Newcastle University

Julian Morris is Professor of Process Control at Newcastle University and Visiting Professor in the Department of Pure and Applied Chemistry at the University of Strathclyde. He is a past head of the School of Chemical Engineering and Advanced Materials; Technical Director Centre for Process Analytics and Control Technology (CPACT) (www.cpact.com), and Associate Director of AJM Consulting (www.ajm.co.uk) where he is guiding the further development of the MS2 multivariate analysis and process data mining system and its expansion into a real-time on-line monitoring system, and past CEO and Non-Executive Director Bioinnovel Ltd.  He is a member of the Centre for Process Innovation (CPI) Advisory Committee and has been since CPI’s inception, a member of the CPI High Temperature Innovation Centre Technology Technical and Innovation Advisory Group, and a member of the NEPIC Innovation and Thrust Team. 

He is a Chartered Engineer and Fellow of the Institution of Chemical Engineers, the Institute of Measurement and Control and a past Fellow of the IEE. He has spent some time as Professor of Chemical Engineering at the University of Alberta in Canada. His research interests include process diagnostics and condition monitoring, process performance monitoring, Process Analytical Technologies, neural networks, and advanced process control and optimisation. His contributions to process control are recognised by the co-receipt of a number of Paper prizes and awards. He has authored/co-authored over 190 articles in scientific journals, conferences and books, given over 75 invited lectures, and 50 Plenary and Keynote presentations. He has been elected to Fellow of the Royal Academy of Engineering for his contributions to process systems engineering.

Research Interests

Process Diagnostics, Process Performance Monitoring, Multivariate Statistical Process Control, Multivariate statistical modelling, Chemometrics, Empirical modelling - statistical, neural networks and hybrid modelling; Development and Application of these methodologies and technologies in pharmaceuticals, speciality chemicals, and the materials processing industries

Esteem Indicators - Invited Presentations

Morris, A.J., Invited presentation, “Smart Process Analytical Technologies for Rapid Scale‐up and Control”, IQPC 9th Annual PAT and Quality by Design, London, February 2012.

Morris, A.J., Invited presentation, "Smart process analytics for faster process scale-up and control", informa life sciences Process Validation Conference, Berlin, November 2011.

Morris, A. J. Invited Meeting Chair and presentation “Small Scale Bio-production – Beyond the Flask”, Welwyn Garden City, November 2011.

Morris, A. J. and D. Littlejohn Invited presentation “Process Measurements at CPACT”, NEPIC Innovation Day - Showcasing UK Excellence & Opportunity, November 15^th, 2011

Morris A. J. and D. Lovett, “PAT and Quality by Design – A Process Systems View”, Advances in process control – APC9, York, September 2011

Morris, A.J., Invited presentation “Rapid Prototyping and Scale-Up in Industrial Process Innovation”, Scientific Update Conference on Scale-up of Chemical Processes, Boston, USA, 11th – 13th July 2011

Morris A.J., Invited Presentation “Challenges in the implementation of PAT and QbD – smart spectroscopic processing and modelling”, 2nd Biannual Conference on Delivering a Potent and High Potent API Manufacturing & Handling Strategies, Munich Germany, May 2011. (Only academic on the Prestigious Speaker Panel)

Morris A.J., Invited presentation “Process Performance (Condition) Monitoring – from Data to Understanding and Know-how”, Institution of Engineering and Technology (IET), South Yorkshire Network Presentation 23rd February 2011

Morris, A.J., Invited presentation “Developments in Process Analysis”, NEPIC Pharmaceutical & Biotechnology Sector Opportuities & Developments in the NE, February 2011.

Morris, A.J., Invited presentation, “Smart Process Analytics & Process Systems Engineering

Contributions to Quality by Design”, IFPAC Baltimore February 2010.

Morris, A.J., Invited Short Course, “Process Control and Automation – Without Equations”, IFPAC Baltimore February 2010.

Morris, A.J., Invited presentation, “Multivariate Statistical Process Control - Moving Towards Model-Based Approaches”, Pharma IQ -  7th Annual PAT and Quality by Design, London January 2010.

Morris, A.J., Invited Opening Keynote presentation, “A Process Systems Engineering View of PAT, QbD and Real-Time-Release (in Chemicals and Materials Manufacturing)”, Workshop on Measurements and Separation Technologies, Kristiansand Norway, February 2010.

Morris, A.J., Invited presentation, “Process Analytical Technologies (PAT) and Quality by Design - the Impact for Process Systems Engineering”, Symposium on New Frontiers in Chemical & Biochemical Engineering, Thessaloniki, 26-28 Nov 2009

Morris, A.J. and Z-P Chen, Invited Opening presentation “PAT and Smart Chemometrics for Assured Pharma Development and Production”, Protein Scale-Up & Manufacturing - Harnessing Complexity, PEGS Summit Conference, Boston USA, 6^th – 10^th April 2009.

Morris, A.J. and Z-P Chen, Invited presentation “From Data to Knowledge through Smart Process Analytical Technologies (PAT) and Process Systems Engineering”, Process Analytical Technology in Organic Process R&D Conference, Brussels, March 2009.

Morris, A.J. Invited Conference Chair, 6th Annual PAT and Quality by Design (IQPC), London, February 24^th 2009. 

Morris, A.J. and Z-P Chen, Invited Keynote presentation, “Challenges for PAT and Chemometrics in Product and Process Development and Production”, 6th Annual PAT and Quality by Design (IQPC), London, February 24^th 2009. 

Morris, A.J. and S. Coleman, Invited Pre-Conference Full Day Workshop “Increasing Process Effectiveness and Efficiency through the Collaboration of PAT, Lean Six Sigma and Data Analysis”, Pharma IQ 6th Annual PAT and Quality by Design, London, February 23^rd 2009.

Morris, A.J. and Z-P Chen, Invited presentation “Bioprocess Understanding through Advanced Chemometrics and PAT Data Fusion”, Applikon Biotechnology Symposium, Liverpool 28^th October 2008.

Morris, A.J. and Z-P Chen, Invited Keynote presentation, “PAT and its Implications for Robust Process Monitoring and Closed loop Control”, EuPAT, Scientific Progress Underpinning Innovative Manufacturing Control and Quality by Design, Göteborg Sweden, 28-29 October 2008.

Morris, A.J. and Z-P Chen, Invited Keynote presentation, “Process Analytical Technologies and Quality by Design – a Process Systems Engineering View”, ISPE Conference: PAT Data Management, September, Manchester, 2008.

Morris, A.J. and Z-P Chen, Invited Keynote presentation, “Process Analytical Technologies and Quality by Design – a Process Systems Engineering View”, 7^th European Symposium on Biochemical Engineering (ESBES 7), Faro Portugal, September 2008.

Morris, A.J. and Z-P Chen, Invited Keynote presentation, “Process Analytical Technologies and Quality by Design – a Process Systems Engineering View”, Royal Statistical Society Conference, Nottingham, September 2008.

Morris, A.J. and Z-P Chen, Invited Keynote presentation, “Chemometrics and its Relation to PAT”, IBC Euroforum Meeting on PAT- Process Analytical Technology, 1-2 April 2008, Copenhagen,

Professional Development Course Teaching

Multivariate Data Analsis;  Modelling and Multivariate Statistical Process Control PAT;  Multivariate Data Analysis and Lean Six-Sigma;  and Introduction to Process Control for Chemists, Pharmacists and Formulation Scientists

• Chen Z-P, Zhong L-J, Nordon A, Littlejohn D, Holden M, Fazenda M, Harvey L, McNeil B, Faulkner J, Morris J. Calibration of Multiplexed Fibre Optic Spectroscopy. Analytical Chemistry 2011. In Press.
• Serradilla J, Shi JQ, Morris AJ. Fault detection based on Gaussian process latent variable models. Chemometrics and Intelligent Laboratory Systems 2011, 109(1), 9-21.
• Hong JJ, Zhang J, Morris J. Fault Localization in Batch Processes through Progressive Principal Component Analysis Modeling. Industrial & Engineering Chemistry Research 2011, 50(13), 8153-8162.
• Yang AD, Martin E, Morris J. Identification of semi-parametric hybrid process models. Computers & Chemical Engineering 2011, 35(1), 63-70.
• Khan S, Ma CY, Mahmud T, Penchev RY, Roberts KJ, Morris J, Ozkan L, White G, Grieve B, Hall A, Buser P, Gibson N, Keller P, Shuttleworth P, Price CJ. In-Process Monitoring and Control of Supersaturation in Seeded Batch Cooliong Cryastallisation of L-Glumatic Acid: From Laboratory to Industrial Plant. Organic Process Research & Development 2011, 15(3), 540-555.
• Chen Z-P, Lovett D, Morris AJ. Process Analytical Technologies and Real Time Process Control A Review of Some Spectroscopic Issues and Challenges. Journal of Process Control 2011. In Press.
• Morris AJ, Littlejohn D, Benson R. Contributing to the Sustainability of the UK Chemicals and Pharmaceuticals Industries. European Pharmaceutical Review 2010, 36-38.
• Benson R, Morris AJ. What Goes Around Comes Around. Pharmaceutical Packing and Manufacturing Sourcer (PMPS) 2010, 82-86.
• Hong JJ, Zhang J, Morris J. Enhanced Predictive Modeling Using Multi Block Methods. In: 19th European Symposium on Computer Aided Process Engineering. 2009, Cracow, Poland: Elsevier BV.
• Stubbs S, Zhang J, Morris J. Fault detection of dynamic processes using a simplified monitoring-specific CVA state space approach. Computer Aided Chemical Engineering 2009, 26, 339-344.
• Zhang J, Nguyan J, Morris J. Iterative learning control of a crystallisation process using batch wise updated linearised models identified using PLS. In: Computer Aided Chemical Engineering: 19th European Symposium on Computer Aided Process Engineering. 2009, Cracow, Poland: Springer.
• Chen ZP, Morris J, Borissova A, Khan S, Mahmud T, Penchev R, Roberts KJ. On-line monitoring of batch cooling crystallization of organic compounds using ATR-FTIR spectroscopy coupled with an advanced calibration method. Chemometrics and Intelligent Laboratory Systems 2009, 96(1), 49-58.
• Morris J, Zhang J. Performance monitoring and batch to batch control of biotechnological processes. Studies in Computational Intelligence 2009, 218, 281-310.
• Chen ZP, Morris J. Process analytical technology and compensating for nonlinear effects in process spectroscopic data for improved process monitoring and control. Biotechnology Journal 2009, 4(5), 610-619.
• Chen Z-P, Fevotte G, Caillet A, Littlejohn D, Morris J. Advanced Calibration Strategy for in Situ Quantitative Monitoring of Phase Transition Processes in Suspensions using FT-Raman Spectroscopy. Analytical Chemistry 2008, 80(17), 6658-6665.
• Dharmayat S, Hammond RB, Lai XJ, Ma CY, Purba E, Roberts KJ, Chen ZP, Martin E, Morris J, Bytheway R. An examination of the kinetics of the solution-mediated polymorphic phase transformation between alpha- and beta-forms of L-glutamic acid as determined using online powder X-ray diffraction. Crystal Growth & Design 2008, 8(7), 2205-2216.
• Chen T, Morris J, Martin E. Dynamic data rectification using particle filters. Computers & Chemical Engineering 2008, 32(3), 451-462.
• Vicevic M, Novakovic K, Boodhoo KVK, Morris AJ. Kinetics of styrene free radical polymerisation in the spinning disc reactor. Chemical Engineering Journal 2008, 135(1-2), 78-82.
• Fletcher NM, Morris AJ, Montague G, Martin EB. Local dynamic partial least squares approaches for the modelling of batch processes. Canadian Journal of Chemical Engineering 2008, 86(5), 960-970.
• Chen ZP, Lovett D, Morris J. Process Analytical Technologies (PAT)-the impact for Process Systems Engineering. Computer Aided Chemical Engineering 2008, 25, 967-972.
• Li B, Martin E, Morris J. Process performance monitoring in the presence of confounding variation. Chemometrics and Intelligent Laboratory Systems 2008, 94(2), 104-111.
• Gani R, Kraslawski A, Morris J. Special topic issue ECCE-6. Chemical Engineering Research and Design 2008, 86(7), 661.
• Yang A, Morris J, Montague G, Martin E. Determination of operating regimes for chemical reactors using incomplete mechanistic knowledge and a mutual information-based dependency test. Industrial and Engineering Chemistry Research 2007, 46(10), 3390-3399.
• Chen T, Morris J, Martin E. Response to the discussion of "Gaussian process regression for multivariate spectroscopic calibration". Chemometrics and Intelligent Laboratory Systems 2007, 87(1), 95-97.
• Chen Y, Morris J, Martin E. Response to the discussion of Gaussian process regression for multivariate spectroscopic calibration. Chemometrics and Intelligent Laboratory Systems 2007, 87(1), 69-71.
• Shivhare MR, Allen RG, Scott K, Morris AJ, Martin EB. A kinetic model for the direct methanol fuel cell anode based on surface coverage. Journal of Electroanalytical Chemistry 2006, 595(2), 145-151.
• Yang A, Martin E, Montague G, Morris J. A model discrimination based approach to the determination of operating regimes for chemical reactors. Computer Aided Chemical Engineering 2006, 21(C), 273-278.
• Choi SW, Martin EB, Morris AJ, Lee I-B. Adaptive multivariate statistical process control for monitoring time-varying processes. Industrial and Engineering Chemistry Research 2006, 45(9), 3108-3118.
• Chen Z-P, Morris J, Martin E. Extracting chemical information from spectral data with multiplicative light scattering effects by optical path-length estimation and correction. Analytical Chemistry 2006, 78(22), 7674-7681.
• Vicevic M, Novakovic K, Boodhoo KVK, Morris AJ. Kinetics of methyl methacrylate free radical polymerisation in the spinning disc reactor. In: 17th International Congress of Chemical and Process Engineering (CHISA). 2006, Prague, Czech Republic: CSCHI.
• Vicevic M, Novakovic K, Boodhoo KVK, Morris AJ. Kinetics of Styrene Free Radical Polymerisation in the Spinning Disc Reactor. In: Process Intensification and Innovation Process (PI)2 Conference II Cleaner, Sustainable, Efficient Technologies for the Future.2006,Christchurch, New Zealand
• Chen T, Morris J, Martin E. Probability density estimation via an infinite Gaussian mixture model: Application to statistical process monitoring. Journal of the Royal Statistical Society. Series C: Applied Statistics 2006, 55(5), 699-715.
• Li B, Hassel PA, Morris AJ, Martin EB. A non-linear nested partial least-squares algorithm. Computational Statistics and Data Analysis 2005, 48(1), 87-101.
• Chen Z-P, Morris J, Martin E. Correction of temperature-induced spectral variations by loading space standardization. Analytical Chemistry 2005,77 5 1376-1384.
• Chen ZP, Morris J, Martin E, Hammond RB, Lai X, Ma C, Purba E, Roberts KJ, Bytheway R. Enhancing the signal-to-noise ratio of X-ray diffraction profiles by smoothed principal component analysis. Analytical Chemistry 2005,77 20 6563-6570.
• Wright AR, Morris AJ. Grid based information models to support the rapid innovation of new high value added chemicals. In: Faster Routes to Speciality Chemicals II.2005,Runcorn, UK
• Alabi SI, Morris AJ, Martin EB. On-line dynamic process monitoring using wavelet-based generic dissimilarity measure. Chemical Engineering Research and Design 2005, 83(6 A), 698-705.
• Simoglou A, Georgieva P, Martin EB, Morris AJ, Feyo De Azevedo S. On-line monitoring of a sugar crystallization process. Computers and Chemical Engineering 2005,29 6 1411-1422.
• Chen T, Morris J, Martin E. Particle filters for state and parameter estimation in batch processes. Journal of Process Control 2005,15 6 665-673.
• Alawi A, Morris A, Martin E. Statistical performance monitoring using state space modelling and wavelet analysis. Computer Aided Chemical Engineering 2005, 20(C), 1459-1464.
• Wong C, Escott R, Morris A, Martin E. The integration of process and spectroscopic data for enhanced knowledge extraction in batch processes. Computer Aided Chemical Engineering 2005, 20(C), 1141-1146.
• Chen L, Hontoir Y, Huang D, Zhang J, Morris AJ. Combining first principles with black-box techniques for reaction systems. Control Engineering Practice 2004,12 7 819-826.
• Tian Y, Zhang J, Morris J. Dynamic on-line reoptimization control of a batch MMA polymerization reactor using hybrid neural network models. Chemical Engineering and Technology 2004,27 9 1030-1038.
• Li B, Morris AJ, Martin EB. Generalized partial least squares regression based on the penalized minimum norm projection. Chemometrics and Intelligent Laboratory Systems 2004,72 1 21-26.
• Novakovic K, Morris J, Martin E. Mathematical analysis of the formation of molecule sizes on a spinning disc reactor. In: 8th Pacific Polymer Conference. 2004, Bangkok, Thailand: Wiley-Blackwell Publishing.
• Martin EB, Fraser AW, Morris AJ. Neural network modelling and prediction in multipass steel processing. Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering 2004,218 3 121-132.
• Simoglou A, Georgieva P, Martin E, Morris A, Feyo de Azevedo S. On-line multivariate statistical monitoring of a fed-batch sugar crystallisation process. Computer Aided Chemical Engineering 2004, 18(C), 817-822.
• Chen T, Morris J, Martin E. Particle filters for the estimation of a state space model. Computer Aided Chemical Engineering 2004, 18(C), 613-618.
• Novakovic K, Boodhoo KVK, Martin EB, Morris AJ. Data Analysis and Modelling of Spinning Disc Polymerisation from Minimal Data. In: First International Symposium on Process Intensification and Miniaturisation. 2003, Newcastle upon Tyne, UK.
• Novakovic K, Martin EB, Morris AJ. Modelling of Kinetics of Free Radical Polymerisation on Spinning Disc Reactor. In: Polymer Reaction Engineering: Modelling, Optimisation and Control. 2003, Lyon, France.
• Novakovic K, Martin EB, Morris AJ. Modelling of the Free Radical Polymerization of Styrene with Benzoyl Peroxide as Initiator. In: European Symposium on Computer Aided Process Engineering-13: 36th European Symposium of the Working Party on Computer Aided Process Engineering. 2003, Lappeenranta, Finland: Computer Aided Chemical Engineering: Elsevier BV.
• Lu Z, Martin E, Morris J. Bayesian parameter estimation in batch polymerisation. In: 12th European Symposium on Computer Aided Process Engineering (ESCAPE-12). 2002, The Hague, The Netherlands: Computer Aided Chemical Engineering: Elsevier BV.
• Fletcher N, Morris A, Martin E. Comparison of dynamic approaches for batch monitoring. In: 12th European Symposium on Computer Aided Process Engineering (ESCAPE-12). 2002, The Hague, The Netherlands: Computer Aided Chemical Engineering: Elsevier BV.
• Kumar S, Martin EB, Morris J. Detection of process model changes in PCA based performance monitoring. In: Proceedings of the American Control Conference. 2002, Anchorage, Alaska: American Automatic Control Council.
• Martin EB, Bettoni A, Morris AJ. Manufacturing Performance Monitoring of a Mixed Batch Continuous Process through Resampling. Journal of Quality Technology 2002, 34(2), 171-186.
• Mercer E, Martin E, Morris A. State-space residual based monitoring. In: Computer Aided Chemical Engineering. 2002, The Hague, The Netherlands: Computer Aided Chemical Engineering: Elsevier BV.
• McPherson L, Morris J, Martin E. Super model-based techniques for batch performance monitoring. In: 12th European Symposium on Computer Aided Process Engineering (ESCAPE-12). 2002, The Hague, The Netherlands: Computer Aided Chemical Engineering: Elsevier BV.
• Mourikas G, Seferlis P, Morris AJ, Kiparissides C. On-line optimal operating policy and control of a batch free-radical polymerization process. In: 11th European Symposium of Computer Aided Process Engineering (ESCAPE-11). 2001, Kolding, Denmark: Computer Aided Chemical Engineering: Elsevier BV.
• Yiagopoulos A, Yiannoulakis H, Morris J, Kiparissides C. Simulation of an industrial olefin polymerization FBR operating under condensed mode. In: 11th European Symposium of Computer Aided Process Engineering (ESCAPE-11). 2001, Kolding, Denmark: Computer Aided Chemical Engineering: Elsevier BV.
• Meng X, Martin E, Morris A. A comparative study of Bi-linear and tri-linear approaches for the monitoring of an industrial batch process. In: 10th European Symposium of Computer Aided Process Engineering (ESCAPE-10). 2000, Florence, Italy: Computer Aided Chemical Engineering: Elsevier BV.
• Zhang J, Morris AJ. Long range predictive control of nonlinear processes based on recurrent neuro-fuzzy network models. Neural Computing and Applications 2000, 9(1), 50-59.
• Lane S, Martin EB, Morris AJ. Monitoring of a dynamic manufacturing process. In: Control Systems, Preprints, Conference. 2000.
• Simoglou A, Martin EB, Morris AJ. Multivariate statistical process control of an industrial fluidised-bed reactor. Control Engineering Practice 2000, 8(8), 893-909.
• Li E, Martin E, Morris A. Non-linear partial least squares through data transformations. In: 10th European Symposium of Computer Aided Process Engineering (ESCAPE-10). 2000, Florence, Italy: Computer Aided Chemical Engineering: Elsevier BV.
• Simoglou A, Martin EB, Morris AJ. Comparison of Canonical Variate Analysis and Partial Least Squares for the identification of dynamic processes. In: Proceedings of the American Control Conference. 1999, San Diego, CA , USA: IEEE.