Newcastle University

Publications

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• Pratt AG, Swan DC, Richardson S, Wilson G, Hilkens C, Young DA, Isaacs JD. A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibodies-negative disease. Annals of the Rheumatic Diseases 2012, 71, 1374-1381.
• Hobbs N, Godfrey A, Mathers J, Rochester L, McDonald S, Araujo-Soares V, White M, Sniehotta F. A meta-analysis of physical activity interventions in the 'retirement window'. In: “Resiliance and Health” : 26th Conference of the European Health Psychology Society. 2012, Prague, Czech Republic: Routledge.
• Horvath R, Holinski Feder E, Neeve VC, Pyle A, Griffin H, Ashok D, Foley C, Hudson G, Rautenstrauss B, Nürnberg G, Nürnberg P, Kortler J, Neitzel B, Bäßmann I, Rahman T, Keavney B, Loughlin J, Hambleton S, Schoser B, Lochmüller H, Santibanez Koref M, Chinnery PF. A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy. Movement Disorders 2012, 76(6), 789-793.
• Nakjang S, Ndeh DA, Wipat A, Bolam DN, Hirt RP. A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes. PLoS One 2012, 7(1), e30287.
• Hyslop L, Prathalingam N, Nowak L, Fenwick J, Harbottle S, Byerley S, Rhodes J, Watson B, Henderson R, Murdoch A, Herbert M. A Novel Isolator-Based System Promotes Viability of Human Embryos during Laboratory Processing. PLoS ONE 2012, 7(2), e31010.
• Tudhope SJ, Wang CC, Petrie JL, Potts L, Malcomson F, Kieswich J, Yaqoob MM, Arden C, Hampson LJ, Agius L. A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5. Diabetes 2012, 61(1), 49-60.
• Craig K, Young MJ, Blakely EL, Longley MJ, Turnbull DM, Copeland WC, Taylor RW. A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase gamma subunits. Mitochondrion 2012, 12(2), 313-319.
• Yarham JW, McFarland R, Taylor RW, Elson JL. A proposed consensus panel of organisms for determining evolutionary conservation of mt-tRNA point mutations. Mitochondrion 2012, 12(5), 533-538.
• Yarham JW, Elson JL, Taylor RW, McFarland R. A proposed consensus panel of organisms for determining evolutionary conservation of mt-tRNA point mutations. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
• Atkinson SP, Collin J, Irina N, Anyfantis G, Kyung BK, Lako M, Armstrong L. A Putative Role for the Immunoproteasome in the Maintenance of Pluripotency in Human Embryonic Stem Cells. Stem Cells 2012, 30(7), 1373-1384.
• Banks AP, Lawless C, Lydall DA. A Quantitative Fitness Analysis Workflow. Journal of Visualised Experiments 2012, 66, e4018.
• Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. A senescent cell bystander effect: senescence-induced senescence. Aging Cell 2012, 11(2), 345-349.
• Lawless C, Jurk D, Gillespie CS, Shanley D, Saretzki G, von Zglinicki T, Passos JF. A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations. PLoS One 2012, 7(2), e32117.
• McAuley MT, Wilkinson DJ, Jones JJL, Kirkwood TBL. A whole body mathematical model of cholesterol metabolism and its age associated dysregulation. BMC Systems Biology 2012, 6(1), 130.
• Pitceathly RDS, Smith C, Fratter C, Alston CL, He LP, Craig K, Blakely EL, Evans JC, Taylor J, Shabbir Z, Deschauer M, Pohl U, Roberts ME, Jackson MC, Halfpenny CA, Turnpenny PD, Lunt PW, Hanna MG, Schaefer AM, McFarland R, Horvath R, Chinnery PF, Turnbull DM, Poulton J, Taylor RW, Gorman GS. Adults with RRM2B-related mitochondrial disease have distinct clinical and molecular characteristics. Brain 2012, 135(11), 3392-3403.
• Wang H, Young DA, Cawston TE. Age-related knee joint cartilage changes in mice. In: Autumn Meeting of the British Society for Matrix Biology (BSMB). 2012, Newcastle upon Tyne, UK: Wiley-Blackwell Publishing Ltd.
• Proctor CJ, Pienaar IS, Elson JL, Kirkwood TBL. Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: A stochastic modelling approach. Molecular Neurodegeneration 2012, 7(1), 32.
• Pearson MJ, Khazaipoul S, Optun A, Pryme IF, Stern B, Hesketh JE. Albumin 3'untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells. Biotechnology Journal 2012, 7(11), 1405-1411.
• Ratnayake M, Reynard LN, Raine EVA, Santibanez-Koref M, Loughlin J. Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3. BMC Medical Genetics 2012, 13(1), 12.
• Bell MJ, Gillespie CS, Swan D, Lord P. An approach to describing and analysing bulk annotation quality: a case study using UniprotKB. Bioinformatics 2012, 28(18), i562-i568.
• Kofler BM, Miles EA, Curtis P, Armah CK, Tricon S, Grew J, Napper FL, Farrell L, Lietz G, Packard CJ, Caslake MJ, Mathers JC, Williams CM, Calder PC, Minihane AM. Apolipoprotein E genotype and the cardiovascular disease risk phenotype: Impact of sex and adiposity (the FINGEN study). Atherosclerosis 2012, 221(2), 467-470.
• Rodriguez-Fontenla C, Carr A, Gomez-Reino JJ, Tsezou A, Loughlin J, Gonzalez A. Association of a BMP5 microsatellite with knee osteoarthritis: case-control study. Arthritis Research & Therapy 2012, 14(6), R257.
• Houseman M, Potter C, Marshall N, Lakey R, Cawston T, Griffiths I, Young-Min S, Isaacs JD. Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Arthritis Research & Therapy 2012, 14(1), R30.
• Baggaley AW, Sarson GR, Shukurov A, Boys RJ, Golightly A. Bayesian inference for a wave-front model of the neolithization of Europe. Physical Review E 2012, 86(1), 016105.
• Gillespie CS, Golightly A. Bayesian inference for the chemical master equation using approximate models. In: 9th International Workshop on Computational Systems Biology (WCSB). 2012, Ulm, Germany.
• Weile J, James K, Hallinan J, Cockell SJ, Lord P, Wipat A, Wilkinson DJ. Bayesian integration of networks without gold standards. Bioinformatics 2012, 28(11), 1495-1500.
• Barron E, Lara J, White M, Mathers J. Blood-borne biomarkers of mortality: A systematic literature review of prospective cohort studies. In: 8th World Congress on Aging and Physical Activity: A Celebration of Diversity and Inclusion in Active Ageing. 2012, Glasgow, UK: Human Kinetics.
• Hallinan JS, Park S, Wipat A. Bridging the Gap Between Design and Reality: A Dual Evolutionary Strategy for the Design of Synthetic Genetic Circuits. In: BioInformatics: International Conference on Bioinformatics Models, Methods and Algorithms. 2012, Algarve, Portugal: ScitePress.
• Hanson PS, Blain PG, Mulligan J, Morris CM. Brominated flame retardants - Neurotoxic to humans?. In: Health Protection. 2012, University of Warwick.
• Staley H, Bradburn DM, Mathers JC. Buccal cells as a potential surrogate for DNA methylation biomarker to identify those at increased colorectal cancer risk. In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
• Staley H, Bradburn DM, Mathers JC. Buccal cells as a potential surrogate for DNA methylation biomarker to identify those at increased colorectal cancer risk. In: International Surgical Congress of the Association of Surgeons of Great Britain and Ireland (ASGBI). 2012, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
• Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB Journal 2012, 26(7), 3000-3011.
• Collerton J, Yousaf F, Kingston A, Kenny A, Davies K, Robinson L, Kirkwood T, Keavney B. Cardiac dysfunction among the community dwelling very old. In: GSA 65th Annual Scientific Meeting. 2012, San Diego, California, USA: Oxford University Press.
• Bates MGD, Bourke JP, Giordano C, d'Amati G, Turnbull DM, Taylor RW. Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management. European Heart Journal 2012, 33(24), 3023-3033.
• Hollingsworth KG, Gorman GS, Trenell MI, McFarland R, Taylor RW, Turnbull DM, Macgowan GA, Blamire AM, Chinnery PF. Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load. Neuromuscular Disorders 2012, 22(7), 592-596.
• Wang H, Young DA, Cawston TE. Cartilage degradation, expression of mmp-13 and oxidation markers increase with age in the knee joints of aged mice. In: World Congress on Osteoarthritis. 2012, Barcelona, Spain: Elsevier Ltd.
• Lax NZ, Hepplewhite PD, Reeve AK, Nesbitt V, McFarland R, Jaros E, Taylor RW, Turnbull DM. Cerebellar Ataxia in Patients With Mitochondrial DNA Disease: A Molecular Clinicopathological Study. Journal of Neuropathology and Experimental Neurology 2012, 71(2), 148-161.
• Ratnaike TE, Murphy J, Krishnan KJ, Taylor RW, Turnbull DM. Changes in mitochondrial function over time and with exercise in patients with mitochondrial disease. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
• van der Walt EM, Smuts I, Taylor RW, Elson JL, Turnbull DM, Louw R, van der Westhuizen FH. Characterization of mtDNA variation in a cohort of South African paediatric patients with mitochondrial disease. European Journal of Human Genetics 2012, 20, 650-656.
• Middleton FK, Chen T, Pollard JR, Curtin NJ. Chemosensitisation By, and Single Agent Activity of, ATR Inhibitor VE-821 in Human Breast Cancer Cells. In: 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2012, Dublin, Ireland: Pergamon.
• Munck JM, Batey MA, Zhao Y, Jenkins H, Richardson C, Cano C, Tavecchio M, Barbeau J, Bardos J, Cornell L, Griffin RJ, Menear KA, Slade A, Thommes P, Martin NMB, Newell DR, Smith GCM, Curtin NJ. Chemosensitisation of cancer cells by KU-0060648; a dual inhibitor of DNA-PK and PI-3K. Molecular Cancer Therapeutics 2012, 11(8), 1789-1798.
• Pearce MS, Mann KD, Martin-Ruiz C, Parker L, White M, von Zglinicki T, Adams J. Childhood Growth, IQ and Education as Predictors of White Blood Cell Telomere Length at Age 49-51 Years: The Newcastle Thousand Families Study. PLoS One 2012, 7(7), e40116.
• Maddison J, Straub V, Lochmuller H, Turnbull D, Chinnery P, Trennell M, McFarland R, Gorman G, Horvath R, Busbhy K. Clinical research activity in Newcastle MRC centre. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
• Mukhopadhyay A, Plummer ER, Elattar A, Soohoo S, Uzir B, Quinn JE, McCluggage WG, Maxwell P, Aneke H, Curtin NJ, Edmondson RJ. Clinicopathological Features of Homologous Recombination-Deficient Epithelial Ovarian Cancers: Sensitivity to PARP Inhibitors, Platinum, and Survival. Cancer Research 2012, 72(22), 5675-5682.
• Campbell GR, Kraytsberg Y, Krishnan KJ, Ohno N, Ziabreva I, Reeve A, Trapp BD, Newcombe J, Reynolds R, Lassmann H, Khrapko K, Turnbull DM, Mahad DJ. Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis. Acta Neuropathologica 2012, 124(2), 209-220.
• Hughes DJ, Jenab M, Meplan C, Schomburg L, Prehn J, Hesketh JE. Colorectal Cancer Risk - the Influence of Selenoprotein Gene Variants and Blood Selenium Status. In: 22nd Biennial Congress of the European Association for Cancer Research. 2012, Barcelona, Spain: Pergamon.
• Agius L. Comment on: Stefanovski et al. Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics. Diabetes Care 2012;35: 1015-1020. Diabetes Care 2012, 35(12), E90-E90.
• Kirkwood TBL. Commentary: Ageing-what's all the noise about? Developments after Gartner. International Journal of Epidemiology 2012, 41(2), 351-352.
• Greaves LC, Elson JL, Nooteboom M, Grady JP, Taylor GA, Taylor RW, Mathers JC, Kirkwood TBL, Turnbull DM. Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations. PLoS Genetics 2012, 8(11), e1003082.
• Bates MGD, Hollingsworth KG, Newman J, Jakovljevic DG, Keavney BD, Blamire AM, MacGowan GA, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. In: Annual Conference of the British Cardiovascular Society (BCS). 2012, Manchester, UK: BMJ Group.
• Bates M, Hollingsworth K, Taylor R, Turnbull D, Trenell MI, Gorman G. Concentric remodeling and increased myocardial torsion in mitochondrial DNA point mutation carriers. In: 61st Annual Scientific Session and Expo of the American College of Cardiology (ACC). 2012, Chicago, Illinois, USA: Elsevier Inc.
• Khaziapoul S, Pearson MJ, Pryme IF, Stern B, Hesketh JE. CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region. Biochemical and Biophysical Research Communications 2012, 426(4), 539-543.
• Murphy JL, Ratnaike TE, Shang ES, Falkous G, Blakely EL, Alston CL, Taivassalo T, Haller RG, Taylor RW, Turnbull DM. Cytochrome c oxidase-intermediate fibres: Importance in understanding the pathogenesis and treatment of mitochondrial myopathy. Neuromuscular Disorders 2012, 22(8), 690-698.
• Hallinan JS. Data mining for microbiologists. In: Harwood, C., Wipat, A, ed. Systems Biology of Bacteria. London: Academic Press, 2012, pp.27-79.
• Collison M, Hirt RP, Wipat A, Nakjang S, Sanseau P, Brown JR. Data mining the human gut microbiota for therapeutic targets. Briefings in Bioinformatics 2012, 13(6), 751-768.
• Cerbinskaite A, Mukhopadhyay A, Plummer ER, Curtin NJ, Edmondson RJ. Defective homologous recombination in human cancers. Cancer Treatment Reviews 2012, 38(2), 89-100.
• Rowan SL, Rygiel K, Purves-Smith FM, Solbak NM, Turnbull DM, Hepple RT. Denervation Causes Fiber Atrophy and Myosin Heavy Chain Co-Expression in Senescent Skeletal Muscle. PLoS One 2012, 7(1), e29082.
• Siler U, Jiang Y, Cowley SA, Melguzo D, Tilgner K, Browne C, deWilton A, Pryzborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L. Derivation and functional analysis of patient specific induced pluripotent stem cells (IPSCS) as an in vitro model of chronic granulomatous disease. In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
• Siler U, Jiang Y, Cowley SA, Melguzo D, Tilgner K, Browne C, Dewilton A, Pryzborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L. Derivation and Functional Analysis of Patient Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease. In: 15th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT). 2012, Philadelphia, Pennsylvania, USA: Nature Publishing Group.
• Yu-Wai-Man P, Gorman GS, Taylor RW, Turnbull DM. Diagnostic investigations of patients with chronic progressive external ophthalmoplegia. British Journal of Ophthalmology 2012, 96(12), 1536-1536.
• Gong G, Meplan C, Gautrey H, Hall J, Hesketh JE. Differential effects of selenium and knock-down of glutathione peroxidases on TNF alpha and flagellin inflammatory responses in gut epithelial cells. Genes & Nutrition 2012, 7(2), 167-178.
• Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nature Reviews Cancer 2012, 12(12), 801-817.
• Cornell L, Munck J, Curtin N, Reeves H. DNA-PK or ATM inhibition inhibits non-homologous end joining and enhances chemo- and radio sensitivity in hepatocellular cancer cell lines. In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
• Krishnan KJ, Nelson G, Romero NB, Ratnaike T, Blakely EL, Ziyadeh-Isleem A, Miller J, Murphy JL, Horvath R, Lochmuller H, Flanigan K, Turnbull DM, Guicheney P, Bitoun M, Taylor RW. DNM2 mutations cause multiple mtDNA deletions in muscle: A novel disorder of mtDNA maintenance. In: 17th International Congress of the World Muscle Society (WMS). 2012, Perth, Australia: Elsevier Ltd.
• Burn J, Mathers JC, Bishop DT. Does aspirin really reduce the risk of colon cancer? Reply. Lancet 2012, 379(9826), 1587-1587.
• Zaini R, Brandt K, Clench MR, LeMaitre CL. Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells. Anti-Cancer Agents in Medicinal Chemistry 2012, 12(6), 640-652.
• Curtis P, Adamson A, Mathers J. Effects on nutrient intake of a family-based intervention to promote increased consumption of low-fat starchy foods through education, cooking skills and personalised goal setting: the Family Food and Health Project. British Journal of Nutrition 2012, 107(12), 1833-1844.
• Mellough CB, Sernagor E, Moreno-Gimeno I, Steel DH, Lako M. Efficient Stage-Specific Differentiation of Human Pluripotent Stem Cells Toward Retinal Photoreceptor Cells. Stem Cells 2012, 30(4), 673-686.
• Bosomworth HJ, Thornton JK, Coneyworth LJ, Ford D, Valentine RA. Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis. Metallomics 2012, 4(8), 771-779.
• Choudhary M, Nesbitt M, Burgess L, Hyslop L, Herbert M, Murdoch A. Egg Sharing for Research: A Successful Outcome for Patients and Researchers. Cell Stem Cell 2012, 10(3), 239-240.
• Thathia SH, Ferguson S, Gautrey HE, van Otterdijk SD, Hili M, Rand V, Moorman AV, Meyer S, Brown R, Strathdee G. Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity. Haematologica 2012, 97(3), 371-378.
• Barter MJ, Bui C, Young DA. Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthritis and Cartilage 2012, 20(5), 339-349.
• Bates MG, Hollingsworth KG, Newman J, Jakovljevic D, Dixon BJ, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Evidence of early cardiac impairment in m.3243A > G mutation carriers. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
• Rashidi A, Kirkwood TBL, Shanley DP. Evolution of Asymmetric Damage Segregation: A Modelling Approach. In: Breitenbach, M., Jazwinski, S.M. Laun, P, ed. Aging Research in Yeast. Berlin; New York: Springer, 2012, pp.315-330.
• Vormoor B, Wilkinson S, Harvey F, Plummer R, Curtin N. Ewing's Sarcoma Cells Can Be Sensitized to Temozolomide and to a Lesser Extent to Radiotherapy by Co-treatment with a PARP-inhibitor (AG014699). In: 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2012, Dublin, Ireland: Pergamon.
• Piceathly RDS, Smith C, Fratter C, Blakely EL, Alston CL, Deschauer M, Horvath R, Hanna MG, Chinnery PF, Turnbull DM, Poulton J, Taylor RW, Gorman GS. Expanding the phenotypic and genotypic spectrum of adult RRM2B-related mitochondrial disease. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
• Elson JL, Howell C, Howell N. Failure of a Molecular Clock Model for Sequence Evolution in Superhaplogroup HV mtDNAs. Ramifications for Age Estimation. Molecular Biology and Evolution 2012. In Preparation.
• Jones D, Stephens S, Yates L, Dunstan H, Richardson JL, Greenall A, Thomas SHL. Fetal Outcomes Following Dosulepin Overdose in Pregnancy. In: International Congress of the European Association of Poisons Centres and Clinical Toxicologists. 2012, London, UK: Informa Healthcare.
• Jones D, Stephens S, Yates L, Dunstan H, Richardson JL, Greenall A, Thomas SHL. Fetal Outcomes Following Fentanyl Exposure in Pregnancy. In: International Congress of the European Association of Poisons Centres and Clinical Toxicologists. 2012, London, UK: Informa Healthcare.
• Collerton J, Martin-Ruiz C, Davies K, Catt M, Jagger C, von Zglinicki T, Kirkwood T. Frailty and biomarkers of inflammation, immunoscience and cellular ageing in the Newcastle 85+ Study. In: GSA 65th Annual Scientific Meeting. 2012, San Diego, California, USA: Oxford University Press.
• Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, Parker C, Dunn M, Catt M, Jagger C, von Zglinicki T, Kirkwood TB. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study. Mechanisms of Ageing and Development 2012, 133(6), 456-466.
• Gorowiec MR, Borthwick LA, Parker SM, Kirby JA, Saretzki GC, Fisher AJ. Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta 1-dependent mechanism. Free Radical Biology & Medicine 2012, 52(6), 1024-1032.
• Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L. Fructose 2,6-bisphosphate is essential for glucose-regulated genetranscription of glucose-6-phosphatase and other ChREBP target genes inhepatocytes. Biochemical Journal 2012, 443(1), 111-123.
• Tavecchio M, Munck JM, Cano C, Newell DR, Curtin NJ. Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination. Cancer Chemotherapy and Pharmacology 2012, 69(1), 155-164.
• Jagger C, Bond J, Robinson L, Kingston A, Collerton J, Davies K, von Zglinicki T, Kirkwood T. Gender differences in the association between self-rated health and mortality: Results from the Newcatle 85+ Study. In: GSA 65th Annual Scientific Meeting. 2012, San Diego, California, USA: Oxford University Press.
• Raine EVA, Wreglesworth N, Dodd AW, Reynard LN, Loughlin J. Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22. Annals of the Rheumatic Diseases 2012, 71(12), 2020-2027.
• McKay JA, Groom A, Potter C, Coneyworth LJ, Ford D, Mathers JC, Relton CL. Genetic and Non-Genetic Influences during Pregnancy on Infant Global and Site Specific DNA Methylation: Role for Folate Gene Variants and Vitamin B₁₂. PLoS One 2012, 7(3), e33290.
• Reynard LN, Loughlin J. Genetics and epigenetics of osteoarthritis. Maturitas 2012, 71(3), 200–204.
• Pearce MS, McConnell JC, Potter C, Barrett LM, Parker L, Mathers JC, Relton CL. Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles. International Journal of Epidemiology 2012, 41(1), 210-217.
• Kurzawa-Akanbi M, Hanson PS, Blain PG, Lett DJ, McKeith IG, Chinnery PF, Morris CM. Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease. Journal of Neurochemistry 2012, 123(2), 298-309.
• Cole-Ezea P, Swan D, Shanley D, Hesketh J. Glutathione Peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells. Free Radical Biology and Medicine 2012, 53(3), 488-497.
• Willmore E, Rodrigues N, Allinson L, Summerfield GP, Wallis J, Lowe C, Curtin N. High Activity of Poly(ADP-Ribose) Polymerase in Chronic Lymphocytic Leukemia. In: 54th Annual Meeting and Exposition of the American Society of Hematology (ASH). 2012, Atlanta, Georgia, USA: American Society of Hematology.
• Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I. High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction. PLoS one 2012, 7(10), e47155.
• Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hofman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonsson H, Kerkhof HJM, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EVA, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai GJ, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O'Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JPA, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JBJ, Chapman K, Deloukas P, Ollier WER, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Wilkinson JM, Ralston SH, Valdes AM, Spector TD, Loughlin J. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012, 380(9844), 815-823.
• Coneyworth LJ, Jackson KA, Tyson J, Bosomworth HJ, vanderHagen E, Hann GM, Ogo OA, Swann DC, Mathers JC, Valentine RA, Ford D. Identification of the human ZTRE (zinc transcriptional regulatory element) - a palindromic protein-binding DNA sequence responsible for zinc-induced transcriptional repression. Journal of Biological Chemistry 2012, 287, 36567-36581.
• Xu Y, Barter MJ, Swan DC, Rankin KS, Rowan AD, Santibanez-Koref M, Loughlin J, Young DA. Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA. Osteoarthritis and Cartilage 2012, 20(9), 1029-1038.
• Newman J, Jakovljevic D, Bates MG, Turnbull DM, Galna B, Trenell MI, Gorman GS. Improving clinical trials evaluation: physiological and functional correlates in mitochondrial disease. In: United Kingdom Neuromuscular Translational Research Conference. 2012, Newcastle upon Tyne, UK: Elsevier Ltd.
• Bos SD, Bovée JV, Duijnisveld BJ, Raine EV, van Dalen WJ, Ramos YF, van der Breggen R, Nelissen RG, Slagboom PE, Loughlin J, Meulenbelt I. Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Annals of the Rheumatic Diseases 2012, 71(7), 1254-1258.
• Baggaley AW, Boys RJ, Golightly A, Sarson GR, Shukurov A. Inference for population dynamics in the Neolithic period. Annals of Applied Statistics 2012, 6(4), 1352-1376.
• Penn L, White M, Lindstrom J, den-Boer ATh, Blaak EE, Ericksson JG, Feskens E, Illanne-Parikka P, Keinanen-Kiukaanniemi SM, Walker M, Mathers JC, Uusitupa M, Tuomilehto J. Intensive lifestyle interventon for prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention Study, a pooled analysis of three randomised controlled trials from Finland, The Netherlands and the UK. In: 7th World Congress on Prevention of Diabetes and its Complications. 2012, Madrid, Spain: Edizioni Minerva Medica.
• Radwan MA, Gabrielides C, Rowan AD, Robinson JH, Cawston TE, Young DA. Involvement of pattern recognition receptors in poly(I:C)-mediated MMP-13 expression. In: Autumn Meeting of the British Society for Matrix Biology (BSMB). 2012, Newcastle upon Tyne, UK: Wiley-Blackwell Publishing Ltd.
• James K, Wipat A, Hallinan J. Is newer better?-evaluating the effects of data curation on integrated analyses in Saccharomyces cerevisiae. Integrative Biology 2012, 4(7), 715-727.
• Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD, Young DA. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Annals of the Rheumatic Diseases 2012, 71(3), 455-462.
• Williamson C, Blackwood JK, Greaves L, Wilson L, Pickard RS, Lako M, Robson CN, Turnbull DM, Taylor RW, Heer R. Lineage tracking in situ: Where are the prostate stem cells? What are they doing?. In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
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