Background

Achim is an international biochemist with over 20 years experience in analytical chemistry and its applications for investigating the structure and function of biomolecules. Since 2011, he is the head of NUPPA, the Newcastle University Protein and Proteome Analysis Facility.

Specialties:Proteomics, mass spectrometry, post-translational modifications, NMR, membrane biochemistry.
Advanced software and bioinformatics skills.
Ability to identify commercial potential of research work.
Excellent public speaker and teacher.

Publications

• Collins DC, Cocchiglia S, Tibbitts P, Solon G, Bane FT, McBryan J, Treumann A, Eustace A, Hennessy B, Hill AD, Young LS. Growth factor receptor/steroid receptor cross talk in trastuzumab-treated breast cancer. Oncogene 2014, 1-6.
• Miwa S, Jow H, Baty K, Johnson A, Czapiewski R, Saretzki G, Treumann A, von Zglinicki T. Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice. Nature Communications 2014, 5, 3837.
• Radziwon-Balicka A, Santos-Martinez MJ, Corbalan JJ, O'Sullivan S, Treumann A, Gilmer JF, Radomski MW, Medina C. Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway. Carcinogenesis 2014, 35(2), 324-332.
• Thiede B, Koehler CJ, Strozynski M, Treumann A, Stein R, Zimny-Arndt U, Schmid M, Jungblut PR. High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture(SILAC), two-dimensional gel electrophoresis(2DE) and nano-liquid chromatograpohy coupled to an LTQ-OrbitrapMass spectrometer. Molecular and Cellular Proteomics 2013, 12(2), 529-538.
• Chen A, Karolczak-Bayatti M, Sweeney M, Treumann A, Morrissey K, Ulrich SM, Europe-Finner GN, Taggart MJ. Lysine deacetylase inhibition promotes relaxation of arterial tone and C-terminal acetylation of HSPB6 (Hsp20) in vascular smooth muscle cells. Physiological Reports 2013, 1(6), e00127.
• Koehler CJ, Arntzen MO, Treumann A, Thiede B. A Rapid Approach for Isobaric Peptide Termini Labeling. In: Marcus, Katrin, ed. Quantitative Methods in Proteomics. Bochum, Germany: Humana Press, 2012, pp.129-141.
• Koehler CJ, Arntzen MØ, Treumann A, Thiede B. Comparison of data analysis parameters and MS/MS fragmentation techniques for quantitative proteome analysis using isobaric peptide termini labeling (IPTL). Analytical and Bioanayltical Chemistry 2012, 404(4), 1103-1114.
• Miwa S, Jow H, Treumann A, von Zglinicki T. Low abundance of the matrix arm of complex I of mice liver mitochondria predicts longevity. In: 17th European Bioenergetics Conference. 2012, Freiburg, Germany: Elsevier BV.
• Radziwon-Balicka A, Medina C, O'Driscoll L, Treumann A, Bazou D, Inkielewicz-Stepniak I, Radomski A, Jow H, Radomski MW. Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance. British Journal of Pharmacology 2012, 167(4), 787-804.
• Heverin M, Brennan GP, Koehler CJ, Treumann A, Henshall DC. Proteomic analysis of 14-3-3 zeta binding proteins in the mouse hippocampus. International Journal of Physiology, Pathophysiology and Pharmacology 2012, 4(2), 74-83.
• Lai VK, Linares-Palomino J, Treumann A, Saeed M, Nadal-Ginard B, Galiñanes M. The effect of diabetes and poor left ventricular function on bone marrow cell-induced myocardial protection. Journal of Surgical Research 2012, 174(1), e1-e10.
• Eeltink S, Wouters B, Desmet G, Ursem M, Blinco D, Kemp GD, Treumann A. High-resolution separations of protein isoforms with liquid chromatography time-of-flight mass spectrometry using polymer monolithic capillary columns. Journal of Chromatography A 2011, 1218(32), 5504-5511.
• Koehler CJ, Arntzen MØ, Strozynski M, Treumann A, Thiede B. Isobaric peptide termini labeling utilizing site-specific N-terminal succinylation. Analytical Chemistry 2011, 83(12), 4775-4781.
• Arntzen MØ, Koehler CJ, Barsnes H, Berven FS, Treumann A, Thiede B. IsobariQ: software for isobaric quantitative proteomics using IPTL, iTRAQ, and TMT. Journal of Proteome Research 2011, 10(2), 913-920.
• Flavin P, Redmond A, McBryan J, Cocchiglia S, Tibbitts P, Fahy-Browne P, Kay E, Treumann A, Perrem K, McIlroy M, Hill AD, Young LS. RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer. FEBS Letters 2011, 585(15), 2537-2544.
• Lynch CM, O'Kelly R, Stuart B, Treumann A, Conroy R, Regan CL. The role of thromboxane A₂ in the pathogenesis of intrauterine growth restriction associated with maternal smoking in pregnancy. Prostaglandins & Other Lipid Mediators 2011, 95(1-4), 63-67.
• Turnbull WB, Shimizu K, Chatterjee D, Homans SW, Treumann A. Identification of the 5-Methylthiopentosyl Substituent in Mycobacterium tuberculosis Lipoarabinomannan. Angewandte Chemie: International Edition 2004, 43(30), 3918-3922.
• Treumann A, Feng XD, McDonnell L, Derrick PJ, Ashcroft AE, Chatterjee D, Homans SW. 5-methylthiopentose: a new substituent on lipoarabinomannan in Mycobacterium tuberculosis. Journal of Molecular Biology 2002, 316(1), 89-100.
• Prins A, Mukubi JM, Pellny TK, Verrier PJ, Beyene G, Lopes MS, Emami K, Treumann A, Lelarge-Trouverie C, Noctor G, Kunert KJ, Kerchev P, Foyer CH. Acclimation to high CO2 in maize is related to water status and dependent on leaf rank. Plant, Cell and Environment 2011, 34(2), 314-331.
• Vivancos PD, Driscoll SP, Bulman CA, Ying L, Emami K, Treumann A, Mauve C, Noctor G, Foyer CH. Perturbations of amino acid metabolism associated with glyphosate-dependent inhibition of shikimic acid metabolism affect cellular redox homeostasis and alter the abundance of proteins involved in photosynthesis and photorespiration. Plant Physiology 2011, 157(1), 256-268.
• Treumann A, Thiede B. Isobaric protein and peptide quantification: Perspectives and issues. Expert Review of Proteomics 2010, 7(5), 647-653.
• Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, Hewitt P, Schmitt M, Uteng M, Kustermann S, STEEL D, Nicholds M, Thomas R, Treumann A, Porter A, Sernagor E, Armstrong L, Lako M. Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency. Stem Cells 2018, 36(10), 1501-1513.
• Armstrong MC, Sestak S, Ali AA, Sagini HAM, Brown M, Baty K, Treumann A, Schroder M. Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1. Molecular and Cellular Biology 2017, 37(16), e00655-16.
• Treumann A, Palmowski P, Tong WC, Taggart J, Mortice N, Europe-Finner GN, Taggart MJ. Depletion of Myofibril-Associated Proteins Using Selective Protein Extraction as a Tool in Cardiac Proteomics. In: Minnie M. Sarwal, Tara K. Sigdel, ed. Tissue Proteomics: Methods and Protocols. New York: Humana Press, 2017, pp.1-9.
• McClurg UL, Cork DMW, Darby S, Ryan-Munden CA, Nakjang S, Mendes-Cortes L, Treumann A, Gaughan L, Robson CN. Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity. Nucleic Acids Research 2017, 45(4), 1793-1804.
• Miwa S, Treumann A, Bell A, Vistoli G, Nelson G, Hay S, von Zglinicki T. Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H₂O₂ release assays. Free Radical Biology and Medicine 2016, 90, 173-183.
• Golla K, Treumann A, Shields D, Moran N. Discovery of Cadherin-5 Protein in Human Platelets. In: RAMI Section of Biomedical Sciences Annual Meetings. 2016, Springer UK.
• Finetti MA, Del Carpio-Pons A, Wong JP, Batting S, Barker J, Wood J, Nakjang S, Crosier S, Smith A, Selby MP, Ramli RA, Grabovska Y, Treumann A, Huang PH, Bailey S, Clifford SC, Williamson D. Integrated pathway analysis of rhabdoid tumor subtypes identifies key SMARCB1-dependencies and therapeutic opportunities. In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO). 2016, Liverpool: Oxford University Press.
• Stewart CJ, Nelson A, Treumann A, Skeath T, Cummings SP, Embleton ND, Berrington JE. Metabolomic and proteomic analysis of serum from preterm infants with necrotising entercolitis and late-onset sepsis. Pediatric Research 2016, 79(3), 425-431.
• Raorane ML, Pabuayon IM, Varadarajan AR, Mutte SK, Kumar A, Treumann A, Kohli A. Proteomic insights into the role of the large-effect QTL qDTY_12.1 for rice yield under drought. Molecular Breeding 2015, 35(6), 139.