Project Leader(s): Thomas von Zglinicki
Staff: Chunfang Wang, Mandy Maddick, Diana Jurk
We have shown that the frequency of senescent cells increases with ageing in many tissues of normal mice (Wang C et al. Aging Cell 9 (2009): 311-6). Now, Chunfang Wang and Mandy Maddick analyse the effects of DR. First results indicate that even relatively short, late-onset DR might reduce frequencies of senescent cells, for instance in the crypts of the gut epithelium.
Pictures show mice intestinal crypts stained with an antibody against activated H2AX (pink), a marker for DNA damage response and senescence.
For more information contact:
Chunfang Wang (Joyce)
Professor Thomas von Zglinicki