Synthetic and Medicinal Chemistry

The Synthetic and Medicinal Group brings together inorganic, organic and medicinal chemists with complementary expertise to tackle challenging problems in the areas of catalysis, lanthanide, transition and main group chemistry, synthetic methodology development, medicinal chemistry and chemical biology. The work of the group ranges from exploratory and targeted synthetic chemistry to mechanistic studies and the development of new catalysts and drugs. Close collaborations exist with the Northern Institute for Cancer Research, the University Research Centre in Catalysis and Intensified Processing, marineNewcastle, and other Schools and Departments across SAgE and Medicine. Subgroupings are outlined below.

Medicinal Chemistry, Synthesis and Biological Chemistry

Dr Mike Carroll
Synthesis and application of labelled bioactive molecules.

Prof Bernard Golding
Synthesis and mechanistic studies aimed at solving problems in bioorganic and medicinal chemistry.

Dr Michael Hall
Organic methodology development and application in the synthesis of biologically-active compounds and in biological imaging.

Catalysis and Synthesis

Dr Simon Doherty
Synthetic methodology directed towards phosphine-based ligands with emphasis on operationally straightforward, inexpensive and highly-modular routes to ligands for a broad platform of Pt-catalyzed asymmetric transformations.

Dr Lee Higham
Investigation (by a variety of physicochemical methods) of highly unusual, air-stable, chiral primary phosphines and their use as ligand precursors for asymmetric catalysis.

Dr Julian Knight
Design and synthesis of chiral catalysts and their applications to the asymmetric synthesis of organic targets.

Prof Mike North
Development of catalysts to catalyse reactions of environmental or commercial importance.

Lanthanide, Transition and Main Group Chemistry

Dr John Errington
Primary studies of molecular metal oxides and the application of metal alkoxides and polyoxometalates in catalysis and nano-scale materials synthesis.

Dr Keith Izod
Frontiers of lanthanide, main group coordination and organometallic chemistry; including development of new methods for stabilisation of heavier group 14 carbene analogues and synthesis of sterically-encumbered lanthanide organometallics.

Dr Ulrich Baisch
Crystal Engineering of rare earth complexes; in particular understanding of the occurrence of polymorphism as well as the influence of intermolecular interactions on materials properties. Development of a new approach for a solvent-free design of lanthanide containing 3D networks.