Newcastle University

Publications

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• Maringele L, Lydall D. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants. Genes & Development 2002, 16(15), 1919-1933.
• Geard N, Wiles J, Hallinan J, Tonkes B, Skellett B. A comparison of neutral landscapes - NK, NKp and NKq. In: Proceedings of the Congress on Evolutionary Computation (CEC). 2002, Honolulu, Hawaii: IEEE.
• Herrnstadt C, Preston G, Andrews R, Chinnery P, Lightowlers RN, Turnbull DM, Kubacka I, Howell N. A high frequency of mtDNA polymorphisms in HeLa cell sublines. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2002, 501(1-2), 19-28.
• Herrnstadt C, Preston G, Andrews R, Chinnery P, Lightowlers RN, Turnbull DM, Kubacka I, Howell N. A high frequency of mtDNA polymorphisms in HeLa cell sublines. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2002, 501(1-2), 19-28.
• Nentwich HA, Mustafa Z, Rugg MS, Marsden BD, Cordell MR, Mahoney DJ, Jenkins SC, Dowling B, Fries E, Milner CM, Loughlin J, Day AJ. A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression. Journal of Biological Chemistry 2002, 277(18), 15354-15362.
• Taylor RW, Schaefer AM, McFarland R, Maddison P, Turnbull DM. A novel mitochondrial DNA tRNAIle (A4267G) mutation in a sporadic patient with mitochondrial myopathy. Neuromuscular Disorders 2002, 12(7-8), 659-664.
• Villette S, Kyle JAM, Brown KM, Pickard K, Milne JS, Nicol F, Arthur JR, Hesketh JE. A novel single nucleotide polymorphism in the 3′ untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism. Blood Cells, Molecules, and Diseases 2002, 29(2), 174-178.
• Cragg RA, Christie GR, Phillips SR, Russi RM, Kury S, Mathers JC, Taylor PM, Ford D. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. Journal of Biological Chemistry 2002, 277(25), 22789-22797.
• Turnbull DM, Lightowlers RN. A roundabout route to gene therapy. Nature Genetics 2002, 30(4), 345-346.
• Miele G, Jeffrey M, Turnbull D, Manson J, Clinton M. Ablation of cellular prion protein expression affects mitochondrial numbers and morphology. Biochemical and Biophysical Research Communications 2002, 291(2), 372-377.
• Chinnery PF, Samuels DC, Elson J, Turnbull DM. Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: Is there a common mechanism?. Lancet 2002, 360(9342), 1323-1325.
• Wilkinson DJ, Yeung SKH. Adaptive Metropolis-Hastings samplers for the Bayesian analysis of large linear Gaussian systems. Comp. Sci. and Stats 2002, 33, 128-138.
• Kirkwood TBL. Ageing – Future Directions for Research in the Biology of Ageing. In: Encyclopedia of Life Sciences. London: Nature Publishing Group, 2002.
• Kirkwood TBL, Finch CE. Ageing: The old worm turns more slowly. Nature 2002, 419(6909), 794-795.
• Lake AA, Craigie AM, Wood C, Gibbons M, Rugg-Gunn AJ, Mathers JC, Adamson AJ. Aggregation of diets containing fatty and sugary foods and fruit and vegetables within cohabiting couples. In: Proceedings of the Nutrition Society. 2002, Heriot-Watt University, Edinburgh, UK: Cambridge University Press.
• Paice AG, Hesketh JE, Towner P, Hirako M, Peters TJ, Preedy VR. Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle. Metabolism 2002, 51(10), 1285-1290.
• Vaidya B, Pearce SHS, Charlton S, Marshall N, Rowan AD, Griffiths ID, Kendall-Taylor P, Cawston TE, Young-Min S. An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies. Rheumatology 2002, 41(2), 180-183.
• Vaidya B, Pearce SHS, Charlton S, Marshall N, Rowan AD, Griffiths ID, Kendall-Taylor P, Cawston TE, Young Min S. An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies. Rheumatology 2002, 41(2), 180-183.
• Tyni T, Pourfarzam M, Turnbull DM. Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle. Pediatric Research 2002, 52(1), 64-70.
• Loughlin J, Dowling B, Mustafa Z, Chapman K. Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis. Arthritis & Rheumatism 2002, 46(6), 1519-1527.
• Harwood CR, Wipat A. Bacterial protein synthesis. In: Sussman, M, ed. Molecular Medical Microbiology. San Diego: Academic Press, 2002, pp.321-388.
• Spiropoulos J, Turnbull DM, Chinnery PF. Can mitochondrial DNA mutations cause sperm dysfunction?. Molecular Human Reproduction 2002, 8(8), 719-721.
• Kirkwood TBL. Changing complexity in aging: A metric not an hypothesis. Neurobiology of Aging 2002, 23(1), 21-22.
• Mathers J. Choosing your carbohydrates to prevent diabetes. British Journal of Nutrition 2002, 88(2), 107-108.
• Korolchuk VI, Banting G. CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles. Traffic 2002, 3(6), 428-439.
• Singleton AB, Wharton A, O'Brien KK, Walker MP, McKeith IG, Ballard CG, O'Brien J, Perry RH, Ince PG, Edwardson JA, Morris CM. Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies. Dementia and Geriatric Cognitive Disorders 2002, 14(3-4), 167-175.
• Kirkwood TBL. Clones, stem cells and immortality?. Medico-Legal Journal 2002, 70(2), 71-79.
• Cragg RA, Christie GR, Taylor PM, Ford D. Cloning and intestinal localisation of hZTL1, a novel zinc transporter. Journal of Physiology 2002, 539(supplement), 5P.
• Forrest IA, Ward C, Pritchard G, Rowan AD, Cawston TE, Corris PA. Co-localisation of MMP-9 with neutrophils in stable lung transplant recipients - A potential role in Bronchiolitis Obliterans. In: Thorax: Winter Meeting of the British Thoracic Society. 2002, London: BMJ Group.
• Simpson A, Wilkinson DJ. Computationally Intensive Techniques for a Fully Bayesian, Decision Theoretic Approach to Financial Forecasting and Portfolio Selection. Computing Science and Statistics 2002, 33, 472-483.
• Wilkinson DJ, Yeung SKH. Conditional simulation from highly structured Gaussian systems, with application to blocking-MCMC for the Bayesian analysis of very large linear models. Statistics and Computing 2002, 12(3), 287-300.
• Northen J, Boyle F, Clegg W, Curtin NJ, Edwards A, Griffin R, Golding B. Controlled stepwise conversion of 2,4,6,8-tetrachloropyrimido-[5,4-d ]pyrimidine into 2,4,6,8-tetrasubstituted pyrimido[5,4-d]pyrimidines. Journal of the Chemical Society. Perkin Transactions 1 2002, 2(1), 108-115.
• Turnbull DM, Taylor RW, McFarland RM, Schaefer AM. Defects of the mitochondrial genome. SAGGI - Child Development and Disabilities 2002, 28(1), 75-82.
• Choo-Kang ATW, Lynn S, Taylor GA, Daly ME, Sihota SS, Wardell TM, Chinnery PF, Turnbull DM, Walker M. Defining the importance of mitochondrial gene defects in maternally inherited diabetes by sequencing the entire mitochondrial genome. Diabetes 2002, 51(7), 2317-2320.
• Martin-Orue SM, O'Donnell AG, Arino J, Netherwood T, Gilbert HJ, Mathers JC. Degradation of transgenic DNA from genetically modified soya and maize in human intestinal simulations. British Journal of Nutrition 2002, 87(6), 533-542.
• He LP, Chinnery PF, Durham SE, Blakely EL, Wardell TM, Borthwick GM, Taylor RW, Turnbull DM. Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR. Nucleic Acids Research 2002, 30(14), e68.
• Fey C, Curtis ARJ, Chinnery PF, Lombes A, Morris CM, Curtis A, Burn J. Did neuroferritinopathy originate in France?. In: European Journal of Human Genetics: European Society of Human Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics. 2002, Strasbourg, France: Nature Publishing Group.
• Mathers J, Wolever T. Digestion and Metabolism of Carbohydrates. In: Gibney, M.J., Vorster, H.H., Kok, F.K, ed. Introduction to Human Nutrition. Oxford: Wiley-Blackwell, 2002, pp.69-80.
• Latsis T, Andersen B, Agius L. Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes. Biochemical Journal 2002, 368, 309-316.
• Monks, N., Blakey, D., East, S., Dowell, R., Calvete, J., Curtin, N.J., Arris, C.E., Newell, D.R. DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767. European Journal of Cancer 2002, 38(11), 1543-1552.
• G. Nelson,G. J. C. Wilde,D. G. Spiller,E. Sullivan,J. F. Unitt,M. R. H. White. Dynamic analysis of STAT6 signalling in living cells. Febs Letters 2002. 532(1-2), 188-192.
• Lietz G, Mathers JC, Seal CJ. Effect of barley beta-glucan on plasma cholesterol may depend on apolipoprotein E4 genotype - results from a pilot study. In: Scientific Meeting of the Nutrition Society. 2002, Leeds, UK: Proceedings of the Nutrition Society: Cambridge University Press.
• Wilson V, Howard A, Ford D, Hirst BH. EGF enhanced transcription of the amino acid transporter hATB(0) in COS-7 cells. In: Journal of Physiology: Conference of the Physiological Society. 2002, Liverpool: Wiley-Blackwell Publishing Ltd.
• Cawston TE. Enzymes. Biological Sciences Review 2002, 15, 2-5.
• Kirkwood TBL. Evolution of ageing. In: Mechanisms of Ageing and Development: Symposium on the Biology of Ageing. 2002, London: Elsevier Ireland Ltd.
• Hallinan JS, Wiles J. Evolutionary Algorithms. In: Nadel, L, ed. Encyclopedia of Cognitive Science. Chichester, UK: Palgrave Macmillan, 2002, pp.40-47.
• Loughlin J, Mustafa Z, Dowling B, Southam L, Marcelline L, Raina SS, Ala-Kokko L, Chapman K. Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6. European Journal of Human Genetics 2002, 10(9), 562-568.
• Chapman K, Mustafa Z, Dowling B, Southam L, Carr A, Loughlin J. Finer linkage mapping of primary hip osteoarthritis susceptibility on chromosome 11q in a cohort of affected female sibling pairs. Arthritis & Rheumatism 2002, 46(7), 1780-1783.
• Nørbæk R, Brandt K, Nielsen JK, Ørgaard M, Jacobsen N. Flower pigment composition of Crocus species and cultivars used for a chemotaxonomic investigation. Biochemical Systematics and Ecology 2002, 30(8), 763-791.
• Lovat, P.E., Oliverio, S., Ranalli, M., Corazzari, M., Rodolfo, C., Bernassola, F., Aughton, K., Maccarrone, M., Campbell-Hewson, Q., Pearson, A.D.J., Melino, G., Piacentini, M., Redfern, C.P.F. GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Research 2002, 62(18), 5158-5167.
• Kirkwood TBL. Genes, sex and ageing. Science in Africa 2002, (21).
• Kirkwood TBL. Genetics of old age. In: Burley, J.C., Harris, J, ed. A Companion to Genethics. Oxford: Wiley-Blackwell, 2002, pp.43-50.
• Loughlin J. Genome studies and linkage in primary osteoarthritis. Rheumatic Disease Clinics of North America 2002, 28(1), 95-109.
• Visapaa I, Fellman V, Vesa J, Dasvarma A, Hutton JL, Kumar V, Payne GS, Makarow M, Van Coster R, Taylor RW, Turnbull DM, Suomalainen A, Peltonen L. GRACILE syndrome is caused by a point mutation in BCS1L suggesting a new role of the BCS1L in iron metabolism. In: American Journal of Human Genetics: 52nd Annual Meeting of the American Society of Human Genetics. 2002, Baltimore, Maryland, USA: Cell Press.
• Visapaa I, Fellman V, Vesa J, Dasvarma A, Hutton JL, Kumar V, Payne GS, Makarow M, Van Coster R, Taylor RW, Turnbull DM, Suomalainen A, Peltonen L. GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L. American Journal of Human Genetics 2002, 71(4), 863-876.
• Lako M, Armstrong L, Cairns PM, Harris S, Hole N, Jahoda C. Hair follicle dermal cells repopulate the mouse haematopoietic system. Journal of Cell Science 2002, 115(20), 3967-3974.
• McFarland R, Taylor RW, Chinnery PF, Lightowlers RN, Turnball DM. Health, disability and death: A new spectrum of disease for homoplasmic mutations of mitochondrial DNA. In: Journal of Neurology, Neurosurgery and Psychiatry: Proceedings of the Association of British Neurologists. 2002, Oxford: BMJ Group.
• Chinnery PF, Samuels DC, Brown DT, Turnbull DM. Heteroplasmic mitochondrial DNA mutations: Determining the mechanism of inheritance. In: Journal of Neurology, Neurosurgery and Psychiatry: Association of British Neurologists Autumn Meeting. 2002, Durham: BMJ Group.
• Saretzki G, Petersen S, Petersen I, Kolble K, Von Zglinicki T. hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines. Cancer Letters 2002, 176(1), 81-91.
• Graham AJ, Martin-Ruiz CM, Teaktong T, Ray MA, Court J. Human brain nicotinic receptors, their distribution and participation in neuropsychiatric disorders. Current Drug Targets 2002, 1, 387-397.
• Serra V, von Zglinicki T. Human fibroblasts in vitro senesce with a donor-specific telomere length. FEBS Letters 2002, 516(1-3), 71-74.
• Graham A, Court JA, Martin-Ruiz CM, Jaros E, Perry R, Volsen SG, Bose S, Evans N, Ince P, Kuryatov A, Lindstrom J, Gotti C, Perry EK. Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum. Neuroscience 2002, 113(3), 493-507.
• Veal, G. J., Errington, J., Redfern, C., Pearson, A. D. J., Boddy, A. V. Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells. Biochemical Pharmacology 2002, 63(2), 207-215.
• Koshy PJ, Henderson N, Logan C, Life PF, Cawston TE, Rowan AD. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Annals of the Rheumatic Diseases 2002, 61(8), 704-713.
• Redfern, C.P.F., Douglas, G., Halliday, T. Intestine length and mass relative to fat in migrating Redwings Turdus iliacus. Ardea 2002, 90(2), 285-292.
• Hesketh JE, Villette S. Intracellular trafficking of micronutrients: from gene regulation to nutrient requirements. In: Proceedings of the Nutrition Society: Symposium on Nutrition in the Post-Genomic Era. 2002, London: Cambridge University Press.
• Lake AA, Craigie AM, Gibbons MR, Wood CE, Hyland RM, Rugg-Gunn AJ, Mathers JC, Adamson AJ. Investigating change in eating patterns from adolescence to adulthood: a preliminary analysis. In: Appetite: 10th Food Choice Conference. 2002, Wageningen, The Netherlands: Elsevier.
• McDermott CJ, Taylor RW, Hayes C, Johnson M, Bushby KMD, Turnbull DM, Shaw PJ. Investigation of mitochondrial function in hereditary spastic paraparesis. In: Journal of Neurology, Neurosurgery and Psychiatry: Proceedings of the Association of British Neurologists. 2002, Oxford: BMJ Group.
• Yu Wai Man P, Turnbull DM, Chinnery PF. Leber hereditary optic neuropathy. Journal of Medical Genetics 2002, 39(3), 162-169.
• Taylor RW, Morris AAM, Hutchinson M, Turnbull DM. Leigh disease associated with a novel mitochondrial DNA ND5 mutation. European Journal of Human Genetics 2002, 10(2), 141-144.
• Cawston TE. Mechanisms of Joint Destruction and Therapeutic Approaches. Medicine 2002, 30(8), 27-31.
• Ford D. Mechanistic explanations for the chemopreventive action of soyabean isoflavones: Reducing the possibilities. British Journal of Nutrition 2002, 88(5), 439-441.
• Vasconcelos MH, Tam SC, Hesketh JE, Reid M, Beattie JH. Metal- and tissue-dependent relationship between metallothionein mRNA and protein. Toxicology and Applied Pharmacology 2002, 182(2), 91-97.
• Menzies FM, Cookson MR, Taylor RW, Turnbull DM, Chrzanowska-Lightowlers ZMA, Dong L, Figlewicz DA, Shaw PJ. Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis. Brain 2002, 125(7), 1522-1533.
• Tyni T, Johnson M, Eaton S, Pourfarzam M, Andrews R, Turnbull DM. Mitochondrial fatty acid beta-oxidation in the retinal pigment epithelium. Pediatric Research 2002, 52(4), 595-600.
• Proctor CJ, Kirkwood TBL. Modelling telomere shortening and the role of oxidative stress. Mechanisms of Ageing and Development 2002, 123(4), 351-363.
• Perucca-Lostanlen D, Taylor RW, Narbonne H, de Camaret BM, Hayes CM, Saunieres A, Paquis-Flucklinger V, Turnbull DM, Vialettes B, Desnuelle C. Molecular and functional effects of the T14709C point mutation in the mitochondrial DNA of a patient with maternally inherited diabetes and deafness. Biochimica et Biophysica Acta: Molecular Basis of Disease 2002, 1588(3), 210-216.
• Kirkwood TBL. Molecular gerontology. Journal of Inherited Metabolic Disease 2002, 25(3), 189-196.
• G. Nelson,L. Paraoan,D. G. Spiller,G. J. C. Wilde,M. A. Browne,P. K. Djali,J. F. Unitt,E. Sullivan,E. Floettmann,M. R. H. White. Multi-parameter analysis of the kinetics of NF-kappa B signalling and transcription in single living cells. Journal of Cell Science 2002. 115(6), 1137-1148.
• Agius L, Centelles J, Cascante M. Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?. In: Biochemical Society Transactions: Meeting on High-Throughput Screening - The Way Ahead. 2002, Bedford, UK: Portland Press Ltd.
• McFarland R, Clark KM, Morris AAM, Taylor RW, Macphail S, Lightowlers RN, Turnbull DM. Multiple neonatal deaths due to a homoplasmic mitochondrial DNA mutation. Nature Genetics 2002, 30(2), 145-146.
• Yu Wai Man P, Brown DT, Wehnert MS, Zeviani M, Carrara F, Turnbull DM, Chinnery PF. NDUFA-1 is not a nuclear modifier gene in Leber hereditary optic neuropathy. Neurology 2002, 58(12), 1861-1862.
• Kirkwood TBL. New science for an old problem. Trends in Genetics 2002, 18(9), 441-442.
• Lee M, Martin-Ruiz C, Graham A, Court J, Jaros E, Perry R, Iversen P, Bauman M, Perry E. Nicotinic receptor abnormalities in the cerebellar cortex in autism. Brain 2002, 125(7), 1483-1495.
• Martin-Ruiz C, Lawrence S, Piggott M, Kuryatov A, Lindstrom J, Gotti C, Cookson MR, Perry RH, Jaros E, Perry EK, Court JA. Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression. Neuroscience Letters 2002, 335(2), 134-138.
• Turnbull DM, Brown DT, Lightowlers RN. Novel therapies for mitochondrial myopathies. In: Neuromuscular Disorders: 7th International Congress of the World Muscle Society. 2002, Rotterdam, Netherlands: Elsevier Ltd.
• Koch SSC, Thoresen LH, Tikhe JG, Maegley KA, Almassy RJ, Li JK, Yu XH, Zook SE, Kumpf RA, Zhang C, Boritzki TJ, Mansour RN, Zhang KE, Ekker A, Calabrese CR, Curtin NJ, Kyle S, Thomas HD, Wang LZ, Calvert AH, Golding BT, Griffin RJ, Newell DR, Webber SE, Hostomsky Z. Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis, and X-ray cocrystal structure. Journal of Medicinal Chemistry 2002, 45(23), 4961-4974.
• Brandt K, Kidmose U. Nutritional consequences of using organic agricultural methods in developing countries. Oxford, UK: Eolss Publishers, 2002. Available at: http://www.eolss.net/Sample-Chapters/C10/E5-21-05.pdf.
• Boys RJ, Henderson DA. On determining the order of Markov dependence of an observed process governed by a hidden Markov model. Scientific Programming 2002, 10(3), 241-251.
• von Zglinicki T. Oxidative stress shortens telomeres. Trends in Biochemical Sciences 2002, 27(7), 339-344.
• Kirkwood TBL. Oxygen: The molecule that made the world. Nature 2002, 419(6909), 785-785.
• Kirkwood TBL. p53 and ageing: Too much of a good thing?. BioEssays 2002, 24(7), 577-579.
• Curtis PJ, Webster S, Adamson AJ, Mathers JC. Parental change in starch and fat intake, after a "starchy food" intervention. In: Proceedings of the Nutrition Society. 2002, University of Leeds: Cambridge University Press.
• Gibson A, Arris CE, Bentley J, Boyle F, Curtin NJ, Davies T, Endicott J, Golding BT, Grant S, Griffin R, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J., Whitfield, H.J. Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O6-substituted guanine derivatives. Journal of Medicinal Chemistry 2002, 45(16), 3381-3393.
• Edwardson JA, Kirkwood TBL. Profile of Gerontological Institutions: The Institute for Ageing and Health, University of Newcastle. Experimental Gerontology 2002, 37(6), 749-756.
• Mathers JC. Pulses and carcinogenesis: potential for the prevention of colon, breast and other cancers. In: British Journal of Nutrition: Meeting on Pulses and Human Health. 2002, Paris, France: Cambridge University Press.
• Robertson MD, Livesey G, Mathers JC. Quantitative kinetics of glucose appearance and disposal following a C-13-labelled starch-rich meal: comparison of male and female subjects. British Journal of Nutrition 2002, 87(6), 569-577.
• Herrnstadt C, Elson JL, Fahy E, Preston G, Turnbull DM, Anderson C, Ghosh SS, Olefsky JM, Beal MF, Davis RE, Howell N. Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. American Journal of Human Genetics 2002, 70(5), 1152-1171.
• Loughlin J, Dowling B, Mustafa Z, Southam L, Chapman K. Refined linkage mapping of a hip osteoarthritis susceptibility locus on chromosome 2q. Rheumatology 2002, 41(8), 955-956.
• Saretzki G, Von Zglinicki T. Replicative aging, telomeres, and oxidative stress. Annals of the New York Academy of Sciences 2002, 959(1), 24-29.
• Saretzki G, Von Zglinicki T. Replicative aging, telomeres, and oxidative stress. In: Increasing Healthy Life Span: Conventional Measures and Slowing the Innate Aging Process. 2002, Vancouver, British Colombia, Canada: New York Academy of Sciences.
• Campbell-Hewson, Q., Lovat, P.E., Pearson, A.D.J., Redfern, C.P.F. Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARβ expression. Journal of Cellular Biochemistry 2002, 87(3), 284-291.
• Rana B, Veal GJ, Pearson ADJ, Redfern CPF. Retinoid X receptors and retinoid response in neuroblastoma cells. Journal of Cellular Biochemistry 2002, 86(1), 67-78.
• Kirkwood TBL. Senescence. In: Pagel, M, ed. Encyclopedia of Evolution. New York: Oxford University Press, 2002, pp.1020-1022.
• Jagoe, R.T., Redfern, C.P.F., Roberts, R.G., Gibson, G.J., Goodship, T.H.J. Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy. Clinical Science 2002, 102(3), 353-361.
• Kirkwood TBL. Slow down ageing with a healthy gut. Health and Ageing 2002, 16-18.
• Roberts, R.G., Redfern, C.P.F., Graham, K.A., Bartlett, K., Wilkinson, R., Goodship, T.H.J. Sodium bicarbonate treatment and ubiquitin gene expression in acidotic human subjects with chronic renal failure. European Journal of Clinical Investigation 2002, 32(7), 488-492.
• Chinnery PF, Brown DT, Archibald K, Curtis A, Turnbull DM. Spinocerebellar ataxia and the A3243G and A8344G mtDNA mutations. Journal of Medical Genetics 2002, 39(5), E22.
• Davies T, Bentley J, Arris CE, Boyle FT, Curtin NJ, Endicott J, Gibson A, Golding BT, Griffin RJ, Hardcastle IR, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J.A., Wang, L., Whitfield, H.J. Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor. Nature Structural Biology 2002, 9(10), 745-749.
• Hesketh JE, Villette S. Symposium on 'nutrition in the post-genomic era' plenary session 2: Nutrient regulation of gene expression: Intracellular trafficking of micronutrients: From gene regulation to nutrient requirements. Proceedings of the Nutrition Society 2002, 61(4), 405-414.
• Kirkwood TBL. The breath of life and death. Nature 2002, 419(6909), 785.
• Bristow EA, Griffiths PG, Andrews RM, Johnson MA, Turnbull DM. The distribution of mitochondrial activity in relation to optic nerve structure. Archives of Ophthalmology 2002, 120(6), 791-796.
• Coulthard, S.A., Hogarth, L.A., Little, M.A., Matheson, E., Redfern, C.P.F., Minto, C.L.J., Hall, A.G. The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs. Molecular Pharmacology 2002, 62(1), 102-109.
• Phillips SR, Russi RM, Cragg RA, Mathers JC, Ford D. The effect of zinc on expression of the novel zinc transporter hZTL1 in human intestinal and placental cell lines. Journal of Physiology 2002, 539(supplement), 18P-19P.
• Edwardson JA, Kirkwood TBL. The Institute for Ageing and Health, University of Newcastle, UK. Experimental Gerontology 2002, 37(6), 749-756.
• Elson JL, Samuels DC, Johnson MA, Turnbull DM, Chinnery PF. The length of cytochrome c oxidase-negative segments in muscle fibres in patients with mtDNA myopathy. Neuromuscular Disorders 2002, 12(9), 858-864.
• Koshy PJT, Lundy CJ, Rowan AD, Porter S, Edwards DR, Hogan A, Clark IM, Cawston TE. The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M - A time-course study using real-time quantitative reverse transcription-polymerase chain reaction. Arthritis & Rheumatism 2002, 46(4), 961-967.
• Kirkwood TBL. The National Service Framework - suggestions about priorities for policy development welcome. Age and Ageing 2002, 31(5), 409A-410.
• McFarland R, Taylor RW, Turnbull DM. The neurology of mitochondrial DNA disease. Lancet Neurology 2002, 1(6), 343-351.
• Cottrell DA, Borthwick GM, Johnson MA, Ince PG, Turnbull DM. The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease. Neuropathology and Applied Neurobiology 2002, 28(5), 390-396.
• Craigie AC, Lake AA, Wood C, Gibbons M, Webster S, Adamson AJ, Rugg-Gunn AJ, Mathers JC. The stability of food intake between adolescence and adulthood: a 21-year follow-up. In: Proceedings of the Nutrition Society. 2002, Heriot-Watt University, Edinburgh: Cambridge University Press.
• Fenwick J, Platteau P, Murdoch AP, Herbert M. Time from insemination to first cleavage predicts developmental competence of human preimplantation embryos in vitro. Human Reproduction 2002, 17(2), 407-412.
• Kirkwood TBL. Unravelling the mysteries of human ageing. Biological Sciences Review 2002, 14, 33-37.
• Lynn S, Evans JC, White C, Frayling TM, Hattersley AT, Turnbull DM, Horikawa Y, Cox NJ, Bell GI, Walker M. Variation in the calpain-10 gene affects blood glucose levels in the British population. Diabetes 2002, 51(1), 247-250.