Newcastle University

The ability to sense and respond appropriately to nutrient availability is critical for cellular homeostasis. The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth, proliferation and metabolism as well as the catabolic process of autophagy. A wide variety of cellular and environment cues signal to mTORC1 to regulate a careful balance between anabolic and catabolic processes. I am working to understand the specific mechanisms via which nutrients including amino acids and growth factors regulate mTORC1 signalling.

BSc and PhD awarded by Imperial College London

Memberships:

Biochemistry Society, British Society of Cell Biology

Projects

• Studies of cellular processes involved in the control of nutrient signalling and their relevance to ageing
  Project Leader(s): Viktor Korolochuk

• Carroll B, Korolchuk VI. Nutrient sensing, growth and senescence. FEBS journal 2018, ePub ahead of print.
• Carroll B, Otten E, Manni D, Stefanatos R, Menzies F, Smith G, Jurk D, Kenneth N, Wilkinson S, Passos J, Attems J, Veal E, Teyssou E, Seilhean D, Millecamps S, Eskelinen E-L, Bronowska A, Rubinsztein DC, Sanz A, Korolchuk V. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nature Communications 2018, 9, 256.
• Carroll B, Korolchuk VI. Dysregulation of mTORC1/autophagy axis in senescence. Aging 2017, 9(8), 1851-1852.
• Korolchuk VI, Miwa S, Carroll B, von Zglinicki T. Mitochondria in cell senescence: Is mitophagy the weakest link?. EBioMedicine 2017, 21, 7-13.
• Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing. Journal of Cell Biology 2017, ePub ahead of print.
• Ward C, Martinez-Lopez N, Otten EG, Carroll B, Maetzel D, Singh R, Sarkar S, Korolchuk VI. Autophagy, lipophagy and lysosomal lipid storage disorders. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2016, 1861(4), 269-284.
• Carroll B, Maetzel D, Maddocks ODK, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. eLIFE 2016, 5, e11058.
• Klinonsky DJ, et, al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Ed.). Autophagy 2016, 12(1), 1-222.
• Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SWG, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal 2016, 35(7), 724-742.
• Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy 2016, 12(10), 1917-1930.
• Carroll B, Dorsal C, Xie L, Lovat P, Korolchuk V. Targeting the persistent activation of mammalian target of rapamycin in BRAF mutated melanoma as a novel therapeutic strategy. In: BSID Annual Meeting. 2016, Dundee, UK: Wiley-Blackwell Publishing Ltd.
• Korolchuk V, Carroll B, Xie L, Dostal C, Lovat P. Targeting the persistent activation of mTOR in B-RAF and NRas mutated melanoma as a novel therapeutic strategy. In: British Skin Foundation, Skin Deep - 20 Years of Research, 20th Anniversary Conference. 2016, London: Wiley-Blackwell Publishing Ltd.
• Carroll B, Korolchuk VI, Sarkar S. Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis. Amino Acids 2015, 47(10), 2065-2088.
• Hewitt G, Carroll B, Korolchuk VI. Mechanisms of cross-talk between intracellular protein degradation pathways. In: Hayat, M, ed. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging : Regulation of Autophagy and Selective Autophagy. San Diego: Academic Press, 2015, pp.103-119.
• Lu W, Zhang Y, McDonald DO, Jing HE, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF, Koref MFS, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S, Su HC. Dual Proteolytic Pathways Govern Glycolysis and Immune Competence. Cell 2014, 159(7), 1578-1590.
• Carroll B, Hewitt G, Korolchuk VI. Autophagy and ageing: implications for age-related neurodegenerative diseases. Essays in Biochemistry: Autophagy: Molecules and Mechanisms 2013, 55, 119-131.
• Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R. Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease. Cell Reports 2013, 5(5), 1302-1315.
• Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM. The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. Developmental Cell 2013, 25(1), 15-28.
• Carroll B, Russell P, Gurnell J, Nettleton P, Sainsbury AW. Epidemics of squirrelpox virus disease in red squirrels (Sciurus vulgaris): temporal and serological findings. Epidemiology and Infection 2009, 137, 257-65.
• Garner TW, Garcia G, Carroll B, Fisher MC. Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles. Dieases of Aquatic Organisms 2009, 83, 257-60.