738.
- Morris CM, Wilson KE. High throughput approaches in neuroscience.
In: International Journal of Developmental Neuroscience: International Conference on Molecular Mechanisms of Neurodegeneration and Neuroprotection. 2004, Leipzig, Germany: Pergamon.
- Wiseman RM, Saxby BK, Burton EJ, Barber R, Ford GA, O'Brien JT. Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects.
Neurology 2004, 63(10), 1892-1897.
- Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT. Hippocampal volume change in depression: Late- and early-onset illness compared.
British Journal of Psychiatry 2004, 184(6), 488-495.
- Amdam GV, Simoes ZLP, Hagen A, Norberg K, Schroder K, Mikkelsen O, Kirkwood TBL, Omholt SW. Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees.
Experimental Gerontology 2004, 39(5), 767-773.
- Kalaria RN, Spoors L, Laude EA, Emery CJ, Thwaites-Bee D, Fairlie J, Oakley AE, Barer DH, Barer GR. Hypoxia of sleep apnoea: cardiopulmonary and cerebral changes after intermittent hypoxia in rats.
Respiratory Physiology & Neurobiology 2004, 140(1), 53-62.
- O'Brien JT, Colloby S, Pakrasi S, Burn D, Williams D, Wyper D, Owens J, McKeith I. I-123-QNB SPECT demonstrates loss of cholinergic muscarinic receptors in Alzheimer's disease, but occipital increases in dementia with lewy bodies and Parkinson's disease dementia.
In: Neurobiology of Aging: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, Pennsylvania, USA: Elsevier Inc.
- Pye D, Watt DJ, Walker C, Lightowlers RN, Turnbull DM. Identification of the RAG-1 as a suitable mouse model for mitochondrial DNA disease.
Neuromuscular Disorders 2004, 14(5), 329-336.
- Murphy DM, Forrest IA, Ward C, Pritchard G, Jones D, Egan JJ, Cawston TE, Corris PA, Lordan JL. IL-17 stimulates IL-8 release in primary epithelial cell cultures derived from lung allografts.
In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
- Rowan EN, Saxby BK, Askew KA, Thomas AJ, Manktelow TC, Wesner LA, McKeith IG. Improved attentional performance in DLB and PDD following donepezil treatment.
In: Journal of Psychopharmacology: Summer Meeting of the British Association for Psychopharmacology. 2004, Harrogate, UK: Sage Publications Ltd.
- Goetz P, Blamire AM, Rajagopalan B, Cadoux-Hudson T, Young D, Styles P. Increase in apparent diffusion coefficient in normal appearing white matter following human traumatic brain injury correlates with injury severity.
Journal of Neurotrauma 2004, 21(6), 645-654.
- Howard A, Goodlad RA, Walters JRF, Ford D, Hirst BH. Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2.
Journal of Nutrition 2004, 134(11), 2957-2964.
- Van Den Biggelaar AHJ, De Craen AJM, Gussekloo J, Huizinga TWJ, Heijmans BT, Frolich M, Kirkwood TBL, Westendorp RGJ. Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming.
FASEB Journal 2004, 18(9), 1022-1024.
- Margallo-Lana M, Morris CM, Gibson AM, Tan AL, Kay DWK, Tyrer SP, Moore B, Ballard CG. Influence of the amyloid precursor protein locus on dementia in Down syndrome.
Neurology 2004, 62(11), 1996-1998.
- Ford D. Intestinal and placental zinc transport pathways.
Proceedings of the Nutrition Society 2004, 63(1), 21-29.
- Kirkwood TBL. Intrinsic ageing of gut epithelial stem cells.
Mechanisms of Ageing and Development 2004, 125(12), 911-915.
- McKeith IG. Introduction - An update on the diagnosis and treatment of dementia with Lewy bodies.
Dementia and Geriatric Cognitive Disorders 2004, 17(s1), 1-2.
- Ray M, Bohr I, McIntosh JM, Ballard C, McKeith I, Chalon S, Guilloteau D, Perry R, Perry E, Court JA, Piggott M. Involvement of alpha 6/alpha 3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [I-125]-alpha-conotoxin MII binding in the thalamus and striatum.
Neuroscience Letters 2004, 372(3), 220-225.
- Corner L, Bond J. Involving people with dementia and their carers in research.
In: INVOLVE 4TH National Conference "People at the Heart of Research". 2004, London, UK.
- Basu A, Dillon RDS, Marshall SM, Taylor R, Davison JM. Is normalisation of serum potassium and magnesium always necessary in Gitelman Syndrome for a successful obstetric outcome?.
BJOG: An International Journal of Obstetrics and Gynaecology 2004, 111(6), 630-634.
- Mickleburgh I, Burtle B, Nury D, Chabanon H, Chrzanowska-Lightowlers ZMA, Hesketh J. Isolation and identification of a protein binding to the localization element of Metallothionein-1 mRNA.
Biochemical Society Transactions 2004, 32(5), 705-7066.
- Moynihan PJ, Wood CE, Hindmarsh PN, Adamson AJ, Seal CJ, Mathers JC. Knowledge of food safety practices amongst older adults.
In: Procedings of the Nutrition Society. 2004, Dublin: Cambridge University Press.
- Kirkwood TBL. Life span: Evolutionary, ecological and demographic perspectives.
The Quarterly Review of Biology 2004, 79(2), 217.
- Victor CR, Scambler SJ, Bond J, Bowling A. Loneliness in later life.
In: Walker, A., Hennessy, C.H, ed. Growing Older: Quality of Life in Old Age. Maidenhead: Open University Press, 2004, pp.107-126.
- Arun CS, Pandit R, Taylor R. Long-term progression of retinopathy after initiation of insulin therapy in Type 2 diabetes: An observational study.
Diabetologia 2004, 47(8), 1380-1384.
- Lake AA, Rugg-Gunn AJ, Hyland RM, Wood CE, Mathers JC, Adamson AJ. Longitudinal dietary change from adolescence to adulthood: perceptions, attributions and evidence.
Appetite 2004, 42(3), 255-263.
- Aspray TJ, Stevenson P, Abdy SE, Rawlings DJ, Holland TM, Francis RM. Low bone mineral density measurements in care home residents - a treatable cause of fractures.
In: 10th Conference of the National Osteoporosis Society. 2004, Harrogate, England: Osteoporosis International: Springer.
- Relton CL, Wilding CS, Laffling AJ, Jonas PA, Burgess T, Binks K, Tawn EJ, Burn J. Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy.
Molecular Genetics and Metabolism 2004, 81(4), 273-281.
- Hampton JL, Parry SW, Kenny RA, Newton JL. Lower 24 hour urinary sodium concentrations are associated with more severe symptoms in subjects with vasovagal syncope.
Heart 2004, 90(6), 687-688.
- Kurz T, Leake A, von Zglinicki T, Brunk UT. Lysosomal redox-active iron is important for oxidative stress-induced DNA damage.
In: Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May be Forseeable. 2004, Cambridge, UK: New York Academy of Sciences.
- Coulthard EJ, Firbank M, English PT, Birchall D, Welch J, O'Brien J, Griffiths D. Magnetic resonance spectroscopy as a diagnostic tool in frontotemporal dementia.
In: Journal of Neurology, Neurosurgery and Psychiatry: Annual Meeting of the British Neuropsychiatry Association. 2004, London, UK: BMJ Group.
- Dashora UK, Taylor R. Maintaining glycaemic control during high-dose prednisolone administration for hyperemesis gravidarum in Type 1 diabetes.
Diabetic Medicine 2004, 21(3), 298-299.
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British Journal of Diabetes and Vascular Disease 2004, 4(4), 227-231.
- Gagliardi D, Stepien PP, Temperley RJ, Lightowlers RN, Chrzanowska-Lightowlers ZMA. Messenger RNA stability in mitochondria: Different means to an end.
Trends in Genetics 2004, 20(6), 260-267.
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Arthritis & Rheumatism 2004, 50(12), 3910-3914.
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In: MULTIPLE SCLEROSIS. 2004.
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Journal of Medical Genetics 2004, 41(2), e19.
- Blakely EL, He L, Taylor RW, Chinnery PF, Lightowlers RN, Schaefer AM, Turnbull DM. Mitochondrial DNA deletion in identical twins.
Journal of Medical Genetics 2004, 41(2), e19.
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Journal of Medical Genetics 2004, 41(4), e41-e41.
- Taylor RW, He L, Proctor SJ, Middleton PG, Turnbull DM. Mitochondrial DNA mutations in the haematopoietic system.
Leukemia 2004, 18(1), 169-170.
- Ince PG, Fernando MS, Matthews F, Brayne C, O'Brien JT. Molecular pathology and vascular morphology of 'incidental' MRI white matter lesions in the ageing brain indicate an ischaemic origin.
In: Stroke: 5th World Stroke Congress. 2004, Vancouver, Canada: Lippincott Williams & Wilkins.
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Magnetic Resonance in Medicine 2004, 51(2), 248-252.
- Kirby DM, McFarland R, Ohtake A, Dunning C, Ryan MT, Wilson C, Ketteridge D, Turnbull DM, Thorburn DR, Taylor RW. Mutations of the mitochondrial ND1 gene as a cause of MELAS.
Journal of Medical Genetics 2004, 41(10), 784-789.
- Nunomura A, Chiba S, Lippa CF, Cras P, Kalaria RN, Takeda A, Honda K, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease.
Neurobiology of Disease 2004, 17(1), 108-113.
- Betts J, Lightowlers RN, Turnbull DM. Neuropathological Aspects of Mitochondrial DNA Disease.
Neurochemical Research 2004, 29(3), 505-511.
- Hendricksen M, Thomas AJ, Ferrier IN, Ince P, O'Brien JT. Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression.
American Journal of Psychiatry 2004, 161(6), 1096-1102.
- Ballard CG, Jacoby R, Del Ser T, Khan MN, Munoz DG, Holmes C, Nagy Z, Perry EK, Joachim C, Jaros E, O'Brien JT, Perry RH, McKeith IG. Neuropathological Substrates of Psychiatric Symptoms in Prospectively Studied Patients With Autopsy- Confirmed Dementia With Lewy Bodies.
American Journal of Psychiatry 2004, 161(5), 843-849.
- Burn DJ, Troster AI. Neuropsychiatric complications of medical and surgical therapies for Parkinson's disease.
Journal of Geriatric Psychiatry and Neurology 2004, 17(3), 172-180.
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Neurology 2004, 63(6), 983-988.
- Deschauer M, Chinnery PF, Schaefer AM, Turnbull DM, Taylor RW, Zierz S, Shanske S, DiMauro S, Mojamaa K, Wilichowski E, Thorburn DR. No association of the mitochondrial DNA A12308G polymorphism with increased risk of stroke in patients with the A3243G mutation.
Journal of Neurology, Neurosurgery and Psychiatry 2004, 75(8), 1204-1205.
- Keers SM, Gibson AM, Turnbull DM, Chinnery PF. No evidence of an association between the mtDNA 16184-93 polyC tract and late onset dementia.
American Journal of Medical Genetics 2004, 41(12), 957-958.
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Journal of Medical Genetics 2004, 41(1), e7.
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European Journal of Human Genetics 2004, 12(9), 778-781.
- Kolesnikova OA, Entelis NS, Jacquin-Becker C, Goltzene F, Chrzanowska-Lightowlers ZM, Lightowlers RN, Martin RP, Tarassov I. Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells.
Human Molecular Genetics 2004, 13(20), 2519-2534.
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In: Gerontologist: Symposium at Gerontological Society of America, 57th Annual Meeting. 2004, Washington, DC, USA: Oxford University Press.
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Acta Neuropathologica 2004, 107(2), 83-90.
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Journal of Drug Targeting 2004, 12(7), 405-413.
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In: Journal of Neurology, Neurosurgery and Psychiatry: Autumn Meeting of the Association of British Neurologists. 2004, Glasgow, UK: BMJ Group.
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In: Journal of Clinical Oncology: 40th Annual Meeting of the American Society of Clinical Oncology. 2004, New Orleans, Lousiana, USA: American Society of Clinical Oncology.
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Age and Ageing 2004, 33(1), 87.
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Journal of the Neurological Sciences 2004, 226(1-2), 1-2.
- McFarland R, Taylor RW, Elson JL, Lightowlers RN, Turnbull DM, Howell N, Scaglia F, Vogel H, Hawkins EP, Vladutiu GD, Guan M-X, Liu L-L, Wong L-JC. Proving pathogenicity: When evolution is not enough.
American Journal of Medical Genetics 2004, 131(1), 107-110.
- Bond J, Corner L. Quality of life and older people.
Buckingham: Open University Press, 2004.
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Magnetic Resonance in Medicine 2004, 51(6), 1122-1128.
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In: 10th Conference of the National Osteoporosis Society. 2004, Harrogate, England: Osteoporosis International: Springer.
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Movement Disorders 2004, 19(5), 534-543.
- Newton JL. Re: Guidelines for the diagnosis and management of PMR/GCA - Reply.
Age and Ageing 2004, 33(2), 211-211.
- Reddy R, Janssens L, Kelly SB, Welfare M, Williams L, Mathers JC. Rectal brush biopsy - Exploration of its role as an alternate source of colorectal tissue for bowel research.
In: Gut: Annual Meeting of the British Society of Gastroenterology. 2004, Glasgow, UK: BMJ Group.
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In: 9th International Conference on Alzheimers Disease and Related Disorders. 2004, Philadelphia, Pennsylvania, USA: Neurobiology of Aging: Elsevier.
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Dysphagia 2004, 19(4), 231-240.
- Kurz T, Leake A, Von Zglinicki T, Brunk UT. Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage.
Biochemical Journal 2004, 378(3), 1039-1045.
- Burn J, Mathers J, Barker G, Bishop T. Resistant starch and aspirin in genetically predisposed people: The CAPP studies.
In: Cancer Epidemiology, Biomarkers & Prevention: 3rd Annual AACR International Conference. 2004, Seattle, Washington, USA: American Association for Cancer Research.
- Newton JL, Bhalla N, Jones DE. Risk factors for sudden cardiac death in primary biliary cirrhosis.
In: Hepatology: 55th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). 2004, Boston, Massachusetts, USA: John Wiley & Sons, Inc.
- Chinnery PF, DiMauro S, Shanske S, Schon EA, Zeviani M, Mariotti C, Carrara F, Lombes A, Laforet P, Ogier H, Jaksch M, Lochmuller H, Horvath R, Deschauer M, Thorburn DR, Bindoff LA, Poulton J, Taylor RW, Matthews JNS, Turnbull DM. Risk of developing a mitochondrial DNA deletion disorder.
The Lancet 2004, 364(9434), 592-596.
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Journal of Geriatric Psychiatry and Neurology 2004, 17(3), 164-171.
- Burn DJ. Role of magnetic resonance spectroscopy in assessing neurodegenerative disease progression.
In: Movement Disorders: 4th International Medical Workshop of the Progressive Supranuclear Palsy Association. 2004, Buckinghamshire, UK: John Wiley & Sons, Inc.
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Diabetologia 2004, 47(5), 957-958.
- Johnson J, Hague SM, Hanson M, Gibson A, Wilson KE, Evans EW, Singleton AA, McInerney-Leo A, Nussbaum RL, Hernandez DG, Gallardo M, McKeith IG, Burn DJ, Ryu M, Hellstrom O, Ravina B, Eerola J, Perry RH, Jaros E, Tienari P, Weiser R, Gwinn-Hardy K, Morris CM, Hardy J, Singleton AB. SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
Neurology 2004, 63(3), 554-556.
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Psychiatry 2004, 3(12), 5-7.
- Bond J, Corner L, Graham RH. Social science theory on dementia research: Normal ageing, cultural representation and social exclusion.
In: Innes A; Archibald C; Murphy C, ed. Dementia and Social Inclusion: Marginalised groups and marginalised areas of dementia research, care and practice. London: Jessica Kingsley, 2004, pp.220-236.
- Adams J, White M, Pearce MS, Martin-Ruiz C, Parker L, von Zglinicki T. Socio-economic position, health behaviours and telomere length at age 50: a prospective cohort study.
In: 4th European Congress of Biogerontology. 2004, Newcastle upon Tyne, UK.
- Bidooki S, Jackson MJ, Johnson MA, Chrzanowska-Lightowlers ZMA, Taylor RW, Venables G, Lightowlers RN, Turnbull DM, Bindoff LA. Sporadic mitochondrial myopathy due to a new mutation in the mitochondrial tRNASer(UCN) gene.
Neuromuscular Disorders 2004, 14(7), 417-420.
- Dehghan-Kooshkghazi M, Mathers JC. Starch digestion, large-bowel fermentation and intestinal mucosal cell proliferation in rats treated with the α-glucosidase inhibitor acarbose.
British Journal of Nutrition 2004, 91(3), 357-365.
- Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, Von Zglinicki T. Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span.
Journal of Biological Chemistry 2004, 279(17), 17826-17833.
- Smith PM, Ross GF, Taylor RW, Turnbull DM, Lightowlers RN. Strategies for treating disorders of the mitochondrial genome.
In: Biochimica et Biophysica Acta: Bioenergetics. 6th European Meeting on Mitochondrial Pathology (Euromit 6). 2004, Nijmegen, Netherlands: Elsevier BV.
- Saretzki G, Armstrong L, Leake A, Lako M, Von Zglinicki T. Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells.
Stem Cells 2004, 22(6), 962-971.
- Walker Z, Costa DC, Walker RWH, Lee L, Livingston G, Jaros E, Perry R, McKeith I, Katona CLE. Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: A comparison.
Neurology 2004, 62(9), 1568-1572.
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British Journal of Clinical Pharmacology 2004, 57(1), 15-26.
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In: 2nd Meeting of the Alzheimers Imaging Consortium. 2004, Stockholm, Sweden: Neurobiology of Aging: Elsevier.
- Keys B, Serra V, Saretzki G, von Zglinicki T. Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang.
Aging Cell 2004, 3(3), 103-109.
- Newton J, Johns CE, May FEB. The ageing bowel and intolerance to aspirin.
Alimentary Pharmacology and Therapeutics 2004, 19(1), 39-45.
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Medical Image Analysis 2004, 8(1), 69-79.
- Colloby SJ, O'Brien JT, Fenwick JD, Firbank MJ, Burn DJ, McKeith IG, Williams ED. The application of statistical parametric mapping to I-123-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease.
NeuroImage 2004, 23(3), 956-966.
- Mathers JC. The biological revolution - Towards a mechanistic understanding of the impact of diet on cancer risk.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2004, 551(1-2), 43-49.
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Wiener Medizinische Wochenschrift 2004, 154(7-8), 159-162.
- Mason JM, Dickinson HO, Ford GA, Williams B. The diabetogenic potential of thiazide-type diuretics and beta-blocker combinations in the management of hypertension.
In: British Hypertension Annual Scientific Meeting. 2004, Cambridge, UK.
- Taylor RW, Schaefer AM, Barron MJ, McFarland R, Turnbull DM. The diagnosis of mitochondrial muscle disease.
Neuromuscular Disorders 2004, 14(4), 237-245.
- Barron MJ, Griffiths P, Turnbull DM, Bates D, Nichols P. The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head.
British Journal of Ophthalmology 2004, 88(2), 286-290.
- Newton JL, James OFW, Williams GV, Allen A. The diurnal profile of gastric pepsin activity is reduced with Helicobacter pylori infection.
Digestive Diseases and Sciences 2004, 49(7-8), 1103-1108.
- Hills SA, Balkau B, Coppack SW, Dekker JM, Mari A, Natali A, Walker M, Ferrannini E. The EGIR-RISC Study (the European group for the study of insulin resistance: Relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and Objectives.
Diabetologia 2004, 47(3), 566-570.
- Schaefer AM, Taylor RW, Turnbull DM, Chinnery PF. The epidemiology of mitochondrial disorders - past, present and future.
In: Biochimica et Biophysica Acta: Bioenergetics. 6th European Meeting on Mitochondrial Pathology (Euromit 6). 2004, Nijmegen, Netherlands: Elsevier BV.
- Wood CE, Land B, Adamson AJ, Seal CJ, Mathers JC, Moynihan PJ. The nutrient intake of older adults living in sheltered housing accommodation.
In: Proceedings of the Nutrition Society. 2004, Dublin: Cambridge University Press.
- Chinnery P, DiMauro S, Zeviani M, Lombes A, Lochmuller H, Thorburn D, Bindoff LA, Poulton J, Deschauer M, Taylor RW, Matthews JNS, Turnbull DM. The risk of developing a mitochondrial DNA deletion disorder.
In: Journal of Medical Genetics: British Human Genetics Conference. 2004, York, UK: BMJ Group.
- Jeyapalan, J., Leake, A., Ahmed, S., Saretzki, G., Tilby, M.J., Von Zglinicki, T. The role of telomeres in etoposide induced tumor cell death.
Cell Cycle 2004, 3(9), 1169-1176.
- Ford GA. Thrombolysis for stroke in the over 80s.
Age and Ageing 2004, 33(2), 95-97.
- Wilding CS, Relton CL, Sutton MJ, Jonas PA, Lynch S-A, Tawn EJ, Burn J. Thymidylate synthase repeat polymorphisms and risk of neural tube defects in a population from the northern United Kingdom.
Birth Defects Research Part A - Clinical and Molecular Teratology 2004, 70(7), 483-485.
- Bond J, Brittain K. Tonsillectomy and Adeno-tonsillectomy in children with recurrent sore throat: evidence based or professional habit?.
ENT News 2004, 13(2), 54-55.
- Gieroba ZJ, Newton JL, Parry SW, Norton M, Lawson J, Kenny RA. Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: A review of 10 years' experience.
Journal of the American Geriatrics Society 2004, 52(11), 1913-1915.
- Belshaw NJ, Elliott GO, Williams EA, Bradbum DM, Mills SJ, Mathers JC, Johnson IT. Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer.
Cancer Epidemiology Biomarkers and Prevention 2004, 13(9), 1495-1501.
- Garg DK, Coupe A, Williams EA, Bradburn M, Mathers JC. Use of gene hypermethylation in stool samples for detection of colorectal cancer: early results.
In: British Journal of Surgery. 2004, John Wiley & Sons Ltd.
- Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG. Visual perception in Parkinson disease dementia and dementia with Lewy bodies.
Neurology 2004, 63(11), 2091-2096.
- Burton EJ, Kenny RA, O'Brien J, Stephens S, Bradbury M, Rowan E, Kalaria R, Firbank M, Wesnes K, Ballard C. White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients.
Stroke 2004, 35(6), 1270-1275.
- Bond J. [abstract] Self-reported health status: an important predictor of function, cognitive impairment and death? Presentation as part of a symposium: The 3 D's - Dementia, Disability and Death: the UK Medical Research Council Cognitive Function and Ageing Study (MRC CFAS); Jagger, C., Brayne, C., Mendes de Leon,C.
Gerontologist 2004, 44(Special Issue 1), 586.
- Attems J, Lintner F, Jellinger KA. [correction] Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology (vol 107, pg 283, 2004).
Acta Neuropathologica 2004, 107(5), 479-480.
- O'Brien J. [meeting abstract] Neurobiological changes in late life depression: Cause or consequence?.
Journal of Affective Disorders 2004, 78(s1), S26-S27.