I studied Organic Chemistry at the University of Poitiers (France) and in 1999, went to Paris as a predoctoral fellow to work on asymmetric synthesis of substituted piperazines from phenylglycinol derivatives, under the supervision of Prof. H.-P. Husson. In 2000, I moved back to Poitiers, where I worked on the synthesis of biomolecules by 1,3-dipolar cycloadditions with carbohydrates and received my Ph.D. degree in 2004. I then joined the group of Prof. John A. Joule at the University of Manchester, U.K. as a postdoctoral fellow and worked on the synthesis of analogues of cofactors of oxomolybdoenzymes. In 2005, I joined the Northern Institute for Cancer Research at Newcastle University, as a research associate and worked on the synthesis of inhibitors of the DNA-dependent protein kinase. Since my appointement as a lecturer in Medicinal Chemistry in 2008, I have been working on the development of small molecule kinase inhibitors within the Drug Discovery and Imaging group.
MSc Organic Chemistry - Poitiers, France
PhD Organic Chemistry - Poitiers, France
2005 - Research associate in the group of Professor John A. Joule - The University of Manchester, UK - "Synthesis of Analogues of Cofactors of Oxomolybdoenzymes".
2005-2007 - Research Associate - Northern Institute for Cancer Research, Newcastle Upon Tyne, UK - "Synthesis of Inhibitors of DNA-Dependent Protein Kinase".
Member of the British Association for Cancer Research; Member of the European Association for Cancer Research
Source - Cancer Research UK, CR UK Centre Award (July 2009 – June 2012), Annual direct costs - £2M – Co-applicant
Source - Cancer Research, CR UK Drug Discovery programme (October 2007 – September 2012), Annual direct costs - £1M – Co-Applicant
Source - Cancer Research UK, Medicinal Chemistry Training Programme (October 2006-September 2014), Annual direct costs - £1.4M – Co-Applicant
Source - KuDOS/AstraZeneca Pharmaceuticals, Development of DNA PK inhibitors (January 2008 – December 2012), Annual direct costs - £160,000 – Co-applicant
Source - EPSRC, PhD Studentship, Medicinal Chemistry (October 2009-September 2012), Annual direct costs - £13,290 maintenance grant (2009-2010); £13,590 (2010-2011) – PI
Source – MRC Doctoral Training Account, PhD Studentship (October 2011-September 2014), Annual direct costs - £13,290 maintenance grant (2009-2010); £13,590 (2010-2011) – Co-applicant
My research interest is in the development of small molecule kinase inhibitors.
Within our Drug Discovery and Imaging Research Group, five targets are currently being exploited:
Member of the Teaching and Training Committee within the Northern Institute for Cancer Research.
Teaching conducted within the School of Chemistry (Undergraduate Programmes in Chemistry and Chemistry with Medicinal Chemistry):
- Module leader of CHY2103 Medicinal Chemistry and Drug Design
- CHY3103 Chemotherapy
- CHY3109 Advanced Medicinal Chemistry
- CHY3001 Advanced Practical Course in Medicinal Chemistry
- CHY8421 Methods in Drug Discovery
- CHY8821 Methods in Drug Discovery
- CHY8823 Theory and Practice of Chemotherapy
Participated in the PARTNERS Scheme each summer over the last 4 years.