Colloquia and Seminars

Computing Science - Colloquia and Seminars

Pay-as-you-go Data Integration: war stories and recurring themes

Location: CLT 701 Date/Time: 31st March 2015, 14:00 - 15:00
Speaker(s): Norman Paton (Computer Science, Manchester University) .

Brief Description:Data integration typically seeks to provide the illusion that data from multiple distributed sources comes from a single, well managed source. Providing this illusion in practice tends to involve the design of a global schema that captures the user's data requirements, followed by manual (with tool support) construction of mappings from sources to the global schema. This overall approach can provide high quality integrations but at high cost, and tends to be unsuitable for areas with large numbers of rapidly changing sources, where users may be willing to cope with a less than perfect integration. Pay-as-you-go data integration has been proposed to overcome the need for costly manual data integration. Pay-as-you-go data integration tends to involve two steps. Initialisation: automatic creation of mappings generally of poor quality) between sources. Improvement: the obtaining of feedback on some aspect of the integration, and the application of this feedback to revise the integration. In this seminar, we review some experiences with pay-as-you-go data integration, with a view to understanding what works well (or not), and identifying recurring themes.

Composomics: Non-RNA Scenario for Life’s Early Evolution

Location: Seminar Room, Baddiley-Clark Building Date/Time: 9th April 2015, 14:00 - 15:00
Speaker(s): Prof. Doron Lancet.

Brief Description:Life's origin is about how sufficient chemical complexity emerged on early earth to afford replication. The graded autocatalysis replication domain (GARD) model (1), in the realm of the lipid world scenario (2), offers a novel route for these events, presumed to have taken place much before the advent of complex biopolymers, such as RNA. In this framework, non-covalent assemblies of diverse amphiphiles, e.g. multi-component lipid micelles or vesicles, can acquire adequate endogenous complexity and harbor considerable inter-assembly variation....

Rational Confederation of Genes and Diseases

Location: Seminar Room, Baddiley-Clark Building Date/Time: 10th April 2015, 11:00 - 12:00
Speaker(s): Prof. Doron Lancet.

Brief Description:Human diseases are disposed at the heart of extensive research that encompasses genomics, bioinformatics, systems biology and systems medicine. Some of the challenges facing disease bioinformatics are disease nomenclature, standard symbols (as for genes), and integration of information from diverse sources. A most important issue to be tackled is generating a global view of gene- disease relationships. This is relatively straightforward for the monogenic diseases, natural human knockouts that constitute a rich source of biological insight....

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