Newcastle University

Publication:

Efficient Cycloisomerisation of Propargyl Amides by Electrophilic Gold(I) Complexes of KITPHOS Monophosphines: A Comparative Study (2010)

Author(s): Doherty S, Knight JG, Smyth CS, Ward NAB, Robson KJ, Tweedly S, Harrington RW, Clegg W

Abstract: Electrophilic gold(I) complexes of diphenyl- and dicyclohexylphosphino-based KITPHOS monophosphines catalyze the 5-exo-dig cycloisomerization of a range of propargyl amides to afford the corresponding alkylidene oxazolines; in all cases catalysts formed from diphenylphosphino-substituted KITPHOS monophosphines outperformed their dicyclohexylphosphino counterparts as well as that based on triphenylphosphine, an indication that the biaryl/biaryl-like framework may be responsible for imparting high catalyst efficiency.

• Type of Article: Full paper

• Date: 17-08-2010
• Journal: Organometallics
• Volume: 29
• Issue: 18
• Pages: 4139-4147
• Publisher: American Chemical Society
• Publication type: Article
• Bibliographic status: Published

• URL: http://dx.doi.org/10.1021/om1006769
• DOI: 10.1021/om1006769
• ISSN (electronic): 1520-6041