Reducing the burden of non-insulin dependent diabetes mellitus:

From June 2000 to May 2007
Project Leader(s): Prof John Mathers, Dr Martin White (Epidemiology and Public Health), Professor Sir George Alberti (Royal College of Physicians)

Sponsors: The Wellcome Trust

Overview: Impaired glucose tolerance (IGT), an abnormal response to an oral glucose tolerance test, is a risk factor in the development of Type 2 diabetes. This project is an integral component of a European intervention trial in people with IGT to test the hypothesis that diet and exercise interventions can prevent diabetes.
We will recruit 50 people with IGT and follow them up for 5 years. Half of the subjects will be allocated to a special diet and physical activity intervention group and the rest to a control group which will receive routinely available lifestyle advice. Subjects will be re-screened annually to check for diabetes and to monitor changes in physical activity, diet and obesity. The pooled European results will be analysed on an intention-to-treat basis.

Value: £249,201

Dates of Project: June 2000 - May 2007


Professor John Mathers
Professor of Human Nutrition