Dr Nicholas Jakubovics
Lecturer

  • Email: nick.jakubovics@ncl.ac.uk
  • Telephone: +44 (0) 191 208 6796
  • Fax: +44 (0) 191 208 6137
  • Address: Oral Biology
    School of Dental Sciences
    Newcastle University
    Newcastle upon Tyne
    NE2 4BW

Introduction

I received a BSc in Biochemistry from the University of Cambridge and a PhD in Microbiology at the University of Warwick. In 1998 I started to apply my experience to the field of Oral Microbiology as a Post-Doctoral researcher in Prof. Howard Jenkinson's group at the Bristol Dental School. I obtained a National Institutes of Health Post-Doctoral Fellowship in 2004 to work in Dr Paul Kolenbrander's lab at the National Institute for Dental and Craniofacial Research in Bethseda, MD, USA. I joined Newcastle Dental School as Lecturer in Oral Microbiology in 2007.

Roles and Responsibilities

I am Stage 1 Director and Senior Tutor for the BDS Programme. I also co-ordinate intercalation within the School of Dental Sciences. Member of Board of Studies and Dental Executive. I participate in administration committees for BDS (Stages 1 and 2) and MRes.

Qualifications

1994 BSc in Biochemistry (Cambridge)
1998 PhD in Microbiology (Warwick)

Previous Positions

1998-2004 Post-Doctoral researcher, Bristol Dental School
2004-2007 Post-Doctoral Fellow, NIDCR, Bethesda, MD, USA

Memberships

Society for Applied Microbiology, member of the Executive Committee (http://www.sfam.org.uk/)
Society for General Microbiology

Research Interests

Molecular mechanisms of adhesion and colonisation by oral streptococci.
Bacterial biofilm formation, and the structure of biofilm matrices.
Interactions and communication between bacteria in mixed-species biofilms.
The formation of biofilms on dental materials.

I have just completed editing a book on Oral Microbial Ecology (http://www.horizonpress.com/oral-ecology)

Current Work

Dental caries and periodontitis (gum disease) are the leading causes of tooth loss in the Western World. Both of these diseases originate from dental plaque, a complex mixture of numerous different bacteria that accumulates on tooth surfaces between cleaning procedures. Detailed molecular studies of bacterial virulence factors require pure cultures of isolated strains, and therefore most of these studies have been conducted on bacteria in monoculture. However, it is becoming clear that bacteria adapt very rapidly to their surroundings and that they alter their make-up upon contact with other bacterial species or with a human host. My research aims to identify changes that occur when one bacterial species interacts with another or with human tissues.

I am also interested in the structure of mixed-species biofilms, and in particular the nature of the extracellular matrix that surrounds bacterial cells and protects them from antimicrobial agents. I am currently collaborating with a team that spans Marine Biotechnology, Chemistry and clinical researchers in a number of different dental and medical disciplines to investigate the potential of novel enzymes to disperse microbial biofilms. This work is focussed on a range of biofilms in the mouth and in the head and neck region as a whole, including biofilms that form on artificial speech valves, in the paranasal sinuses (causing chronic rhinosinusitis) and in the middle ear (causing glue ear).

Biofilm formation on artificial surfaces that are placed in the body is particularly problematic since, unlike our own tissues, the artificial surfaces do not contain protective mechanisms to limit microbial colonisation. Work in my lab is aimed towards understanding how micro-organisms interact with different surfaces such as acrylic materials used for prosthodontics, with a view to providing more effective measures for reducing microbial contamination.

Future Research

Future work will continue to be directed towards understanding the molecular mechanisms of bacterial cell-cell interactions and biofilm formation. The development of new agents for disrupting biofilm matrices is a high priority.

Postgraduate Supervision

Currently (2012-13) 3 PhD students.

Funding

New Lecturer Award, Society for Applied Microbiology - 'The Role of Extracellular DNA in Oral Bacterial Biofilms' (2010) £10,000

Newcastle Healthcare Charities - 'A novel anti-biofilm agent for oral healthcare' (2011) £7,000

Undergraduate Teaching

I am Director of Stage 1 of the BDS programme.

I lead the Orientation course in Stage 1 BDS, and teach on Cell Biology. I also teach on Stage 2 Oral Environment course of BDS.

I supervise undergraduate student laboratory projects from Marine Science and Technology and Biomedical Sciences courses.

Postgraduate Teaching

I teach on the MClinDent course in the School of Dental Sciences, and I regularly supervise MRes students.