Dr Eimer Tuite
Senior Lecturer in Physical Chemistry

Introduction

The Tuite group works at the interface of life and physical sciences, applying physical and chemical tools to biological and environmental problems. We have particular interests in DNA chemistry and how it relates to nano-assembly and synthetic biology.

Background

My undergraduate and postgraduate studies were at Trinity College Dublin (www.tcd.ie) where I completed my PhD in 1992 with Prof John Kelly on photosensitized damage of DNA. I then moved to Gothenburg on the Swedish west coast for postdoctoral work with Prof Bengt Norden at Chalmers University of Technology (www.chalmers.se) in the field of biocolecular recognition, and subsequently accepted a lecturing position there. In 2000 I moved to Newcastle where I have continued to expand my research interests in Biophysical Chemistry and Photochemistry, as a member of the Chemical Nanoscience Lab.

Qualifications and Previous Positions

1987: BA (4 yrs) in Natural Sciences, specialising in Chemistry, Trinity College Dublin (Cocker Medallist)
1992: PhD in Chemistry with John Kelly, Trinity College Dublin
1993-1995: Wenner-Gren Research Fellow with Bengt Norden, Chalmers University of Technology, Göteborg
1995-1996: Marie Curie Fellow with Bengt Norden, Chalmers University of Technology, Göteborg
1996-2000: Assistant Professor in Biophysical Chemistry, Chalmers University of Technology, Göteborg
1998: Docent in Biophysical Chemistry, Chalmers University of Technology, Göteborg

External Activities

EPSRC Peer Review College (2003-2014)
BBSRC Pool of Experts (2009-2014)
– TRDF, Committee C, and ALERT panels
EU Evaluation Expert (2010-2014)
– Life and Chemistry Fellowships panels
ERC Expert (2014)
– Early Stage Awards (LS7 - Diagnostics) panel

Research Topics

  • Spectroscopic and biophysical studies of drug interactions with DNA and analogues (especially phenothiazines, cyanines, acridines, ruthenium complexes) including chiral, sequence, and structural recognition.
  • Mechanisms of photocleavage of DNA, including metal complex and cyanine photosensitizers.
  • Electron and energy transfer mediated by DNA and PNA for structural and dynamic studies of nucleic acids, especially with metal complexes.
  • DNA conductivity and charge migration.
  • Nucleic acid-based assembly of nanoscopic architectures.
  • Quantum dots, SERS, and near-field microscopy.
  • Enzymatic DNA synthesis.

Chemical Nanoscience Labs Research Pages 

Current PhD Students

  • Colette Whitfield (MRes/PhD): Enzymatic Synthesis of Micrometer Repeat Sequence DNA (with Andrew Pike and Bernard Connolly)

Postgraduate Alumni

  • 2013: Samira Hribesh, PhD: 2'-Deoxy-6-Thioguanosine: Monomer, Oligomer and Long Duplex Synthesis and Binding with Metal Ions (with Andrew Pike)
  • 2013: Shahrbanou "Fariba" Moradpourhafshejani, PhD: Acridine Intercalators as Anchors for Click Functionalisation of DNA (with Andrew Pike)
  • 2008: Andrew McKinley, PhD: Photophysics and DNA Binding of Ruthenium Complexes with Modified DPPZ Ligands
  • 2007: Fiona Dickinson, PhD: Unusual Mechanisms of DNA Damage Induced by Cyanine Dye Photosensitization
  • 2004: Jashveer Grewel, MPhil: DNA Damage Photosensitized by Cobalt and Ruthenium Complexes
  • 2001: Claire Kanony, PhD: DNA Photosensitization by New Drugs for Photoinactivation of Viruses and Phototherapy of Tumours (Thesis awarded PhD Prize for best Chemistry thesis in Toulouse 2001)

Research Sponsors

  • EPSRC, BBSRC, CENAMPS, COST Chemistry, Royal Society, Nuffield Foundation

Metrics (WoS)

37 : Peer-Reviewed Papers and Reviews
22 : h-index
37 : g-index
53 : citations per paper (without self-citations)
  7 : highly cited (≥100) papers
  1 : patent

Projects

Undergraduate Teaching

CHY2003 Topics in Chemistry
CHY2201 Physical Chemistry
CHY3401 Biomimetic Problem Solving
CHY3402 Problem Solving in Chemistry
CHY3007 Chemical Biology
CHY8410 MChem Research Project