IAH Seminar - A stem cell derived model of Alzheimer's Disease

Location: Great Gable Meeting Room, Clinical Ageing Research Unit, Campus for Ageing and Vitality
Time/Date: 18th October 2012, 12:15 - 13:00

You are invited to the IAH research seminar which will take place on Thursday 18 October 2012 in the Great Gable meeting room of the Clinical Ageing Research Unit. The meeting will start at 12.15 and will be followed at approximately 13.00 by a sandwich lunch.

The presentation today will be given by Dr Eric Hill, Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham and the title of his talk will be 'A stem cell derived model of Alzheimer's Disease'

Abstract:

The development of stem cell derived neuronal networks is of great interest in order to generate model systems for drug screening, toxicological testing and disease modelling. As such it is of great importance that these models possess the functional competencies of their in vivo counterparts.

The NT2.D1 cell line is one of the best documented embryocarcinoma cell lines, and can be differentiated into neurons and astrocytes. Great focus has also been placed on defining the electrophysiological properties of these cells, and more recently we have investigated the functional properties of their associated astrocytes.

We now show that these cultures are also metabolically competent and demonstrate the effect of Amyoid Beta 1-42. Using mixed cultures of NT2 derived neurons and astrocytes we have shown that these cells modulate their glucose uptake, glycogen turnover and lactate production in response to aggregated Amyloid beta 1-42.

Dr Eric Hill web profile

Published: 11th September 2012