Dr Carmen Martin-RuizSenior Research Associate
Email: carmen.martin-ruiz@ncl.ac.uk Telephone: +44 (0) 191 2481107 Fax: +44 (0) 191 248 1101 Address: Institute for Ageing and Health
Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. A senescent cell bystander effect: senescence-induced senescence .
Aging Cell 2012, 11 (2), 345-349.
Pearce MS, Mann KD, Martin-Ruiz C, Parker L, White M, von Zglinicki T, Adams J. Childhood Growth, IQ and Education as Predictors of White Blood Cell Telomere Length at Age 49-51 Years: The Newcastle Thousand Families Study .
PLoS One 2012, 7 (7), e40116.
Collerton J, Martin-Ruiz C, Davies K, Catt M, Jagger C, von Zglinicki T, Kirkwood T. Frailty and biomarkers of inflammation, immunoscience and cellular ageing in the Newcastle 85+ Study .
In: GSA 65th Annual Scientific Meeting . 2012, San Diego, California, USA: Oxford University Press.
Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, Parker C, Dunn M, Catt M, Jagger C, von Zglinicki T, Kirkwood TB. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study .
Mechanisms of Ageing and Development 2012, 133 (6), 456-466.
Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I. High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction .
PLoS one 2012, 7 (10), e47155.
Harris SE, Martin-Ruiz C, vonZglinicki T, Starr JM, Deary IJ. Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936 .
Neurobiology of Aging 2012, 33 (7), 1486.e3-1486.e8.
Martin Ruiz C, Jagger C, Kingston A, Collerton J, Catt M, Davies K, Dunn M, Hilkens C, Keavney B, Pearce S, den Elzen W, Talbot D, Wiley L, Bond J, Mathers J, Eccles M, Robinson L, James O, Kirkwood T, von Zglinicki T. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study .
Mechanisms of Ageing and Development 2011, 132 (10), 496-502.
Jagger C, Collerton JC, Davies K, Kingston A, Robinson LA, Eccles MP, von Zglinicki T, Martin-Ruiz C, James OFW, Kirkwood TBL, Bond J. Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs .
BMC Geriatrics 2011, 11 , 21.
Den Elzen WPJ, Martin-Ruiz C, von Zglinicki T, Westendorp RGJ, Kirkwood TBL, Gussekloo J. Telomere length and anaemia in old age: results from the Newcastle 85-plus Study* and the Leiden 85-plus Study .
Age and Ageing 2011, 40 (4), 494-500.
Kirkwood T, Martin-Ruiz C, Jagger C, Collerton J, Kingston A, von Zglinicki T. Biomarkers of ageing and their relationship to disability and cognition [abstract] .
Gerontologist 2010, 50 , 375.
Domínguez-Garrido E, Martínez-Redondo D, Martín-Ruiz C, Gómez-Durán A, Ruiz-Pesini E, Madero P, Tamparillas M, Montoya J, von Zglinicki T, Díez-Sánchez C, López-Pérez M. Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations .
Biogerontology 2009, 10 (4), 435-442.
Wang CF, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. DNA damage response and cellular senescence in tissues of aging mice .
Aging Cell 2009, 8 (3), 311-323.
Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles M, Robinson L, Martin-Ruiz C, Von Zglinicki T, James O, Kirkwood T. Health and disease in 85 year olds: Baseline findings from the Newcastle 85+ cohort study .
British Medical Journal 2009, 339 , b4904.
Hapangama DK, Turner MA, Drury JA, Quenby S, Hart A, Maddick M, Martin-Ruiz C, von Zglinicki T. Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response .
Human Reproduction 2009, 24 (3), 687-696.
Hapangama DK, Turner MA, Drury JA, Martin-Ruiz C, von Zglinicki T, Farquharson RG, Quenby S. Endometrial telomerase shows specific expression patterns in different types of reproductive failure .
Reproductive BioMedicine Online 2008, 17 (3), 416-424.
Hapangama DK, Turner MA, Drury JA, Quenby S, Saretzki G, Martin-Ruiz C, Von Zglinicki T. Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length .
Human Reproduction 2008, 23 (7), 1511-1519.
Pearce MS, Adams JM, Martin-Ruiz CM, White M, von Zglinicki TW. Growth and white blood cell telomere length at age 50: the Newcastle Thousand Families Study .
In: 5th International Congress on Developmental Origins of Health & Disease . 2007, Perth, Western Australia: Early Human Development: Elsevier Ireland.
Adams JM, Martin-Ruiz CM, Pearce MS, White M, Parker L, von Zglinicki TW. No association between socio-economic status and white blood cell telomere length .
Aging Cell 2007, 6 (1), 125-128.
Ksiazek K, Passos JF, Olijslagers S, Saretzki G, Martin-Ruiz C, von Zglinicki T. Premature senescence of mesothelial cells is associated with non-telomeric DNA damage .
Biochemical and Biophysical Research Communications 2007, 362 (3), 707-711.
Collerton J, Martin-Ruiz C, Kenny A, Barrass K, Von Zglinicki T, Kirkwood T, Keavney B, Bond J, Eccles M, Jagger C, James O, Robinson L. Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study .
European Heart Journal 2007, 28 (2), 172-176.
Collerton J, Barrass K, Bond J, Eccles M, Jagger C, James O, Martin-Ruiz C, Robinson L, Von Zglinicki T, Kirkwood T. The Newcastle 85+ study: Biological, clinical and psychosocial factors associated with healthy ageing: Study protocol .
BMC Geriatrics 2007, 7 (14).
Collerton J, Martin-Ruiz C, Kenny M, Barrass K, von Zglinicki T, Kirkwood T, Keavney B. White blood cell telomere length is associated with left ventricular function in the oldest old: The newcastle 85+study .
Heart 2007, 93 , A25-A26.
Getliffe KM, Martin Ruiz C, Passos JF, Von Zglinicki T, Nwokolo CU. Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients .
European Journal of Gastroenterology and Hepatology 2006, 18 (2), 133-141.
Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, De Ponte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, Von Zglinicki T, Kirkland JL. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes .
Diabetes 2006, 55 (9), 2571-2578.
Martin-Ruiz C, Dickinson HO, Keys B, Rowan E, Kenny RA, von Zglinicki T. Telomere length predicts poststroke mortality, dementia, and cognitive decline .
Annals of Neurology 2006, 60 (2), 174-180.
Getliffe KM, Al Dulaimi D, Martin-Ruiz C, Holder RL, Von Zglinicki T, Morris A, Nwokolo CU. Lymphocyte telomere dynamics and telomerase activity in inflammatory bowel disease: Effect of drugs and smoking .
Alimentary Pharmacology and Therapeutics 2005, 21 (2), 121-131.
Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RGJ. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study .
Aging Cell 2005, 4 (6), 287-290.
von Zglinicki T, Martin-Ruiz CM. Telomeres as biomarkers for ageing and age-related diseases .
Current Molecular Medicine 2005, 5 (2), 197-203.
Von Zglinicki T, Martin-Ruiz CM, Saretzki G. Telomeres, cell senescence and human ageing .
Signal Transduction 2005, 5 (3), 103-114.
Martin-Ruiz CM, Lee M, Perry RH, Baumann M, Court JA, Perry EK. Molecular analysis of nicotinic receptor expression in autism .
Molecular Brain Research 2004, 123 (1-2), 81-90.
Adams J, White M, Pearce MS, Martin-Ruiz C, Parker L, von Zglinicki T. Socio-economic position, health behaviours and telomere length at age 50: a prospective cohort study .
In: 4th European Congress of Biogerontology . 2004, Newcastle upon Tyne, UK.
Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, Von Zglinicki T. Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span .
Journal of Biological Chemistry 2004, 279 (17), 17826-17833.
Martin-Ruiz CM, Haroutunian VH, Long P, Young AH, Davis KL, Perry EK, Court JA. Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia .
Biological Psychiatry 2003, 54 (11), 1222-1233.
Graham AJ, Martin-Ruiz CM, Teaktong T, Ray MA, Court J. Human brain nicotinic receptors, their distribution and participation in neuropsychiatric disorders .
Current Drug Targets 2002, 1 , 387-397.
Graham A, Court JA, Martin-Ruiz CM, Jaros E, Perry R, Volsen SG, Bose S, Evans N, Ince P, Kuryatov A, Lindstrom J, Gotti C, Perry EK. Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum .
Neuroscience 2002, 113 (3), 493-507.
Lee M, Martin-Ruiz C, Graham A, Court J, Jaros E, Perry R, Iversen P, Bauman M, Perry E. Nicotinic receptor abnormalities in the cerebellar cortex in autism .
Brain 2002, 125 (7), 1483-1495.
Martin-Ruiz C, Lawrence S, Piggott M, Kuryatov A, Lindstrom J, Gotti C, Cookson MR, Perry RH, Jaros E, Perry EK, Court JA. Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression .
Neuroscience Letters 2002, 335 (2), 134-138.
Perry EK, Lee MLW, Martin-Ruiz CM, Court JA, Volsen SG, Merrit J, Folly E, Iversen PE, Bauman ML, Perry RH, Wenk GL. Cholinergic activity in autism: Abnormalities in the cerebral cortex and basal forebrain .
American Journal of Psychiatry 2001, 158 (7), 1058-1066.
Court J, Martin-Ruiz C, Piggott M, Spurden D, Griffiths M, Perry E. Nicotinic receptor abnormalities in Alzheimer's disease .
Biological Psychiatry 2001, 49 (3), 175-184.
Perry EK, Martin-Ruiz CM, Court JA. Nicotinic receptor subtypes in human brain related to aging and dementia .
In: Alcohol: 10th Congress of the International Society for Biomedical Research on Alcholism (ISBRA) . 2001, Yokohama, Japan: Elsevier Inc.
Martin-Ruiz CM, Piggott M, Gotti C, Lindstrom J, Mendelow AD, Siddique MS, Perry RH, Perry EK, Court JA. Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease .
Neuropharmacology 2000, 39 (13), 2830-2839.
Martin-Ruiz CM, Lee M, Court J, Iversen P, Merrit J, Folly E, et al. Cholinergic activities in autism: nicotinic and muscarinic receptor abnormalities in the cerebral cortex .
Soc Neurosci Abstracts 2000, 26 , 1403.
Perry E, Martin-Ruiz C, Lee M, Griffiths M, Johnson M, Piggott M, Haroutunian V, Buxbaum JD, Nasland J, Davis K, Gotti C, Clementi F, Tzartos S, Cohen O, Soreq H, Jaros E, Perry R, Ballard C, McKeith I, Court J. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases .
European Journal of Pharmacology 2000, 393 (1-3), 215-222.
Martin-Ruiz C, Court J, Lee M, Piggott M, Johnson M, Ballard C, Kalaria R, Perry R, Perry E. Nicotinic receptors in dementia of Alzheimer, lewy body and vascular types .
Acta Neurologica Scandinavica, Supplement 2000, 102 (176), 34-41.
Court JA, Martin-Ruiz C, Graham A, Perry E. Nicotinic receptors in human brain: Topography and pathology .
Journal of Chemical Neuroanatomy 2000, 20 (3-4), 281-298.
Martin-Ruiz CM, Court JA, Molnar E, Lee M, Gotti C, Perry EK. Alpha4 but not alpha3 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease .
Fundamental and Clinical Pharmacology 1999, 13 (Suppl.1), 143.
Perry EK, Lee M, Martin-Ruiz CM, et al. Cholinergic component of vascular dementia .
Alzheimer's Reports 1999, 2 (Suppl), 576.
Martin-Ruiz CM, Court JA, Molnar E, Lee M, Gotti C, Mamalaki A, Tsouloufis T, Tzartos S, Ballard C, Perry RH, Perry EK. α4 but not α3 and α7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease .
Journal of Neurochemistry 1999, 73 (4), 1635-1640.
Martinez F, Tesarik J, Martin-Ruiz CM, Soler A, Mendoza C. Stimulation of tyrosine phosphorylation by progesterone and its 11-OH derivatives: dissection of a Ca(2+)-dependent and a Ca(2+)-independent mechanism .
Biochem Biophys Res Commun 1999, 255 (1), 23-27.
Finaz, C., Martin-Ruiz, C.M., Lefèvre, A. L'interaction des gamètes: molécules et mécanismes .
Médecine et Science 1998, 2 , 175-182.
Martin-Ruiz C, Duquenne C, Treton D, Lefevre A, Finaz C. SOB3, a human sperm protein involved in zona pellucida binding: physiological and biochemical analysis, purification .
Mol Reprod Dev 1998, 49 (3), 286-97.
Lefevre A, Martin-Ruiz C, Chokomian S, Duquenne C, Finaz C. Characterization and isolation of SOB2, a human sperm protein with a potential role in oocyte membrane binding .
Mol Hum Reprod 1997, 3 (6), 507-16.
