D.Phil. Spatial models of antipredator vigilance in birds. University of Sussex. 2000
MSc Applied stochastic processes. University College London 1997
BSc Mathematics. The Open University 1995
BEd Education and mathematics. University of Leicester. 1975
My main areas of research are modelling the molecular mechanisms of ageing such as telomere shortening and uncapping; DNA damage checkpoint response pathways; cell signalling pathways; and the role of chaperones and protein degradation pathways in maintaining protein homeostasis; and the decline of these systems with age. I have extensively modelled the mechanisms and pathways involved in the decline in protein homeostasis and how this leads to the aggregation of proteins, a key feature of many neurodegenerative diseases.
I am also interested in the molecular mechanisms which are important in musculoskeletal ageing. I am using systems biology approaches to investigate this in collaboration with other members of the Centre for Integrated research into Musculoskeletal Ageing (CIMA).
Stochastic simulation, systems biology markup language
I am currently building models of the different mechanisms involved in the maintenance of articular cartilage to examine the effects of age-related changes in this tissue. I am particularly focus on signalling pathways, oxidative stress, epigenetic changes and protein degradation pathways. I am using experimental data from the Musculoskeletal Research Group to test and validate the models. The models will then be used to make predictions which can be tested in the laboratory.
I will build similar models for bone and muscle to investigate common molecular mechanims involved in musculoskeletal ageing. This will involve working with members of CIMA at Newcastle, Liverpool and Sheffield.
Medical Research Council and Arthriits Research UK
Alzheimer Scotland and Alzheimer's Research Trust Fellowship
Five lectures for BMS2014
One lecture for MRes in Medical & Molecular Biosciences,Biology of Ageing module
One lecture for MRes in Medical & Molecular Biosciences, Systems Biology module