From April 2002 to September 2005
Project Leader(s): Prof John Mathers, & Dr E. A. Williams (Uni of Sheffield)
Staff: Kevin Waltham (Research Associate)
Sponsors: World Cancer Research Fund
Overview of project: Epidemiological and animal studies suggest that folic acid reduces the risk of colo-rectal cancer. The very high rate of somatic mutation in utero coupled with comprised folate status may elevate cancer risk at this early stage of life. In order to investigate the relationship between in utero nutritional status and disease outcome later in life would take decades to accomplish in a human trial. A study was designed to test the hypothesis that folate deficiency during embryogenesis increases the risk of colo-rectal cancer later in life. Folic acid supplementation in the offspring reduces the cancer risk posed by folate deficient embryogenesis.
The objectives of the study are:
Professor John Mathers