IAH Special Seminar - Generating rodent models of chronic cerebral hypoperfusion and investigating the pathogenesis of cerebral amyloid angiopathy and vascular cognitive impairment
Location: Great Gable Seminar Room, CARU, Campus for Ageing and Vitality
Time/Date: 8th February 2012, 12:30 - 13:30
You are invited to a special seminar being given by visiting speaker Dr Masafumi Ihara (Associate Prof, Kyoto University) who will be giving a talk entitled: Generating rodent models of chronic cerebral hypoperfusion and investigating the pathogenesis of cerebral amyloid angiopathy and vascular cognitive impairment.
Masafumi is a former research fellow in the IAH and we are very pleased to welcome him back for this seminar.
The seminar will be held on Wednesday 8 February in the Great Gable seminar room of CARU at the Campus for Ageing and Vitality from 12:30 to 13:30, with a sandwich lunch available from 12:00 in the Scafell meeting room.
Abstract:
Vascular cognitive impairment is the second most common type of dementia after Alzheimer’s disease and is frequently responsible for the cognitive decline of the elderly. It is characterized by cerebrovascular white matter changes; thus, in order to investigate the underlying mechanisms involved in white matter changes, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils.
The purpose of this talk is to provide a comprehensive summary of the achievements made with the model that shows good reproducibility of the white matter changes characterized by blood-brain barrier disruption, glial activation, oxidative stress, and oligodendrocyte loss following chronic cerebral hypoperfusion.
Biography:
Dr Masafumi Ihara MD PhD is attending neurologist and a neuroscientist in the Department of Neurology, Kyoto University, Japan. He is also a fellow of the American College of Physicians and the American Academy of Neurology.
His research interests have focussed on the pathological changes in brain blood vessels and how the alterations impact on brain health during old age. Dr Ihara has used brain autopsy materials and experimental rodent models to publish widely on these issues.
Masafumi was a research fellow with the Neurovascular Group at the IAH from Sept 2006 to January 2008.
Published: 3rd February 2012
