Newcastle University

Publications

Year: 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1980 1979

• Tilgner K, Neganova I, Moreno I, AlAama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Pryzborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M. A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors. Cell Death and Differentiation 2013. In Press.
• Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, DeDeyn PP, Van Broeckhoven C, Mann DM, Snowden J, Pickering-Brown S, Halliwell N, Davidson Y, Gibbons L, Harris J, Sheerin UM, Bras J, Hardy J, Clark L, Marder K, Honig LS, Berg D, Maetzler W, Brockmann K, Gasser T, Novellino F, Quattrone A, Annesi G, De Marco EV, Rogaeva E, Masellis M, Black SE, Bilbao JM, Foroud T, Ghetti B, Nichols WC, Pankratz N, Halliday G, Lesage S, Klebe S, Durr A, Duyckaerts C, Brice A, Giasson BI, Trojanowski JQ, Hurtig HI, Tayebi N, Landazabal C, Knight MA, Keller M, Singleton AB, Wolfsberg TG, Sidransky E. A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies. JAMA Neurology 2013, (epub ahead of print).
• Moad M, Pal D (joint first author), Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco O, Cates J, Fordham SE, Przyborskid S, Carr-Wilkinson J, Robson CN, Heer R. A novel model of urinary tract differentiation, tissue regeneration, and disease: Reprogramming of human prostate and bladder cells into induced pluripotent stem cells. European Urology 2013, (epub ahead of print).
• Dodd AW, Syddall CM, Loughlin J. A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression. European Journal of Human Genetics 2013, 21(5), 517-521.
• Raine EV, Dodd AW, Reynard LN, Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues. BMC Musculoskeletal Disorders 2013, 14(85), 1-8.
• Baylis O, Rooney P, Figueiredo F, Lako M, Ahmad S. An investigation of donor and culture parameters which influence epithelial outgrowths from cultured human cadaveric limbal explants. Journal of Cellular Physiology 2013, 228(5), 1025-1030.
• Hobbs N, Godfrey A, Lara J, Errington L, Meyer TD, Rochester L, White M, Mathers JC, Sniehotta FF. Are behavioural interventions effective in increasing physical activity at 12-36 months in adults aged 55 to 70 years? A systematic review and meta-analysis. BMC Medicine 2013, 11, 75.
• Brandt K. Are Organic Foods Safer or Healthier?. Annals of Internal Medicine 2013, 158(4), 295-295.
• Misirli G, Wipat A, Mullen J, James K, Pocock M, Smith W, Allenby N, Hallinan J. BacillOndex: An Integrated Data Resource for Systems and Synthetic Biology. Journal of Integrative Bioinformatics 2013, 10(2), 224.
• Brain JG, Robertson H, Thompson EH, Humphreys E, Gardner A, Booth TA, Jones DEJ, Afford SC, von Zglinicki T, Burt AD, Kirby JA. Biliary epithelial senescence and plasticity in acute cellular rejection. American Journal of Transplantation 2013, (epub ahead of print).
• Cockell S, Bashton M, Gillespie CS. Bioconductor tools for microarray analysis. In: Microarray Image and Data Analysis: Theory and Practice. CRC Press, 2013. Submitted.
• Jones KL, Whittaker RG, Miller JA, Jakovljevic DG, Turnbull DM, Gorman GS. Can high intensity interval training improve functional capacity and clinical symptoms in inflammatory and mitochondrial myopathies?. In: 6th Annual Translational Research Conference. 2013, Oxford, UK.
• Brandt K, Fawcett L, Haldar S, Seal CJ. Changes in markers of cardiovascular disease risk in healthy volunteers consuming increasing doses of either wholegrain wheat or wholegrain rye. American Journal of Clinical Nutrition 2013. In Preparation.
• Migheli F, Stoccoro A, Coppede F, Omar WAW, Failli A, Consolini R, Seccia M, Spisni R, Miccoli P, Mathers JC, Migliore L. Comparison Study of MS-HRM and Pyrosequencing Techniques for Quantification of APC and CDKN2A Gene Methylation. PLoS One 2013, 8(1), e52501.
• Bates MG, Hollingsworth KG, Newman J, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodeling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. European Heart Journal - Cardiovascular Imaging 2013, (epub ahead of print).
• Lloyd AJ, Beckmann M, Haldar S, Seal C, Brandt K, Draper J. Data-driven strategy for the discovery of potential urinary biomarkers of habitual dietary exposure. The American Journal of Clinical Nutrition 2013, 97(2), 377-389.
• Lax NZ, Gnanapavan S, Dowson SJ, Alston CL, He LP, Polvikoski TM, Jaros E, O'Donovan DG, Yarham JW, Turnbull DM, Dean AF, Taylor RW. Early-Onset Cataracts, Spastic Paraparesis, and Ataxia Caused by a Novel Mitochondrial tRNA(Glu) (MT-TE) Gene Mutation Causing Severe Complex I Deficiency: A Clinical, Molecular, and Neuropathologic Study. Journal of Neuropathology and Experimental Neurology 2013, 72(2), 164-175.
• Ions LJ, Wakeling LA, Bosomworth HJ, Hardyman JEJ, Escolme SM, Swan DC, Valentine RA, Mathers JC, Ford D. Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction. Age 2013, (epub ahead of print).
• Elliott KS, Chapman K, Day-Williams A, Panoutsopoulou K, Southam L, Lindgren CM, The GIANT Consortium, Arden N, Aslam N, Birrell F, Carluke I, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WE, Rai A, Ralston S, Reed MR, Spector TD, Valdes AM, Wallis GA, Wilkinson M, The arcOGEN Consortium, Zeggini E. Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Annals of the Rheumatic Diseases 2013, (epub ahead of print).
• Collerton J, Ashok D, Martin Ruiz C, Pyle A, Hudson G, Yadegarfar M, Davies K, Jagger C, von Zglinicki T, Kirkwood T, Chinnery P. Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old. Neurobiology of Aging 2013, (epub ahead of print).
• Beekman M, Blanche H, Perola M, Hervonen A, Bezrukov V, Sikora E, Flachsbart F, Christiansen L, De Craen AJM, Kirkwood TBL, Rea IM, Poulain M, Robine JM, Valensin S, Stazi MA, Passarino G, Deiana L, Gonos ES, Paternoster L, Sorensen TIA, Tan QH, Helmer Q, van den Akker EB, Deelen J, Martella F, Cordell HJ, Ayers KL, Vaupel JW, Tornwall O, Johnson TE, Schreiber S, Lathrop M, Skytthe A, Westendorp RGJ, Christensen K, Gampe J, Nebel A, Houwing-Duistermaat JJ, Slagboom PE, Franceschi C, GEHA Consortium. Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell 2013, 12(2), 184-193.
• Petrie JL, Al-Oanzi ZH, Arden C, Tudhope SJ, Mann J, Kieswich J, Yaqoob MM, Towle HC, Agius L. Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter. Molecular and Cellular Biology 2013, 33(4), 725-738.
• Agius L. High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload. Biochemical Pharmacology 2013, 85(3), 306-312.
• Beckmann M, Lloyd AJ, Haldar S, Seal CJ, Brandt K, Draper J. Hydroxylated phenylacetamides derived from bioactive benzoxazinoids are bioavailable in humans after habitual consumption of whole grain sourdough rye bread. Molecular Nutrition & Food Research 2013, (epub ahead of print).
• Penn L, White M, Lindstrom L, den Boer A, Blaak E, Eriksson JG, Feskens E, Ilanne-Parikka P, Keinänen-Kiukaanniemi SM, Walker M, Mathers JC, Uusitupa M, Tuomilehto J. Importance of Weight Loss Maintenance and Risk Prediction in the Prevention of Type 2 Diabetes: Analysis of European Diabetes Prevention Study RCT. PLoS One 2013, 8(2), e57143.
• Elson JL, Cadogan M, Apabhai S, Whittaker RG, Phillips A, Trennell MI, Horvath R, Taylor RW, McFarland R, McColl E, Turnbull DM, Gorman GS. Initial development and validation of a mitochondrial disease quality of life scale. Neuromuscular Disorders 2013, 23(4), 324-329.
• Picard M, Turnbull DM. Linking the Metabolic State and Mitochondrial DNA in Chronic Disease, Health, and Aging. Diabetes 2013, 62(3), 672-678.
• Langie SAS, Achterfeldt S, Gorniak JP, Halley-Hogg KJA, Oxley D, van Schooten FJ, Godschalk RWL, McKay JA, Mathers JC. Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring. FASEB Journal 2013, (epub ahead of print).
• Radwan M, Gavriilidis C, Robinson JH, Davidson R, Clark IM, Rowan AD, Young DA. Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes. Arthritis & Rheumatism 2013, 65(5), 1290-1301.
• Gaymes TJ, Mohamedali AM, Patterson M, Matto N, Smith A, Kulasekararaj A, Chelliah R, Curtin N, Farzaneh F, Shall S, Mufti G. Microsatellite instability induced mutations in DNA repair genes Ctip and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors in myeloid malignancies. Haematologica 2013. In Press.
• Gavriilidis C, Miwa S, von Zglinicki T, Taylor RW, Young DA. Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2. Arthritis & Rheumatism 2013, 65(2), 378-387.
• Picard M, White K, Turnbull DM. Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study. Journal of Applied Physiology 2013, 114(2), 161-171.
• Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC. Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis. PLoS One 2013, 8(1), e52989.
• Milner P, Gillespie CS, Wilkinson DJ. Moment closure based parameter inference of stochastic kinetic models. Statistics and Computing 2013, 23(2), 287-295.
• Young DA. More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis. Arthritis and Rheumatism 2013, (epub ahead of print).
• Bogle H, Lax NZ, Jaros E, McFarland R, Taylor RW, Turnbull DM. Neuropathological changes in Alpers' syndrome. In: 114th Meeting of the British Neuropathological Society: Symposium on Advances in Motor Neuron Diseases. 2013, London: Wiley-Blackwell Publishing Ltd.
• Hudson G, Panoutsopoulou K, Wilson I, Southam L, Rayner NW, Arden N, Birrell F, Carluke I, Carr A, Chapman K, Deloukas P, Doherty M, McCaskie A, Ollier WE, Ralston SH, Reed MR, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Zeggini E, Samuels DC, Loughlin J, Chinnery PF, arcOGEN Consortium. No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Annals of Rheumatic Diseases 2013, 72(1), 136-139.
• Dang TS, Walker M, Ford D, Valentine R. Nutrigenetics and Nutrigenomics; the role of nutrition in gene expression. Periodontology 2000 2013. In Press.
• Tapp HS, Commane DM, Bradburn DM, Arasaradnam R, Mathers JC, Johnson IT, Belshaw NJ. Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa. Aging Cell 2013, 12(1), 148-155.
• Bechmann LP, Vetter D, Ishida J, Hannivoort RA, Lang UE, Kocabayoglu P, Fiel MI, Muñoz U, Patman GL, Ge F, Yakar S, Li X, Agius L, Lee YM, Zhang W, Hui KY, Televantou D, Schwartz GJ, Leroith D, Berk PD, Nagai R, Suzuki T, Reeves HL, Friedman SL. Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. Journal of Hepatology 2013, 58(5), 1000-1006.
• Atkinson SP, Lako M, Armstrong L. Potential for Pharmacological Manipulation of Human Embryonic Stem Cells. British Journal of Pharmacology 2013, (epub ahead of print).
• Walker L, Thomas AJ, Morris CM, Attems J. Quantification of pathology in mixed Alzheimer's disease and Lewy body dementia. In: 114th Meeting of the British Neuropathological Society: Symposium on Advances in Motor Neuron Diseases. 2013, London: Wiley-Blackwell Publishing Ltd.
• Elliott GO, Johnson IT, Scarll J, Dainty J, Williams EA, Garg D, Coupe A, Bradburn DM, Mathers JC, Belshaw NJ. Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection. International Journal of Colorectal Disease 2013, 28(1), 35-42.
• Baron AW, Rushton SP, Rens N, Morris CM, Blain PG, Judge SJ. Sex differences in effects of low level domoic acid exposure. NeuroToxicology 2013, 34, 1-8.
• Golighty A, Gillespie CS. Simulation of stochastic kinetic models. In: Schneider, M.V, ed. In-silico Systems Biology: A systems-based approach to understanding biological processes. Humana Press, 2013. In Press.
• Bell N, Hann V, Redfern CPF, Cheek TR. Store-operated Ca²⁺ entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells. Biochimica et Biophysica Acta: Molecular Cell Research 2013, 1833(3), 643-651.
• Heaven B, Brown L, White M, Errington L, Mathers JC, Moffatt S. Supporting well-being in retirement through meaningful social roles: systematic review of intervention studies. Milbank Quarterly 2013, 91(2), 222-287.
• Dolan D, Nelson G, Zupanic A, Smith G, Shanley D. Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci. PLoS One 2013, 8(2), e55190.
• Jefferis JM, Taylor JP, Collerton J, Jagger C, Kingston A, Davies K, Kirkwood T, Clarke MP. The association between diagnosed glaucoma and cataract and cognitive performance in very old people: Cross sectional findings from the Newcastle 85+ cohort study. Ophthalmic Epidemiology 2013, 20(2), 82–88.
• Reynard LN, Loughlin J. The genetics and functional analysis of primary osteoarthritis susceptibility. Expert Reviews in Molecular Medicine 2013, 15, e2-e16.
• Osei-Bempong C, Figueiredo FC, Lako M. The limbal epithelium of the eye A review of limbal stem cell biology, disease and treatment. BioEssays 2013, 35(3), 211-219.
• Yarham JW, Blakely EL, Alston CL, Roberts ME, Ealing J, Pal P, Turnbull DM, McFarland R, Taylor RW. The m.3291T > C mt-tRNA^Leu(UUR) mutation is definitely pathogenic and causes multisystem mitochondrial disease. Journal of the Neurological Sciences 2013, 325(1-2), 165-169.
• van den Heuvel J, Saastamoinen M, Brakefield PM, Kirkwood TBL, Zwaan BJ, Shanley DP. The Predictive Adaptive Response: Modeling the Life-History Evolution of the Butterfly Bicyclus anynana in Seasonal Environments. American Naturalist 2013, 181(2), E28-E42.
• Nesbitt V, Pitceathly RD, Turnbull DM, Taylor RW, Sweeney MG, Mudanohwo EE, Rahman S, Hanna MG, McFarland R. The UK MRC Mitochondrial Disease Patient Cohort Study: clinical phenotypes associated with the m.3243A>G mutation—implications for diagnosis and management. Journal of Neurology, Neurosurgery and Psychiatry 2013, (epub ahead of print).