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British Science Week Mitochondria debate

As part of British Science Week 2016 Simon Woods contributed to the Mitochondria: exploring the science debate at EXPLORE, on Saturday 12th March in Newcastle city centre. The event was chaired by Dorothy Stainsby, Chair of the EXPLORE board.

EXPLORE is a lively, ambitious programme of talks, workshops and visits and is run by The Joseph Cowen Lifelong Learning Centre, a Community Interest Company with an elected board of directors. 

Alongside Simon, the panel of speakers included members of Newcastle University’s Wellcome Trust Centre for Mitochondrial Research team Felix ChanDr Lindsey Butterworth and Dr Julie Murphy.


CIVI Seminar Series Spring-Summer 2016

Our Spring-Summer Seminar Series 2016 will start on Friday 8th April 2016 and information can be found on our seminar pages

For more information, please contact Sandra Blackwood (sandra.blackwood@ncl.ac.uk).


PhD Studentship in Cellular Medicine - Mitochondrial epigenetics; a molecular link between ageing and age-related disease

Value of award

100% of UK/EU tuition fees paid and annual living expenses of £14,296.  Successful international candidates will be required to make up the difference between the UK/EU fees and international fees.

Number of awards

1

Start date and duration

September 2016 for 3 years.

Application closing date

30 June 2016

Overview

Interested in how the ‘ageing process’ drives the development of age-related diseases? This project will investigate epigenetics mechanisms which may explain the relationship between ageing and age-related diseases.

Ageing is the main risk factor for most non-communicable diseases, including hypertension and cardiovascular disease (CVD). This risk is modified by lifestyle, and notably diet. We hypothesise that changes in mitochondrial epigenetic patterns with ageing contribute to the development of age-related disease and that dietary factors can ameliorate these effects. We will examine mechanisms that underlie ageing and their modulation by specific nutritional factors, and lay the basis for strategies to delay the development of age-related diseases.

The PhD student will develop knowledge of mitochondrial biology, ageing, age-related disease, genomics, epigenomics, nutrition, and the molecular techniques that will be used within the project, such as DNA/RNA extraction, pyrosequencing for analysing locus-specific DNA methylation, transfection using lipofectamine, and commonly used in vitro cell culture techniques. The PhD student will also learn bioinformatics tools for use in analysing the acquired DNA methylation data.

Sponsor

Research Excellence Academy, Faculty of Medical Sciences, Newcastle University

Name of supervisor(s)

Dr H M Byun, Human Nutrition Research Centre, Institute of Cellular Medicine
Professor J C Mathers, Human Nutrition Research Centre, Institute of Cellular Medicine

Eligibility Criteria

You must have, or expect to achieve, at least a 2:1 Honours degree in biomedicine, physiology, microbiology or a related area. A further qualification such as an MSc or MRes is advantageous.

The award is available to UK/EU and international applicants.  If English is not your first language, you must have IELTS 6.5, or equivalent.

How to apply

You must apply through the University’s online postgraduate application system. To do this please ‘Create a new account’.

Only mandatory fields need to be completed. However, you will need to include the following information:

  • insert the programme code 8300F in the programme of study section 
  • select ‘PhD in the Faculty of Medical Sciences – Cellular Medicine' as the programme of study 
  • insert the studentship code 08MREA in the studentship/partnership reference field 
  • attach a covering letter and CV.  The covering letter must state the title of the studentship, quote the studentship reference code 08MREA and state how your interests and experience relate to the project 
  • attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications.

Contact

For further details, please contact:

Dr H M Byun, Human Nutrition Research Centre
Institute of Cellular Medicine
E-mail: hyang-min.byun@ncl.ac.uk


ICM Research Seminar

Speaker 1: Kile Green (Prof M Collin, Dr V Bigley, Dr G Smith)

Speaker 2: Rebecca Brown (Prof J Mathers, Dr L Avery, Dr N O'Brien)

Speaker 3: Dr Pawel Palmowski (Prof N Europe-Finner)

Speaker 1: Kile Green (Prof M Collin, Dr V Bigley, Dr G Smith)

Array-based gene signature generation and gene set reduction in human blood monocyte and dendritic cell subsets;

Gene expression microarray data is typically composed of far more variables than samples. A major issue with this data format is revealed when using the data for the classification of samples or in the prediction of a clinical outcome. The problem of 'small n, large p' may be addressed through gene selection and dimension reduction under the presumption that while there are a large number of genes in the dataset, only a small number of these may actually account for the majority of the sample variation. 

Speaker 2: Rebecca Brown (Prof J Mathers, Dr L Avery, Dr N O'Brien) 

The Impact of Vitamin D and Physical Activity on Older Obese people with Knee Osteoarthritis - a cross sectional study; 

Speaker 3: Dr Pawel Palmowski (Prof N Europe-Finner)

Protein expression changes in heart development.  Mass spectrometry based proteomics analysis of fetal and adult guinea pig ventricular muscle. 

Over the past 10 years we can observe a rapid expansion of proteomics technologies into all branches of biological science. They have a potential to provide an in depth qualitative and quantitative characterisation of a biological system in terms of protein expression, post translational modifications and interactions. In our study we utilise proteomics tools to identify processes and pathways involved in the process of heart development/maturation

Dental Lecture Theatre F

9 March 2016, 13.00 


Faculty Guest Lecture: Curing CML: Hope or Reality?

Speaker: Professor Jane Apperley, Chair of the Department of Haematology, Imperial College London

Speaker: Professor Jane Apperley, Chair of the Department of Haematology, Imperial College London

Herschel Building

23 March 2016, 12.30 p.m. 


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