Newcastle University

Molecular Nutrition Past Projects

• Can increased physical activity reduce bowel cancer risk?
  Project Leader(s): Prof John Mathers, & Dr E. A. Williams (Uni of Sheffield)
  
• The CAPP Studies
  Project Leader(s): Professor John Mathers, Professor John Burn (Biochemistry and Genetics) and Professor Tim Bishop (University of Leeds).
  
• Dietary and genetic factors modulating DNA repair capacity
  Project Leader(s): Prof John Mathers, Prof John Hesketh, Prof Anne Daly, Dr E. A. Williams (Uni of Sheffield)
• Nutrient-gene interactions underlying responses of selenoenzyme gene expression to dietary selenium
  Project Leader(s): Prof John Mathers, Prof John Hesketh
• Can folate deficiency in utero increase the risk of cancer in later life?
  Project Leader(s): Prof John Mathers, & Dr E. A. Williams (Uni of Sheffield)
  
• Developing new biomarkers of colorectal neoplasia: Quantification of aberrant CpG island methylation in human faecal DNA
  Project Leader(s): Professor John Mathers, Dr E.A. Williams (Uni of Sheffield), Prof Ian Johnson (IFR)
  
• Molecular basis of differential intestinal and placental responses to zinc nutrition
  Project Leader(s): Prof John Mathers, Dr. Dianne Ford
• Biochemical and physiological responsiveness to low dose fish-oil intakes: Impact of genotype, gender, age and geography
  Project Leader(s): Prof John Mathers , Dr Georg Lietz, Dr. A. Minnihane (University of Reading)
  
• SNPs as determinants of inter-individual variation in ß-carotene/vitamin A metabolism.
  Project Leader(s): Dr Georg Lietz
• Role of DNA mismatch repair gene MLH1 in modulating effects of butyrate on gut epithelial cells kinetics and gene expression
  Project Leader(s): Professor John Mathers, & Dr E. A. Williams(Uni of Sheffield)
  
• Investigating Novel Diet Related Biomarkers of Colorectal Cancer Risk. (The BORICC study)
  Project Leader(s): Prof. John Mathers
• CISBAN
  Project Leader(s): Tom Kirkwood (PI), Thomas von Zglinicki (PI), David Lydall (PI), Anil Wipat (PI)
• Markers of systemic and mucosal inflammation as biomarkers of vulnerability to colorectal cancer. (BORICC2)
  Project Leader(s): Professor John Mathers
• Development of metabolomics as novel approach to biological indicators which characterise and quantify dietary exposure
  Project Leader(s): Prof John Mathers
• The contribution of genetic factors to inter-individual variability in dietary isoflavone absorption and metabolism
  Project Leader(s): Dr Dianne Ford
• Intracellular trafficking of splice variants of the zinc transporter SLC30A5 in response to zinc
  Project Leader(s): Dr Ruth Valentine
• Characterisation of a novel transcriptional mechanism for the regulation of mammalian gene expression by zinc
  Project Leader(s): Dr Dianne Ford
• DNA Methylation, Developmental Programming and Cellular Memory: The Molecular Consequences of Folate Depletion In Utero
  Project Leader(s): Prof John Mathers, Dr. Dianne Ford
• Heterologous expression of ZnT8 allelic variants associated with increased risk of type 2 diabetes in an insulin-secreting beta cell line model
  Project Leader(s): Dr Ruth Valentine