Newcastle University

Publications

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• Kirkwood TBL. A Biological Perspective on Aging. In: Pathy MS; Sinclaire AJ; Morley JE, ed. Principles and Practice of Geriatric Medicine. Chichester: John Wiley & Sons Ltd, 2006, pp.13-18.
• Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. A Genome-Wide Screen Identifies the Evolutionarily Conserved KEOPS Complex as a Telomere Regulator. Cell 2006, 124(6), 1155-1168.
• Meplan C, Crosley K, Nicol F, Beckett GJ, Arthur JR, Mathers JC, Hesketh JE. A polymorphism in the coding region of human selenoprotein P gene influences the response to selenium supplementation in healthy volunteers. In: Scientific Meeting of the Nutrition Society. 2006, Aberdeen, UK: Proceedings of the Nutrition Society: Cambridge University Press.
• Oldroyd J, Unwin N, White M, Mathers JC, Alberti KGMM. A randomised controlled trial evaluating the effectiveness of lifestyle interventions in people with impaired glucose tolerance in Newcastle upon Tyne, UK. Diabetes Research and Clinical Practice 2006, 72(2), 117-127.
• Phoenix C, Schaefer AM, Elson JL, Morava E, Bugiani M, Uziel G, Smeitink JA, Turnbull DM, McFarland R. A scale to monitor progression and treatment of mitochondrial disease in children. Neuromuscular Disorders 2006, 16(12), 814-820.
• Foster E, Matthews JNS, Nelson M, Harris JM, Mathers JC, Adamson AJ. Accuracy of estimates of food portion size using food photographs - The importance of using age-appropriate tools. Public Health Nutrition 2006, 9(4), 509-514.
• Christensen LP, Brandt K. Acetylenes and Psoralens. In: Crozier, A; Clifford, M; Ashihara, H, ed. Plant Secondary Metabolites: Occurence, Structure and Role in the Human Diet. Oxford: Wiley-Blackwell, 2006, pp.137-173.
• Kirkwood T. Ageing: Too fast by mistake. Nature 2006, 444(7122), 1015-1017.
• Kirkwood TBL. Alzheimer's disease, mild cognitive impairment, and the biology of intrinsic aging. Philosophy, Psychiatry & Psychology 2006, 13(1), 79-82.
• Peake NJ, Foster HE, Khawaja K, Cawston TE, Rowan AD. Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography. Annals of the Rheumatic Diseases 2006, 65(4), 501-507.
• Yu Wai Man CY, Smith T, Chinnery PF, Turnbull DM, Griffiths PG. Assessment of visual function in chronic progressive external ophthalmoplegia. Eye 2006, 20(5), 564-568.
• Southam L, Heath O, Chapman K, Loughlin J. Association analysis of the interleukin 17 genes IL17A and IL17F as potential osteoarthritis susceptibility loci. Annals of the Rheumatic Diseases 2006, 65(4), 556-557.
• Chapman K, Loughlin J. Association of the interleukin-1 gene cluster with osteoarthritis of the hip: comment on the article by Meulenbelt et al and the letter by Smith et al. Arthritis & Rheumatism 2006, 54(11), 3722-3723.
• Shen H, Nelson G, Nelson DE, Kennedy S, Spiller DG, Griffiths T, Paton N, Oliver SG, White MRH, Kell DB. Automated tracking of gene expression in individual cells and cell compartments. Journal of the Royal Society Interface 2006, 3(11), 787-794.
• Shaw O, Steggles J, Wipat A. Automatic Parameterisation of Stochastic Petri Net Models of Biological Networks. In: Second International Workshop on the Practical Application of Stochastic Modeling (PASM 2005). 2006, Newcastle upon Tyne: Electronic Notes in Theoretical Computer Science: Elsevier BV.
• Shen HL, Nelson G, Kennedy S, Nelson D, Johnson J, Spiller D, White MRH, Kell DB. Automatic tracking of biological cells and compartments using particle filters and active contours. Chemometrics and Intelligent Laboratory Systems 2006, 82(1-2), 276-282.
• Gillespie CS, Wilkinson DJ, Shanley DP, Proctor CJ, Boys RJ, Kirkwood TBL. BASIS: an internet resource for network modelling. Journal of Integrative Bioinformatics 2006, 3(2), [12].
• Golightly A, Wilkinson DJ. Bayesian sequential inference for nonlinear multivariate diffusions. Statistics and Computing 2006, 16(4), 323-338.
• Golightly A, Wilkinson DJ. Bayesian sequential inference for stochastic kinetic biochemical network models. Journal of Computational Biology 2006, 13(3), 838-851.
• Christensen LP, Brandt K. Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis. Journal of Pharmaceutical and Biomedical Analysis 2006, 41(3), 683-693.
• Hampson LJ, Arden C, Agius L, Ganotidis M, Kosmopoulou MN, Tiraidis C, Elemes Y, Sakarellos C, Leonidas DD, Oikonomakos NG. Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site. Bioorganic and Medicinal Chemistry 2006, 14(23), 7835-7845.
• Bergmann MM, Bodzioch M, Bonet ML, Defoort C, Lietz G, Mathers JC. Bioethics in human nutrigenomics research: European Nutrigenomics Organisation workshop report. British Journal of Nutrition 2006, 95(5), 1024-1027.
• Lagou M, Gillespie JI, Andersson K-E, Kirkwood T, Drake MJ. Bladder volume alters cholinergic responses of the isolated whole mouse bladder. Journal of Urology 2006, 175(2), 771-776.
• Kirkwood T. Book review: Longevity in perspective. The Lancet 2006, 367(9511), 624-624.
• Shanley DP, Kirkwood TBL. Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans. Biogerontology 2006, 7(3), 165-168.
• Mathers JC. Candidate Mechanisms for Interactions between Nutrients and Genes. In: Choi Sang-Woon, Friso Simonetta, ed. Nutrient-Gene Interactions in Cancer. Boca Raton, Fl, US: Taylor & Francis, 2006, pp.19-36.
• McDonald SAC, Preston SL, Greaves LC, Leedham SJ, Lovell MA, Jankowski JAZ, Turnbull DM, Wright NA. Clonal expansion in the human gut - Mitochondrial DNA mutations show us the way. Cell Cycle 2006, 5(8), 808-811.
• Hallinan J, Wipat A. Clustering and cross-talk in a yeast functional interaction network. In: IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB). 2006, Toronto, Ontario, Canada: IEEE.
• Kirkwood TBL, Boys RJ, Gillespie CS, Proctor CJ, Shanley DP, Wilkinson DJ. Computer modeling in the study of aging. In: Masoro, E.J., Austad, S.N, ed. Handbook of The Biology of Aging. London, UK: Academic Press, 2006, pp.334-356.
• Kidmose U, Yang R-Y, Thilsted SH, Christensen LP, Brandt K. Content of carotenoids in commonly consumed Asian vegetables and stability and extractability during frying. Journal of Food Composition and Analysis 2006, 19(6-7), 562-571.
• Ahmad S, Figueiredo F, Lako M. Corneal epithelial stem cells: characterization, culture and transplantation. Regenerative Medicine 2006, 1(1), 29-44.
• Zhang X, Stojkovic P, Przyborski S, Cooke M, Armstrong L, Lako M, Stojkovic M. Derivation of human embryonic stem cells from developing and arrested embryos. Stem Cells 2006, 24(12), 2669-2676.
• Zubko MK, Maringele L, Foster SS, Lydall D. Detecting repair intermediates in vivo: Effects of DNA damage response genes on single-stranded DNA accumulation at uncapped telomeres in budding yeast. Methods in Enzymology 2006, 409, 285-300.
• Catterall JB, Rowan AD, Sarsfield S, Saklatvala J, Wait R, Cawston TE. Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M. Rheumatology 2006, 45(9), 1101-1109.
• Elson JL, Herrnstadt C, Preston G, Thal L, Morris CM, Edwardson JA, Beal MF, Turnbull DM, Howell N. Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?. Human Genetics 2006, 119(3), 241-254.
• Craddock T, Lord P, Harwood C, Wipat A. e-science tools for the genomic scale characterisation of bacterial secreted proteins. In: Proceedings of the UK e-Science All Hands Meeting 2006. 2006, Nottingham, UK: National e-Science Centre.
• Tyson J, Spiers A, Caple F, Hesketh JE, Mathers JC. Effects of age, body mass index and genotype on nucleotide excision repair in healthy adults. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.
• Hallinan J, Bradley D, Wiles J. Effects of an RNA control layer on the state space of Boolean models of genetic regulatory networks. In: IEEE Congress on Evolutionary Computation (CEC). 2006, Vancouver, BC: IEEE.
• Hallinan J, Bradley D, Wiles J. Effects of constitutive gene expression on the dynamics of random Boolean netorks. In: IEEE Congress on Evolutionary Computation (CEC). 2006, Vancouver, BC: IEEE.
• McKay JA, Russi RM, Philips SR, Mathers JC, Ford D. Effects of dietary zinc during pregnancy upon placental insulin-like growth factor 2 mRNA expression in C57BL/J6 mice. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.
• Mickleburgh I, Chabanon H, Nury D, Fan K, Burtle B, Chrzanowska-Lightowlers Z, Hesketh J. Elongation factor 1α binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization - Importance of an internal stem-loop. RNA 2006, 12(7), 1397-1407.
• Taivassalo T, Gardner JL, Taylor RW, Schaefer AM, Newman J, Barron MJ, Haller RG, Turnbull DM. Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions. Brain 2006, 129(12), 3391-3401.
• Armstrong L, Lako M, Dean W, Stojkovic M. Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer. Stem Cells 2006, 24(4), 805-814.
• Getliffe KM, Martin Ruiz C, Passos JF, Von Zglinicki T, Nwokolo CU. Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients. European Journal of Gastroenterology and Hepatology 2006, 18(2), 133-141.
• Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, De Ponte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, Von Zglinicki T, Kirkland JL. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Diabetes 2006, 55(9), 2571-2578.
• Milner JM, Kevorkian L, Young DA, Jones D, Wait R, Donell ST, Barksby HE, Patterson AM, Middleton JM, Cravatt BF, Clark IM, Rowan AD, Cawston TE. Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. Arthritis Research & Therapy 2006, 8(1), R23.
• Brandt K, Mølgaard J-P. Food quality and organic agriculture. In: Kristiansen, P., Taji, A., Reganold, J, ed. Organic Agriculture A Global Perspective. Wallingford, Connecticut, USA: CABI Publishing, 2006, pp.305-327.
• Lake AA, Hyland RM, Mathers JC, Rugg-Gunn AJ, Wood CE, Adamson AJ. Food shopping and preparation among the 30-somethings: whose job is it? (The ASH30 study). British Food Journal 2006, 108(6), 475-486.
• Gibson F, Wipat A, Pocock M, Morris N. GELI: a data model for the representation of a gel electrophoresis experiment. Newcastle upon Tyne: School of Computing Science, University of Newcastle upon Tyne, 2006. School of Computing Science Technical Report Series 942.
• Arden C, Baltrusch S, Agius L. Glucokinase regulatory protein is associated with mitochondria in hepatocytes. FEBS Letters 2006, 580(8), 2065-2070.
• Forrest IA, Ward C, Murphy DM, Johnson GE, Jones D, Lordan JL, Cawston TE, Corris PA. Hepatocyte growth factor - A link between neutrophilic inflammation and BOS?. The Journal of Heart and Lung Transplantation 2006, 25(2), S91.
• Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nature Genetics 2006, 38(5), 515-517.
• Morgan TG, Rowan AD, Dickinson SC, Jones D, Hollander AP, Deehan D, Cawston TE. Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases. Annals of the Rheumatic Diseases 2006, 65(2), 184-190.
• Oikonomakos NG, Tiraidis C, Leonidas DD, Zographos SE, Kristiansen M, Jessen CU, Norskov-Lauritsen L, Agius L. Iminosugars as potential inhibitors of glycogenolysis: Structural insights into the molecular basis of glycogen phosphorylase inhibition. Journal of Medicinal Chemistry 2006, 49(19), 5687-5701.
• Venchard GR, Thomson PJ, Boys R. Improved sedation for oral surgery by combining nitrous oxide and intravenous Midazolam: a randomized, controlled trial. International Journal of Oral and Maxillofacial Surgery 2006, 35(6), 522-527.
• Andrews H, White K, Thomson C, Edgar J, Bates D, Griffiths I, Turnbull D, Nichols P. Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouse. Journal of Neuroscience Research 2006, 83(8), 1533-1539.
• Arden C, Green AR, Hampson LJ, Aiston S, Harndahl L, Greenberg CC, Brady MJ, Freeman S, Poucher SM, Agius L. Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats. FEBS Journal 2006, 273(9), 1989-1999.
• Meplan C, Crosley K, Nicol F, Arthur JR, Mathers JC, Hesketh JE. Influences of gender and genetic variation in the 3 ' untranslated region of the glutathione peroxidise 4 gene on the response to selenium supplementation in healthy volunteers. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.
• Wilkinson SC, Maas WJM, Nielsen JB, Greaves LC, van de Sandt JJM, Williams FM. Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies. International Archives of Occupational and Environmental Health 2006, 79(5), 405-413.
• Barksby HE, Hui W, Wappler I, Peters HH, Milner JM, Richards CD, Cawston TE, Rowan AD. Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes - Implications for cartilage destruction and repair. Arthritis & Rheumatism 2006, 54(2), 540-550.
• Valentine RA, Jackdon KA, Mathers JC, Ford D. Intracellular trafficking and functional activity of splice variants of the zinc transporter SLC30A5. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.
• Zubko MK, Lydall D. Linear chromosome maintenance in the absence of essential telomere-capping proteins. Nature Cell Biology 2006, 8(7), 734-740.
• Toussaint O, Rayet B, Chainiaux F, Zouboulis CC, Butler-Browne G, Chen C, Kirkwood TBL. LINK-AGE: Coordination and consolidation of European biogerontology: en route towards formation of a European college of biogerontology. Mechanisms of Ageing and Development 2006, 127(10), 761-762.
• Lagou M, De Vente J, Kirkwood TB, Hedlund P, Andersson K-E, Gillespie JI, Drake MJ. Location of interstitial cells and neurotransmitters in the mouse bladder. BJU International 2006, 97(6), 1332-1337.
• Lake AA, Mathers JC, Rugg-Gunn AJ, Adamson AJ. Longitudinal change in food habits between adolescence (11–12 years) and adulthood (32–33 years): the ASH30 Study. Journal of Public Health 2006, 28(1), 10-16.
• Barksby HE, Milner JM, Patterson AM, Peake NJ, Hui W, Robson T, Lakey R, Middleton J, Cawston TE, Richards CD, Rowan AD. Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis. Arthritis & Rheumatism 2006, 54(10), 3244-3253.
• Stewart R, Stojkovic M, Lako M. Mechanisms of self-renewal in human embryonic stem cells. European Journal of Cancer 2006, 42(9), 1257-1272.
• Atherton KM, Mutch E, Ford D. Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity. Biochemical Pharmacology 2006, 72(5), 624-631.
• Milner JM, Rowan AD, Cawston TE, Young DA. Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis. Arthritis Research & Therapy 2006, 8(5), R142.
• Schaefer AM, Phoenix C, Elson JL, McFarland R, Chinnery PF, Turnbull DM. Mitochondrial disease in adults: A scale to monitor progression and treatment. Neurology 2006, 66(12), 1932-1934.
• Arasaradnam RP, Greaves LC, Commane D, Mathers JC, Taylor RW, Turnbull DM. Mitochondrial DNA (MTDNA) mutations in human colonic crypts: A novel biomarker of colorectal cancer. GUT 2006, 55(S2), A24.
• Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M, Sasieni P, Novelli MR, Jankowski JAZ, Turnbull DM, Wright NA, McDonald SAC. Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(3), 714-719.
• Greaves LC, Taylor RW. Mitochondrial DNA mutations in human disease. IUBMB Life 2006, 58(3), 143-151.
• Wilding CS, Cadwell K, Tawn EJ, Relton CL, Taylor GA, Chinnery PF, Turnbull DM. Mitochondrial DNA mutations in individuals occupationally exposed to ionizing radiation. Radiation Research 2006, 165(2), 202-207.
• Passos JF, Von Zglinicki T, Saretzki G. Mitochondrial dysfunction and cell senescence: Cause or consequence?. In: 2nd Conference on Strategies for Engineered Negligible Senescence (SENS). 2006, Cambridge: Rejuvenation Research, Mary Ann Liebert, Inc. Publishers.
• Smeitink JA, Zeviani M, Turnbull DM, Jacobs HT. Mitochondrial medicine: A metabolic perspective on the pathology of oxidative phosphorylation disorders. Cell Metabolism 2006, 3(1), 9-13.
• Gupta S, Wyllie J, Wright C, Turnbull D, Taylor R. Mitochondrial respiratory chain defects and developmental diaphragmatic dysfunction in the neonatal period. Journal of Maternal-Fetal and Neonatal Medicine 2006, 19(9), 587-589.
• Steggles LJ, Banks R, Wipat A. Modelling and analysing genetic networks: From Boolean networks to Petri nets. In: Computational Methods in Systems Biology: International Conference (CMSB 2006). 2006, Trento, Italy: Springer-Verlag.
• Steggles LJ, Banks R, Wipat A. Modelling and Analysing Genetic Networks: From Boolean Networks to Petri Nets. Newcastle upon Tyne: School of Computing Science, University of Newcastle upon Tyne, 2006. School of Computing Science Technical Report Series 962.
• Betts J, Jaros E, Perry RH, Schaefer AM, Taylor RW, Abdel-All Z, Lightowlers RN, Turnbull DM. Molecular neuropathology of MELAS: Level of heteroplasmy in individual neurones and evidence of extensive vascular involvement. Neuropathology and Applied Neurobiology 2006, 32(4), 359-373.
• Borthwick GM, Taylor RW, Walls TJ, Tonska K, Taylor GA, Shaw PJ, Ince PG, Turnbull DM. Motor neuron disease in a patient with a mitochondrial tRNA^lle mutation. Annals of Neurology 2006, 59(3), 570-574.
• Foster SS, Zubko MK, Guillard S, Lydall D. MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants. DNA Repair 2006, 5(7), 840-851.
• Lagou M, Gillespie J, Kirkwood T, Harvey I, Drake MJ. Muscarinic stimulation of the mouse isolated whole bladder: Physiological responses in young and ageing mice. Autonomic and Autacoid Pharmacology 2006, 26(3), 253-260.
• Longley MJ, Clark S, Man CYW, Hudson G, Durham SE, Taylor RW, Nightingale S, Turnbull DM, Copeland WC, Chinnery PF. Mutant POLG2 disrupts DNA polymerase γ subunits and causes progressive external ophthalmoplegia. American Journal of Human Genetics 2006, 78(6), 1026-1034.
• Jeyapalan J, Saretzki G, Leake A, Tilby MJ, VonZglinicki TW. Neuroblastoma cell apoptosis induction after cisplatin treatment is not telomere–dependent. International Journal of Cancer 2006, 118(11), 2727-34.
• Hesketh J, Wybranska I, Dommels Y, King M, Elliott R, Pico C, Keijer J. Nutrient-gene interactions in benefit-risk analysis. British Journal of Nutrition 2006, 95(6), 1232-1236.
• Kirkwood TBL. Nutrition for a longer life. Nutrition Bulletin 2006, 31(2), 88-92.
• Mathers JC. Nutritional modulation of ageing: Genomic and epigenetic approaches. Mechanisms of Ageing and Development 2006, 127(6), 584-589.
• Loughlin J. Osteoarthritis linkage scan: more loci for the geneticists to investigate. Annals of the Rheumatic Diseases 2006, 65(10), 1265-6.
• Levadoux-Martin M, Li Y, Blackburn A, Chabanon H, Hesketh JE. Perinuclear localisation of cellular retinoic acid binding protein I mRNA. Biochemical and Biophysical Research Communications 2006, 340(1), 326-331.
• Horvath R, Hudson G, Ferrari G, Futterer N, Ahola S, Lamantea E, Prokisch H, Lochmuller H, McFarland R, Ramesh V, Klopstock T, Freisinger P, Salvi F, Mayr JA, Santer R, Tesarova M, Zeman J, Udd B, Taylor RW, Turnbull D, Hanna M, Fialho D, Suomalainen A, Zeviani M, Chinnery PF. Phenotypic spectrum associated with mutations of the mitochondrial polymerase γ gene. Brain 2006, 129(7), 1674-1684.
• Mathers JC. Plant foods for human health: Research challenges. In: Summer Meeting of the Nutrition Society. 2006, University of East Anglia, Norwich: Proceedings of the Nutrition Society, Cambridge University Press.
• Hudson G, Deschauer M, Taylor RW, Hanna MG, Fialho D, Schaefer AM, He L-P, Blakely E, Turnbull DM, Chinnery PF. POLG1, C10ORF2, and ANT1 mutations are uncommon in sporadic progressive external ophthalmoplegia with multiple mitochondrial DNA deletions. Neurology 2006, 66(9), 1439-1441.
• Zhao Y, Thomas HD, Batey M, Cowell I, Richardson C, Griffin RJ, Calvert AH, Newell DR, Smith G, Curtin NJ. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Research 2006, 66(10), 5354-5362.
• Chapman K, Carr A, Loughlin J, Sinsheimer JS. Presence of a primary hip osteoarthritis susceptibility locus on chromosome 6: comment on the article by Meenagh et al. Arthritis Rheum 2006, 54(3), 1026-1027.
• Mathers JC. Prevention of lifestyle-related diseases. Scandinavian Journal of Food & Nutrition 2006, 50(S1), 18-20.
• Pye D, Kyriakouli DS, Taylor GA, Johnson R, Elstner M, Meunier B, Chrzanowska-Lightowlers ZMA, Taylor RW, Turnbull DM, Lightowlers RN. Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants. Nucleic Acids Research 2006, 34(13), e95.
• Durham SE, Brown DT, Turnbull DM, Chinnery PF. Progressive depletion of mtDNA in mitochondrial myopathy. Neurology 2006, 67(3), 502-504.
• Polley ACJ, Mulholland F, Pin C, Williams EA, Bradburn DM, Mills SJ, Mathers JC, Johnson IT. Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia. Cancer Research 2006, 66(13), 6553-6562.
• Swalwell H, Deschauer M, Hartl H, Strauss M, Turnbull DM, Zierz S, Taylor RW. Pure myopathy associated with a novel mitochondrial tRNA gene mutation. Neurology 2006, 66(3), 447-449.
• Oldroyd JC, Unwin NC, White M, Mathers JC, Alberti KGMM. Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance. Diabetes Research and Clinical Practice 2006, 72(2), 117-127.
• Coxhead JM, Bal W, Williams EA, Mathers JC. Reactive oxygen species generation in mismatch repair-proficient and -deficient colorectal cancer cell lines exposed to butyrate. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.
• Waltham KJ, Williams EA, Mathers JC. Reduced maternal folate supply decreases genomic DNA methylation in the offspring of C57Bl/6J mice. In: Proceedings of the Nutrition Society. 2006, Aberdeen, Scotland: Cambridge University Press.
• Valdes AM, van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, Spector TD. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis & Rheumatism 2006, 54(2), 533-539.
• Andrews GR, Sidorenko AV, Gutman C, Gray JE, Anisimov VN, Bezrukov VV, Botev N, Davidovich M, Fernandez-Ballesteros R, Hoskins I, Goodwin J, Kirkwood TB, Knipscheer K, Lomranz J, Nies H, Nizamuddin M, Stuckleberger A, Topinkova E, Troisi J, Walker A. Research on ageing: priorities for the European region. Advances in Gerontology 2006, 18, 7-14.
• Griffin RJ, Henderson A, Curtin NJ, Echalier A, Endicott J, Hardcastle IR, Newell DR, Noble M, Wang L, Golding BT. Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination. Journal of the American Chemical Society 2006, 128(18), 6012-6013.
• Mitchell AL, Elson JL, Howell N, Taylor RW, Turnbull DM. Sequence variation in mitochondrial complex I genes: Mutation or polymorphism?. Journal of Medical Genetics 2006, 43(2), 175-179.
• Blakely EL, Rennie KJ, Jones L, Elstner M, Chrzanowska-Lightowlers ZMA, White CB, Shield JPH, Pilz DT, Turnbull DM, Poulton J, Taylor RW. Sporadic intragenic inversion of the mitochondrial DNA MTND1 gene causing fatal infantile lactic acidosis. Pediatric Research 2006, 59(3), 440-444.
• Wilkinson DJ. Stochastic Modelling for Systems Biology. London, UK: Chapman & Hall/CRC, 2006.
• Angelini C, Federico A, Reichmann H, Lombes A, Chinnery P, Turnbull D. Task force guidelines handbook: EFNS guidelines on diagnosis and management of fatty acid mitochondrial disorders. European Journal of Neurology 2006, 13(9), 923-929.
• Oinn T, Greenwood M, Addis M, Alpdemir MN, Ferris J, Glover K, Goble C, Goderis A, Hull D, Marvin D, Li P, Lord P, Pocock MR, Senger M, Stevens R, Wipat A, Wroe C. Taverna: lessons in creating a workflow environment for the life sciences. Concurrency and Computation: Practice and Experience 2006, 18(10), 1067-1100.
• Martin-Ruiz C, Dickinson HO, Keys B, Rowan E, Kenny RA, von Zglinicki T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Annals of Neurology 2006, 60(2), 174-180.
• Loughlin J, Sinsheimer JS, Carr A, Chapman K. The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population. Osteoarthritis Cartilage 2006, 14(3), 295-298.
• Kirkwood TBL. The developmental environment: implications for ageing and life span. In: Gluckman, P.D., Hanson, M.A, ed. Developmental Origins of Health and Disease. Cambridge: Cambridge University Press, 2006, pp.426-435.
• Armstrong L, Lako M. The future of human nuclear transfer?. Stem Cell Reviews 2006, 2(4), 351-358.
• Bigg HF, Wait R, Rowan AD, Cawston TE. The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation. Journal of Biological Chemistry 2006, 281(30), 21082-21095.
• Harndahl L, Schmoll D, Herling AW, Agius L. The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism. FEBS Journal 2006, 273(2), 336-346.
• Andrews R, Ressiniotis T, Turnbull DM, Birch M, Keers S, Chinnery PF, Griffiths PG. The role of mitochondrial haplogroups in primary open angle glaucoma. British Journal of Ophthalmology 2006, 90(4), 488-490.
• Armstrong L, Hughes O, Yung S, Hyslop L, Stewart R, Wappler I, Peters H, Walter T, Stojkovic P, Evans J, Stojkovic M, Lako M. The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Human Molecular Genetics 2006, 15(11), 1894-1913.
• Aiston S, Hampson LJ, Arden C, Iynedjian PB, Agius L. The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes. Diabetologia 2006, 49(1), 174-182.
• Gillespie C, Wilkinson D, Proctor CJ, Shanley D, Boys RJ, Kirkwood TBL. Tools for the SBML community. Bioinformatics 2006, 22(5), 628-629.
• Drenos F, Westendorp RGJ, Kirkwood TBL. Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions. Biogerontology 2006, 7(4), 287-295.
• Brown D, Herbert M, Lamb V, Chinnery PF, Taylor R, Lightowlers R, Craven L, Cree L, Gardner JL, Turnbull DM. Transmission of mitochondrial DNA disorders: possibilities for the future. Lancet 2006, 368(9529), 87-89.
• Chinnery P, Majamaa K, Turnbull D, Thorburn D. Treatment for mitochondrial disorders. Cochrane Database of Systematic Reviews 2006, (1), CD004426.
• Friedrichsen S, Harper CV, Semprini S, Wilding M, Adamson AD, Spiller DG, Nelson G, Mullins JJ, White MRH, Davis JRE. Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappa B signaling. Endocrinology 2006, 147(2), 773-781.
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