Newcastle University

Publications

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• Poulton J, Turnbull DM. 74th ENMC International Workshop: Mitochondrial Diseases 19-20 November 1999, Naarden, The Netherlands. Neuromuscular Disorders 2000, 10(6), 460-462.
• Adamson A, Curtis P, Loughridge J, Rugg-Gunn A, Spendiff A, Mathers J. A family-based intervention to increase consumption of starchy foods. Nutrition and Food Science 2000, 30(1), 19-23.
• Kowald A, Kirkwood TBL. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells. Journal of Theoretical Biology 2000, 202, 145-160.
• von Zglinicki T, Pilger R, Sitte N. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radical Biology and Medicine 2000, 28(1), 64-74.
• Daly ME, Vale C, Walker M, Littlefield A, George K, Alberti MM, Mathers J. Acute fuel selection in response to high-sucrose and high-starch meals in healthy men. American Journal of Clinical Nutrition 2000, 71(6), 1516-1524.
• Martin K, Potten CS, Kirkwood TBL. Age-Related Changes in Irradiation-Induced Apoptosis and Expression of p21 and p53 in Crypt Stem Cells of Murine Intestine. Annals of the New York Academy of Sciences 2000, 908, 315-318.
• Martin-Ruiz CM, Piggott M, Gotti C, Lindstrom J, Mendelow AD, Siddique MS, Perry RH, Perry EK, Court JA. Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease. Neuropharmacology 2000, 39(13), 2830-2839.
• Taylor RW, Wardell TM, Blakely EL, Borthwick GM, Brierley EJ, Turnbull DM. Analysis of Mitochondrial DNA Mutations. Methods in Molecular Medicine: Aging Methods and Protocols 2000, 38, 245-264.
• Taylor RW, Andrews RM, Chinnery PF, Turnbull DM. Analysis of mitochondrial DNA mutations: point mutations. In: Barnett, YA; Barnett, CR, ed. Ageing Methods and Protocols. New Jersey: Humana Press, 2000, pp.265-277.
• Loughlin J, Dowling B, Mustafa Z, Smith A, Sykes B, Chapman K. Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: comment on the article by Meulenbelt et al. Arthritis Rheum 2000, 43(6), 1423-1425.
• Loughlin J, Sinsheimer JS, Mustafa Z, Carr AJ, Clipsham K, Bloomfield VA, Chitnavis J, Bailey A, Sykes B, Chapman K. Association analysis of the vitamin D receptor gene, the type I collagen gene COL1A1, and the estrogen receptor gene in idiopathic osteoarthritis. Journal of Rheumatology 2000, 27(3), 779-784.
• Goldstein M, Wilkinson DJ. Bayes linear analysis for graphical models: The geometric approach to local computation and interpretive graphics. Statistics and Computing 2000, 10(4), 311-324.
• Kirkwood TBL. Biological origins of aging. In: Evans, J.G., Williams T.F., Beattie, B.L., Michel, J.P., Wilcock, G.K, ed. Oxford Textbook of Geriatric Medicine. Oxford: Oxford University Press, 2000, pp.35-42.
• Toussaint O, Remacle J, Clark BFC, Gonos ES, Franceschi C, Kirkwood TBL. Biology of ageing. BioEssays 2000, 22(10), 954-956.
• Leake A, Morris CM, Whateley J. Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease. Neuroscience Letters 2000, 291(3), 201-203.
• Twist SJ, Taylor GA, Weddell A, Weightman DR, Edwardson JA, Morris CM. Brain oestradiol and testosterone levels in Alzheimer's disease. Neuroscience Letters 2000, 286(1), 1-4.
• Kirkwood TBL, Shanley DP. Caloric restriction, hormesis and life history plasticity. Human and Experimental Toxicology 2000, 19(6), 338-339.
• Kirkwood TBL, Shanley DP. Caloric restriction, hormesis and life-history plasticity. BELLE Newsletter 2000, 8(3).
• Shanley DP, Kirkwood TBL. Calorie Restriction and Aging: A Life-History Analysis. Evolution 2000, 54(3), 740-750.
• Rowan AD, Billington CJ, Knight CG, Cawston TE. Cartilage destruction in arthritis: Collagen and aggrecan-degrading proteinases. In: Conference on Tissue Inhibitors of Metalloproteinases in Development and Disease. 2000, Banff, Canada: Harwood Academic Publishers, Gmbh.
• Rowan AD, Billington CJ, Knight CG, Cawston TE. Cartilage destruction in Arthritis: Collagen and Aggrecan-degrading Proteins. In: Tissue inhibitors of metalloproteinases in development and diseases: proceedings of the Inhibitors of Metalloproteinases Conference. 2000, Banff, Canada: Harwood Academic.
• Toussaint O, Medrano EE, Von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Experimental Gerontology 2000, 35(8), 927-945.
• Lu, X., Errington, J., Chen, V., Curtin, N. J., Boddy, A. V., Newell, D. R. Cellular ATP depletion by LY309887 as a predictor of growth inhibition in human tumor cell lines. Clinical Cancer Research 2000, 6(1), 271-277.
• Monks, N., Calvete, J., Curtin, N.J., Blakey, D., East, S., Newell, D.R. Cellular glutathione as a determinant of the sensitivity of colorectal tumour cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT). British Journal of Cancer 2000, 83(2), 267-269.
• Finch CE, Kirkwood TBL. Chance, Development and Aging. New York: Oxford University Press, 2000.
• Oldroyd JC, Unwin NC, Mathers JC, White M. Changes in diet, exercise and coronary heart disease risk factors: results of a lifestyle intervention in men and women with impaired glucose tolerance after 6 months follow-up. In: PROCEEDINGS OF THE NUTRITION SOCIETY. 2000.
• Howard A, Jordinson M, Goodlad RA, Walters JR, Ford D, Hirst BH. Changes in expression of intestinal peptide and amino acid transporters in rats fed by total parenteral nutrition. In: GASTROENTEROLOGY. 2000.
• Birkett AM, Mathers JC, Jones GP, Walker KZ, Roth MJ, Muir JG. Changes to the quantity and processing of starchy foods in a Western diet can increase polysaccharides escaping digestion and improve in vitro fermentation variables. British Journal of Nutrition 2000, 84(1), 63-72.
• Lydall D. Checkpoint proteins and the metabolism of DNA damage. In: W.L. Fangman;T. Kishimoto;M. Kohiyama;C. Coath, ed. Cell Division and the Replicon: From workshop IX, The Human Frontiers Science Program based on a meeting held in Strasbourg from May 31 to June 2 1999. Strasbourg, France: Human Frontier Science Program, 2000.
• Martin-Ruiz CM, Lee M, Court J, Iversen P, Merrit J, Folly E, et al. Cholinergic activities in autism: nicotinic and muscarinic receptor abnormalities in the cerebral cortex. Soc Neurosci Abstracts 2000, 26, 1403.
• Walker M, Jackson S, Yeaman SJ, Turnbull DM. Decreased glucose uptake in myoblasts from insulin resistant non-diabetic relatives of type 2 diabetic families. Diabetes 2000, 48(s1), A263-A264 abstract no. 1154.
• Boys RJ, Henderson DA, Wilkinson DJ. Detecting homogeneous segments in DNA sequences by using hidden Markov models. Journal of the Royal Statistical Society. Series C: Applied Statistics 2000, 49(2), 269-285.
• Mathers JC. Dietary strategies to reduce the burden of cancer and cardiovascular disease in the UK. British Journal of Nutrition 2000, 84(2), S211-S216.
• Smith, P., Marshman, E., Newell, D.R., Curtin, N.J. Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport. British Journal of Cancer 2000, 82(4), 924-930.
• Lovat, P.E., Ranalli, M., Bernassola, F., Tilby, M., Malcolm, A.J., Pearson, A.D.J., Piacentini, M., Melino, G., Redfern, C.P.F. Distinct properties of fenretinide and CD437 lead to synergistic responses with chemotherapeutic reagents. Medical and Pediatric Oncology 2000, 35(6), 663-668.
• Barnett YA, Barnett CR, Von Zglinicki T. DNA damage and telomere length in human T cells. JOURNAL OF ANTI-AGING MEDICINE 2000, 3(4), 383-388.
• Mellon AF, Deshpande SA, Mathers JC, Bartlett K. Effect of oral antibiotics on intestinal production of propionic acid. Archives of Disease in Childhood 2000, 82(2), 169-172.
• Lovat, P.E., Ranalli, M., Annichiarrico-Petruzzelli, M., Bernassola, F., Piacentini, M., Malcolm, A.J., Pearson, A.D.J., Melino, G., Redfern, C.P.F. Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma. Experimental Cell Research 2000, 260(1), 50-60.
• Wiles J, Chenery H, Hallinan J, Blair A, Naumann D. Effects of damage to the CDM Stroop model. In: Cognitive Science in Australia: Proceedings of the Fifth Biennial Conference of the Australasian Cognitive Science Society. 2000, Melbourne, Australia: Causal Productions.
• Griffiths TA, Murdoch AP, Herbert M. Embryonic development in vitro is compromised by the ICSI procedure. Human Reproduction 2000, 15(7), 1592-1596.
• Denise Robertson M, Livesey G, Hampton SM, Mathers JC. Evidence for altered control of glucose disposal after total colectomy. British Journal of Nutrition 2000, 84(6), 813-819.
• Kirkwood TBL. Evolution of aging: how genetic factors affect the end of life. Generations 2000, 24, 12-18.
• Kirkwood TBL. Evolution of aging: How genetic factors affect the end of life. GENERATIONS-JOURNAL OF THE AMERICAN SOCIETY ON AGING 2000, 24(1), 12-18.
• Kirkwood TBL, Kapahi P, Shanley DP. Evolution, stress, and longevity. Journal of Anatomy 2000, 197, 587-590.
• Tyrer SP, Margallo-Lana ML, Moore PD, Kay DW, Perry RH, Berney TP, Morris C. Factors associated with cognitive decline in Down syndrome. In: 11th World Congress of the International Association for the Scientific Study of Intellectual Disabilities (IASSID). 2000, Seattle, Washington, USA: John Wiley & Sons.
• Redfern, C.P.F., Slough, A., Dean, B., Brice, J., Jones, P. Fat and body condition migrating Redwings Turdus iliacus. Journal of Avian Biology 2000, 31(2), 197-205.
• Hallinan J. Feature selection and classification in the diagnosis of cervical cancer. In: Chambers, L, ed. The Practical Handbook of Genetic Algorithms: Applications. Boca Raton, Florida, USA: CRC Press, 2000, pp.167-202.
• Robertson MD, Mathers JC. Gastric emptying rate of solids is reduced in a group of ileostomy patients. Digestive Diseases and Sciences 2000, 45(7), 1285-1292.
• Taylor RW, McGregor A, Lightowlers RN, Turnbull DM. Gene therapy for mitochondrial DNA defects. In: Ebadi, MS, ed. Mitochondrial Ubiquinone (Coenzyme Q10): biochemical, functional, medical and therapeutic aspects in human health and diseases. Prominent Press, Arizona, 2000.
• Henderson S, Sillence D, Loughlin J, Bennetts B, Sykes B. Germline and somatic mosaicism in achondroplasia. Journal of Medical Genetics 2000, 37(12), 956-958.
• McDermott CJ, Dayaratne RK, Tomkins J, Johnson MA, Casari G, Turnbull DM, Bushby K, Shaw PJ. Hereditary spastic paraparesis with amyotrophy and OXPHOS muscle defect associated with a deletion in the paraplegin (SPG7) gene with apparent autosomal dominant transmission. Neurology 2000, 54, A425-A425.
• Thomas NJ, Morris CM, Scaravilli F, Johansson J, Rossor M, De Lange R, St Clair D, Nicoll J, Blank C, Coulthard A, Bushby K, Ince PG, Burn D, Kalaria RN. Hereditary vascular dementia linked to Notch 3 mutations: CADASIL in British families. Annals of the New York Academy of Sciences 2000, 903, 293-298.
• Armstrong F, Kirby J, Higgins CA, Coaker J, Mathers JC. High dose Hylon VII increases tumourigenesis and decreases lymphocyte proliferation in Min mice. In: PROCEEDINGS OF THE NUTRITION SOCIETY. 2000.
• Kirkwood TBL, Westendorp RGJ. Human longevity at the cost of reproductive success: trade-offs in the life history. In: Robine, J-M ; Kirkwood, TBL; Allard, M, ed. Sex and Longevity: Sexuality, Gender, Reproduction, Parenthood. New York: Springer, 2000, pp.1-6.
• Arris, C. E., Boyle, F., Calvert, A. H., Curtin, N. J., Endicott, J. A., Garman, E. F., Gibson, A. E., Golding, B. T., Grant, S., Griffin, R. J., Jewsbury, P., Johnson, L., Lawrie, A., Newell, D. R., Noble, M., Sausville, E., Schultz, R., Yu, W. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. Journal of Medicinal Chemistry 2000, 43(15), 2797-2804.
• Aiston S, Peak M, Agius L. Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: The role of increased phosphorylase activity. Diabetologia 2000, 43(5), 589-597.
• Glazebrook KD, Wilkinson DJ. Index-based policies for discounted multi-armed bandits on parallel machines. Annals of Applied Probability 2000, 10(3), 877-896.
• Mickleburgh I, Buddles M, West SP, Mathers JC, Curtis A. Interaction of selected food constituents with APC function in enterocytes. In: JOURNAL OF MEDICAL GENETICS. 2000.
• Lynn S, Hattersley AT, McCarthy MI, Frayling TM, Turnbull DM, Walker M. Intermediate expansions of a X25/frataxin gene GAA repeat and Type II diabetes: Assessment using parent-offspring trios [1]. Diabetologia 2000, 43(3), 384-385.
• Agius L, Stubbs M. Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: Evidence for two glucose binding sites. Biochemical Journal 2000, 346(2), 413-421.
• Armstrong F, Mathers JC. Kill and cure: Dietary augmentation of immune defences against colon cancer. Proceedings of the Nutrition Society 2000, 59(2), 215-220.
• Birch-Machin MA, Taylor RW, Cochran B, Ackrell BAC, Turnbull DM. Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene. Annals of Neurology 2000, 48(3), 330-335.
• Mustafa Z, Chapman K, Irven C, Carr AJ, Clipsham K, Chitnavis J, Sinsheimer JS, Bloomfield VA, McCartney M, Cox O, Sykes B, Loughlin J. Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritis. Rheumatology 2000, 39(3), 299-306.
• Loughlin J, Mustafa Z, Smith A, Irven C, Carr AJ, Clipsham K, Chitnavis J, Bloomfield VA, McCartney M, Cox O, Sinsheimer JS, Sykes B, Chapman KE. Linkage analysis of chromosome 2q in osteoarthritis. Rheumatology 2000, 39(4), 377-381.
• Clark IM, Rowan AD, Cawston TE. Matrix metalloproteinases inhibitors in the treatment of arthritis. Current Opinions in Anti-inflammatory and Immunomodulatory Investigative Drugs 2000, 2, 16-25.
• Bigg HF, McLeod R, Waters JG, Cawston TE, Clark IM. Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor. FEBS Journal 2000, 267(13), 4150-4156.
• Kalaria RN, Cookson NJ, Mizuno T, Oakley A, Singleton AB, Morris CM, Coulthard A, Blank SC, Bushby KMD, Nicoll J, De Lange RPJ, Burn DJ, St Clair D. Microvascular pathology in familial multi-infarct dementia or CADASIL: implications for cerebral blood flow. In: Fukuuchi, Y; Tomita, M; Koto, A, ed. Ischemic Blood Flow in the Brain. Tokyo, New York: Springer, 2000, pp.431-442.
• Cottrell DA, Turnbull DM. Mitochondria and ageing. Current Opinion in Clinical Nutrition and Metabolic Care 2000, 3(6), 473-478.
• Cottrell DA, Turnbull DM. Mitochondria and Aging (Review). Current Opinion in Clinical Nutrition and Metabolic Care 2000, 3(6), 473-478.
• Chinnery PF, Taylor GA, Howell N, Andrews RM, Morris CM, Taylor RW, McKeith IG, Perry RH, Edwardson JA, Turnbull DM. Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies. Neurology 2000, 55(2), 302-304.
• Chinnery PF, Turnbull DM. Mitochondrial DNA mutations in the pathogenesis of human disease. Molecular Medicine Today 2000, 6(11), 425-432.
• Hallinan JS, Wiles J. Modelling the spread of antibiotic resistance. In: Proceedings of the 2000 Congress on Evolutionary Computation (CEC). 2000, La Jolla, California, USA: IEEE.
• Taylor RW, Wardell TM, Lightowlers RN, Turnbull DM. Molecular basis for treatment of mitochondrial myopathies. Neurological Sciences 2000, 21(9), S909-S912.
• Kirkwood TBL. Molecular gerontology. Bridging the simple and the complex. Annals of the New York Academy of Sciences 2000, 908, 14-20.
• Armstrong L, Lako M, Lincoln J, Cairns PM, Hole N. mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells. Mechanics of Development 2000, 97(1-2), 109-116.
• Simpson A, Wilkinson DJ. Multivariate DLMs for Forecasting Financial Time series, with Application to the Management of Portfolios. In: 14th Proceedings in Computational Statistics 2000 - COMPSTAT. 2000, Utrecht, The Netherlands: Physica-Verlag.
• Cottrell DA, Ince PG, Blakely EL, Johnson MA, Chinnery PF, Hanna M, Turnbull DM. Neuropathological and histochemical changes in a multiple mitochondrial DNA deletion disorder. Journal of Neuropathology and Experimental Neurology 2000, 59(7), 621-627.
• Perry E, Martin-Ruiz C, Lee M, Griffiths M, Johnson M, Piggott M, Haroutunian V, Buxbaum JD, Nasland J, Davis K, Gotti C, Clementi F, Tzartos S, Cohen O, Soreq H, Jaros E, Perry R, Ballard C, McKeith I, Court J. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases. European Journal of Pharmacology 2000, 393(1-3), 215-222.
• Martin-Ruiz C, Court J, Lee M, Piggott M, Johnson M, Ballard C, Kalaria R, Perry R, Perry E. Nicotinic receptors in dementia of Alzheimer, lewy body and vascular types. Acta Neurologica Scandinavica, Supplement 2000, 102(176), 34-41.
• Court JA, Martin-Ruiz C, Graham A, Perry E. Nicotinic receptors in human brain: Topography and pathology. Journal of Chemical Neuroanatomy 2000, 20(3-4), 281-298.
• Singleton AB, Hall R, Ballard CG, Perry RH, Xuereb JH, Rubinsztein DC, Tysoe C, Matthews P, Cordell B, Kumar-Singh S, De Jonghe C, Cruts M, van Broeckhoven C, Morris CM. Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation. Brain 2000, 123(12), 2467-2474.
• Delaney, C.A., Wang, L., Kyle, S., White, A.W., Calvert, A.H., Curtin, N.J., Durkacz, B.W., Hostomsky, Z, Newell, D.R. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clinical Cancer Research 2000, 6(7), 2860-2867.
• Sitte N, Huber M, Grune T, Ladhoff A, Doecke WD, von Zglinicki TW, Davies KJA. Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts. FASEB Journal 2000, 14, 1490-1498.
• Sitte N, Merker K, Zglinicki vonT, Grune T, Davies KJA. Protein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part I -Effects of proliferative senescence. FASEB Journal 2000, 14, 2495-2502.
• Sitte N, Merker K, Zglinicki vonT, Davies KJA, Grune T. Protein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part II -Aging of non-dividing cells. FASEB Journal 2000, 14, 2503-2510.
• Sitte N, Merker K, von Zglinicki T, Grune T. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radical Biology and Medicine 2000, 28(5), 701-708.
• Campbell-Hewson, Q., Lovat, P.E., Malcolm, A.J., Pearson, A.D.J., Redfern, C.P.F. Receptor mechanisms mediating differentiation and proliferation effects of retinoids on neuroblastoma cells. Neuroscience Letters 2000, 279(2), 113-116.
• von Zglinicki T, Saretzki G. Regeneration der Telomeren als Basis zellulaerer Immortalitaet. In: Sames, K, ed. Medizinische Regeneration und Tissue Engineering. Landsberg: Ecomed, 2000, pp.IV.4.1 - IV.4.9.
• Yang SH, Galanis A, Vickers E, Greenall A, Yates P, Willingham N, Sharrocks A. Regulation of ETS transcription factor activity. In: BRITISH JOURNAL OF CANCER. 2000.
• Clark IM, Bigg HF, Rowan AD, Edwards DR, Mann DA, Bahr MJ, Cawston TE. Regulation of human TIMP-1 Gene Expression. In: Tissue Inhibitors of metalloproteinases in development and disease: proceedings of the Inhibitors of Metalloproteinases Conference. 2000, Banff, Canada: Harwood Academic Press.
• Gray PA, Ford D, Hirst BH. Regulation of the amino acid transporter hEAAC1 in human intestinal Caco-2 cells. In: FASEB JOURNAL. 2000.
• von Zglinicki T. Research on ageing in Germany. Experimental Gerontology 2000, 35(3), 259-270.
• Griffin, R. J., Arris, C. E., Bleasdale, C. , Boyle, F., Calvert, A. H., Curtin, N. J., Dalby, C., Kanugula, S., Lembicz, N., Newell, D. R., Pegg, A., Golding, B. T. Resistance-modifying agents. 8. Inhibition of O⁶-alkylguanine-DNA alkyltransferase by O⁶-alkenyl-, O⁶-cycloalkenyl-, and O⁶-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O⁶-(1-cyclopentenylmethyl) guanine. Journal of Medicinal Chemistry 2000, 43(22), 4071-4083.
• White, A.W., Almassy, R., Calvert, A.H., Curtin, N.J., Griffin, R.J., Hostomsky, Z., Maegley, K., Newell, D.R., Srinivasan, S, Golding, B.T. Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. Journal of Medicinal Chemistry 2000, 43(22), 4084-4097.
• Barlow, H. C., Bowman, K. J., Curtin, N. J., Calvert, A. H., Golding, B. T., Huang, B., Loughlin, P. J., Newell, D. R., Smith, P. G., Griffin, R. J. Resistance-modifying agents. Part 7: 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP). Bioorganic and Medicinal Chemistry Letters 2000, 10(6), 585-589.
• Shingleton WD, Ellis AJ, Rowan AD, Cawston TE. Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown. Journal of Cellular Biochemistry 2000, 79(4), 519-531.
• Miedzybrodzka Z, Morris AAM, Olpin S, Gerrie L, Dean JCS, Haites NE, Pollit R, Turnbull D. Riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency: A treatable cause of myopathy and metabolic crisis. In: JOURNAL OF MEDICAL GENETICS. 2000.
• Cottrell DA, Blakely EL, Johnson MA, Borthwick GM, Ince PG, Turnbull DM. Role of Mitochondrial DNA Mutations in Ageing and Health. The proceedings of the Japanese-UK co-operative study on longevity sciences, Newcastle (UK). National Institute for Longevity Sciences for the Japan Ministry of Health and Welfare 2000.
• Cottrell DA, Blakely EL, Borthwick GM, Johnson MA, Taylor GA, Brierley EJ, Ince PG, Turnbull DM. Role of mitochondrial DNA mutations in disease and aging. Annals of the New York Academy of Sciences 2000, 908(1), 199-207.
• Von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Annals of the New York Academy of Sciences 2000, 908, 99-110.
• von Zglinicki TW. Role of oxidative stress in telomere length regulation and replicative senescence. Annals of the New York Academy of Sciences 2000, 908(1), 99-110.
• Lako M, Hole N. Searching the unknown with gene trapping. Expert Reviews in Molecular Medicine 2000.
• von Zglinicki T, Serra V, Lorenz M, Saretzki G, Lenzen-Grossimlighaus R, Gessner R, Risch A, Steinhagen-Thiessen E. Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?. Laboratory Investigation 2000, 80(11), 1739-1747.
• Kirkwood TBL. Similarities of general and reproductive aging. In: te Velde, ER; Pearson, PL; Broekmans,FJ, ed. Female Reproductive Aging. United Kingdom: Parthenon Publishing, 2000, pp.43-47.
• Wiles J, Chenery HJ, Hallinan J, Blair A, Naumann D. Stroop performance in Alzheimer's disease: A preliminary test of theories of damage using a connectionist simulation. Brain and Language 2000, 74(3), 341-344.
• Bentley J, Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury PJ, Johnson LN, Noble MEM, Newell DR. Structure-activity relationships and cellular effects of novel purine- and pyrimidine-based cyclin dependent kinase inhibitors. Clinical Cancer Research 2000, 6, 328.
• Stubbs M, Aiston S, Agius L. Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells. Diabetes 2000, 49(12), 2048-2055.
• Lovat, P.E., Ranalli, M., Bernassola, F., Tilby, M.J., Malcolm, A.J., Pearson, A.D.J., Piacentini, M, Melino, G., Redfern, C.P.F. Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs. International Journal of Cancer 2000, 88(6), 977-985.
• Howard A, Gray PA, Ford D, Hirst BH. System ASC activity and expression of the amino acid transporter ASCT1 in human intestinal Caco-2 cells. In: JOURNAL OF PHYSIOLOGY-LONDON. 2000.
• Serra V, Grune T, Sitte N, Saretzki G, Von Zglinicki T. Telomere length as a marker of oxidative stress in primary human fibroblast cultures. Annals of the New York Academy of Sciences 2000, 908, 327-330.
• Agius L, Aiston S, Newgard CB. The control strength of glucokinase in hepatocytes: A predictor of metabolic defects in maturity onset diabetes of the young, type 2. In: NATO Advanced Research Workshop on Technological and Medical Implications of metabolic Control Analysis. 2000, Visegrad, Hungary: Springer.
• Chinnery PF, Johnson MA, Wardell TM, Singh-Kler R, Hayes C, Brown DT, Taylor RW, Bindoff LA, Turnbull DM. The epidemiology of pathogenic mitochondrial DNA mutations. Annals of Neurology 2000, 48(2), 188-193.
• Barron MJ, Andrews RM, Griffiths PG, Johnson MA, Bristow E, He LP, Durham S, Turnbull DM, Clarke MP. The macular photoreceptor layer accumulates the mitochondrial DNA(4977) deletion with age. In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2000.
• Curtis PJ, Adamson AJ, Mathers JC. The relationship between starch and fat consumption in a UK population. In: Proceedings of the Nutrition Society. 2000, University College, Cork, Republic of Ireland: Cambridge University Press.
• De La Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L. The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. Journal of Biological Chemistry 2000, 275(14), 10597-10603.
• Howell N, Chinnery PF, Ghosh SS, Fahy E, Turnbull DM. Transmission and segregation of the human mitochondrial genome. Human Reproduction 2000, 15(Supp. 2), 235-245.
• Howell N, Chinnery PF, Ghosh SS, Fahy E, Turnbull DM, Jansen R. Transmission of the human mitochondrial genome. Human Reproduction 2000, 15(2), 235-245.
• Kirkwood TBL. Understanding the biological determinants of longevity: new opportunities and challenges. In: Butler, RN;Jasmin, C, ed. Longevity & Quality of Life: Opportunities and Challenges. New York: Kluwer Academic /Plenum, 2000, pp.77-81.
• Cascante M, Centelles JJ, Agius L. Use of α-toxin from Staphylococcus aureus to test for channelling of intermediates of glycolysis between glucokinase and aldolase in hepatocytes. Biochemical Journal 2000, 352(3), 899-905.
• Kirkwood TBL, Austad SN. Why do we age?. Nature 2000, 408(6809), 233-238.