The Newcastle Anticancer Drug Discovery Initiative (ADDI) is a collaborative research programme between Professor B T Golding, Dr R J Griffin and Dr I R Hardcastle in the Department of Chemistry, and Professor A H Calvert, Professor D R Newell and Dr N J Curtin in the Cancer Research Unit of the Medical School. The programme was initiated in 1990 and currently comprises some twenty staff and postgraduate researchers. Research centres on the design, synthesis and biological evaluation of new antitumour agents, In addition to the development of compounds directed at targets identified from an understanding of the molecular pathology of cancer, the design of agents (resistance-modifiers) that potentiate the antitumour activity of existing drugs by modulating a resistance mechanism, is a major area of research interest.
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Professor Roger Griffin
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