Newcastle University

I have spent several years developing mathematical models that examine ageing as an integral part of an optimal life history. One of my main aims is to gain a more in-depth understanding of the ageing process by building models with a solid mechanistic base and making them available for use by others.

I was appointed Director of CISBAN in 2012.

Projects

• Computational Modelling of Insulin Signalling and Ageing
  Project Leader(s): Daryl Shanley, Graham Smith
• The Biology of Ageing e-Science Integration and Simulation system (BASIS)
  Project Leader(s): Darren Wilkinson

• Dolan D, Nelson G, Zupanic A, Smith G, Shanley D. Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci. PLoS One 2013, 8(2), e55190.
• van den Heuvel J, Saastamoinen M, Brakefield PM, Kirkwood TBL, Zwaan BJ, Shanley DP. The Predictive Adaptive Response: Modeling the Life-History Evolution of the Butterfly Bicyclus anynana in Seasonal Environments. American Naturalist 2013, 181(2), E28-E42.