Background

Qualifications

University of Newcastle upon Tyne:
1999 BSc Molecular Biology
2000 MSc Industrial Biotechnology:
2004 PhD: Institute of Cell and Molecular Biosciences, title: “The phosphate stimulon of Bacillus subtilis”

Previous Positions

Research contractor for;
GlaxoSmithKline (GSK)
Immunodiagnostic Systems (IDS) Ltd.

Memberships

Society for General Microbiology (SGM) since 2000
Society for Applied Microbiology (SFAM) since 2001
British society for antimicrobial chemotherapy (BSAC) since 2006

Research

Research Interests

The Actinomycetes, especially the streptomycetes, are fruitful produces of secondary metabolites. Recent studies have shown that the genes encoding antibiotic gene clusters are present in the genomes of these organisms at a much higher rate than predicted by fermentation studies. My work is focused on the search and discovery of antibiotic gene clusters using microarrays, within the streptomyces species.

Publications

• Kepplinger B, Morton S, Seistrup K, Marrs E, Hopkins A, Perry J, Strahl H, Hall M, Errington J, Allenby N. Mode of Action and Heterologous Expression of the Natural Product Antibiotic Vancoresmycin. ACS Chemical Biology 2018, 13(1), 207-214.
• Baksh A, Kepplinger B, Isah H, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ. Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745. Natural Product Research 2017, 31(16), 1895-1900.
• Emami K, Guyet A, Kawai Y, Devi J, Wu LJ, Allenby N, Daniel RA, Errington J. RodA as the missing glycosyltransferase in Bacillus subtilis and antibiotic discovery for the peptidoglycan polymerase pathway. Nature Microbiology 2017, 2, 16253.
• Tyler A, Mosaei H, Morton S, Waddell PG, Wills C, McFarlane W, Gray J, Goodfellow M, Errington J, Allenby N, Zenkin N, Hall MJ. Structural Reassignment and Absolute Stereochemistry of Madurastatin C1 (MBJ-0034) and the Related Aziridine Siderophores: Madurastatins A1, B1 and MBJ-0035. Journal of Natural Products 2017, 80(5), 1558–1562.
• Allenby NEE, Watts CA, Homuth G, Pragai Z, Wipat A, Ward AC, Harwood CR. Phosphate starvation induces the sporulation killing factor of Bacillus subtilis. Journal of Bacteriology 2006, 188(14), 5299-5303.
• Allenby NEE, O'Connor N, Pragai Z, Ward AC, Wipat A, Harwood CR. Genome-wide transcriptional analysis of the phosphate starvation stimulon of Bacillus subtilis. Journal of Bacteriology 2005, 187(23), 8063-8080.
• Allenby NEE, O'Connor N, Pragai Z, Carter NM, Miethke M, Engelmann S, Hecker M, Wipat A, Ward AC, Harwood CR. Post-transcriptional regulation of the Bacillus subtilis pst operon encoding a phosphate-specific ABC transporter. Microbiology 2004, 150(8), 2619-2628.
• Pragai Z, Allenby NEE, O'Connor N, Dubrac S, Rapoport G, Msadek T, Harwood CR. Transcriptional Regulation of the phoPR Operon in Bacillus subtilis. Journal of Bacteriology 2004, 186(4), 1182-1190.