I am a founding member of the basic biology branch of the Newcastle Ageing Institute and its present scientific director. My principal research interest is in understanding the cellular and molecular signaling pathways connecting DNA damage responses (specifically emanating from dysfunctional telomeres) with mitochondrial function and metabolism, thus causing and maintaining cell senescence, and how these contribute to organism ageing. I was the first to discover oxidative stress and resulting DNA damage as a major cause of telomere shortening and to propose telomere length as a biomarker of ageing in humans. I chair the Scientific Advisory Board (SAB) of the Leibniz Institute for Environmental Medicine Dusseldorf (Germany) and am a member of the Mayo Clinic Robert and Arlene Kogod Center on Aging SAB. I am a Trustee of the Seneca Award for Ageing Research of the Industry Club Dusseldorf and serve on the editorial boards of Aging Cell, Aging (Albany) and other journals in the field. I published over 200 papers on cell and molecular biology of ageing, resulting in an h-index of 50.