Newcastle University

Publications

Year: 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1980 1979

• Issaeva N, Thomas HD, Djurenovic T, Jaspers JE, Stoimenov I, Kyle S, Pedley N, Gottipati P, Zur R, Sleeth K, Chatzakos V, Mulligan EA, Lundin C, Gubanova E, Kersbergen A, Harris AL, Sharma RA, Rottenberg S, Curtin NJ, Helleday T. 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance. Cancer Research 2010, 70(15), 6268-6276.
• Kerkhof HJM, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JPA, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HAP, Rivadeneira F, Slagboom EP, Styrkársdóttir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JBJ. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis & Rheumatism 2010, 62(2), 499-510.
• Wang CF, Maddick M, Miwa S, Jurk D, Czapiewski R, Saretzki G, Langie SAS, Godschalk RWL, Cameron K, von Zglinicki T. Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging 2010, 2(9), 555-566.
• Nooteboom M, Johnson R, Taylor RW, Wright NA, Lightowlers RN, Kirkwood TBL, Mathers JC, Turnbull DM, Greaves LC. Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts. Aging Cell 2010, 9(1), 96-99.
• Lister LM, Kouznetsova A, Hyslop LA, Kalleas D, Pace SL, Barel JC, Nathan A, Floros V, Adelfalk C, Watanabe Y, Jessberger R, Kirkwood TB, Hoog C, Herbert M. Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2. Current Biology 2010, 20(17), 1511-1521.
• Cockell SJ, Weile J, Lord P, Wipat C, Andriychenko D, Pocock M, Wilkinson D, Young M, Wipat A. An integrated dataset for in silico drug discovery. Journal of Integrative Bioinformatics 2010, 7(3), 116.
• Gillespie CS, Lei G, Boys RJ, Greenall AJ, Wilkinson DJ. Analysing time course microarray data using Bioconductor: a case study using yeast2 Affymetrix arrays. BMC Research Notes 2010, 3(81).
• Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, García-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC. Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Human Molecular Genetics 2010, 19(17), 3413-3429.
• Penn L, Boeing H, Boushey CJ, Dragsted LO, Kaput J, Scalbert A, Welch AA, Mathers JC. Assessment of dietary intake: NuGO symposium report. Genes & Nutrition 2010, 5(3), 205-213.
• Yarham J, Elson JL, Blakely EL, Alston CL, Turnbull DM, McFarland R, Taylor RW. Assigning pathogenicity to mitochondrial tRNA gene mutations. In: Journal of Medical Genetics: British Human Genetics Conference. 2010, Warwick, UK: BMJ Group.
• Henderson DA, Boys RJ, Wilkinson DJ. Bayesian calibration of a stochastic kinetic computer model using multiple data sources. Biometrics 2010, 66(1), 249-256.
• Gillespie CS, Golightly A. Bayesian inference for generalized stochastic population growth models with application to aphids. Journal of the Royal Statistical Society. Series C: Applied Statistics 2010, 59(2), 341-357.
• Kirkwood T, Martin-Ruiz C, Jagger C, Collerton J, Kingston A, von Zglinicki T. Biomarkers of ageing and their relationship to disability and cognition [abstract]. Gerontologist 2010, 50, 375.
• Snelling SJB, Hulley PA, Loughlin J. BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model. Growth Factors 2010, 28(4), 268-279.
• Chen YH, Lawless C, Gillespie CS, Wu J, Boys RJ, Wilkinson DJ. CaliBayes and BASIS: integrated tools for the calibration, simulation and storage of biological simulation models. Briefings in Bioinformatics 2010, 11(3), 278-289.
• Burn J, Mathers JC, Gerdes AM, Bisgaard ML, Evans G, Eccles D, Lindblom A, Macrae F, Maher ER, Mecklin JP, Moslein G, Olschwang S, Ramesar R, Vasen HFA, Wijnen J, Barker G, Elliott F, Lynch H, Bishop DT, CAPP2 Consortium. Cancer Occurrence During Follow-Up of the CAPP2 Study: Aspirin Use For Up To Four Years Significantly Reduces Lynch Syndrome Cancers for up to Several Years After Completion of Therapy. In: Annals of Oncology: European Multidisciplinary Colorectal Cancer Congress. 2010, Nice, France: Oxford University Press.
• Saretzki G. Cellular senescence in the development and treatment of cancer. Current Pharmaceutical Design 2010, 16(1), 79-100.
• Daniel RA, Rozanska AL, Mulligan EA, Drew Y, Thomas HD, Castelbuono DJ, Hostomsky Z, Plummer ER, Tweddle DA, Boddy AV, Clifford SC, Curtin NJ. Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. British Journal of Cancer 2010, 103(10), 1588-1596.
• van Ommen B, Bouwman J, Dragsted LO, Drevon CA, Elliott R, de Groot P, Kaput J, Mathers JC, Muller M, Pepping F, Saito J, Scalbert A, Radonjic M, Rocca-Serra P, Travis A, Wopereis S, Evelo CT. Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies. Genes & Nutrition 2010, 5(3), 189-203.
• Spitzer P, Klafki H, Blennow K, Buée L, Esselmann H, Herruka S, Jimenez C, Klivenyi P, Lewczuk P, Maler J, Markus K, Meyer H, Morris C, Müller T, Otto M, Parnetti L, Soininen H, Schraen S, Teunissen C, Vecsei L, Zetterberg H, Wiltfang J. CNEUPRO: Novel biomarkers for neurodegenerative diseases. International Journal of Alzheimer's Disease 2010, 548145.
• Lawless C, Wilkinson DJ, Young A, Addinall SG, Lydall DA. Colonyzer: automated quantification of micro-organism growth characteristics on solid agar. BMC Bioinformatics 2010, 11(1), 287.
• Kerkhof HJM, Meulenbelt I, Carr A, Gonzalez A, Hart D, Hofman A, Kloppenburg M, Lane NE, Loughlin J, Nevitt MC, Pols HAP, Rivadeneira F, Slagboom EP, Spector TD, Stolk L, Tsezou A, Uitterlinden AG, Valdes AM, van Meurs JBJ. Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis. BMC Medical Genetics 2010, 11(1), 164.
• Riancho JA, Garcia-Ibarbia C, Gravani A, Raine EV, Rodriguez-Fontenla C, Soto-Hermida A, Rego-Perez I, Dodd AW, Gomez-Reino JJ, Zarrabeitia MT, Garces CM, Carr A, Blanco F, Gonzalez A, Loughlin J. Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study. Osteoarthritis and Cartilage 2010, 18(7), 927-933.
• Miwa S, Lawless C, von Zglinicki T. Correction of radiolabel pulse-chase data by a mathematical model: application to mitochondrial turnover studies. Biochemical Society Transactions 2010, 38, 1322-1328.
• Greaves LC, Barron MJ, Plusa S, Kirkwood TB, Mathers JC, Taylor RW, Turnbull DM. Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts. In: Experimental Gerontology: International Conference on Mitochondria in Aging and Age-related Disease. 2010, Les Diablerets, Switzerland: Elsevier Inc.
• Greaves L, Barron M, Plusa S, Kirkwood T, Mathers J, Taylor R, Turnbull D. Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts. Experimental Gerontology 2010, 45(7-8), 573-579.
• Weatherhead SC, Farr PM, Hallinan JS, Wipat A, Reynolds NJ. Development of a dynamic mathematical model of epidermis reveals critical importance of increasing the proportion of both cycling stem and transient amplifying cells, in the development of psoriatic plaques. In: 40th Annual Meeting of the European Society for Dermatological Research. 2010, Helsinki, Finland: Journal of Investigative Dermatology: Nature Publishing Group.
• Mukhopadhyay A, Elattar A, Cerbinskaite A, Wilkinson SJ, Drew Y, Kyle S, Los G, Hostomsky Z, Edmondson RJ, Curtin NJ. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clinical Cancer Research 2010, 16(8), 2344-2351.
• Dronamraju SS, Coxhead JM, Kelly SB, Mathers JC. Differential antineoplastic effects of butyrate in cells with and without a functioning DNA mismatch repair. Nutrition and Cancer 2010, 62(1), 105-115.
• Cui Y, Yu J, Urban JPG, Young DA. Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors A Comparison Between Bovine Intervertebral Disc Nucleus Pulposus Cells and Articular Chondrocytes. Spine 2010, 35(11), 1101-1108.
• Jagger C, Collerton J, Robinson L, Eccles MP, Kingston A, von Zglinicki T, Kirkwood T, Bond J. Disability and dependency: How much care is in the community? [abstract]. Gerontologist 2010, 50(s1), 375-375.
• Golightly A, Wilkinson DJ. Discussion to "Particle Markov chain Monte Carlo Methods" by Andrieu, Doucet and Holenstein. Journal of the Royal Statistical Society Series B: Statistical Methodology 2010, 72(3), 322-323.
• Strathdee G, Ferguson S, Sim A, Brown R. DNA methylation does not regulate JUNB expression in CML: Comment on "Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia" by Hoshino et al. [Leuk. Res. 33 (2009) 1361-1366]. Leukemia Research 2010, 34(5), 685-686.
• Arasaradnam RP, Khoo K, Bradburn M, Mathers JC, Kelly SB. DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC). Epigenetics 2010, 5(5), 422-426.
• Cano C, Barbeau OR, Bailey C, Cockroft XL, Curtin NJ, Duggan H, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Knights C, Menear KA, Newell DR, Richardson CJ, Smith GC, Spittle B, Griffin RJ. DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype. Journal of Medicinal Chemistry 2010, 53(24), 8498–8507.
• Zaremba T, Thomas H, Cole M, Plummer ER, Curtin NJ. Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials. Cancer Chemotherapy and Pharmacology 2010, 66(4), 807-812.
• Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, Åkesson B, Rohrmann S, Linseisen J. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men. Cancer Epidemiology Biomarkers and Prevention 2010, 19(11), 2958-2968.
• Lisanti S, von Zglinick T, Mathers JC. Epigenomics: Understanding How Nutrition Modulates the Ageing Process [abstract]. Journal of Nutrigenetics and Nutrigenomics 2010, 3(2-3), 61.
• Santos F, Hyslop L, Stojkovic P, Leary C, Murdoch A, Reik W, Stojkovic M, Herbert M, Dean W. Evaluation of epigenetic marks in human embryos derived from IVF and ICSI. Human Reproduction 2010, 25(9), 2387-2395.
• Hallinan J, Misirli G, Wipat A. Evolutionary computation for the design of a stochastic switch for synthetic genetic circuits. In: 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2010, Buenos Aires, Argentina: IEEE.
• Tang MY, Proctor CJ, Woulfe J, Gray DA. Experimental and computational analysis of polyglutamine-mediated cytotoxicity. PLoS Computational Biology 2010, 6(9), e1000944.
• Tilgner K, Atkinson SP, Yung S, Golebiewska A, Stojkovic M, Moreno R, Lako M, Armstrong L. Expression of GFP Under the Control of the RNA Helicase VASA Permits Fluorescence-Activated Cell Sorting Isolation of Human Primordial Germ Cells. Stem Cells 2010, 28(1), 84-92.
• Tchkonia T, Morbeck D, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen M, Kirkland J. Fat tissue, aging, and cellular senescence. Aging Cell 2010, 9(5), 667-684.
• Passos JF, Nelson G, Wang CF, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TBL, von Zglinicki T. Feedback between p21 and reactive oxygen production is necessary for cell senescence. Molecular Systems Biology 2010, 6, 347.
• McKay J, Waltham K, Williams E, Mathers J. Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring. Genes and Nutrition 2010, 6(2), 189-196.
• Meplan C, Hughes DJ, Pardini B, Naccarati A, Soucek P, Vodickova L, Hlavata I, Vrana D, Vodicka P, Hesketh JE. Genetic variants in selenoprotein genes increase risk of colorectal cancer. Carcinogenesis 2010, 31(6), 1074-1079.
• Howard A, Tahir I, Javed S, Waring SM, Ford D, Hirst BH. Glycine transporter GLYT1 is essential for glycine-mediated protection human intestinal epithelial cells against oxidative damage. Journal of Physiology 2010, 588(6), 995–1009.
• Proctor CJ, Gray DA. GSK3 and p53 - is there a link in Alzheimer's disease?. Molecular Neurodegeneration 2010, 5, 7.
• Barter MJ, Pybus L, Litherland GJ, Rowan AD, Clark IM, Edwards DR, Cawston TE, Young DA. HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes. Matrix Biology 2010, 29(7), 602-612.
• Moreno-Gimeno I, Ledran MH, Lako M. Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations. Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague. FEBS Journal 2010, 277(24), 5014-5025.
• Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles MP, Robinson L, Kirkwood T. High levels of disease and health service use but good functional status and self-rated health are found in 85 year olds [abstract]. Gerontologist 2010, 50(s1), 375.
• Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M. Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells. Stem Cells 2010, 28(4), 661-673.
• Bowl MR, Mirczuk SM, Grigorieva IV, Piret SE, Cranston T, Southam L, Allgrove J, Bahl S, Brain C, Loughlin J, Mughal Z, Ryan F, Shaw N, Thakker YV, Tiosano D, Nesbit MA, Thakker RV. Identification and characterization of novel parathyroid-specific transcription factor Glial Cells Missing Homolog B (GCMB) mutations in eight families with autosomal recessive hypoparathyroidism. Human Molecular Genetics 2010, 19(10), 2028-2038.
• Daniels DJ, Clothier C, Swan DC, Saretzki G. Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts. Biochemical and Biophysical Research Communications 2010, 399(1), 7-13.
• Knecht E, Aguado C, Sarkar S, Korolchuk VI, Criado-García O, Vernia S, Boya P, Sanz P, de Córdoba SR, Rubinsztein DC. Impaired autophagy in Lafora disease. Autophagy 2010, 6(7), 991-993.
• Lako M, Armstrong L, Stojkovic M. Induced Pluripotent Stem Cells : It Looks Simple but Can Looks Deceive?. Stem Cells 2010, 28(5), 845-850.
• Mathers J, Strathdee G, Relton C. Induction of Epigenetic Alterations by Dietary and Other Environmental Factors. In: Herceg, Z., Ushijima, T, ed. Advances in Genetics: Epigenetics and Cancer, Part B. Amsterdam; London: Academic Press, 2010, pp.4-39.
• Vaes BLT, Lute C, van der Woning SP, Piek E, Vermeer J, Blom HJ, Mathers JC, Muller M, de Groot LCPGM, Steegenga WT. Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism. Bone 2010, 46(2), 514-523.
• Caple F, Williams EA, Spiers A, Tyson J, Burtle B, Daly AK, Mathers JC, Hesketh JE. Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype. British Journal of Nutrition 2010, 103(11), 1585-1593.
• Moxley G, Meulenbelt I, Chapman K, van Duijn CM, Slagboom PE, Neale MC, Smith AJP, Carr AJ, Loughlin J. Interleukin-1 region meta-analysis with osteoarthritis phenotypes. Osteoarthritis and Cartilage 2010, 18(2), 200-207.
• Basterfield L, Mathers JC. Intestinal tumours, colonic butyrate and sleep in exercised Min mice. British Journal of Nutrition 2010, 104(3), 355-363.
• Herbert M, Fenwick J, Harbottle S, Walker J. Laboratory Apparatus with Incubator. UK: NHS Innovations, 12/083996, 18/11/2010.
• Aguado C, Sarkar S, Korolchuk VI, Criado O, Vernia S, Boya P, Sanz P, de Córdoba SR, Knecht E, Rubinsztein DC. Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Human Molecular Genetics 2010, 19(14), 2867-2876.
• Lako M, Trounson A, Daher S. Law, Ethics, Religion, and Clinical Translation in the 21(st) Century - A Discussion with Pete Coffey. Stem Cells 2010, 28(4), 636-638.
• Lako M, Trounson A, Daher S. Law, Ethics, Religion, and Clinical Translation in the 21st Century - A Discussion with Stephen Bellamy. Stem Cells 2010, 28(2), 177-180.
• Lako M, Trounson A, Daher S. Law, Ethics, Religion, and Clinical Translation in the 21st Century-A Conversation with Il-Hoan Oh. Stem Cells 2010, 28(12), 2121-2123.
• Lako M, Trounson AO, Daher S, Webster A. Law, Ethics, Religion, and Clinical Translation in the 21st Century-A Discussion with Andrew Webster. Stem Cells 2010, 28(11), 1915-1917.
• Lako M, Trounson AO, Daher SR. Law, Ethics, Religion, and Clinical Translation in the 21st Century-A Discussion with Derek Hei. Stem Cells 2010, 28(3), 387-389.
• Lako M, Trounson A, Daher S, Sinden J. Law, Ethics, Religion, and Clinical Translation in the 21st Century-A Discussion with John Sinden. Stem Cells 2010, 28(1), 3-4.
• Henderson DA, Boys RJ, Proctor CJ, Wilkinson DJ. Linking systems biology models to data: a stochastic kinetic model of p53 oscillations. In: A. O'Hagan and M. West, ed. The Oxford Handbook of Applied Bayesian Analysis. Oxford University Press, 2010, pp.155-187.
• Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA. Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. Annals of the Rheumatic Diseases 2010, 69(12), 2189-2198.
• Hui W, Litherland GJ, Jefferson M, Barter MJ, Elias MS, Cawston TE, Rowan AD, Young DA. Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway. Rheumatology 2010, 49(11), 2043-2053.
• Lister AL, Datta RS, Hofmann O, Krause R, Kuhn M, Roth B, Schneider R. Live Coverage of Intelligent Systems for Molecular Biology/European Conference on Computational Biology (ISMB/ECCB) 2009. PLoS Computational Biology 2010, 6(1), e1000640.
• Lister AL, Datta RS, Hofmann O, Krause R, Kuhn M, Roth B, Schneider R. Live Coverage of Scientific Conferences Using Web Technologies. PLoS Computational Biology 2010, 6(1), e1000563.
• Bechmann LP, Vetter D, Hannivoort RA, Patman G, Lee UE, Fiel MI, Agius L, Reeves H, Friedman SL. Liver-specific deletion of KLF6 uncovers novel transcriptional pathways linked to lipid and glucose homeostasis. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
• Wilkinson DJ, Golightly A. Markov chain Monte Carlo algorithms for SDE parameter estimation. In: Lawrence, ND; Girolami, M; Rattray, M; Sanguinetti, G, ed. Learning and Inference in Computational Systems Biology. London: MIT Press, 2010, pp.253-276.
• Milner JM, Patel A, Davidson RK, Swingler TE, Desilets A, Young DA, Kelso EB, Donell ST, Cawston TE, Clark IM, Ferrell WR, Plevin R, Lockhart JC, Leduc R, Rowan AD. Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis & Rheumatism 2010, 62(7), 1955-1966.
• Korolchuk VI, Menzies FM, Rubinsztein DC. Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Letters 2010, 584(7), 1393-1398.
• Greaves LC, Yu-Wai-Man P, Blakely EL, Krishnan KJ, Beadle NE, Kerin J, Barron MJ, Griffiths PG, Dickinson AJ, Turnbull DM, Taylor RW. Mitochondrial DNA Defects and Selective Extraocular Muscle Involvement in CPEO. Investigative Ophthalmology & Visual Science 2010, 51(7), 3340-3346.
• Yarham JW, Elson JL, Blakely EL, McFarland R, Taylor RW. Mitochondrial tRNA mutations and disease. Wiley Interdisciplinary Reviews: RNA 2010, 1(2), 304-324.
• Santibanez Koref M, Wilson V, Cartwright N, Cunnington MS, Mathers JC, Bishop DT, Curtis A, Dunlop MG, Burn J. MLH1 Differential Allelic Expression in Mutation Carriers and Controls. Annals of Human Genetics 2010, 74(6), 479-488.
• Swingler TE, Kevorkian L, Culley KL, Illman SA, Young DA, Parker AE, Lohi J, Clark IM. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. Biochemical Journal 2010, 427, 391-400.
• Smith GR, Shanley DP. Modelling the Response of FOXO Transcription Factors to Multiple Post-Translational Modifications Made by Ageing-Related Signalling Pathways. PLoS ONE 2010, 5(6), e11092.
• Proctor CJ, Tangeman PJ, Ardley HC. Modelling the Role of UCH-L1 on Protein Aggregation in Age-Related Neurodegeneration. PLoS ONE 2010, 5(10), e13175.
• Elson JL, Apabhai S, Gorman G, Whittaker RG, Krishnan KJ. Older mothers are not at risk of having grandchildren with sporadic mtDNA deletions. Genetics in Medicine 2010, 12(5), 313-314.
• Yang CB, Atkinson SP, Vilella F, Lloret M, Armstrong L, Mann DA, Lako M. Opposing Putative Roles for Canonical and Noncanonical NF kappa B Signaling on the Survival, Proliferation, and Differentiation Potential of Human Embryonic Stem Cells. Stem Cells 2010, 28(11), 1970-1980.
• Foster E, Mathers JC, Adamson AJ. Packaged food intake by British children aged 0 to 6 years. Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment 2010, 27(3), 380-388.
• Dewar JM, Lydall D. Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping. EMBO Journal 2010, 29(23), 4020-4034.
• Mathers JC, Meplan C, Hesketh JE. Polymorphisms Affecting Trace Element Bioavailability. International Journal for Vitamin and Nutrition Research 2010, 80(4-5), 314-318.
• Tilgner K, Armstrong L, Lako M. Positive effect of human ESC conditioned medium on somatic cell reprogramming. Serbian Journal of Experimental and Clinical Research 2010, 11(1), 3-5.
• Johnson N, Bentley J, Wang LZ, Newell DR, Robson CN, Shapiro GI, Curtin NJ. Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells. British Journal of Cancer 2010, 102(2), 342-350.
• Craven L, Tuppen HA, Greggains GD, Harbottle SJ, Murphy JL, Cree LM, Murdoch AP, Chinnery PF, Taylor RW, Lightowlers RN, Herbert M, Turnbull DM. Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease. Nature 2010, 465(7294), 82-85.
• Cawston TE, Young DA. Proteinases involved in matrix turnover during cartilage and bone breakdown. Cell and Tissue Research 2010, 339(1), 221-235.
• Lawless C, Wang CF, Jurk D, Merz A, von Zglinicki T, Passos JF. Quantitative assessment of markers for cell senescence. Experimental Gerontology 2010, 45(10), 772-778.
• Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo SQ, Massey DCO, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC. Regulation of Mammalian Autophagy in Physiology and Pathophysiology. Physiological Reviews 2010, 90(4), 1383-1435.
• Christie VB, Maltman DJ, Henderson AP, Whiting A, Marder TB, Lako M, Przyborski SA. Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro. Journal of Neuroscience Methods 2010, 193(2), 239-245.
• Yu Wai Man P, Lai-Cheong J, Borthwick GM, He LP, Taylor GA, Greaves LC, Taylor RW, Griffiths PG, Turnbull DM. Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles. Investigative Ophthalmology & Visual Science 2010, 51(7), 3347-3353.
• Cooling MT, Rouilly V, Misirli G, Lawson J, Yu T, Hallinan J, Wipat A. Standard virtual biological parts: a repository of modular modeling components for synthetic biology. Bioinformatics 2010, 26(7), 925-931.
• Kolli S, Ahmad S, Lako M, Figueiredo F. Successful Clinical Implementation of Corneal Epithelial Stem Cell Therapy for Treatment of Unilateral Limbal Stem Cell Deficiency. Stem Cells 2010, 28(3), 597-610.
• Scott JL, Gabrielides C, Davidson RK, Swingler TE, Clark IM, Wallis GA, Boot-Handford RP, Kirkwood TBL, Talyor RW, Young DA. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Annals of the Rheumatic Diseases 2010, 69(8), 1502-1510.
• Ngo HP, Lydall D. Survival and Growth of Yeast without Telomere Capping by Cdc13 in the Absence of Sgs1, Exo1, and Rad9. PLoS Genetics 2010, 6(8), e1001072.
• Marchetti F, Cano C, Curtin NJ, Golding BT, Griffin RJ, Haggerty K, Newell DR, Parsons RJ, Payne SL, Wang LZ, Hardcastle IR. Synthesis and biological evaluation of 5-substituted O-4-alkylpyrimidines as CDK2 inhibitors. Organic & Biomolecular Chemistry 2010, 8(10), 2397-2407.
• Cornell L, Munck JM, Budhisetiawan F, Newell DR, Bardos JI, Manas D, Curtin NJ, Reeves H. Synthetic lethality in liver cancer cell lines treated with inhibitors of DNA double strand break repair. In: 61st Annual Meeting of the American Association for the Study of Liver Diseases. 2010, Boston, MA: Hepatology: Wiley-Blackwell.
• Hucka M, Bergmann F, Hoops S, Keating S, Sahle S, Wilkinson DJ. Systems Biology Markup Language (SBML): Language specification for Level 3 Version 1 Core. Nature Publishing Group: Nature Precedings, 2010. Available at: http://dx.doi.org/10.1038/npre.2010.4123.1.
• Hiscutt EL, Hill DS, Martin S, Kerr R, Harbottle A, Birch-Machin M, Redfern CPF, Fulda S, Armstrong JL, Lovat PE. Targeting X-Linked Inhibitor of Apoptosis Protein to Increase the Efficacy of Endoplasmic Reticulum Stress-Induced Apoptosis for Melanoma Therapy. Journal of Investigative Dermatology 2010, 130(9), 2250-2258.
• Dewar JM, Lydall D. Telomere Replication: Mre11 Leads the Way. Molecular Cell 2010, 38(6), 777-779.
• Kirkwood TBL, Shanley DP. The connections between general and reproductive senescence and the evolutionary basis of menopause. In: Annals of the New York Academy of Sciences: Reproductive Aging. 2010, Georgetown University, Washington, DC, USA: Wiley-Blackwell Publishing, Inc.
• Jow H, Bhattacharjee M, Boys RJ, Wilkinson DJ. The integration of genetic maps using Bayesian inference. Journal of Computational Biology 2010, 17(6), 825-840.
• van Ommen B, El-Sohemy A, Hesketh J, Kaput J, Fenech M, Evelo CT, McArdle HJ, Bouwman J, Lietz G, Mathers JC, Fairweather-Tait S, van Kranen H, Elliott R, Wopereis S, Ferguson LR, Meplan C, Perozzi G, Allen L, Rivero D, Micronutrient Genomics Project Wor. The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research. Genes & Nutrition 2010, 5(4), 285-296.
• Tuppen HA, Hogan VE, He L, Blakely EL, Worgan L, Al-Dosary M, Saretzki G, Alston CL, Morris AA, Clarke M, Jones S, Devlin AM, Mansour S, Chrzanowska-Lightowlers ZMA, Thorburn DR, McFarland R, Taylor RW. The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families. Brain 2010, 133(10), 2952-2963.
• Penn L, Lordon J, Lowry R, Mathers J, Smith W, Walker M, White M. Towards the translation of research evidence to service provision: experience from North East England, UK. In: Schwarz, P.E.H., Reddy, P., Greaves, C.J., Dunbar, J.A., Schwarz, J, ed. Diabetes Prevention in Practice. Dresden, Germany: WCPD Dresden, 2010, pp.189-196.
• Chen A, Siow B, Blamire AM, Lako M, Clowry GJ. Transplantation of magnetically labeled mesenchymal stem cells in a model of perinatal brain injury. Stem Cell Research 2010, 5(3), 255-266.
• Büchner N, Altschmied J, Jakob S, Saretzki G, Haendeler J. Well-known signaling proteins exert new functions in the nucleus and mitochondria. Antioxidants and Redox Signaling 2010, 13(4), 551-558.
• Kirkwood T. Why can't - We live forever?. Scientific American 2010, 303(3), 42-49.
• Kirkwood T. Why women live longer. Scientific American 2010, 303(5), 34-35.