Publication:

Synthesis of Biaryl Diphosphines via a Stepwise Regioselective Double Diels-Alder Cycloaddition Elimination Sequence: Efficient Ligands for the Palladium-Catalyzed Amination of Aromatic Bromides (2009)

Author(s): Doherty S, Smyth CH, Harrington RW, Clegg W

    Abstract: Tropos and atropos biaryl diphosphines have been prepared in a stepwise highly regioselective double Diels-Alder cycloaddition-elimination sequence between 1,4-bis(diphenylphosphinoyl)buta-1,3-diyne and various 1,3-dienes; the unsymmetrical phosphine 2,6´-bis(diphenylphosphino)-2´-methoxy-1,1´-biphenyl prepared using this approach forms an efficient catalyst for the amination of a range of aromatic bromides, giving conversions that rival those obtained with its BIPHEP counterpart.

      • Date: 18-08-2009
      • Journal: Organometallics
      • Volume: 28
      • Issue: 17
      • Pages: 5273-5276
      • Publisher: American Chemical Society
      • Publication type: Article
      • Bibliographic status: Published
      Staff

      Emeritus Professor William Clegg
      Senior Research Investigator

      Dr Simon Doherty
      Senior Lecturer

      Dr Ross Harrington
      X-Ray Crystallography Officer