Dr Graham Smith
Experimental Scientific Officer

Roles and Responsibilities

I joined the Bioinformatics Support Unit at Newcastle in February 2014 to apply my range of skills to assist in bioinformatics, data analysis, modelling and teaching in the ICM.

Previous Positions

Research Associate, Institute for Ageing and Health, University of Newcastle upon Tyne, 2008-13

Head of Protein-Protein Interactions Group, Biosystems Informatics Institute, Newcastle upon Tyne, 2005-07

Research Fellow, Cancer Research UK London Research Institute, 2000-04

Postdoctoral Research Assistant, Laboratory of Molecular Biophysics, University of Oxford, 1995-2000

Qualifications

PhD in Physics (Edinburgh, 1995)

BSc in Natural Sciences (Cambridge, 1990)

Memberships of Professional Organisations

Biochemical Society

Other information

Google Scholar 

ORCID entry


Main Expertise

Analysis of Next-generation sequencing data (RNA-Seq, ChIP-Seq). Wide range of bioinformatics techniques including interpretation of gene lists in term of pathways. Statistical analysis with R/Bioconductor.

Other Expertise and Interests

Kinetic modelling of metabolic and signalling pathways with Ordinary Differential Equations. Ageing. Modelling of the cardiovascular system, with application to the investigation of orthostatic symptoms in Chronic Fatigue Syndrome. Structural aspects of biomolecular interactions, especially protein-protein interactions. Homology modelling. The computational prediction of the structure and affinity of protein-protein complexes using docking and electrostatics calculations. Molecular Dynamics simulation.


Projects