Newcastle University

Publications

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• Gilbert HJ, O'Donnell AG, Mathers JC. 'Informative' horizontal gene transfer. Nature Biotechnology 2004, 22(9), 1076-.
• Boys RJ, Henderson DA. A Bayesian Approach to DNA Sequence Segmentation. Biometrics 2004, 60(3), 573-581.
• Blankley RT, Lydall D. A domain of Rad9 specifically required for activation of Chk1 in budding yeast. Journal of Cell Science 2004, 117(4), 601-608.
• Sun Y, Wipat A, Pocock M, Lee P, Watson P, Flanagan K, Worthington J. A Grid-based System for Microbial Genome Comparison and Analysis. Newcastle upon Tyne: School of Computing Science, University of Newcastle upon Tyne, 2004. School of Computing Science Technical Report Series 881.
• Gillespie C, Proctor CJ, Boys R, Shanley D, Wilkinson D, Kirkwood T. A mathematical model of ageing in yeast. Journal of Theoretical Biology 2004, 229(2), 189-196.
• Hui W, Cawston TE, Richards CD, Rowan AD. A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL. Arthritis Research & Therapy 2004, 7(1), R57-R64.
• Maniura-Weber K, Taylor RW, Johnson MA, Chrzanowska-Lightowlers Z, Morris AAM, Charlton CPJ, Turnbull DM, Bindoff LA. A novel point mutation in the mitochondrial tRNA(Trp) gene produces a neurogastrointestinal syndrome. European Journal of Human Genetics 2004, 12(6), 509-512.
• McFarland R, Taylor RW, Chinnery PF, Howell N, Turnbull DM. A novel sporadic mutation in cytochrome c oxidase subunit II as a cause of rhabdomyolysis. Neuromuscular Disorders 2004, 14(2), 162-166.
• Armstrong L, Lako M, van Herpe I, Evans J, Saretzki G, Hole N. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mechanisms of Development 2004, 121(12), 1509-1522.
• Armstrong L, Lako M, Herpe Van, Saretzki IG, Hole N. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mechanisms of Development 2004, 121(12), 1509-22.
• Wilkinson DJ, Yeung SKH. A sparse matrix approach to Bayesian computation in large linear models. Computational Statistics and Data Analysis 2004, 44(3), 493-516.
• Howell N, Elson JL, Turnbull DM, Herrnstadt C. African haplogroup L mtDNA sequences show violations of clock-like evolution. Molecular Biology and Evolution 2004, 21(10), 1843-1854.
• Kirkwood TBL. Alchemy of aging (Book review of Merchants of Immortality: Chasing the Dream of Human Life Extension). Nature Medicine 2004, 10(6), 575.
• Andrews HE, Barron MJ, Edgar J, Turnbull DM, Bates D, Griffiths IR, Nichols P. AN INVESTIGATION INTO THE ROLE OF MITOCHONDRIA IN THE AXONAL RESPONSE TO DEMYELINATION USING A MYELIN BASIC PROTEIN MUTANT (SHIVERER) MOUSE MODEL. In: Association of British Neurologists’ Spring Meeting. 2004.
• Calabrese C, Almassy R, Barton S, Batey M, Calvert AH, Canan-Koch S, Durkacz B, Hostomsky Z, Kumpf R, Kyle S, Li J, Maegley K, Newell DR, Notarianni E, Stratford I, Skalitzky D, Thomas HD, Wang L, Webber S, William K, Curtin NJ. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. Journal of the National Cancer Institute 2004, 96(1), 56-67.
• Shaw O, Koelmans A, Steggles J, Wipat A. Applying Petri Nets to Systems Biology using XML Technologies. Newcastle upon Tyne: School of Computing Science, University of Newcastle upon Tyne, 2004. School of Computing Science Technical Report Series 827.
• Shaw O, Koelmans A, Steggles J, Wipat A. Applying Petri Nets to Systems Biology using XMLTechnologies. In: Workshop on the Definition, Implementation and Application of a Standard Interchange Format for Petri Nets. Satellite event of ATPN : 25th International Conference on Application and Theory of Petri Nets. 2004, Bologna, Italy.
• Netherwood T, Martin-Orue SM, O'Donnell AG, Gockling S, Graham J, Mathers JC, Gilbert HJ. Assessing the survival of transgenic plant DNA in the human gastrointestinal tract. Nature Biotechnology 2004, 22(2), 204-209.
• McFarland R, Elson JL, Taylor RW, Howell N, Turnbull DM. Assigning pathogenicity to mitochondrial tRNA mutations: when 'definitely maybe' is not good enough. Trends in Genetics 2004, 20(12), 591-596.
• Li P, Hayward K, Jennings C, Owen K, Oinn T, Stevens R, Pearce S, Wipat A. Association of variations in I kappa B-epsilon with Graves’ disease using classical and myGrid methodologies. In: 2004 UK e-Science All Hands Meeting. 2004, Nottingham, UK: Engineering and Physical Sciences Research Council.
• Hallinan J, Wiles J. Asynchronous dynamics of an artificial genetic regulatory network. In: Artificial Life IX: Proceedings of the Ninth International Conference on the Simulation and Synthesis of Living Systems. 2004, Boston, Massachusetts, USA: MIT Press.
• Nelson G, Kozlova-Zwinderman O, Collis AJ, Knight MR, Fincham JRS, Stanger CP, Renwick A, Hessing JGM, Punt PJ, van den Hondel CAMJJ, Read ND. Calcium measurement in living filamentous fungi expressing codon-optimized aequorin. Molecular Microbiology 2004, 52(5), 1437-1450.
• Taylor RW, Schaefer AM, McDonnell MT, Petty RKH, Thomas AM, Blakely EL, Hayes CM, McFarland R, Turnbull DM. Catastrophic presentation of mitochondrial disease due to a mutation in the tRNAHis gene. Neurology 2004, 62(8), 1420-1423.
• Mathers JC. Chairman's introduction: What can we expect to learn from genomics?. In: Summer Meeting of the Nutrition Society: Symposium on 'How and why measure individual variability'. 2004, King's College, London: Cambridge University Press.
• Craigie AM, Mathers JC, Rugg-Gunn AJ, Adamson AJ. Change in nutrient intake between adolescence and adulthood: A 21-year longitudial study. Nutrition Bulletin 2004, 29(3), 204-212.
• Zohouri FV, Rugg-Gunn AJ, Fletcher ES, Hackett AF, Moynihan PJ, Mathers JC, Adamson AJ. Changes in water intake of Northumbrian adolescents 1980 to 2000. British Dental Journal 2004, 196(9), 547-552.
• Fletcher ES, Rugg-Gunn AJ, Matthews JNS, Hackett A, Moynihan PJ, Mathers JC, Adamson AJ. Changes over 20 years in macronutrient intake and body mass index in 11- to 12-year-old adolescents living in Northumberland. British Journal of Nutrition 2004, 92(2), 321-333.
• Hallinan JS. Cluster analysis of the p53 genetic regulatory network: Topology and biology. In: IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). 2004, La Jolla, California, USA: IEEE.
• Forster T, Chapman K, Loughlin J. Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis. Human Genetics 2004, 114(4), 391-395.
• Elson JL, Turnbull DM, Howell N. Comparative Genomics and the Evolution of Human Mitochondrial DNA: Assessing the Effects of Selection. American Journal of Human Genetics 2004, 74(2), 229-238.
• Goranov BB, Redfern CPF. Cytogenetic differences and neuroblastoma cell interconversion. Cancer Genetics and Cytogenetics 2004, 149(2), 173-174.
• McFarland R, Kirby DM, Fowler KJ, Ohtake A, Ryan MT, Amor DJ, Fletcher JM, Dixon JW, Collins FA, Turnbull DM, Taylor RW, Thorburn DR. De Novo Mutations in the Mitochondrial ND3 Gene as a Cause of Infantile Mitochondrial Encephalopathy and Complex I Deficiency. Annals of Neurology 2004, 55(1), 58-64.
• Oinn T, Addis M J, Ferris J, Marvin DJ, Greenwood M, Goble C, Wipat A, Li P, Carver T. Delivering Web service coordination capability to users. In: 13th World Wide Web Conference (WWW2004). 2004, New York, USA: ACM.
• Stojkovic M, Lako M, Stojkovic P, Stewart R, Przyborski S, Armstrong L, Evans J, Herbert M, Hyslop L, Ahmad S, Murdoch A, Strachan T. Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture. Stem Cells 2004, 22(5), 790-797.
• Stojkovic M, Lako M, Strachan T, Murdoch A. Derivation, growth and applications of human embryonic stem cells. Reproduction 2004, 128(3), 259-267.
• Tikhe J, Webber S, Hostomsky Z, Maegley K, Ekkers A, Li J, Yu X, Almassy R, Kumpf R, Boritzki T, Zhang C, Calabrese C, Curtin NJ, Kyle S, Thomas HD, Wang L, Calvert AH, Golding B, Griffin RJ, Newell DR. Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1- hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase. Journal of Medicinal Chemistry 2004, 47(22), 5467-5481.
• Wipat A, Sun Y, Pocock M, Lee P, Watson P, Flanagan K. Developing Grid-based Systems for Microbial Genome. In: UK e-Science All Hands Meeting 2004. 2004, Nottingham UK: EPSRC.
• Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE. Developmental plasticity and human health. Nature 2004, 430(6998), 419-421.
• Lake AA, Adamson AJ, Hyland RM, Mathers JC. Dietary change and perceptions of change over time. Nutrition Bulletin 2004, 29(3), 199-203.
• Brocklehurst KJ, Davies RA, Agius L. Differences in regulatory properties between human and rat glucokinase regulatory protein. Biochemical Journal 2004, 378(2), 693-697.
• White M, Bunting J, Williams E, Raybould S, Adamson A, Mathers JC. Do 'food deserts' exist? A multi-level, geographical analysis of the relationship between retail food access, socio-economic position and dietary intake. London: Food Standards Agency, 2004.
• Adamson AJ, Mathers JC. Effecting dietary change. Proceedings of the Nutrition Society 2004, 63(4), 537-547.
• Veuger SJ, Curtin NJ, Smith GCM, Durkacz BW. Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. Oncogene 2004, 23(44), 7322–7329.
• Veuger SJ, Curtin NJ, Smith G, Durkacz BW. Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. Oncogene 2004, 23(44), 7322-7329.
• Burkle A, Leake A, Muller M, Kirkwood TB, Pfeiffer R. Efficiency of repair of DNA single-strand breaks correlates with life span of mammalian species. In: Naunyn-Schmiedeberg's Archives of Pharmacology. 2004, Mainz, Germany: Springer.
• Sanderson P, Johnson IT, Mathers JC, Powers HJ, Downes CS, McGlynn AP, Dare R, Kampman E, Pool-Zobel BL, Bingham SA, Rafter JJ. Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report. British Journal of Nutrition 2004, 91(2), 315-322.
• Forrest IA, Murphy D, Lordan JL, Pritchard GE, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Corris PA, Ward C. Epithelial to mesenchymal transition in clinically stable lung transplantation. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
• Hallinan J, Wiles J. Evolving genetic regulatory networks using an artificial genome. In: Bioinformatics: Second Asia-Pacific Bioinformatics Conference (APBC). 2004, Dunedin, New Zealand: Australian Computer Society Inc.
• Zubko MK, Guillard S, Lydall D. Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics 2004, 168(1), 103-115.
• Maringele L, Lydall D. EXO1 Plays a Role in Generating Type I and Type II Survivors in Budding Yeast. Genetics 2004, 166(4), 1641-1649.
• Kirkwood TBL. Expectations of Life. British Actuarial Journal 2004, 10(1), 75-100.
• Loughlin J. Familial inheritance of osteoarthritis: documented family subsets. Clinical Orthopaedics and Related Research 2004, 427(supplement), S22-25.
• McFarland R, Schaefer AM, Gardner JL, Lynn S, Hayes CM, Barron MJ, Walker M, Chinnery PF, Taylor RW, Turnbull DM. Familial Myopathy: New Insights into the T14709C Mitochondrial tRNA Mutation. Annals of Neurology 2004, 55(4), 478-484.
• Forster T, Chapman K, Marcelline L, Mustafa Z, Southam L, Loughlin J. Finer linkage mapping of primary osteoarthritis susceptibility loci on chromosomes 4 and 16 in families with affected women. Arthritis & Rheumatism 2004, 50(1), 98-102.
• McKay JA, Williams EA, Mathers JC. Folate and DNA methylation during in utero development and aging. Biochemical Society Transactions 2004, 32(6), 1006-1007.
• Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, Ferreira A, Ciesielski C, Carson DA, Corr M. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proceedings of the National Academy of Sciences of the United States of America 2004, 101(26), 9757-9762.
• Lovat, P.E., Di Sano, F., Corazzari, M., Fazi, B., Donnorso, R., Pearson, A.D.J., Hall, A.G., Redfern, C.P.F., Piacentini, M. Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. Journal of the National Cancer Institute 2004, 96(17), 1288-1299.
• Hallinan J. Gene duplication and hierarchical modularity in intracellular interaction networks. BioSystems 2004, 74(1-3), 51-62.
• Arden C, Harboottle A, Baltrusch S, Tiedge M, Agius L. Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation. Diabetes 2004, 53(9), 2346-2352.
• Aiston S, Green A, Mukhtar M, Agius L. Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose. Biochemical Journal 2004, 377(1), 195-204.
• Bermano G, Pagmantidis V, Holloway N, Kadri S, Mowat A, Broom J, Hesketh JE. Glutathione peroxidase 4 gene polymorphism and susceptibility to colorectal cancer. In: Journal of Nutrition: International Research Conference on Food, Nutrition, and Cancer. 2004, Washington, DC, USA: American Society for Nutrition.
• Brandt K, Christensen LP, Hansen-Moller J, Hansen SL, Haraldsdottir J, Jespersen L, Purup S, Kharazmi A, Barkholt V, Frokiaer H, Kobaek-Larsen M. Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health. Trends in Food Science and Technology 2004, 15(7-8), 384-393.
• Morris CM, Wilson KE. High throughput approaches in neuroscience. In: International Journal of Developmental Neuroscience: International Conference on Molecular Mechanisms of Neurodegeneration and Neuroprotection. 2004, Leipzig, Germany: Pergamon.
• Amdam GV, Simoes ZLP, Hagen A, Norberg K, Schroder K, Mikkelsen O, Kirkwood TBL, Omholt SW. Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees. Experimental Gerontology 2004, 39(5), 767-773.
• Stewart R, Coyne L, Lako M, Halliwell RF, Przyborski SA. Human embryonal carcinoma stem cells expressing green fluorescent protein form functioning neurons in vitro: A research tool for co-culture studies. Stem Cells and Development 2004, 13(6), 646-657.
• Hickson, I., Zhao, Y., Richardson, C., Green, S., Martin, N., Orr, A., Reaper, P., Jackson, S., Curtin, N.J., Smith, G. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Research 2004, 64(24), 9152-9159.
• Pye D, Watt DJ, Walker C, Lightowlers RN, Turnbull DM. Identification of the RAG-1 as a suitable mouse model for mitochondrial DNA disease. Neuromuscular Disorders 2004, 14(5), 329-336.
• Murphy DM, Forrest IA, Ward C, Pritchard G, Jones D, Egan JJ, Cawston TE, Corris PA, Lordan JL. IL-17 stimulates IL-8 release in primary epithelial cell cultures derived from lung allografts. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
• Howard A, Goodlad RA, Walters JRF, Ford D, Hirst BH. Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2. Journal of Nutrition 2004, 134(11), 2957-2964.
• Van Den Biggelaar AHJ, De Craen AJM, Gussekloo J, Huizinga TWJ, Heijmans BT, Frolich M, Kirkwood TBL, Westendorp RGJ. Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming. FASEB Journal 2004, 18(9), 1022-1024.
• Margallo-Lana M, Morris CM, Gibson AM, Tan AL, Kay DWK, Tyrer SP, Moore B, Ballard CG. Influence of the amyloid precursor protein locus on dementia in Down syndrome. Neurology 2004, 62(11), 1996-1998.
• Ford D. Intestinal and placental zinc transport pathways. Proceedings of the Nutrition Society 2004, 63(1), 21-29.
• Kirkwood TBL. Intrinsic ageing of gut epithelial stem cells. Mechanisms of Ageing and Development 2004, 125(12), 911-915.
• Mickleburgh I, Burtle B, Nury D, Chabanon H, Chrzanowska-Lightowlers ZMA, Hesketh J. Isolation and identification of a protein binding to the localization element of Metallothionein-1 mRNA. Biochemical Society Transactions 2004, 32(5), 705-7066.
• Moynihan PJ, Wood CE, Hindmarsh PN, Adamson AJ, Seal CJ, Mathers JC. Knowledge of food safety practices amongst older adults. In: Procedings of the Nutrition Society. 2004, Dublin: Cambridge University Press.
• Kirkwood TBL. Life span: Evolutionary, ecological and demographic perspectives. The Quarterly Review of Biology 2004, 79(2), 217.
• Lake AA, Rugg-Gunn AJ, Hyland RM, Wood CE, Mathers JC, Adamson AJ. Longitudinal dietary change from adolescence to adulthood: perceptions, attributions and evidence. Appetite 2004, 42(3), 255-263.
• Syed, A.A., Irving, J.A.E., Redfern, C.P.F., Hall, A.G., Unwin, N.C., White, M., Bhopal, R., Alberti, K., Weaver, J.U. Low Prevalence of the N363S Polymorphism of the Glucocorticoid Receptor in South Asians Living in the United Kingdom. Journal of Clinical Endocrinology and Metabolism 2004, 89(1), 232-235.
• Kurz T, Leake A, von Zglinicki T, Brunk UT. Lysosomal redox-active iron is important for oxidative stress-induced DNA damage. In: Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May be Forseeable. 2004, Cambridge, UK: New York Academy of Sciences.
• Jia X, Weinert T, Lydall D. Mec1 and Rad53 Inhibit Formation of Single-Stranded DNA at Telomeres of Saccharomyces cerevisiae cdc13-1 Mutants. Genetics 2004, 166(2), 753-764.
• Southam L, Dowling B, Ferreira A, Marcelline L, Mustafa Z, Chapman K, Bentham G, Carr A, Loughlin J. Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3-q13. Arthritis & Rheumatism 2004, 50(12), 3910-3914.
• Andrews H, Barron M, Edgar J, Turnbull D, Bates D, Griffiths I, Nichols R. Mitochondria in multiple sclerosis: the missing link?. In: MULTIPLE SCLEROSIS. 2004.
• Blakely EL, He LP, Taylor RW, Chinnery PF, Lightowlers RN, Schaefer AM, Turnbull DM. Mitochondrial DNA deletion in "identical" twin brothers. Journal of Medical Genetics 2004, 41(2), e19.
• Blakely EL, He L, Taylor RW, Chinnery PF, Lightowlers RN, Schaefer AM, Turnbull DM. Mitochondrial DNA deletion in identical twins. Journal of Medical Genetics 2004, 41(2), e19.
• Yu Wai Man P, Howell N, Mackey DA, Nørby S, Rosenberg T, Turnbull DM, Chinnery PF. Mitochondrial DNA haplogroup distribution within Leber hereditary optic neuropathy pedigrees. Journal of Medical Genetics 2004, 41(4), e41-e41.
• Taylor RW, He L, Proctor SJ, Middleton PG, Turnbull DM. Mitochondrial DNA mutations in the haematopoietic system. Leukemia 2004, 18(1), 169-170.
• Martin-Ruiz CM, Lee M, Perry RH, Baumann M, Court JA, Perry EK. Molecular analysis of nicotinic receptor expression in autism. Molecular Brain Research 2004, 123(1-2), 81-90.
• Lovat, P.E., Corazzari, M., Goranov, B., Piacentini, M., Redfern, C.P.F. Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells. Annals of the New York Academy of Sciences 2004, 1028, 81-89.
• Kirby DM, McFarland R, Ohtake A, Dunning C, Ryan MT, Wilson C, Ketteridge D, Turnbull DM, Thorburn DR, Taylor RW. Mutations of the mitochondrial ND1 gene as a cause of MELAS. Journal of Medical Genetics 2004, 41(10), 784-789.
• Stevens R, McEntire R, Goble C, Greenwood M, Zhao J, Wipat A, Li P. myGrid and the drug discovery process. Drug Discovery Today: BIOSILICO 2004, 4(2), 140-148.
• Hardcastle IR, Arris CE, Bentley J, Boyle FT, Chen Y, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Jewsbury, P., Menyerol, J., Mesguiche, V., Newell, D.R., Noble, M., Pratt, D., Wang, L., Whitfield, H.J. N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2. Journal of Medicinal Chemistry 2004, 47(15), 3710-3722.
• Betts J, Lightowlers RN, Turnbull DM. Neuropathological Aspects of Mitochondrial DNA Disease. Neurochemical Research 2004, 29(3), 505-511.
• Deschauer M, Chinnery PF, Schaefer AM, Turnbull DM, Taylor RW, Zierz S, Shanske S, DiMauro S, Mojamaa K, Wilichowski E, Thorburn DR. No association of the mitochondrial DNA A12308G polymorphism with increased risk of stroke in patients with the A3243G mutation. Journal of Neurology, Neurosurgery and Psychiatry 2004, 75(8), 1204-1205.
• Keers SM, Gibson AM, Turnbull DM, Chinnery PF. No evidence of an association between the mtDNA 16184-93 polyC tract and late onset dementia. American Journal of Medical Genetics 2004, 41(12), 957-958.
• Gibson AM, Edwardson JA, Turnbull DM, McKeith IG, Morris CM, Chinnery PF. No evidence of an association between the T16189C mtDNA variant and late onset dementia. Journal of Medical Genetics 2004, 41(1), e7.
• McDonnell MT, Schaefer AM, Blakely EL, McFarland R, Chinnery PF, Turnbull DM, Taylor RW. Nonivasive diagnosis of the 3243A > G mitochondrial DNA mutation using urinary epithelial cells. European Journal of Human Genetics 2004, 12(9), 778-781.
• Curtin NJ, Wang L, Yiakouvaki A, Kyle S, Arris C, Canan-Koch S, Webber S, Durkacz BW, Calvert AH, Hostomsky Z, Newell DR. Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells. Clinical Cancer Research 2004, 10(3), 881-889.
• Nelson DE, Ihekwaba AEC, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB, White MRH. Oscillations in NF-kappa B signaling control the dynamics of gene expression. Science 2004. 306(5296), 704-708.
• Nelson DE, See V, Nelson G, White MRH. Oscillations in transcription factor dynamics: a new way to control gene expression. Biochemical Society Transactions 2004, 32(6), 1090-1092.
• Chan LMS, Cooper AE, Dudley ALJ, Ford D, Hirst BH. P-glycoprotein potentiates CYP3A4-mediated drug disappearance during Caco-2 intestinal secretory detoxification. Journal of Drug Targeting 2004, 12(7), 405-413.
• Armstrong L, Stojkovic M, Dimmick I, Ahmad S, Stojkovic P, Hole N, Lako M. Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity. Stem Cells 2004, 22(7), 1142-1151.
• White, A., Curtin, N.J., Eastman, B., Golding, B.T., Hostomsky, Z., Kyle,S., Li, J., Maegley, K., Skalitzky, D., Webber, S., Yu, X., Griffin, R.J. Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors. Bioorganic and Medicinal Chemistry Letters 2004, 14(10), 2433-2437.
• Liljegren A, Barker G, Mathers J, Lindblom A, Nilsson B, Rotstein S, Burn J, Bishop T, CAPP2 Study Grp. Prevalence of adenomas and hyperplastic polyps in carriers of HNPCC (LYNCH Syndrome). In: Journal of Clinical Oncology: 40th Annual Meeting of the American Society of Clinical Oncology. 2004, New Orleans, Lousiana, USA: American Society of Clinical Oncology.
• McFarland R, Taylor RW, Elson JL, Lightowlers RN, Turnbull DM, Howell N, Scaglia F, Vogel H, Hawkins EP, Vladutiu GD, Guan M-X, Liu L-L, Wong L-JC. Proving pathogenicity: When evolution is not enough. American Journal of Medical Genetics 2004, 131(1), 107-110.
• Reddy R, Janssens L, Kelly SB, Welfare M, Williams L, Mathers JC. Rectal brush biopsy - Exploration of its role as an alternate source of colorectal tissue for bowel research. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2004, Glasgow, UK: BMJ Group.
• Kurz T, Leake A, Von Zglinicki T, Brunk UT. Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochemical Journal 2004, 378(3), 1039-1045.
• Curtin, N., Barlow, H., Bowman, K., Calvert, A. H., Davison, R., Golding, B., Huang, B., Loughlin, P., Newell, D., Smith, P., Griffin, R. Resistance-modifying agents. 11. Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to α₁-acid glycoprotein. Journal of Medicinal Chemistry 2004, 47(20), 4905-4922.
• Burn J, Mathers J, Barker G, Bishop T. Resistant starch and aspirin in genetically predisposed people: The CAPP studies. In: Cancer Epidemiology, Biomarkers & Prevention: 3rd Annual AACR International Conference. 2004, Seattle, Washington, USA: American Association for Cancer Research.
• Chinnery PF, DiMauro S, Shanske S, Schon EA, Zeviani M, Mariotti C, Carrara F, Lombes A, Laforet P, Ogier H, Jaksch M, Lochmuller H, Horvath R, Deschauer M, Thorburn DR, Bindoff LA, Poulton J, Taylor RW, Matthews JNS, Turnbull DM. Risk of developing a mitochondrial DNA deletion disorder. The Lancet 2004, 364(9434), 592-596.
• Shaw OJ, Harwood C, Steggles LJ, Wipat A. SARGE: A tool for creation of putative genetic networks. Bioinformatics 2004, 20(18), 3638-3640.
• Johnson J, Hague SM, Hanson M, Gibson A, Wilson KE, Evans EW, Singleton AA, McInerney-Leo A, Nussbaum RL, Hernandez DG, Gallardo M, McKeith IG, Burn DJ, Ryu M, Hellstrom O, Ravina B, Eerola J, Perry RH, Jaros E, Tienari P, Weiser R, Gwinn-Hardy K, Morris CM, Hardy J, Singleton AB. SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies. Neurology 2004, 63(3), 554-556.
• Adams J, White M, Pearce MS, Martin-Ruiz C, Parker L, von Zglinicki T. Socio-economic position, health behaviours and telomere length at age 50: a prospective cohort study. In: 4th European Congress of Biogerontology. 2004, Newcastle upon Tyne, UK.
• Bidooki S, Jackson MJ, Johnson MA, Chrzanowska-Lightowlers ZMA, Taylor RW, Venables G, Lightowlers RN, Turnbull DM, Bindoff LA. Sporadic mitochondrial myopathy due to a new mutation in the mitochondrial tRNASer(UCN) gene. Neuromuscular Disorders 2004, 14(7), 417-420.
• Dehghan-Kooshkghazi M, Mathers JC. Starch digestion, large-bowel fermentation and intestinal mucosal cell proliferation in rats treated with the α-glucosidase inhibitor acarbose. British Journal of Nutrition 2004, 91(3), 357-365.
• Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L. Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators. Diabetes 2004, 53(3), 535-541.
• Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, Von Zglinicki T. Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span. Journal of Biological Chemistry 2004, 279(17), 17826-17833.
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