Dr Heath Murray
Royal Society Research Fellow

  • Email: heath.murray@ncl.ac.uk
  • Telephone: +44 (0) 191 208 3233
  • Fax: +44 0 (191) 208 7424
  • Address: The Centre for Bacterial Cell Biology
    Medical Science New Building
    Medical School
    Newcastle University
    Richardson Road
    Newcastle upon Tyne
    NE2 4AX
    United Kingdom

RESEARCH EXPERIENCE

Royal Society University Research Fellow (2009-2017)

Postdoctoral Fellow (2004-2009) - Professor Jeff Errington, FRS FMedSci

Graduate Fellow (1998-2003) -  Professor Richard Gourse, PhD

Undergraduate Scholar (1994-1998) - Associate Professor Robert Simons, PhD

 

EDUCATION

Ph.D. Genetics  (University of Wisconsin-Madison, USA)

B.S. Microbiology & Molecular Genetics (University of California-Los Angeles, USA)

 

HONORS AND AWARDS

Royal Society University Research Fellow (2009-2014)

Human Frontier Science Program Postdoctoral Fellowship (2005-2007)

European Molecular Biology Organization Postdoctoral Fellowship (2004)

USA National Institutes of Health Postdoctoral Fellowship (2004; declined)

UW-Madison Genetics Department Outstanding Graduate Student Award (2003)

National Institutes of Health Genetics Training Fellowship (1998-2001)

Howard Hughes Undergraduate Research Fellowship (1996, 1997)

University of California Regents Scholarship (1994-1998)

 

Regulation of Bacterial DNA Replication Initiation

We use the model organism Bacillus subtilis to study the regulation of DNA replication initiation. We have discovered that the highly conserved Soj/ParA protein regulates the AAA+ DNA replication initiator protein DnaA, and we have proposed that Soj/ParA acts as a molecular switch to control DnaA activity (Murray and Errington, 2008). Using a combination of genetics, cell biology, molecular biology, and biochemistry, we are investigating the mechanism of DnaA regulation by Soj/ParA and the cellular signals that govern the Soj/ParA switch. Our long-term goal is to understand the molecular mechanisms that coordinate bacterial DNA replication initiation with cell growth and division.

 

Research Team

Alan Koh - PhD student

Tom Richardson - Postdoc

Nadia Rostami - PhD student

 

Opportunities

Individuals interested in Post-doctoral research positions within our group should have a strong background in general microbiology, molecular biological, biochemistry, and/or cell biology methods, and should have a demonstrated record of high productivity in peer-reviewed literature. Interested candidates should send a CV, along with two reference letters, directly to heath.murray@newcastle.ac.uk.

MMB8016 - Control of DNA Replication in Bacteria