Newcastle University

Publications

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• Bashir R, Britton S, Strachan T, Keers S, Vafiadaki E, Lako M, Richard I, Marchand S, Bourg N, Argov Z, Sadeh M, Mahjneh I, Marconi G, Passos-Bueno MR, Moreira Ede S, Zatz M, Beckmann JS, Bushby K. A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B. Nature Genetics 1998, 20(1), 37-42.
• Lako M, Lindsay S, Bullen P, Wilson DI, Robson SC, Strachan T. A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. Human Molecular Genetics 1998, 7(5), 813-822.
• Matthews, C.J., McEwan, G.T.A., Redfern, C.P.F., Thomas, E.J., Hirst, B.H. Absorptive apical amiloride-sensitive Na+ conductance in human endometrial epithelium. Journal of Physiology 1998, 513(2), 443-452.
• Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radical Biology & Medicine 1998, 24, 885-893.
• Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in flbroblasts after extended periods of confluency. Free Radical Biology and Medicine 1998, 24, 885-893.
• Martin K, Kirkwood TBL, Potten CS. Age changes in stem cells of murine small intestinal crypts. Experimental Cell Research 1998, 241, 316-323.
• T.B.L. Kirkwood. Age-related changes in stem cells. In: Intervention in Aging VI. 1998, Rome: Societa' Italiana Di Gerontologia E Geriatria.
• Kirkwood TBL. Alex Comfort and the measure of aging. Experimental Gerontology 1998, 33, 135-140.
• Martin K, Potten CS, Roberts SA, Kirkwood TBL. Altered stem cell regeneration in irradiated intestinal crypts of senescent mice. Journal of Cell Science 1998, 111, 2297-2303.
• Billington CJ, Clark IM, Cawston TE. An aggrecan-degrading activity associated with chondrocyte membranes. Biochemical Journal 1998, 336(1), 207-212.
• Kirkwood TBL. Biological theories of aging: An overview. Aging-Clinical and Experimental Research 1998, 10, 144-146.
• T.B.L. Kirkwood. Book review of 'Ageing and Human Longevity' by Schulz-Aellen M-F. Cell Proliferation 1998, 31, 172.
• T.B.L. Kirkwood. Book review of 'Why We Age' by Austad SN. Age and Ageing 1998, 27, 661-662.
• Pountain, G., Hazleman, B. and Cawston, T.E. Circulating levels of IL-1 beta, IL-6 and soluble IL-2 receptor in polymyalgia rheumatics and giant cell arteritis and rheumatoid arthritis. British Journal of Rheumatology 1998, 37, 797-798.
• Kirkwood TBL. Design and analysis of aging studies. Aging-Clinical and Experimental Research 1998, 9, 438-439.
• Marshman, E., Newell, D.R., Calvert, A.H., Dickinson, A., Patel, H., Campbell, F., Curtin, N.J. Dipyridamole potentiates antipurine antifolate activity in the presence of hypoxanthine in tumor cells but not in normal tissues in vitro. Clinical Cancer Research 1998, 4(11), 2895-2902.
• T.B.L. Kirkwood. Disposable soma theory (and other contributions). In: P. Calow, ed. The Encyclopaedia of Ecology & Environmental Management. Oxford: Blackwell Science, 1998, pp.192-193.
• Sommerburg O, Ullrich O, Sitte N, von Zglinicki T, Siems W, Grune T. Dose- and wavelength-dependent oxidation of crystallins by UV light - Selective recognition and degradation by the 20S proteasome. Free Radical Biology and Medicine 1998, 24, 1369-1374.
• M. E. Hurles,C. Irven,J. Nicholson,P. G. Taylor,F. R. Santos,J. Loughlin,M. A. Jobling,B. C. Sykes. European Y-chromosomal lineages in Polynesians: a contrast to the population structure revealed by mtDNA. Am J Hum Genet 1998, 63(6), 1793-806.
• T.B.L. Kirkwood. Evolution theory and the mechanisms of ageing. In: J.C. Brocklehurst;R.C. Tallis, ed. Textbook of Geriatric Medicine and Gerontology. London: Churchill Livingstone, 1998, pp.45-49.
• W. Lowes, M. Walker, K. Alberti and L. Agius. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. Biochimica Et Biophysica Acta-General Subjects 1998, 1379, 134-142.
• Westendorp RGJ, Kirkwood TBL. Human longevity at the cost of reproductive success. Nature 1998, 396, 743-746.
• J. Loughlin,C. Irven,Z. Mustafa,M. D. Briggs,A. Carr,S. A. Lynch,R. G. Knowlton,D. H. Cohn,B. Sykes. Identification of five novel mutations in cartilage oligomeric matrix protein gene in pseudoachondroplasia and multiple epiphyseal dysplasia. Hum Mutat 1998, Suppl 1, S10-7.
• Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S. Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. Gene 1998, 219(1-2), 101-110.
• Finaz, C., Martin-Ruiz, C.M., Lefèvre, A. L'interaction des gamètes: molécules et mécanismes. Médecine et Science 1998, 2, 175-182.
• Mueller JD, Haegle N, Keller G, Mueller E, Saretzky G, Bethke B, Stolte M, Hofler H. Loss of heterozygosity and microsatellite instability in de novo versus ex-adenoma carcinomas of the colorectum. Am J Pathol 1998, 153(6), 1977-84.
• Cawson TE. Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases. Molecular Medicine Today 1998, 4(3), 130-137.
• Cawston TE. Mechanisms of joint destruction and therapeutic approaches. Medicine 1998, 26(5), 4-10.
• T.B.L. Kirkwood,A Kowald. Modeling mitochondrial DNA mutations. In: K.K. Singh, ed. Mitochondrial DNA Mutations in Aging, Disease and Cancer. Austin: Springer-Verlag and R.G. Landes Biomedical, 1998, pp.129-145.
• D. J. Wilkin,J. K. Szabo,R. Cameron,S. Henderson,G. A. Bellus,M. L. Mack,I. Kaitila,J. Loughlin,A. Munnich,B. Sykes,J. Bonaventure,C. A. Francomano. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet 1998, 63(3), 711-6.
• Kirkwood TBL. Ovarian ageing and the general biology of senescence. Maturitas 1998, 30, 105-111.
• Bowman, J., White, A.W., Golding, B.T., Griffin, R.J., Curtin, N.J. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. British Journal of Cancer 1998, 78(10), 1269-1277.
• Petersen S, Saretzki G, von Zglinicki T. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Experimental Cell Research 1998, 239(1), 152-160.
• Weinert T, Lydall D. Puzzles and pathways in DNA damage checkpoints in yeast. In: J.A. Nickoloff;M. Hoekstra, ed. DNA damage and repair ; Volume 1: DNA repair in prokaryotes and Lower Eukaryotes. Totawa New Jersey, USA: Humana Press, 1998.
• Griffin, R. J., Srinivasan, S., Bowman, K., Calvert, A. H., Curtin, N. J., Newell, D. R., Pemberton, L. C., Golding, B. T. Resistance-modifying agents. 5.1 Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). Journal of Medicinal Chemistry 1998, 41(26), 5247-5256.
• G. H. Thoresen, T. K. Guren, D. Sandnes, M. Peak, L. Agius and T. Christoffersen. Response to transforming growth factor or (TGF alpha) and epidermal growth factor (EGF) in hepatocytes: Lower EGF receptor affinity of TGF alpha is associated with more sustained activation of p42/p44 mitogen-activated protein kinase and greater efficacy in stimulation of DNA synthesis. Journal of Cellular Physiology 1998, 175, 10-18.
• Redfern CPF. Retinoic acid receptors. British Journal of Pharmacology 1998, 124(Supplement), U78-U78.
• Irving, H., Lovat, P.E., Campbell-Hewson, Q., Malcolm, A., Pearson, A.D.J., Redfern, C.P.F. Retinoid-induced differentiation of neuroblastoma: Comparison between LG69, an RXR-selective analogue and 9-cis retinoic acid. European Journal of Cancer 1998, 34(1), 111-117.
• Linnane AW, Ernster L, Nohl H, Orrenius S, Harman D, Ozawa T, Ji LL, Beckman K, Aiken JM, Pepe S, Feuers RJ, Wei YH, Mori A, Barja G, Hipkiss AR, von Zglinicki T, Driver C, Goto S, Curtay JP. Roundtable discussion - How best to ameliorate the normal increase in mitochondrial superoxide formation with advancing age. Towards Prolongation of the Healthy Life Span 1998, 854, 251-267.
• E. Milne. Share Options. Health Service Journal 1998, 108(5621), 22-24.
• Saretzki G, Feng JL, von Zglinicki T, Villeponteau B. Similar gene expression pattern in senescent and hyperoxic- treated fibroblasts. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 1998, 53, B438-B442.
• Saretzki G, Feng J, von Zglinicki T, Villeponteau B. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts. Journals of Gerontology Series A-Biological Sciences & Medical Sciences 1998, 53, B438-B442.
• Saretzki G, von Zglinicki T, Villeponteau B. Similar gene expression patterns in senescent and hyperoxically blocked fibroblasts. Towards Prolongation of the Healthy Life Span 1998, 854, 482-482.
• Martin-Ruiz C, Duquenne C, Treton D, Lefevre A, Finaz C. SOB3, a human sperm protein involved in zona pellucida binding: physiological and biochemical analysis, purification. Mol Reprod Dev 1998, 49(3), 286-97.
• Ford D, Thwaites D, Simmons N, Gilbert H, Hirst B. Substrate upregulation of the human small intestinal peptide transporter, hPepT1. Journal of Physiology 1998, 507(3), 697-706.
• Muller A, Saretzki G, von Zglinicki T. Telomerase inhibition by induced expression of antisense RNA. Gene Therapy of Cancer 1998, 451, 23-26.
• Muller A, Saretzki G, von Zglinicki T. Telomerase inhibition by induced expression of antisense RNA. Advances in Experimental Medicine & Biology 1998, 451, 23-26.
• von Zglinicki T. Telomeres: Influencing the rate of aging. Towards Prolongation of the Healthy Life Span 1998, 854, 318-327.
• L. Agius. The physiological role of glucokinase binding and translocation in hepatocytes. Advances in Enzyme Regulation, Vol 38 1998, 38, 303-331.
• Wipat A, Brignell SC, Guy BJ, Rose M, Emmerson PT, Harwood CR. The yvsA-yvqA (293°-289°) region of the Bacillus subtilis chromosome containing genes involved in metal ion uptake and a putative sigma factor. Microbiology 1998, 144(6), 1593-1600.